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Dynamic regulation of neural circuit remodeling by scrap & build system

Planned Research

Project AreaDynamic regulation of brain function by Scrap & Build system
Project/Area Number 16H06456
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Emoto Kazuo  東京大学, 大学院理学系研究科(理学部), 教授 (80300953)

Co-Investigator(Kenkyū-buntansha) 小澤 岳昌  東京大学, 大学院理学系研究科(理学部), 教授 (40302806)
今井 猛  九州大学, 医学研究院, 教授 (70509851)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥241,800,000 (Direct Cost: ¥186,000,000、Indirect Cost: ¥55,800,000)
Fiscal Year 2020: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2019: ¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2018: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2017: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2016: ¥60,450,000 (Direct Cost: ¥46,500,000、Indirect Cost: ¥13,950,000)
Keywords可塑性 / シナプス / 樹状突起 / ショウジョウバエ / 変態 / 変態期 / 回路リモデリング / 感覚ニューロン / 軸索 / 除去 / 再編 / 回路再編 / 刈り込み / マイクロRNA / 再生 / 受容領域 / 神経突起 / ニューロン / カルシウム / コンパートメント / 区画化 / カルシウムシグナル
Outline of Final Research Achievements

Developing neurons often remove existing compartments such as axons, dendrites, and synapses to refine functionally nascent circuits in a compartment-specific manner, yet how neurons selectively eliminate distinct compartments remains elusive. Drosophila sensory neurons provide an excellent model system to investigate the molecular and cellular mechanisms underlying developmental neuronal remodeling, as larval neurons are extensively remodeled to establish adult-specific circuits during metamorphosis. For the past decade, we have studied the mechanisms of developmental dendrite pruning in Drosophila sensory neurons during metamorphosis. Here we show that presynapses/axons as well as dendrites are eliminated in Drosophila sensory neurons during metamorphosis. To understand the molecular mechanisms of the presynapse/axon elimination, we performed a genetic screen and found that the ubiquitin proteasome systems is required for the presynapse/axon elimination as well as dendrite pruning.

Academic Significance and Societal Importance of the Research Achievements

脳神経回路の可塑性と頑強性は、神経細胞が自らの突起やシナプスの一部を選択的に除去もしくは付加できる能力に起因するが、その制御メカニズムについてはほとんど理解されていない。本研究を推進することにより、神経回路スクラップ&ビルドを制御する新たな分子細胞基盤と作動原理を明らかにし、研究分野を牽引できる可能性が高い。また、神経回路スクラップ&ビルド異常が自閉症など発達障害の一因であることが指摘されており、本研究を推進することにより、神経回路スクラップ&ビルドを担う基本分子メカニズムを明らかにすることは、将来的に発達障害の予防や治療に貢献し得る基礎データやモデルシステムを提供できる可能性がある

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (42 results)

All 2023 2022 2021 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (31 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] ワシントン大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] カリフォルニア大学/スクリプス研究所/ワシントン大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity2023

    • Author(s)
      Takeuchi Shunsuke、Shimizu Kimiko、Fukada Yoshitaka、Emoto Kazuo
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 332-332

    • DOI

      10.1038/s42003-023-04691-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency2022

    • Author(s)
      Nakahama Ryota、Saito Aika、Nobe Sensho、Togashi Kazuya、Suzuki Ikuo K.、Uematsu Akira、Emoto Kazuo
    • Journal Title

      Molecular Brain

      Volume: 15 Issue: 1 Pages: 70-70

    • DOI

      10.1186/s13041-022-00957-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain2021

    • Author(s)
      Bergoglio Emilia、Suzuki Ikuo K.、Togashi Kazuya、Tsuji Masato、Takeuchi Shunsuke、Koizumi Hiroyuki、Emoto Kazuo
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 156-162

    • DOI

      10.1016/j.neures.2020.12.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus2021

    • Author(s)
      Hiroshi Hamamoto*, Suresh Panthee*, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Su Jie, Atsushi Miyashita, Hiroaki Itoh, Kotaro Tokumoto, Masayuki Inoue, Kazuhisa Sekimizu
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 6364-6364

    • DOI

      10.1038/s41467-021-26702-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae.2018

    • Author(s)
      Utashiro N, Williams CR, Parrish JZ, Emoto K.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 8580-8580

    • DOI

      10.1038/s41598-018-26825-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural circuitry that evokes escape behavior in response to nociceptive stimuli in Drosophila larvae.2017

    • Author(s)
      Yoshino J, Morikawa R, Hasegawa E, Emoto K
    • Journal Title

      Curr Biol

      Volume: 27 Issue: 16 Pages: 2499-2504

    • DOI

      10.1016/j.cub.2017.06.068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DCLK1 phosphorylates the microtubule-associate protein MAP7D1 to promote axonal elongation in cortical neurons.2017

    • Author(s)
      Koizumi H, Fujioka H, Togashi K, Thompson J, Yate J, Gleeson J and Emoto K
    • Journal Title

      Developmental Neurobiology

      Volume: 77 Issue: 4 Pages: 1-13

    • DOI

      10.1002/dneu.22428

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Cellular and moleculars mechanims underlying species-specific control of developmental neurogenesis2023

    • Author(s)
      Yuki Yamauchi, Ikuo Suzuki, Kazuo Emoto
    • Organizer
      第16回神経発生討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Human neural progenitors produce larger apical lumen in vitro comparing to Chimpanzee progenitors2023

    • Author(s)
      Xuanhao Zhou, Ikuo Suzuki, Kazuo Emoto
    • Organizer
      第16回神経発生討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 心臓が行動を制御するメカニズムの解明に向けて2023

    • Author(s)
      陣駒大輔、植村友貴、辻眞人、榎本和生
    • Organizer
      日本動物学会関東支部第75回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性ストレスによる末梢神経系のヒストン修飾変動と痛覚感受性の連関2023

    • Author(s)
      山本侑輝、古澤孝太郎、榎本和生
    • Organizer
      日本動物学会関東支部第75回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neural stem cell mechanism underlying species-specific control of neuronal number2022

    • Author(s)
      Yuki Yamauchi, Ikuo Suzuki, Kazuo Emoto
    • Organizer
      第55回 発生生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A Long-term Single Neural Stem Cell Tracking in in vitro Culture to Reveal Human-specific2022

    • Author(s)
      Xuanhao Zhou, Ikuo Suzuki, Kazuo Emoto
    • Organizer
      第55回 発生生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The tyrosine capsid mutations on retrograde adeno-associated virus enhance gene transduction efficiency2022

    • Author(s)
      中浜諒大、植松朗、榎本和生
    • Organizer
      NEURO2022
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neuronal mechanisms underlying behavioral switching during nociceptive2022

    • Author(s)
      Mami Dojo-Nakamizo, Kenichi Ishii, and Kazuo Emoto
    • Organizer
      NEURO2022
    • Related Report
      2020 Annual Research Report
  • [Presentation] Molecular control of developmental neuronal remodeling in Drosophila neurons2022

    • Author(s)
      Kotaro Furusawa, Kenichi Ishii, Kazuo Emoto
    • Organizer
      NEURO2022
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト固有遺伝子NOTCH2NLによるヒトらしい神経回路形成メカニズムの解明2022

    • Author(s)
      石渡麗依那、鈴木郁夫、榎本和生
    • Organizer
      第93回 日本動物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A proto-oncogene homolog "nervy" mediates experience-dependent suppression of aggression2022

    • Author(s)
      Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N. Shokhirev, Kazuo Emoto, Kenta Asahina
    • Organizer
      第15回 日本ショウジョウバエ研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Protein degradation systems in functional remodeling of Drosophila nociceptive circuits2021

    • Author(s)
      Kotaro Furusawa, Kenichi Ishii, Kazuo Emoto
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Cellular and Molecular Mechanisms of Circadian Regulation in the Mouse Olfactory System2021

    • Author(s)
      竹内俊祐、清水貴美子、深田吉孝、榎本和生
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neural mechanisms that control the initiation and termination of fear2021

    • Author(s)
      Haruka Kobayashi, Masato Tsuji, Kazuo Emoto
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 種固有の脳サイズを決める組織間発生制御メカニズムの探索2021

    • Author(s)
      山内優季、鈴木郁夫、榎本和生
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antidepressant-Responsive Anhedonia in Drosophila2021

    • Author(s)
      Yuto Nishizuka, Masato Tsuji, Emoto Kazuo
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo calcium imaging in the ventral hippocampus during fear extinction2021

    • Author(s)
      Aika Saito, Akira Uematsu, Kazuo Emoto
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neural mechanisms that control the initiation and termination of fear2021

    • Author(s)
      Haruka Kobayashi, Masato Tsuji, Kazuo EmotV
    • Organizer
      日本ショウジョウバエ学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 恐怖による逃避行動の持続時間を規定する神経メカニズムの解明2021

    • Author(s)
      小林遥香、辻真人、榎本和生
    • Organizer
      日本動物学会米子大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antidepressant-Responsive Anhedonia in Drosophila2021

    • Author(s)
      Yuto Nishizuka, Masato Tsuji, Emoto Kazuo
    • Organizer
      日本動物学会米子大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大脳皮質進化を駆動したヒト特異的重複遺伝子の網羅的探索2021

    • Author(s)
      中野陽介、鈴木郁夫、榎本和生
    • Organizer
      日本動物学会米子大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウスにおける恐怖消去学習を制御する視床皮質投射2021

    • Author(s)
      望月祐希、植松朗、榎本和生
    • Organizer
      日本動物学会米子大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A long-term tracking of a single cortical progenitor in the nascent organoid culture2021

    • Author(s)
      Xuanhao Zhou, Ikuo K. Suzuki, Kazuo Emoto
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 発達初期における「細切れ睡眠」の制御メカニズムの解明2021

    • Author(s)
      逸見知世、石井健一、榎本和生
    • Organizer
      日本動物学会関東支部第74回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒト固有遺伝子NOTCH2NLによるヒトらしい神経回路形成メカニズム2021

    • Author(s)
      石渡麗依那、鈴木郁夫、榎本和生
    • Organizer
      日本動物学会関東支部第74回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全脳の自発活動パターンが、感覚応答を制御するメカニズムの解明2021

    • Author(s)
      植村友貴、辻真人、榎本和生
    • Organizer
      日本動物学会関東支部第74回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ショウジョウバエ幼虫における痛覚応答の日内変動2021

    • Author(s)
      本吉真菜、石井健一、榎本和生
    • Organizer
      日本動物学会関東支部第74回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Calcium control of neural development and remodeling2018

    • Author(s)
      Kazuo Emoto
    • Organizer
      CSHA Neuroscience Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcium signaling in spatio-temporal regulation of neuronal development and remodeling2017

    • Author(s)
      Kazuo Emoto
    • Organizer
      Annual Meeting of European Developmental Biology
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcium signaling in spatio-temporal regulation of neuronal development and remodeling2017

    • Author(s)
      Kazuo Emoto
    • Organizer
      The 48th NIPS international Symposium
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuronal basis for emotion in invertebrates2017

    • Author(s)
      Kazuo Emoto
    • Organizer
      Invited seminar series in Department of Biology at University of British Columbia
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 遺伝子命名物語-名前に秘められた生物学のドラマ (中公新書ラクレ, 742) 中央公論新社2021

    • Author(s)
      坪子理美、石井健一
    • Total Pages
      320
    • Publisher
      中央公論新社
    • ISBN
      9784121507426
    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] CSHA Neuroscience Meeting2018

    • Related Report
      2018 Annual Research Report

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Published: 2016-07-04   Modified: 2024-01-30  

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