| Budget Amount *help |
¥158,990,000 (Direct Cost: ¥122,300,000、Indirect Cost: ¥36,690,000)
Fiscal Year 2020: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2019: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2018: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
Fiscal Year 2017: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2016: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
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| Outline of Final Research Achievements |
In the cerebral cortex of the postnatal animals, neuronal circuits are reorganized in an activity-dependent manner. In particular, during the neonatal stage, neuronal circuit refinement involves drastic scrap and build of dendrites and axons. In this research, using the mouse primary somatosensory cortex (barrel cortex) layer 4 (L4) as a model, we revealed dynamic mechanisms of dendritic refinement of the barrel cortex L4 neurons using the original in vivo two-photon imaging system. We also found a molecular pathway involving Btbd3 for the dendritic refinement.
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