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Symbiotic Relationship between Influenza Virus and Waterfowl in Nature

Planned

Project AreaNeo-virology: the raison d'etre of viruses
Project/Area Number 16H06434
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University (2020)
The University of Tokyo (2016-2019)

Principal Investigator

渡辺 登喜子  大阪大学, 微生物病研究所, 教授 (60557479)

Co-Investigator(Kenkyū-buntansha) 河岡 義裕  東京大学, 医科学研究所, 教授 (70135838)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥59,280,000 (Direct Cost: ¥45,600,000、Indirect Cost: ¥13,680,000)
Fiscal Year 2020: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2019: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2018: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Keywordsインフルエンザウイルス / ウイルスー宿主の共生関係 / 共生 / バイローム解析 / ウイルス―宿主の共生関係
Outline of Annual Research Achievements

インフルエンザウイルスは、人間界では病原微生物として認識されているが、自然宿主であるカモなどの野生の水禽では、感染しても病気を発症することはない。 本研究では、インフルエンザウイルスと水禽との共生の自然界における意義を理解するために、1)インフルエンザウイルスとの共生が水禽の腸内微生物叢や生理機能に及ぼす影響の解析、2)インフルエンザウイルスと水禽との共生メカニズムの解析、および 3)野生動物におけるバイローム解析による新規ウイルスの探索を行っている。
インフルエンザウイルスに感染した野生の水禽が病気を発症することはないが、感染個体においてどのような宿主応答が起きているかはよく分かっていない。そこで、本研究において、鳥インフルエンザウイルスを感染させたマガモにおける宿主応答を調べたところ、感染初期には抗ウイルス活性およびインターフェロン応答に関わる遺伝子群の発現上昇が見られた。それに対して、感染後期には、B細胞や免疫グロブリンが関与する免疫応答に関わる遺伝子群の発現が上昇していることが分かった。以上の結果から、鳥インフルエンザウイルスを感染させたマガモの腸管では、感染初期(1,3日目)に自然免疫応答が、そして感染後期(6,9日目)には獲得免疫応答が誘導されていることが明らかとなった。
野生動物におけるバイローム解析については、鹿児島県に飛来するツルの糞便サンプルのメタゲノム解析によって、新規のツルアデノウイルスを同定した。またアフリカ・シエラレオネで採取したコウモリサンプルの解析を進めている。さらに、令和元年度は、南米・ブラジルにおける野生動物のサンプリングのため、新たに共同研究を開始した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究では、インフルエンザウイルスと水禽との共生が、水禽の腸内環境に与える影響を調べるため、腸内微生物叢のメタゲノム解析を行う。また、本ウイルスとの共生が、水禽の免疫系や生命活動に及ぼす影響を明らかにする。さらに、国内外の野生動物におけるバイローム解析によって、新規ウイルスの探索を試みる。カモを用いた鳥インフルエンザウイルスの感染実験を行ない、感染個体の腸における宿主応答解析を行ったところ、感染初期には抗ウイルス活性およびインターフェロン応答に関わる遺伝子群の発現上昇が、そして、感染後期には、B細胞や免疫グロブリンが関与する免疫応答に関わる遺伝子群の発現が上昇していることが明らかとなった。さらに野生動物のバイローム解析用に、アフリカ・シエラレオネのコウモリの臓器から抽出したRNAを用いて、次世代シークエンスを行い、バイローム解析を行っている。また鹿児島県に飛来するツルから採取したサンプルのメタゲノム解析の結果、新規ツルアデノウイルスを同定することができた。以上の結果が得られたことから、本研究は、おおむね順調に進展していると考えられる。

Strategy for Future Research Activity

今後も引き続き、国内外における水禽や野生動物から採取したサンプルの解析データを用いて、新規ウイルスの探索を試みる。具体的には、公募班の中川先生(東海大)との共同研究によって、シエラレオネとブラジルで採取したコウモリの臓器サンプルから抽出したRNAの次世代シークエンスデータを用いてバイローム解析を行う。さらに、鹿児島県で採取したツルの糞便データを用いたバイローム解析を行う。また、感染実験したカモから採取した糞便サンプルを用いて、腸内微生物叢のメタゲノム解析を行う。インフルエンザウイルスを保有している個体と保有していない個体における腸内微生物叢の違いを調べ、宿主応答などとの関連性について調べる。

Report

(4 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(187 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (10 results) Journal Article (87 results) (of which Int'l Joint Research: 54 results,  Peer Reviewed: 71 results,  Open Access: 34 results,  Acknowledgement Compliant: 7 results) Presentation (88 results) (of which Int'l Joint Research: 48 results,  Invited: 53 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Sierra Leone(シエラレオネ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] UNSEP/Universidade Estadual do Maranhao/LACEN(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ガブリエル・レネ・モレノ自治大学(ボリビア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Animal Health Research Institute(エジプト)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chinese Academy of Agricultural Sciences(中国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Villains or heroes? The raison detre of viruses2021

    • Author(s)
      Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Clinical and Translational Immunology

      Volume: 9

    • DOI

      10.1002/cti2.1114

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets2020

    • Author(s)
      Zhong G, Fan S, Hatta M, Nakatsu S, Walters KB, Lopes TJS, Wang JI, Ozawa M, Karasin A, Li Y, Tong S, Donis RO, Neumann G, Kawaoka Y.
    • Journal Title

      Journal of Virology

      Volume: -

    • DOI

      10.1128/jvi.01416-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Baloxavir marboxil treatment of nude mice infected with influenza A virus.2020

    • Author(s)
      Kiso M, Yamayoshi S, Murakami J, Kawaoka Y.
    • Journal Title

      The Journal of Infectious Diseases

      Volume: - Pages: 1699-1702

    • DOI

      10.1093/infdis/jiz665

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway.2020

    • Author(s)
      Kuwahara T, Yamayoshi S, Noda T, Kawaoka Y.
    • Journal Title

      Mbio

      Volume: 10

    • DOI

      10.1128/mbio.02867-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS2020

    • Author(s)
      Ueki Hiroshi、Wang I-Hsuan、Zhao Dongming、Gunzer Matthias、Kawaoka Yoshihiro
    • Journal Title

      Nat Protoc

      Volume: 15 Pages: 1041-1065

    • DOI

      10.1038/s41596-019-0275-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan2020

    • Author(s)
      Mitake H, Yasuhara A, Lopes TJS, Tagawa-Sakai Y, Shimizu K, Ozawa H, Kawakami C, Morikawa S, Sugaya N, Watanabe T, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 12

    • DOI

      10.3390/v12020155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 新規抗インフルエンザ薬ゾフルーザ感受性低下ウイルスの性状について2020

    • Author(s)
      今井正樹、河岡義裕
    • Journal Title

      東京小児科医会報

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 鳥インフルエンザA(H5N1)について2020

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 21

    • Related Report
      2019 Annual Research Report
  • [Journal Article] エボラウイルス制圧にむけて~エボラワクチン開発研究とシエラレオネでの研究活動~2020

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      LABIO21

      Volume: - Pages: 25-29

    • Related Report
      2019 Annual Research Report
  • [Journal Article] C57BL/6J and C57BL/6NJ Mice Are Differentially Susceptible to Inflammation-Associated Disease Caused by Influenza A Virus2019

    • Author(s)
      Eisfeld AJ, Gasper DJ, Suresh M, KawaokaY.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 3307-3307

    • DOI

      10.3389/fmicb.2018.03307

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Injectable Excipients as Novel Influenza Vaccine Adjuvants2019

    • Author(s)
      Feng H, Yamashita M, da Silva Lopes TJ, Watanabe T, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 1-9

    • DOI

      10.3389/fmicb.2019.00019

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus2019

    • Author(s)
      Ito Mutsumi、Yamayoshi Seiya、Murakami Kazushi、Saito Kenji、Motojima Atsuo、Nakaishi Kazunari、Kawaoka Yoshihiro
    • Journal Title

      Viruses

      Volume: 11 Pages: 149-149

    • DOI

      10.3390/v11020149

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and antigenic characterisation of influenza A(H3N2) viruses isolated in Yokohama during the 2016/17 and 2017/18 influenza seasons2019

    • Author(s)
      Kawakami Chiharu、Yamayoshi Seiya、Akimoto Miki、Nakamura Kazuya、Miura Hideka、Fujisaki Seiichiro、Pattinson David J.、Shimizu Kohei、Ozawa Hiroki、Momoki Tomoko、Saikusa Miwako、Yasuhara Atsuhiro、Usuku Shuzo、Okubo Ichiro、Toyozawa Takahiro、Sugita Shigeo、Smith Derek J.、Watanabe Shinji、Kawaoka Yoshihiro
    • Journal Title

      Euro Surveill

      Volume: 24 Pages: 1800467-1800467

    • DOI

      10.2807/1560-7917.es.2019.24.6.1800467

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasma lipidome reveals critical illness and recovery from human Ebola virus disease.2019

    • Author(s)
      Kyle JE, Burnum-Johnson KE, Wendler JP, Eisfeld AJ, Halfmann PJ, Watanabe T, Sahr F, Smith RD, Kawaoka Y, Waters KM, Metz TO
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 116 Pages: 3919-3928

    • DOI

      10.1073/pnas.1815356116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus.2019

    • Author(s)
      4.Yasuhara A, Yamayoshi S, Kiso M, Sakai-Tagawa Y, Koga M, Adachi E, Kikuchi T, Wang IH, Yamada S, Kawaoka Y.
    • Journal Title

      Nat Microbiol

      Volume: 4(6) Pages: 1024-1034

    • DOI

      10.1038/s41564-019-0401-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity2019

    • Author(s)
      Oishi K, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 432-432

    • DOI

      10.3389/fmicb.2019.00432

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2019

    • Author(s)
      Takada K, Kawakami C, Fan S, Chiba S, Zhong G, Gu C, Shimizu K, Takasaki S, Sakai-Tagawa Y, Lopes TJS, Dutta J, Khan Z, Kriti D, van Bakel H, Yamada S, Watanabe T, Imai M, Kawaoka Y.
    • Journal Title

      Nature Microbiology

      Volume: 4(8) Pages: 1268-1273

    • DOI

      10.1038/s41564-019-0433-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 20182019

    • Author(s)
      Okuda Moe、Yamayoshi Seiya、Uraki Ryuta、Ito Mutsumi、Hamabata Taiki、Kawaoka Yoshihiro
    • Journal Title

      Viruses.

      Volume: 11 Pages: 321-321

    • DOI

      10.3390/v11040321

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009-2013 in Vietnam2019

    • Author(s)
      Zhong G, Fan S, Lopes TJS, Le MQ, van Bakel H, Dutta J, Smith GJD, Jayakumar J, Nguyen HLK, Hoang PVM, Halfmann P, Hatta M, Su YCF, Neumann G, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 1411-1411

    • DOI

      10.3389/fmicb.2019.01411

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study2019

    • Author(s)
      Halfmann Peter J.、Eisfeld Amie J.、Watanabe Tokiko、Maemura Tadashi、Yamashita Makoto、Fukuyama Satoshi、Armbrust Tammy、Rozich Isaiah、N’jai Alhaji、Neumann Gabriele、Kawaoka Yoshihiro、Sahr Foday
    • Journal Title

      . PLoS Negl Trop Dis

      Volume: 13

    • DOI

      10.1371/journal.pntd.0007654

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term culture of human lung adenocarcinoma A549 cells enhances the replication of human influenza A viruses.2019

    • Author(s)
      Ujie M, Takada K, Kiso M, Sakai-Tagawa Y, Ito M, Nakamura K, Watanabe S, Imai M, Kawaoka Y.
    • Journal Title

      Journal of General Virology

      Volume: 100 Pages: 1345-1349

    • DOI

      10.1099/jgv.0.001314

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of a distinct lineage of aviadenovirus from crane feces.2019

    • Author(s)
      Mukai Y, Tomita Y, Kryukov K, Nakagawa S, Ozawa M, Matsui T, Tomonaga K, Imanishi T, Kawaoka Y, Watanabe T, Horie M
    • Journal Title

      Virus Genes

      Volume: 55 Pages: 815-824

    • DOI

      10.1007/s11262-019-01703-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Soluble Recombinant Hemagglutinin Protein of H1N1pdm09 Influenza Virus Elicits Cross-Protection Against a Lethal H5N1 Challenge in Mice.2019

    • Author(s)
      Yamada S, Yasuhara A, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 4(10) Pages: 1268-1273

    • DOI

      10.3389/fmicb.2019.02031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Food Additives as Novel Influenza Vaccine Adjuvants2019

    • Author(s)
      Feng Huapeng、Yamashita Makoto、Wu Li、Jose da Silva Lopes Tiago、Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Vaccines

      Volume: 7 Pages: 127-127

    • DOI

      10.3390/vaccines7040127

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment.2019

    • Author(s)
      2.Furusawa Y, Yamada S, da Silva Lopes TJ, Dutta J, Khan Z, Kriti D, van Bakel H, Kawaoka Y.
    • Journal Title

      mBio

      Volume: 10(5)

    • DOI

      10.1128/mbio.01794-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Glycolipid Adjuvant, 7DW8-5, Enhances the Protective Immune Response to the Current Split Influenza Vaccine in Mice2019

    • Author(s)
      Feng Huapeng、Nakajima Noriko、Wu Li、Yamashita Makoto、Lopes Tiago J. S.、Tsuji Moriya、Hasegawa Hideki、Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Front Microbio

      Volume: 10 Pages: 2157-2157

    • DOI

      10.3389/fmicb.2019.02157

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oseltamivir is effective against 1918 influenza virus infection of macaques but vulnerable to escape.2019

    • Author(s)
      Feldmann F, Kobasa D, Embury-Hyatt C, Grolla A, Taylor T, Kiso M, Kakugawa S, Gren J, Jones SM, Kawaoka Y, Feldmann H.
    • Journal Title

      mBio

      Volume: 10

    • DOI

      10.1128/mbio.02059-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of H7N9 avian influenza viruses isolated from duck meat products.2019

    • Author(s)
      Wu L, Mitake H, Kiso M, Ito M, Iwatsuki-Hirimoto K, Yamayoshi S, Lopes TJS, Feng H, Sumiyoshi R, Shibata A, Osaka H, Imai M, Watanabe T, Kawaoka Y.
    • Journal Title

      Transbound Emerg Dis

      Volume: 67 Pages: 1-7

    • DOI

      10.1111/tbed.13398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antigenic change in human influenza A(H2N2) viruses detected by using human plasma from aged and younger adult individuals.2019

    • Author(s)
      Matsuzawa Y, Iwatsuki-Horimoto K, Nishimoto Y, Abe Y, Fukuyama S, Hamabata T, Okuda M, Go Y, Watanabe T, Imai M, Arai Y, Fouchier RAM, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 11

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sensitivity of commercially available influenza rapid diagnostic tests in the 2018-2019 influenza season.2019

    • Author(s)
      Sakai-Tagawa Y, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 2342-2342

    • DOI

      10.3389/fmicb.2019.02342

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment of highly pathogenic H7N9 virus-infected mice with baloxavir marboxil.2019

    • Author(s)
      Kiso M, Yamayoshi S, Furusawa Y, Imai M, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 11

    • DOI

      10.3390/v11111066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets2019

    • Author(s)
      Imai M、Yamashita M、Sakai-Tagawa Y、Iwatsuki-Horimoto Ki、Kiso M、Murakami J、Yasuhara A、Takada K、Ito M、Nakajima N、Takahashi K、Hasegawa H、Kawaoka Y, et al
    • Journal Title

      Nat Microbiol

      Volume: 5 Pages: 27-33

    • DOI

      10.1038/s41564-019-0609-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neo-virology: The raison d'etre of viruses.2019

    • Author(s)
      Watanabe T, Suzuki N, Tomonaga K, Sawa H, Matsuura Y, Kawaguchi Y, Takahashi H, Nagasaki K, Kawaoka Y.
    • Journal Title

      Virus Research

      Volume: 274 Pages: 197751-197751

    • DOI

      10.1016/j.virusres.2019.197751

    • NAID

      130006183770

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A型インフルエンザの流行の特徴2019

    • Author(s)
      渡辺登喜子
    • Journal Title

      チャイルドヘルス

      Volume: 9

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 季節性インフルエンザの流行について2019

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 39-43

    • Related Report
      2019 Annual Research Report
  • [Journal Article] インフルエンザ迅速診断キットの性能比較2019

    • Author(s)
      坂井(田川)優子、河岡義裕
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 15-21

    • NAID

      40022107999

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Network-Guided Discovery of Influenza Virus Replication Host Factors.2019

    • Author(s)
      Ackerman EE, Kawakami E, Katoh M, Watanabe T, Watanabe S, Tomita Y, Lopes TJ, Matsuoka Y, Kitano H, Shoemaker JE, Kawaoka Y
    • Journal Title

      MBio

      Volume: 9

    • DOI

      10.1128/mbio.02002-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 高病原性H7N9鳥インフルエンザウイルスはヒトの間で大流行を起こすのか2019

    • Author(s)
      今井正樹、河岡義裕
    • Journal Title

      臨牀と研究

      Volume: 95 Pages: 1245-1248

    • Related Report
      2018 Annual Research Report
  • [Journal Article] スペイン・インフルエンザ その2 スペイン・インフルエンザの病原性の謎2019

    • Author(s)
      渡辺登喜子.
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 37-40

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エボラ出血熱の重症かメカニズムならびに予後を予測するためのバイオマーカーの同定2019

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      感染・炎症・免疫

      Volume: 49 Pages: 65-67

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エボラ出血熱について-エボラウイルス感染者の宿主応答解析から得られた知見-2019

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      最新医学

      Volume: 74 Pages: 51-57

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis2018

    • Author(s)
      Eisfeld Amie J.、Halfmann Peter J. et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 22 Pages: 3919-3928

    • DOI

      10.1016/j.chom.2017.10.011

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of a Feline Influenza A(H7N2) Virus2018

    • Author(s)
      Hatta M, Zhong G, Gao Y, Nakajima N, Fan S, Chiba S, Deering KM, Ito M, Imai M, 他13名
    • Journal Title

      Emerging Infectious Diseases

      Volume: 24 Pages: 75-86

    • DOI

      10.3201/eid2401.171240

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combination Therapy With Neuraminidase and Polymerase Inhibitors in Nude Mice Infected With Influenza Virus2018

    • Author(s)
      Kiso Maki、Lopes Tiago J S、Yamayoshi Seiya、Ito Mutsumi、Yamashita Makoto、Nakajima Noriko、Hasegawa Hideki、Neumann Gabriele、Kawaoka Yoshihiro
    • Journal Title

      J Infect Dis

      Volume: 217 Pages: 887-896

    • DOI

      10.1093/infdis/jix606

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syrian hamster as an animal model for the study of human influenza virus infection2018

    • Author(s)
      Iwatsuki-Horimoto Kiyoko、Nakajima Noriko、Ichiko Yurie、Sakai-Tagawa Yuko、Noda Takeshi、Hasegawa Hideki、Kawaoka Yoshihiro
    • Journal Title

      J Virol

      Volume: 92

    • DOI

      10.1128/jvi.01693-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast2018

    • Author(s)
      Oishi Kohei、Yamayoshi Seiya、Kawaoka Yoshihiro
    • Journal Title

      Virology

      Volume: 516 Pages: 71-75

    • DOI

      10.1016/j.virol.2018.01.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influenza C and D Viruses Package Eight Organized Ribonucleoprotein Complexes2018

    • Author(s)
      Nakatsu Sumiho、Murakami Shin、Shindo Keiko、Horimoto Taisuke、Sagara Hiroshi、Noda Takeshi、Kawaoka Yoshihiro
    • Journal Title

      J Virol

      Volume: 92

    • DOI

      10.1128/jvi.02084-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging.2018

    • Author(s)
      Noda T, Murakami S, Nakatsu S, Imai H, Muramoto Y, Shindo K, Sagara H, Kawaoka Y.
    • Journal Title

      Nat Commun

      Volume: 9 Pages: 54-54

    • DOI

      10.1038/s41467-017-02517-w

    • NAID

      120006376026

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human protective monoclonal antibodies against the HA stem of group 2 HAs derived from H3N2 virus-infected humans.2018

    • Author(s)
      Yamayoshi S, Ito M, Uraki R, Sasaki T, Ikuta K, Kawaoka Y.
    • Journal Title

      J Infect

      Volume: 76 Pages: 177-185

    • DOI

      10.1016/j.jinf.2017.12.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles2018

    • Author(s)
      Nanbo Asuka、Maruyama Junki、Imai Masaki、Ujie Michiko、Fujioka Yoichiro、Nishide Shinya、Takada Ayato、Ohba Yusuke、Kawaoka Yoshihiro
    • Journal Title

      PLOS Pathogens

      Volume: 14

    • DOI

      10.1371/journal.ppat.1006848

    • NAID

      120006416019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lung-derived exosomal miR-483-3p regulates the innate immune response to influenza virus infection.2018

    • Author(s)
      Maemura T, Fukuyama S, Sugita Y, Lopes TJS, Nakao T, Noda T, Kawaoka Y.
    • Journal Title

      J Infect Dis.

      Volume: 217 Pages: 1372-1382

    • DOI

      10.1093/infdis/jiy035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Pages: 746-750

    • DOI

      10.3201/eid2404.171509

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of alpha2-adrenergic receptors impairs influenza virus infection.2018

    • Author(s)
      Matsui K, Ozawa M, Kiso M, Yamashita M, Maekawa T, Kubota M, Sugano S, Kawaoka Y.
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 4631-4631

    • DOI

      10.1038/s41598-018-22927-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the fusion partner cell line SPYMEG for obtaining human monoclonal antibodies against influenza B virus2018

    • Author(s)
      Soni P, Yasuhara A, Takenaga T, Iwatsuki-Horimoto K, Uraki R, Ito M, Sasaki T, Ikuta K, Yamayoshi S, Kawaoka Y.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 80 Issue: 6 Pages: 1020-1024

    • DOI

      10.1292/jvms.18-0146

    • NAID

      130007412681

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The marmoset as an animal model of influenza: infection with A(H1N1)pdm09 and highly pathogenic A(H5N1) viruses via the conventional or tracheal spray route.2018

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 844-844

    • DOI

      10.3389/fmicb.2018.00844

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of influenza A(H5N1) Viruses in infected humans, Northern Vietnam, 2004-2010.2018

    • Author(s)
      Imai H, Dinis JM, Zhong G, Moncla LH, Lopes TJS, McBride R, Thompson AJ, Peng W, Le MTQ, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O'Connor DH, Suzuki Y, Hatta M, Paulson JC, Neumann G, Friedrich TC, Kawaoka Y.
    • Journal Title

      Emerging Infectious Diseases

      Volume: 24 Pages: 1128-1238

    • DOI

      10.3201/eid2407.171441

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs.2018

    • Author(s)
      Ueki H, Wang IH, Fukuyama S, Katsura H, da Silva Lopes TJ, Neumann G, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of an influenza rapid diagnostic kit specific for the H7 subtype.2018

    • Author(s)
      Iwatsuki-Horimoto K, Shi J, Wang X, Sakai-Tagawa Y, Ito M, Murakami K, da Silva Lopes TJ, Nakaishi K, Yamayoshi S, Watanabe S, Chen H, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1346-1346

    • DOI

      10.3389/fmicb.2018.01346

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain-specific contribution of eukaryotic elongation factor 1 gamma to the translation of influenza A virus proteins.2018

    • Author(s)
      Sammaibashi S, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1446-1446

    • DOI

      10.3389/fmicb.2018.01446

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X.2018

    • Author(s)
      Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M, Kawaoka Y.
    • Journal Title

      Cell Rep

      Volume: 24 Pages: 851-860

    • DOI

      10.1016/j.celrep.2018.06.078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.2018

    • Author(s)
      Furusawa Y, Yamada S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1675-1675

    • DOI

      10.3389/fmicb.2018.01675

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus.2018

    • Author(s)
      Yamayoshi S, Yasuhara A, Ito M, Uraki R, Kawaoka Y.
    • Journal Title

      J Clin Virol

      Volume: 108 Pages: 105-111

    • DOI

      10.1016/j.jcv.2018.09.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 A resolution.2018

    • Author(s)
      Sugita Y, Matsunami H, Kawaoka Y, Noda T, Wolf M.
    • Journal Title

      nature

      Volume: 563 Pages: 137-140

    • DOI

      10.1038/s41586-018-0630-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses2018

    • Author(s)
      Yasuhara Atsuhiro、Yamayoshi Seiya、Ito Mutsumi、Kiso Maki、Yamada Shinya、Kawaoka Yoshihiro
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 2660-2660

    • DOI

      10.3389/fmicb.2018.02660

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] スペインかぜ その1 100年前に起こった疫学史上最悪の出来事2018

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 19 Pages: 49-52

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 新興再興感染症に対するワクチン開発~エボラワクチン開発における最近の進展~.2018

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 25-29

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence.2018

    • Author(s)
      Zhong G, Le MQ, Lopes TJS, Halfmann P, Hatta M, Fan S, Neumann G, Kawaoka Y.
    • Journal Title

      Journal of Virology

      Volume: 92

    • DOI

      10.1128/jvi.01557-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.2018

    • Author(s)
      Menachery VD, Sch?er A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB,
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115

    • DOI

      10.1073/pnas.1706928115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route2018

    • Author(s)
      Watanabe Tokiko、Iwatsuki-Horimoto Kiyoko、Kiso Maki、Nakajima Noriko、Takahashi Kenta、Jose da Silva Lopes Tiago、Ito Mutsumi、Fukuyama Satoshi、Hasegawa Hideki、Kawaoka Yoshihiro
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 4801-4801

    • DOI

      10.1038/s41598-018-23022-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] エボラ出血熱に対するワクチン開発の進展2018

    • Author(s)
      今井正樹、渡辺登喜子、河岡義裕
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 419-422

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 鳥インフルエンザウイルスのヒトへの感染と伝播の可能性2018

    • Author(s)
      渡邉真治、今井正樹
    • Journal Title

      インフルエンザ

      Volume: 62 Pages: 37-42

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response.2017

    • Author(s)
      Zhao D,Liang L,Wang S,Nakao T,Li Y,Liu L,Guan Y,Fukuyama S,Bu Z,Kawaoka Y,Chen H
    • Journal Title

      J Virol

      Volume: 91

    • DOI

      10.1128/jvi.02215-16

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of seasonal influenza vaccinese for H1N1pdm09 and type B viruses based on a replication-incompetent PB2-KO virus.2017

    • Author(s)
      Ui H, Yamayoshi S, Uraki R, Kiso M, Oishi K, Murakami S, Mimori S, Kawaoka Y.
    • Journal Title

      Vaccine

      Volume: 4;35(15) Pages: 1892-1897

    • DOI

      10.1016/j.vaccine.2017.02.041

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza.2017

    • Author(s)
      Hatta Y, Boltz D, Sarawar S, Kawaoka Y, Neumann G, Bilsel P.
    • Journal Title

      Vaccine

      Volume: 35 Pages: 4177-4183

    • DOI

      10.1016/j.vaccine.2017.06.039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets2017

    • Author(s)
      Imai Masaki、Watanabe Tokiko et al
    • Journal Title

      Cell Host & Microbe

      Volume: 22 Pages: 615-626

    • DOI

      10.1016/j.chom.2017.09.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques2017

    • Author(s)
      Kiso Maki et al.
    • Journal Title

      J Infect Dis

      Volume: 216 Pages: 582-593

    • DOI

      10.1093/infdis/jix296

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactivity and sensitivity of commercially available influenza rapid diagnostic tests in Japan.2017

    • Author(s)
      Sakai-Tagawa Y, Yamayoshi S, Kawakami C, Le MQ, Uchida Y, Saito T, Nidom CA, Humaira I, Toohey-Kurth K, Arafa AS, Liu MT, Shu Y, Kawaoka Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 14483-14483

    • DOI

      10.1038/s41598-017-14536-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.2017

    • Author(s)
      Yasuhara A, Yamayoshi S, Soni P, Takenaga T, Kawakami C, Takashita E, Sakai-Tagawa Y, Uraki R, Ito M, Iwatsuki-Horimoto K, Sasaki T, Ikuta K, Yamada S, Kawaoka Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 17735-17735

    • DOI

      10.1038/s41598-017-17986-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NS1 is the fluid for “flu-transmission”2017

    • Author(s)
      Watanabe Tokiko、Imai Masaki、Kawaoka Yoshihiro
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 114 Pages: 11012-11014

    • DOI

      10.1073/pnas.1715239114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 季節性インフルエンザウイルスの抗原変異株の出現予測2017

    • Author(s)
      今井正樹、渡邉真治、河岡義裕
    • Journal Title

      インフルエンザ

      Volume: 61 Pages: 31-34

    • NAID

      40021350846

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Complete and incomplete genome packaging of influenza A and B viruses2017

    • Author(s)
      Nakatsu S, Sagara H, Sakai-Tagawa Y, Sugaya N, Noda T, Kawaoka Y
    • Journal Title

      mBio

      Volume: 7(5)

    • DOI

      10.1128/mbio.01248-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Microminipig as an Animal Model for Influenza A Virus Infection2017

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Shibata M, Takahashi K, Sato Y, Kiso M, Yamayoshi S, Ito M, Enya S, Otake M, Kangawa A, da Silva Lopes TJ, Ito H, Hasegawa H, Kawaoka Y.
    • Journal Title

      Journal of Viriology

      Volume: 91 Pages: 1-9

    • DOI

      10.1128/jvi.01716-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Broadly Reactive Human Anti-hemagglutinin Stem Monoclonal Antibody That Inhibits Influenza A Virus Particle Release.2017

    • Author(s)
      Yamayoshi S, Uraki R, Ito M, Kiso M, Nakatsu S, Yasuhara A, Oishi K, Sasaki T, Ikuta K,Kawaoka Y.
    • Journal Title

      EBioMedicine

      Volume: 17 Pages: 182-191

    • DOI

      10.1016/j.ebiom.2017.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Risk assessment of recent Egyptian H5N1 influenza viruses2016

    • Author(s)
      Arafa AS, Yamada S, Imai M, Watanabe T et al
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 38388-38388

    • DOI

      10.1038/srep38388

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of high-yield influenza B virus vaccine viruses.2016

    • Author(s)
      Ping J, Lopes TJ, Neumann G, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113

    • DOI

      10.1073/pnas.1616530113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] インフルエンザウイルスの抗原変異とその予測2016

    • Author(s)
      渡辺登喜子、今井正樹、河岡義裕
    • Journal Title

      医学のあゆみ

      Volume: 260 Pages: 17034-17038

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] 新学術領域「ネオウイルス学:生命源流から超個体、そしてエコ・スフィアーへ」 Neo-Virology: the raison d’etre of viruses ~ウイルスのレゾンデートルを探る!~2016

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      学会誌「ウイルス」

      Volume: 66 Pages: 155-162

    • Related Report
      2016 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Presentation] エボラ出血熱の制圧に向けたワクチン開発研究2020

    • Author(s)
      渡辺登喜子
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鶏卵での増殖過程でHAの抗原性変化を伴わないH3N2インフルエンザウイルスの作出2020

    • Author(s)
      山田晋弥、千葉志穂、安原敦洋、高田光輔、柳本周、Ryan McBride、 Charli Worth、Andrew J. Thompson、Tiago J.S. Lopes、山吉誠也、James C. Paulson、河岡義裕
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザウイルス感染肺における免疫細胞応答の生体イメージング解析2020

    • Author(s)
      植木紘史, 河岡義裕.
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヌードマウスにおけるインフルエンザ感染と抗インフルエンザ薬及び抗体の併用効果2020

    • Author(s)
      木曽真紀、山吉誠也、河岡義裕
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Human monoclonal antibodies that recognize the HA of both influenza B lineages2020

    • Author(s)
      Yamayoshi S, Yasuhara A, Kiso M, Kawaoka Y
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antigenic variants of influenza B viruses isolated in Japan during the 2017-2018 and 2018-2019 influenza seasons2020

    • Author(s)
      Sari Kato, Yuko Sakai-Tagawa, Masaki Imai and Yoshihiro Kawaoka
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Challenges in Influenza2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      The 2nd Joint Meeting of Veterinary Science in East Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for the development of next-generation Influenza vaccines2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      ISIRV Influenza Vaccine Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathogens and Transmission of Negative Strand RNA Viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Virus and Cells Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Centers of Excellence for Influenza Research and Surveillance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Working with deadly viruses?シ喘attling Ebola and Influenza2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Conference of Research Workers in Animal Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New approaches to the development of effective influenza vaccines2019

    • Author(s)
      Tokiko Watanabe
    • Organizer
      The 7th International Conference & Exhibition on Influenza Vaccines for The World.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] deltaVP30 vaccine for control of Ebola virus disease2019

    • Author(s)
      Watanabe T and Kawaoka Y
    • Organizer
      BARDA Industry Day
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第66回日本実験動物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第40回阿蘇シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第7回アフリカ開発会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Neo-Virology: The raison detre of viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第125回日本小児科学会甲信地方会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルス感染個体における生体イメージング2019

    • Author(s)
      植木紘史, 河岡義裕
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Genetic and antigenic analyses of influenza B viruses isolated in Japan during the 2017-2018 and 2018-2019 influenza seasons.2019

    • Author(s)
      Sari Kato, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Masaki Imai.
    • Organizer
      Options X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The marmoset as an animal model of influenza.2019

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y.
    • Organizer
      Options X for the Control of Influenza.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The marmoset as an animal model of influenza.2019

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections 2019.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subclade 2.2.1-specific human monoclonal antibodies that recognize an epitope in antigenic site A of influenza A (H5) virus HA detected between 2015 and 20182019

    • Author(s)
      Moe Okuda, Seiya Yamayoshi, Ryuta Uraki, Mutsumi Ito, Taiki Hamabata, and Yoshihiro Kawaoka
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging of the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung2019

    • Author(s)
      Hiroshi Uek, I-Hsuan Wang, Satoshi Fukuyama, Hiroaki Katsura, Tiago Jose da Silva Lopes, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      Focus on Microscopy 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two-photon imaging of the in vivo dynamics of immune cells and cellular pathophysiology in influenza virus-infected lung2019

    • Author(s)
      Hiroshi Uek, I-Hsuan Wang, Satoshi Fukuyama, Hiroaki Katsura, Tiago Jose da Silva Lopes, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      17th International Congress of Immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-Term Cultured Human Lung Adenocarcinoma A549 Cells Show Enhanced Susceptibility to Human Influenza A Viruses2019

    • Author(s)
      Ujie M, Imai, M, Nakamura K, Watanabe S, Kawaoka Y, Long-Term Cultured Human Lung Adenocarcinoma A549 Cells Show Enhanced Susceptibility to Human Influenza A Viruses
    • Organizer
      OPTIONS X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2019

    • Author(s)
      K. Takada, C. Kawakami, S. Fan, S. Chiba, G. Zhong, C. Gu, K. Shimizu, S. Takasaki, Y. Sakai-Tagawa, T. J. S. Lopes, J. Dutta, H. van Bakel, Z. Khan, D. Kriti, S. Yamada, T. Watanabe, M. Imai, Y. Kawaoka.
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus2019

    • Author(s)
      Atsuhiro Yasuhara, Seiya Yamayoshi, Maki Kiso, Yuko Sakai-Tagawa, Michiko Koga, Eisuke Adachi, Tadashi Kikuchi, I-Hsuan Wang, Shinya Yamada, and Yoshihiro Kawaoka
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The antigenic change in the hemagglutinin of A(H7N9) influenza virus2019

    • Author(s)
      Ito M, Yamayoshi S, Murakami K, Saito K, Motojima A, Nakaishi K, and Kawaoka Y
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of deletion and stabilization of foreign gene inserted into influenza virus genome.2019

    • Author(s)
      Yuri Furusawa, Shinya Yamada, Tiago Jose da Silva Lopes, Jayeeta Dutta, Zenab Khan, Divya Kriti, Harm van Bakel, Yoshihiro Kawaoka
    • Organizer
      Options X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of Ebola virus disease: vaccine development and our project in Sierra Leone2018

    • Author(s)
      Tokiko Watanabe
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Research of zoonotic diseases: Control of Ebola virus disease.2018

    • Author(s)
      Tokiko Watanabe
    • Organizer
      Workshop on Environmental Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A hightly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets.2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      10th International Symposium on Avian Influenza
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-Vision: Imaging systems for analyzing influenza virus infection2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Philipps University Marburg Current Topics in Influenza and Filovirus Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Centenary of the 1918 Spanish Influenza, the Worst Pandemic in the Recent History of the World2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Influenza Virus Virulence factors, International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision, total imaging systems for analyzing influenza virus infection.2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Nature Conference on Viral Infection and Immune Response
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human Ebola Virus Disease Pathogenesis Revealed by Multi`Platform Omics Analysis,2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Keystone Symposia in Hong Kong
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of N-terminal acetylation by NatB in the shutoff activity of PA-X.2018

    • Author(s)
      Yamayoshi S, Oishi K, Kawaoka Y.
    • Organizer
      The 7th China-Japan Bilateral Symposium on All Influenza virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human monoclonal antibodies against influenza virus2018

    • Author(s)
      Yamayoshi S, Kawaoka Y
    • Organizer
      MEDLAB Asia Pacific & Asia Health Exhibition & Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Influenza Research.2018

    • Author(s)
      Iwatsuki-Horimoto K.
    • Organizer
      Symposium “Zoonosis Research in Veterinary Science” at University of Tokyo
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] スペイン風邪から100年2018

    • Author(s)
      河岡義裕
    • Organizer
      インフルエンザ研究者交流の会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラ出血熱の制圧に向けて. ワクチン開発とシエラレオネでの研究活動2018

    • Author(s)
      渡辺登喜子
    • Organizer
      プラチナ勉強会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザウイルスならびにエボラ出血熱-2018

    • Author(s)
      河岡義裕
    • Organizer
      横浜市医師会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザウイルスならびにエボラ出血熱-2018

    • Author(s)
      河岡義裕
    • Organizer
      小児感染症専門医育成フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ並びにエボラ出血熱2018

    • Author(s)
      河岡義裕
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ2018

    • Author(s)
      河岡義裕
    • Organizer
      小児感染症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラ出血熱の制圧に向けて~ワクチン開発とシエラレオネでの研究活動2018

    • Author(s)
      渡辺登喜子
    • Organizer
      北海道大学獣医学研究談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラウイルスに挑む!2018

    • Author(s)
      渡辺登喜子
    • Organizer
      AMED感染症研究事業 市民向けシンポジウム「みるみる興味が湧いてくる!感染症研究の世界」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略2018

    • Author(s)
      渡辺登喜子
    • Organizer
      日本大学動物医科学研究センターセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Identification of amino acids that enhance virus replication in mammalian hosts in the PB2 and PA proteins of a highly pathogenic H7N9 influenza virus isolated from a human2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Kawaoka Y.
    • Organizer
      8th Orthomyxovirus research conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X2018

    • Author(s)
      Kohei Oishi, Seiya Yamayoshi, Hiroko Kozuka-Hata, Masaaki Oyama and Yoshihiro Kawaoka
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging captures the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung.2018

    • Author(s)
      H. Ueki, IH. Wang, S. Fukuyama, H. Katsura, T. Lopes, M. Gunzer, G. Neumann, and Y. Kawaoka
    • Organizer
      The 2018 Negative Strand RNA Virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The potential of human monoclonal antibodies that recognize the influenza A(H1N1)pdm09 virus hemagglutinin receptor-binding site as anti-influenza agents.2018

    • Author(s)
      Atsuhiro Yasuhara, Seiya Yamayoshi, Maki Kiso, Shinya Yamada, Yoshihiro Kawaoka
    • Organizer
      The 2018 Negative Strand RNA Virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2018

    • Author(s)
      Kosuke Takada, Chiharu Kawakami, Shufang Fan, Shiho Chiba, Gongxun Zhong, Chunyang Gu, Kohei Shimizu, Sara Takasaki, Yuko Sakai-Tagawa, Tiago J. S. Lopes, Jayeeta Dutta, Harm van Bakel, Zenab Khan, Divya Kriti, Shinya Yamada, Tokiko Watanabe, Masaki Imai, Yoshihiro Kawaoka.
    • Organizer
      Influenza and Other Infections Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of amino acids that enhance virus replication in mammalian hosts in the PB2 and PA proteins of a highly pathogenic H7N9 influenza virus isolated from a human2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
    • Organizer
      17th Negative Strand Virus Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amino acid substitutions in the PB2 protein of an H5N1 avian influenza virus enhance its replication efficiency and pathogenicity in mammalian hosts.2018

    • Author(s)
      Takeaki Imamura, Shinya Yamada, Kiyoko Iwatsuki-Horimoto, Reviany V. Nidom, Setyarina Indrasari, Kuncoro P. Santoso, Chairul.A Nidom, Yoshihiro Kawaoka
    • Organizer
      XVII International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Host Factor Nucleoporin 93 Is Involved in The Nuclear Export of Influenza Virus RNA.2018

    • Author(s)
      Yuri Furusawa, Shinya Yamada, Yoshihiro Kawaoka.
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスモデルにてアジュバント効果を示す食品添加物の探索2018

    • Author(s)
      渡辺登喜子、Huapeng Feng, 山下誠、河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus2018

    • Author(s)
      S. Yamayoshi, A. Yasuhara, M. Ito, R. Uraki, Y. Kawaoka
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マーモセットのインフルエンザ感染霊長類モデル動物としての検証2018

    • Author(s)
      岩附研子、中島典子、木曽真紀、高橋健太、伊藤睦美、井上貴史、堀内真千子、岡原則夫、佐々木えりか、長谷川秀樹、河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Understanding influenza A virus budding by direct visualization of viral ribonucleoproteins at the plasma membrane.2018

    • Author(s)
      I-Hsuan Wang, Jiro Usukura, and Yoshihiro Kawaoka
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2光子励起顕微鏡を用いたインフルエンザウイルス感染マウスにおける肺の生体イメージングの試み2018

    • Author(s)
      植木紘史, J. IH. Wang, 福山聡, 桂廣亮, Lopes TJS, Gabriele Neumann, 河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2光子励起顕微鏡法を用いたインフルエンザウイルス感染肺の病態生理学的変化の観察2018

    • Author(s)
      植木紘史, I-Hsuan Wang, 福山聡, 桂廣亮, Lopes TJS, Gabriele Neumann, 河岡義裕
    • Organizer
      第26回日本血管生物医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In vivo imaging of the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung.2018

    • Author(s)
      Hiroshi Ueki, Satoshi Fukuyama, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Injectable excipients as novel influenza vaccine adjuvants.2018

    • Author(s)
      Huapeng Feng, Makoto Yamashita, Tiago Jose da Silva Lopesa, Tokiko Watanabe, Yoshihiro Kawaoka
    • Organizer
      66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of a highly pathogenic avian H7N9 influenza virus2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      20th International Conference on Emerging Infectious Diseases in the Pacific Rim
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Influenza Research2018

    • Author(s)
      Kiyoko Iwatsuki-Horimoto
    • Organizer
      A New Paradigm for Laboratory Influenza Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Influenza Basics and Applications of Reverse Genetics2018

    • Author(s)
      Shinya Yamada
    • Organizer
      A New Paradigm for Laboratory Influenza Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a novel influenza rapid diagnostic kit specific for the H7 subtype.2017

    • Author(s)
      Iwatsuki-Horimoto K.
    • Organizer
      The Sixth China-Japan Bilateral Symposium on All Influenza Viruses.
    • Place of Presentation
      Chinese Academy of Sciences (Beijing, China)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略2017

    • Author(s)
      渡辺登喜子
    • Organizer
      農研機構動物衛生研究部門 水曜会(第700回特別記念講演)
    • Place of Presentation
      農研機構動物衛生研究部門
    • Year and Date
      2017-02-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding Antiviral Targets2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Understanding Antiviral Targets
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Transmission of respiratory viruses:from basic science to evidence based options for control Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      IMS-JSI2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A broadly reactive anti-HA stem monoclonal antibody that inhibits influenza A virus particle release2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models in influenza Research2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      NIAID-Sponsored Workshop on Pathway to a Universal Influenza Vaccine.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      The 6th ESWI Influenza Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Working with deadly viruses:Battling Ebola and Influenza2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第29回世界病理臨床検査医学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A highly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Hanoi GARAD 2018 Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インフルエンザ研究の最前線2017

    • Author(s)
      河岡義裕
    • Organizer
      第120回日本小児科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ研究の最前線2017

    • Author(s)
      河岡義裕
    • Organizer
      第16回みちのくウイルス塾
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルス感染マウスの生体イメージング研究2017

    • Author(s)
      福山聡, 植木紘史, 仲尾朋美, 三竹博道, Dongming Zhao, 桂廣亮, 今井正樹, 野田岳志, 河岡義裕.
    • Organizer
      第 32 回中国四国ウイルス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略 Host adaptation of influenza A viruses.2017

    • Author(s)
      渡辺登喜子
    • Organizer
      東海医学会講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 海外でアウトブレイク発生!我々にどのような対応ができるか2017

    • Author(s)
      渡辺登喜子
    • Organizer
      ピース・ウィンズ・ジャパン(NPO団体)勉強会.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ制圧を目指したウイルスと宿主とのインタラクトーム解析2017

    • Author(s)
      渡辺登喜子
    • Organizer
      第49回日本小児感染症学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 潜んでいた悪者が世に現れるとき2017

    • Author(s)
      渡辺登喜子
    • Organizer
      第7回微生物学連盟フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] サルモデルにおけるインフルエンザウイルスのエアロゾル感染系の確立2016

    • Author(s)
      渡辺登喜子、岩附研子、木曽真紀、伊藤睦美、河岡義裕
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 近年のヒト分離H3N2インフルエンザウイルスに対するハムスターの感受性2016

    • Author(s)
      岩附研子、中島典子、長谷川秀樹、河岡義裕
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Book] 猛威をふるう「ウイルス・感染症」にどう立ち向かうのか2018

    • Author(s)
      河岡 義裕、今井 正樹
    • Total Pages
      141
    • Publisher
      ミネルヴァ書房
    • ISBN
      9784623080816
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] アジュバントおよび該アジュバントを含むワクチン2018

    • Inventor(s)
      河岡義裕・渡辺登喜子・山下誠・ホアパンフェン
    • Industrial Property Rights Holder
      河岡義裕・渡辺登喜子・山下誠・ホアパンフェン
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-059532
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2021-01-27  

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