| Budget Amount *help |
¥161,720,000 (Direct Cost: ¥124,400,000、Indirect Cost: ¥37,320,000)
Fiscal Year 2020: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2019: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2018: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2017: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2016: ¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
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| Outline of Final Research Achievements |
In this study, we conducted a comprehensive detection for the existence of endogenous RNA virus sequences in mammalian genomes and elucidated their functions. First, we constructed a program that predicts unknown endogenous RNA virus sequences by using a machine learning method to determine the sequence characteristics of endogenous RNA viruses. We succeeded in identifying unknown endogenous RNA virus-like sequences in the human genome. We also elucidated the functions of endogenous bornavirus-like sequences in the human and bat genomes and revealed that these sequences have been co-opted by host cells as functional proteins, such as RNA-binding protein, during the evolutionary process.
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