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神経幹細胞の発生タイマー実行因子の解析

Planned

Project AreaInterplay of developmental clock and extracellular environment in brain formation
Project/Area Number 16H06481
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

後藤 由季子  東京大学, 大学院薬学系研究科(薬学部), 教授 (70252525)

Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥138,580,000 (Direct Cost: ¥106,600,000、Indirect Cost: ¥31,980,000)
Fiscal Year 2020: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2018: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Keywordsポリコーム / HMGA / 神経系前駆細胞 / 増幅期 / ヌクレオソーム / 発生時間 / 幹細胞分化運命制御 / 神経幹細胞
Outline of Annual Research Achievements

本研究において我々は、遺伝子の発現抑制に働くエピジェネティック因子ポリコーム複合体が、神経幹細胞においてニューロン分化関連遺伝子を抑制することを報告し、これが大脳新皮質の発生後期において神経幹細胞が「ニューロン分化期」から「グリア分化期」と転換する際の鍵となるメカニズムであることを示した。特に、ポリコーム複合体が「ニューロン分化期」においてはニューロン分化遺伝子をRing1BによるヒストンH2Aユビキチン化を介して「仮抑え」 し発現可能状態を維持していること、一方「グリア分化期」ではポリコーム複合体はPhc2によるクロマチン凝集を介してニューロン分化遺伝子を「永続抑制」していることを見出した(Tsuboi et al. 2018)。これらは幹細胞の「分化能がある状態」と「分化能がない状態」をポリコーム複合体のふたつの異なる抑制モードが説明するという新しい概念を提唱するものである。また、ポリコーム複合体による抑制モードの転換において、MBD3を主要構成因子とするNuRD複合体が関与することも見出し報告した(Tsuboi et al. 2018)。
神経幹細胞は発生過程で「ニューロン分化期」に入る前に「増幅期」と呼ばれる時期を経ることでまず神経幹細胞のプールを増やす。本研究においてこの「増幅期」から「ニューロン分化期」への転換の時期において神経幹細胞の遺伝子発現変化を網羅的に調べた。その結果、クロマチン因子HMGA2の発現量がこの転換期において上昇すること、またHMGA2の上昇がこの転換期におけるニューロン分化能の亢進に必須であることを示唆する結果を得た(Kuwayama et al. bioRxiv 2020)。このように、発生時間に依存した「増幅期」から「ニューロン分化期」への転換を引き起こすトリガー候補分子を同定した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

神経幹細胞の「増幅期からニューロン分化期への転換」に関わる因子のスクリーニングを行い、HMGA2がニューロン分化期開始におけるニューロン分化能の獲得に重要な役割を果たすという発見に至った。これは、前年度までのポリコーム複合体による「ニューロン分化期からグリア分化期」転換メカニズムの発見に引き続き、神経幹細胞の発生時間に伴う運命転換機構の鍵となる部分を明らかにした知見である。
スクリーニングの中でHMGA2以外にも「増幅期からニューロン分化期への転換」期にかかわる因子の候補を得ている。
また、HMGA2タンパク質が幹細胞の機能を制御する際の分子的な性質(特にクロマチン状態の制御機構)も明らかにしつつある。
いずれも、当初の計画を上回る結果と言える。

Strategy for Future Research Activity

神経幹細胞においてHMGA2がニューロン分化期開始におけるニューロン分化能の獲得に重要な役割を果たすという本研究の発見に基づき、HMGA2の生化学的性質を現在解明しつつある。すでに、クロマチン状態に対する影響を示す予備的結果を得ているので、今後はさらにその点について生化学的再構成の手法と分子細胞生物学的な解析、およびマウス個体を使ったフェノタイプ解析を組み合わせて研究を進める予定である。
発生時間に従った大脳新皮質神経幹細胞の「増幅期からニューロン分化期への転換」期に関わるHMGA2以外の候補因子について、さらに神経幹細胞のin vitro培養系ならびにin vivo個体を用いて解析を進める予定である。
本研究で行ってきたポリコーム複合体の発生時期依存的な活性制御メカニズムについてもさらに生化学的および分子細胞生物学的な解析を進める。

Report

(4 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(177 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 12 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (160 results) (of which Int'l Joint Research: 67 results,  Invited: 59 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Role of the imprinted allele of the Cdknlc gene in mouse neocortical development.2020

    • Author(s)
      Imaizumi, Y., Furutachi, S., Watanabe, T., Miya, H., Kawaguchi, D., Gotoh, Y.
    • Journal Title

      Sci. Rep.

      Volume: 10 Pages: 1884-1884

    • DOI

      10.1038/s41598-020-58629-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endfoot regrowth for neural stem cell renewal.2020

    • Author(s)
      Tsuboi, M. and Gotoh, Y.
    • Journal Title

      Nature Cell Biology

      Volume: 22 Pages: 3-5

    • DOI

      10.1038/s41556-019-0448-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plagl regulates neuronal gene expression and neuronal differentiation of neocortical neural progenitor cells2019

    • Author(s)
      Hiroshi Sakai, Yuki Fujii, Naohiro Kuwayama, Keita Kawaji, Yukiko Gotoh, and Yusuke Kishi
    • Journal Title

      Genes to Cells

      Volume: 24 Pages: 650-666

    • DOI

      10.1111/gtc.12718

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diverse gene regulatory mechanisms mediated by Polycomb group proteins during neural development2019

    • Author(s)
      Tsuboi, M., Hirabayashi, Y. and Gotoh, Y.
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 59 Pages: 164-173

    • DOI

      10.1016/j.conb.2019.07.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurexin nanoclusters: A novel structure at presynaptic terminals2019

    • Author(s)
      Daichi Kawaguchi, Yukiko Gotoh
    • Journal Title

      Journal of Cell Biology

      Volume: 218 Pages: 2442-2443

    • DOI

      10.1083/jcb.201907074

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis2019

    • Author(s)
      Tanaka H., Okazaki T., Aoyama S., Yokota M., Koike M., Okada Y., Fujiki Y. and Gotoh Y.
    • Journal Title

      JOURNAL OF CELL SCIENCE

      Volume: -

    • DOI

      10.1242/jcs.224766

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of chromatin structure during neural development.2018

    • Author(s)
      Kishi, Y. and Gotoh, Y.
    • Journal Title

      Frontiers Neurosci.

      Volume: 12 Pages: 874-874

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquitination-independent repression of PRC1 targets during neuronal fate restriction in the developing mouse neocortex2018

    • Author(s)
      Masafumi Tsuboi, Yusuke Kishi, Wakana Kyozuka, Haruhiko Koseki, Yusuke Hirabayashi, and Yukiko Gotoh*
    • Journal Title

      Dev. Cell

      Volume: 47 Pages: 758-772

    • DOI

      10.1016/j.devcel.2018.11.018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An unexpected calm: Mfge8 controls stem cell quiescence and maintenance.2018

    • Author(s)
      Okazaki, T. and Gotoh, Y.
    • Journal Title

      Cell Stem Cell

      Volume: 23 Pages: 311-312

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers2018

    • Author(s)
      Darin Lanjakornsiripan, Baek-Jun Pior, Daichi Kawaguchi, Shohei Furutachi, Tomoaki Tahara, Yu Katsuyama, Yutaka Suzuki, Yugo Fukazawa & Yukiko Gotoh
    • Journal Title

      Nat. Comm.

      Volume: 9 Pages: 1623-1623

    • DOI

      10.1038/s41467-018-03940-3

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Area-specific regulation of quiescent neural stem cells by Notch3 in the adult mouse subependymal zone.2017

    • Author(s)
      Kawai H, Kawaguchi D, Kuebrich B, Kitamoto T, Yamaguchi M, Gotoh Y, Furutachi S
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Pages: 11867-11880

    • DOI

      10.1523/jneurosci.0001-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The PDK1-Akt Pathway Regulates Radial Neuronal Migration and Microtubules in the Developing Mouse Neocortex2016

    • Author(s)
      Itoh, Y., Higuchi, M., Oishi, K.,Kishi, Y., Okazaki, T., Sakai, H., Miyata, T., Nakajima, K., Gotoh, Y.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 113(21) Pages: 2955-64

    • DOI

      10.1073/pnas.1516321113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Epigenetic regulation of neural stem-progenitor cell fate in the developing mouse neocortex2020

    • Author(s)
      Naohiro Kuwayama,Daichi Kawaguchi,Yusuke Kishi,○Yukiko Gotoh
    • Organizer
      2nd Neuroepigenetics & Neuroepitranscriptomics’ Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fate determination of ependymal cells and adult neural stem cells during brain development2020

    • Author(s)
      Hanae Omiya,Shima Yamaguchi,Takaaki Kuniya,Daichi Kawaguchi,Masahide Seki,Yutaka Suzuki,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanistic links between cell cycle arrest and postnatal/adult neural stem cells at the mouse subventricular zone2020

    • Author(s)
      Yujin Harada,Mayumi Yamada,Itaru Imayoshi,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maintenance of neural stem/progenitor cells by the lysosomal biosynthesis regulator TFEB2020

    • Author(s)
      Naoya Yuizumi,Yujin Harada,Takehiko Sunabori,Masato Koike,Masaki Wakabayashi,Yasushi Ishihama,Yutaka Suzuki,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin regul ation during neural development2020

    • Author(s)
      Yusuke Kishi,Tanita Miriam Frey,Seishin Sakai,Keita Kawaji,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of the ECM-regulator TIMP3 in the genesis of adult neural stem cells2020

    • Author(s)
      Lingyan Fang,Takaaki Kuniya,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the expansion-to-neurogenic phase transition in neocortical neural progenitor cells2020

    • Author(s)
      Naohiro Kuwayama,Yusuke Kishi,Yurie Nishiumi,Yukiko Gotoh
    • Organizer
      German-Japanese Developmental Neuroscience Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NUDT21 Links Cytoplasmic Stress Granules to Mitochondrial IPS-1 and Activates Host Defense Responses Against Viral Infection2019

    • Author(s)
      Saeko Aoyama-Ishiwatari,Tomohiko Okazaki,Yukiko Gotoh
    • Organizer
      ASCB/EMBO 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成体神経幹細胞の胎生期起源細胞ニッチの解析2019

    • Author(s)
      丁悦文,川口大地,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉症早期にみられる領域特異的な大脳皮質肥大化に関わる分子機構2019

    • Author(s)
      渡邊信斗,川口大地,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳内へのウイルス感染応答防御を担う免疫細胞の同定の試み2019

    • Author(s)
      里見明澤,岡崎朋彦,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポリコーム群タンパク質Ezh1による視床皮質回路形成の制御2019

    • Author(s)
      後藤昂宏,城野克磨,川口大地,壷井將史,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎生期の神経幹細胞における脂質代謝の解析、2019

    • Author(s)
      外川諒也,湯泉直也,原田雄仁,川口大地,青柳良平,有田誠,可野 行,青木淳賢,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成体神経幹細胞の胎生期「起源細胞」の同定とその性質の解明2019

    • Author(s)
      大宮英恵,山口詩真,國屋敬章,川口大地,関真秀,鈴木穣,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペルオキシソームによる新規ミトコンドリア2019

    • Author(s)
      岡崎朋彦,田中秀明,王雨竹,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウイルス感染細胞において インターフェロン産生細胞が少数選ばれる機構と意義の解明2019

    • Author(s)
      豊田伸平,岡崎朋彦,後藤由季子
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Regulation of neural progenitor-stem cell fate during development2019

    • Author(s)
      Yukiko Gotoh
    • Organizer
      The Hospital for Sick Children symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin regulation during neural development2019

    • Author(s)
      Yusuke Kishi,Seishin Sakai,Keita Kawaji,Yukiko Gotoh
    • Organizer
      Scoping meeting on neuronal maturation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A division of labour for the type I Interferon and apoptosis induction after viral infection2019

    • Author(s)
      Tomohiko Okazaki,Moe Inoue,Yukiko Gotoh
    • Organizer
      The 17th International Congress of Immunology (IUIS 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of adult neural stem/progenitor cell fate2019

    • Author(s)
      Yukiko Gotoh
    • Organizer
      The Notch Meeting XI
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin-level regulation of neural stem/progenitor cell fate2019

    • Author(s)
      Naohiro Kuwayama,Daichi Kawaguchi,Yusuke Kishi,○Yukiko Gotoh
    • Organizer
      2019 The International Brain Research Organization (IBRO)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Vitamin K and carboxylation of MAVS converts apoptotic response to interferon production and protects against viral infection in the central nervous system2019

    • Author(s)
      Tomohiko Okazaki,Akisawa Satomi,Yukiko Gotoh
    • Organizer
      Cell symposia Neuro-Immune Axis: Reciprocal Regulation in Development, Health, and Disease
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペルオキシソームによるミトコンドリアの動態・機能制御2019

    • Author(s)
      田中秀明,岡崎朋彦,後藤由季子
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規IPS-1結合タンパク質による抗ウイルス応答誘導メカニズムの解析2019

    • Author(s)
      青山幸恵子,岡崎朋彦,後藤由季子
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Zfp57による組織特異的なアレス性発現制御メカニズム2019

    • Author(s)
      今泉結,岸雄介,川口大地,後藤由季子
    • Organizer
      日本遺伝学会第91回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳はどのように発達してきたかのか?その謎にせまる2019

    • Author(s)
      後藤由季子
    • Organizer
      第199回二木会研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Embryonic origin of neural stem cells in the adult mouse subependymal zone2019

    • Author(s)
      Ryoya Sotokawa,Naoya Yuizumi,Yujin Harada,Daichi Kawaguchi,○Yukiko Gotoh
    • Organizer
      Current Trends and Future Directions of Synapse-Circuit Plasticity Research 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder2019

    • Author(s)
      D. Kawaguchi,N. Watanabe,K. Nagahama,T. Watanabe,M. Kano,Y. Gotoh
    • Organizer
      日米脳:シナプスー回路シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳内へのウィルス感染応答防御を担う免疫細胞の同定の試み2019

    • Author(s)
      里見明澤,岡崎朋彦,後藤由季子
    • Organizer
      第31回高遠・分子細胞生物学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎生期の神経幹細胞における脂質代謝の解析2019

    • Author(s)
      外川諒也,湯泉直也,原田雄仁,川口大地,青柳良平,有田誠,可野邦行,青木淳賢,後藤由季子
    • Organizer
      第31回高遠・分子細胞生物学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞周期の抑制はNotchシグナルを活性化することで胎生期神経系前駆細胞の運命決定を制御する2019

    • Author(s)
      原田 雄仁,山田 真弓,今吉 格,川口 大地,後藤 由季子
    • Organizer
      第42回日本神経科学大会(NEURO2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス大脳新皮質におけるアストロサイトの多様性についての解析2019

    • Author(s)
      表 伯俊,Lanjakornsiripan Darin,川口 大地,後藤由季子
    • Organizer
      第42回日本神経科学大会(NEURO2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニューロン分化過程におけるクロマチン構造変化2019

    • Author(s)
      岸 雄介,坂井 星辰,和田 恵邦,後藤 由季子
    • Organizer
      第42回日本神経科学大会(NEURO2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経幹細胞の発生タイマー実行因子の解析2019

    • Author(s)
      後藤由季子
    • Organizer
      領域班会議 脳構築における発生時計と場の連携
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成体神経幹細胞の起源細胞の形成・維持における細胞外基質制御因子TIMP3 の機能解析2019

    • Author(s)
      方凌艶
    • Organizer
      第4回領域班会議脳構築における発生時計と場の連携
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉症早期にみられる領域特異的な大脳皮質肥大化に関わる分子機構2019

    • Author(s)
      川口大地
    • Organizer
      第4回領域班会議脳構築における発生時計と場の連携
    • Related Report
      2019 Annual Research Report
  • [Presentation] ニューロン分化過程におけるクロマチン構造変化連携2019

    • Author(s)
      岸雄介
    • Organizer
      第4回領域班会議脳構築における発生時計と場の連携
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウィルス感染細胞における抗ウィルス応答の使い分け戦略2019

    • Author(s)
      岡崎朋彦,井上萌,豊田伸平,後藤由季子
    • Organizer
      第28回日本Cell Death学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Chromatin-level regulation of neural stem/progenitor cell fate2019

    • Author(s)
      Daichi Kawaguchi,Yusuke Kishi,○Yukiko Gotoh
    • Organizer
      NCCR-IRCN “22q” Workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural progenitor fate during development2019

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Center for Regenerative Therapies TU Dresden (CRTD) Summer Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 成体神経幹細胞の胎生期「起源細胞」の同定とその性質の解明2019

    • Author(s)
      山口 詩真,國屋 敬章,大宮 英恵,川口 大地,鈴木 穣,後藤 由季子
    • Organizer
      第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉症早期にみられる領域特異的な大脳皮質肥大化に関わる分子機構2019

    • Author(s)
      川口 大地,渡邊 信斗,後藤 由季子
    • Organizer
      第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Polycomb Group Protein Ring1 regulates early-stage patterning of mouse telencephalon2019

    • Author(s)
      Hikaru Eto,Yusuke Kishi,Haruhiko Koseki,Yukiko Gotoh
    • Organizer
      Gordon Research Conference:Developmental Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニューロン分化期に多数の遺伝子の発現を制御する機構の解析2019

    • Author(s)
      坂井 星辰,岸 雄介,後藤 由季子
    • Organizer
      第13回エピジェネティクス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hmga2による神経幹細胞の運命転換制御メカニズムの解明2019

    • Author(s)
      岸雄介,桑山尚大,和田 惠邦,後藤由季子
    • Organizer
      第13回エピジェネティクス研究会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Zfp57による組織特異的アレル性発現制御メカニズムの解明2019

    • Author(s)
      今泉 結,岸 雄介,川口 大地,後藤 由季子
    • Organizer
      第13回エピジェネティクス研究会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chromatin-level regulation of neural stem/progenitor cell fate2019

    • Author(s)
      Naohiro Kuwayama,Yusuke Kishi,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      第13回エピジェネティクス研究会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Major satellite 転写によるクロマチン構造制御2019

    • Author(s)
      木下隆太,岸雄介,鈴木伸之介,安倍訓也,後藤由季子
    • Organizer
      第13回エピジェネティクス研究会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Elucidation of the expansion-to-neurogenic phase transition in neocortical neural progenitor cells.2019

    • Author(s)
      桑山尚大,岸雄介,西海友梨恵,後藤由季子
    • Organizer
      第17回幹細胞シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成体神経幹細胞の胎生期起源細胞ニッチの解析2019

    • Author(s)
      丁悦文,川口大地,後藤由季子
    • Organizer
      第17回幹細胞シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification and characterization of embryonic origin of adult subventricular neural stem cells2019

    • Author(s)
      Shima Yamaguchi,Takaaki Kuniya,Hanae Omiya,Daichi Kawaguchi,Yutaka Suzuki,Yukiko Gotoh
    • Organizer
      第17回幹細胞シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Investigation of transcriptional diversity of embryonic mouse neural progenitor cells in the ganglionic eminence2019

    • Author(s)
      Shima Yamaguchi,Takaaki Kuniya,Hanae Omiya,Daichi Kawaguchi,Masahide Seki,Yutaka Suzuki,Yukiko Gotoh
    • Organizer
      EMBO Workshop : Single Cell Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin regulation in neocortical deep-layer excitatory neurons during differentiation2019

    • Author(s)
      Seishin Sakai,Yusuke Kishi,Yukiko Gotoh
    • Organizer
      EMBO Workshop : Single Cell Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] division of labour for the type ? interferon and apoptosis induction after viral infection2019

    • Author(s)
      Tomohiko Okazaki,Moe Inoue,Shinpei Toyoda,Yukiko Gotoh
    • Organizer
      EMBO:Single cell biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fate determination of ependymal cells and adult neural stem cells during brain development.2019

    • Author(s)
      大宮英恵,山口詩真,國屋敬章,渡辺智幸,川口大地,後藤由季子
    • Organizer
      第12回神経発生討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成体神経幹細胞の起源細胞の形成・維持における細胞外基質制御因子TIMP3の機能解析2019

    • Author(s)
      方凌艶,國屋敬章,川口大地,後藤由季子
    • Organizer
      第12回 神経発生討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ‘Life Science Alliance Journal Lecture’ Regulation Of Neocortical Neural Stem/Progenitor Cell Fate During Development.2019

    • Author(s)
      Yukiko Gotoh
    • Organizer
      2nd Neurogenesis Conference (Plenary lecture)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin-level regulation of neural stem/progenitor cell fate.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      2nd IRCN International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Elucidation of the expansion-to-neurogenic phase transition in neocortical neural progenitor cells.2018

    • Author(s)
      桑山尚大,西海友梨恵,岸雄介,後藤由季子
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成体神経幹細胞の起源細胞の形成・維持における細胞外基質制御因子TIMP3の機能解析2018

    • Author(s)
      方凌艶,國屋敬章,川口大地,後藤由季子
    • Organizer
      次世代脳プロジェクト・冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] A division of labour for the type I interferon and apoptosis induction after viral infection.2018

    • Author(s)
      岡崎朋彦,井上萌,後藤由季子
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of neural stem/progenitor cell fate.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      National Chung Kung University (NCKU) Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem/progenitor cell fate.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Neuroscience Program of Academia Sinica (NPAS) Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of the cdk inhibitor p57kip2 in regulating the fate of embryonic neural progenitor cells.2018

    • Author(s)
      Yujin Harada,Shohei Furutachi,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the expansion-to-neurogenic phase transition in neocortical neural progenitor cells.2018

    • Author(s)
      桑山尚大,西海友梨恵,岸雄介,後藤由季子
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経発生におけるペリセントロメア領域の役割2018

    • Author(s)
      岸雄介,木下隆太,後藤由季子
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質発生におけるp57インプリント鎖の役割の解明2018

    • Author(s)
      今泉 結,渡邊 知幸,古舘 昌平,川口 大地,後藤 由季子
    • Organizer
      第41回分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of neural stem cell and its involvement in brain development.2018

    • Author(s)
      Hanae Omiya, Shima Yamaguchi, Takaaki Kuniya, Daichi Kawaguchi and ○Yukiko Gotoh
    • Organizer
      Japan-Asia-NIBR Drug Discovery and Translational Medicine Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem/progenitor cell fate during brain development.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Vienna BioCenter (VBC) Seminars Seminars
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳を創る神経幹細胞2018

    • Author(s)
      後藤由季子
    • Organizer
      第26回「脳の世紀」シンポジウム 「AIと脳」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regulation of astrocyte production during neocortical development.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural progenitor/stem cell fate during development.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Stem Cell Dynamics Throughout Life: From Development to the Adult
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 成体神経幹細胞と上衣細胞の系譜選択機構の解析2018

    • Author(s)
      大宮英恵,山口詩真,渡辺知幸,川口大地,後藤由季子
    • Organizer
      第30回 高遠・分子細胞生物学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成体神経幹細胞の起源細胞の形成・維持における細胞外基質制御因子TIMP3の機能解析2018

    • Author(s)
      方凌艶,國屋敬章,川口大地,後藤由季子
    • Organizer
      第30回 高遠・分子生物学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自閉症早期にみられる領域特異的な大脳皮質肥大化に関わる分子機構2018

    • Author(s)
      川口大地,後藤由季子
    • Organizer
      新学術領域「脳構築における発生時計と 場の連携」第3回 領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経幹細胞の発生タイマー実行因子の解析2018

    • Author(s)
      後藤 由季子
    • Organizer
      新学術領域「脳構築における発生時計と 場の連携」第3回 領域班会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳を創る神経幹細胞の制御メカニズム2018

    • Author(s)
      後藤 由季子
    • Organizer
      自閉症学研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2018

    • Author(s)
      後藤 由季子
    • Organizer
      名古屋大学 IGER NSIセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regulation of neural stem/progenitor cell fate during neocortical development.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      134th WPI-IIIS Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regulation of neural stem/progenitor cell fate during neocortical development2018

    • Author(s)
      Naohiro Kuwayama, Hikaru Eto, Yusuke Kishi, and ○Yukiko Gotoh
    • Organizer
      International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem/progenitor cell fate during development.2018

    • Author(s)
      Lingyang Fang, Yusuke Kishi, Daichi Kawaguchi and ○Yukiko Gotoh
    • Organizer
      The Company of Biologists Workshop:Development and evolution of the human neocortex
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromatin regulation of neural stem cell fate during neocortical development.2018

    • Author(s)
      Yukiko Gotoh
    • Organizer
      2018 Joint Meeting between The Neurodevelopmental Biology Section of The Korean Society for Molecular and Cellular Biology and Japanese Developmental Neuroscientists
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A Division Of Labour For The Type 1 Interferon And Apoptosis Induction After Viral Infection.2018

    • Author(s)
      Tomohiko Okazaki,Moe Inoue,Yukiko Gotoh
    • Organizer
      The TOLL2018 conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functions of the p57 imprinted allele in mouse neocortical development.2018

    • Author(s)
      Yui Imaizumi,Tomoyuki Watanabe,Shohei Furutachi,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      第70回 日本細胞生物学会 第51回 日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the expansion-to-neurogenic phase transition in neocortical neural progenitor cells.2018

    • Author(s)
      Naohiro Kuwayama,Yusuke Kishi,Yurie Nishiumi,Yukiko Gotoh
    • Organizer
      第70回 日本細胞生物学会 第51回 日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of lysosomes in embryonic neural stem/progenitor cells.2018

    • Author(s)
      Naoya Yuizumi,Yujin Harada,Daichi Kawaguchi,Shohei Furutachi,Yukiko Gotoh
    • Organizer
      第70回 日本細胞生物学会 第51回 日本発生生物学会 合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Peroxisomes govern mitochondrial dynamics and the mitochondrial-dependent apoptotic pathway.2018

    • Author(s)
      桑山尚大,西海友梨恵,岸雄介,後藤由季子
    • Organizer
      第51回日本発生生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Polycomb Group Proteins Ring1A/B regulate early-stage patterning in the telencephalic development.2018

    • Author(s)
      Hikaru Eto,Yusuke Kishi,Yukiko Gotoh
    • Organizer
      16th Stem Cell Research Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニューロン分化期に多数の遺伝子の発現を制御する機構の解析2018

    • Author(s)
      坂井 星辰,岸 雄介,後藤 由季子
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of lysosomes in embryonic neural stem/progenitor cells.2018

    • Author(s)
      Naoya Yuizumi,Yujin Harada,Daichi Kawaguchi,Shohei Furutachi,Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018 in Nara
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin regulation of neural stem cell fate during neocortical development.2018

    • Author(s)
      Yusuke Kishi,Masafumi Tsuboi,Naohiro Kuwayama,Yusuke Hirabayashi,Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018 in Nara
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder.2018

    • Author(s)
      Daichi Kawaguchi,Dennis O'Leary,Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018 in Nara
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functions of the p57 imprinted allele in mouse neocortical development.2018

    • Author(s)
      Yui Imaizumi,Tomoyuki Watanabe,Shohei Furutachi,Daichi Kawaguchi,Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018 in Nara
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of embryonic and adult neural stem cell fate.2018

    • Author(s)
      Naoya Yuizumi,Nohiro Kuwayama,Yusuke Kishi,Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of the cdk inhibitor p57kip2 in regulating the fate of embryonic neural progenitor cells.2018

    • Author(s)
      Yujin Harada, Shohei Furutachi, Daichi Kawaguchi, Yukiko Gotoh
    • Organizer
      International Society for Developmental Neuroscience (ISDN) 2018 in Nara
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of embryonic and adult neural stem cell fate.2018

    • Author(s)
      Hikaru Eto, Yusuke Kishi and ○Yukiko Gotoh
    • Organizer
      Cold Spring Harbor (CSH) Asia 2018, Stem Cell Crossroads
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peroxisomes govern mitochondrial dynamics and the mitochondrion-dependent apoptotic pathway.2018

    • Author(s)
      Hideaki Tanaka,Yukiko Gotoh,Tomohiko Okazaki
    • Organizer
      Keystone Symposia Mitochondrial Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of neural stem/progenitor cell fate during development and in the adult.2018

    • Author(s)
      Yuewen Ding, Daichi Kawaguchi and ○Yukiko Gotoh
    • Organizer
      Bordeaux Cajal School 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of embryonic and adult neural stem cell fate.2018

    • Author(s)
      湯泉直也、原田雄仁、川口大地、後藤由季子
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chromatin regulation of neural stem cell fate during neocortical development.2018

    • Author(s)
      Yusuke Kishi and Yukiko Gotoh
    • Organizer
      International Young Scientists Workshop on Neural Development and Stem Cells 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Large-scale changes in the chromatin structure during neuronal differentiation.2018

    • Author(s)
      Seishin Sakai, Yusuke Kishi and Yukiko Gotoh
    • Organizer
      新学術領域「脳構築の時計と場」若手研究者海外連携ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 発生早期神経系前駆細胞のHMGAタンパク質群による運命制御2018

    • Author(s)
      桑山尚大、西海友梨恵、岸雄介、後藤由季子
    • Organizer
      新学術領域「脳構築の時計と場」若手研究者海外連携ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of embryonic and adult neural stem cell fate.2018

    • Author(s)
      後藤由季子
    • Organizer
      理研エピジェネティクスセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2018

    • Author(s)
      後藤由季子
    • Organizer
      立命館大学システム視覚科学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2018

    • Author(s)
      後藤由季子
    • Organizer
      大阪大学微生物研究所・部員会共催ブリッジセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2018

    • Author(s)
      後藤由季子
    • Organizer
      新学術領域「酸素生物学・ダイイングコード」合同若手の会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ポリコーム群タンパク質による視床皮質回路形成の制御2017

    • Author(s)
      城野克磨、川口大地、壷井將史、後藤由季子
    • Organizer
      次世代脳シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Layer-specific heterogeneity of astrocytes in the mouse neocortex.2017

    • Author(s)
      表伯俊、ランジャコンシリパン・ダーリン、古舘昌平、川口大地、後藤由季子
    • Organizer
      次世代脳シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリコーム構成因子Ring1A/Bを介した終脳パターニング制御2017

    • Author(s)
      衛藤光、岸雄介、後藤由季子
    • Organizer
      次世代脳シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of neural stem/progenitor cell fate.2017

    • Author(s)
      後藤由季子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Polycomb複合体による神経幹細胞の運命制御機構2017

    • Author(s)
      岸雄介、壺井將史、平林祐介、衛藤光、桑山尚大、古関明彦、後藤由季子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ビタミンK依存性カルボキシラーゼGGCXによる脳内ウイルス感染時の恒常性維持機構の解析2017

    • Author(s)
      岡崎朋彦、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 原癌遺伝子Aktによる上皮細胞間接着の制御機構の解明2017

    • Author(s)
      西春佳、カン洪月、西川紗織、後藤由季子、樋口麻衣子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ニューロン分化過程におけるクロマチン構造変化2017

    • Author(s)
      Seishin Sakai, Yusuke Kishi and Yukiko Gotoh
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリコーム群タンパク質による視床皮質回路形成の制御2017

    • Author(s)
      城野克磨、川口大地、壷井將史、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス大脳新皮質におけるアストロサイトの多様性の解析2017

    • Author(s)
      表伯俊、ランジャコンシリパン・ダーリン、古舘昌平、川口大地、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎生期の神経幹細胞におけるリソソームの機能解析2017

    • Author(s)
      湯泉直也、原田雄仁、川口大地、古舘昌平、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成体神経幹細胞の胎生期起源細胞nicheの解析2017

    • Author(s)
      丁悦文、川口大地、原田雄仁、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 大脳皮質発生におけるp57インプリント鎖の役割の解明2017

    • Author(s)
      今泉結、渡邊知幸、古舘昌平、川口大地、後藤由季子
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Adult neural stem cells and their embryonic origin.2017

    • Author(s)
      Naoya Yuizumi, Yuewen Ding, Katsuma Jono, Daichi Kawaguchi and Yukiko Gotoh
    • Organizer
      Stem Cells in Disease Modeling and Therapeutics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Major satellite転写によるクロマチン構造制御2017

    • Author(s)
      木下隆太、岸雄介、鈴木伸之介、阿部訓也、後藤由季子
    • Organizer
      RNAフロンティアミーティング2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epigenetic control of neural precursor cell fate.2017

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Keystone Symposia, Regenerative Biology and Applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem cell fate during development and in the adult.2017

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Italian Society for Neuroscience 2017 (plenary lecture)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Vitamin K-dependent γ-glutamyl carboxylase (GGCX) switches MAVS-mediated immune responses and protects against viral infection of the central nervous system.2017

    • Author(s)
      Tomohiko Okazaki and Yukiko Gotoh
    • Organizer
      Cell Symposia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Role of Phosphorylation of Histone H1 during Neuronal Maturation. Keita Kawaji2017

    • Author(s)
      Keita Kawaji, Yusuke Kishi and Yukiko Gotoh
    • Organizer
      The 72nd Fujihara Seminar: International Symposium on Molecular Mechanism of Molding and Disruption of the Epigenomes Underlying Cellular Community
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin regulation during neuronal maturation in the mouse neocortex.2017

    • Author(s)
      Yukiko Gotoh
    • Organizer
      EMBO Conference, Gene regulatory mechanisms in neural fate decisions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder.2017

    • Author(s)
      Daichi Kawaguchi, Dennis O’Leary and Yukiko Gotoh
    • Organizer
      EMBO conference: Gene regulatory mechanisms in neural fate decisions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functions of the p57 imprinted allele in mouse neocortical development.2017

    • Author(s)
      Yui Imaizumi, Tomoyuki Watanabe, Shohei Furutachi, Daichi Kawaguchi and Yukiko Gotoh
    • Organizer
      EMBO conference: Gene regulatory mechanisms in neural fate decisions
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎生期の神経幹細胞におけるリソソームの機能解析2017

    • Author(s)
      湯泉直也、原田雄仁、川口大地、古舘昌平、後藤由季子
    • Organizer
      第29回高遠シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリコーム群タンパク質による視床皮質回路形成の制御2017

    • Author(s)
      城野克磨、川口大地、壷井將史、後藤由季子
    • Organizer
      第29回高遠シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロマチン制御による神経幹細胞の運命制御機構2017

    • Author(s)
      岸雄介、平林祐介、壺井將史、衛藤光、桑山尚大、鈴木穣、古関明彦、後藤由季子
    • Organizer
      新学術領域研究「発生時計」第2回班会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of neural stem cell fate during development and in the adult.2017

    • Author(s)
      Yukiko Gotoh
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society (lecture)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自閉症における領域特異的な大脳皮質肥大化に関与するメカニズムの解析2017

    • Author(s)
      川口大地、 Dennis O’Leary、後藤由季子
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Role of the cdk inhibitor p57kip2 in regulating the fate of embryonic neural progenitor cells.2017

    • Author(s)
      Yujin Harada, Shohei Furutachi, Daichi Kawaguchi and Yukiko Gotoh
    • Organizer
      第40回日本神経科学大会 2017年7月20日
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of thalamocortical connections by histone modification in the target cortical area.2017

    • Author(s)
      Katsuma Jono, Daichi, Kawaguchi, Masafumi Tsuboi and Yukiko Gotoh
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] クロマチン構造変化の可視化によるニューロン分化遺伝子群制御機構の解明2017

    • Author(s)
      岸雄介、後藤由季子
    • Organizer
      新学術領域研究「動的クロマチン構造と機能」第5回班会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] 発生早期神経系前駆細胞のHMGA タンパク質群による運命制御2017

    • Author(s)
      桑山尚大、西海友里恵、岸雄介、後藤由季子
    • Organizer
      第2回クロマチン動構造ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of astrocyte production in the mouse neocortex.2017

    • Author(s)
      Baekjun Pior, Darin Lanjakornsiripan, Daichi Kawaguchi and Yukiko Gotoh
    • Organizer
      XIII European Meeting on Glial Cells 2017(plenary lecture)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチン制御による神経幹細胞の運命制御機構2017

    • Author(s)
      岸雄介、後藤由季子
    • Organizer
      Active Motif Tokyo Chromatin Club 2nd Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] 微小管結合分子EB2/RP1による微小管動態制御2017

    • Author(s)
      樋口麻衣子、大西啓介、久保田紘史、後藤由季子
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス体節期胚への遺伝子導入法の確立2017

    • Author(s)
      岸雄介、後藤由季子
    • Organizer
      新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」「ステムセルエイジングから解明する疾患原理」「動的クロマチン構造と機能」3領域合同若手勉強会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリコーム構成因子による神経系前駆細胞の制御2017

    • Author(s)
      衛藤光、岸雄介、後藤由季子
    • Organizer
      新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」「ステムセルエイジングから解明する疾患原理」「動的クロマチン構造と機能」合同若手勉強会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Emergence of embryonic origin of adult neural stem cells.2017

    • Author(s)
      Shima Yamaguchi, Yujin Harada, Takaaki Kuniya, Daichi Kawaguchi, Shohei Furutachi and Yukiko Gotoh
    • Organizer
      EMBO Conference, Advances in Stem Cell and Regenerative Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クロマチン制御による神経幹細胞の運命制御機構2017

    • Author(s)
      岸雄介、平林祐介、衛藤光、桑山尚大、鈴木穣、古関明彦、後藤由季子
    • Organizer
      第11回日本エピジェネティクス研究会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳を作る神経幹細胞の運命制御2017

    • Author(s)
      後藤由季子
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ポリコーム構成因子 Ring1A/B による発生早期の神経系前駆細胞の制御2017

    • Author(s)
      衛藤光、岸雄介、後藤由季子
    • Organizer
      第17回東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳を作る神経幹細胞の運命制御2017

    • Author(s)
      後藤由季子
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Special Lectures/Regulation of Neural stem cell fate during development and in the adult2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Society for Neuroscience 46th Annual Meeting,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem cell fate during development and in the adult2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      第14回RCGMフロンティア国際シンポジウム
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of Neural stem cell fate during mouse development2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      EMBO workshop Neural Function and Cell Fate Choice
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intrinsic and Extrinsic Regulators of Neural Stem Cells2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Gordon Research Conference, Neural Development
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of neural stem cell fate during mouse development,2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      Gordon Research Conference, Molecular & Cellular Neurobiology
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Mechanisms Regulating the Neurogenic Stem Cell Niche in the Embryo and Adult Brain2016

    • Author(s)
      Yukiko Gotoh
    • Organizer
      18th International Neuroscience Winter Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳を作る幹細胞の運命制御2016

    • Author(s)
      後藤由季子
    • Organizer
      第6回東北ウインタースクール
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2016

    • Author(s)
      後藤由季子
    • Organizer
      科学技術交流フォーラム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Regulation of neural stem cell fate by intrinsic and extrinsic factors2016

    • Author(s)
      後藤由季子
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御2016

    • Author(s)
      後藤由季子
    • Organizer
      六甲医学研究会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Regulation of neural stem cell fate during development and in the adult2016

    • Author(s)
      後藤由季子
    • Organizer
      熊本大学リエゾンラボ研究会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳発生および成体における神経幹細胞の運命制御2016

    • Author(s)
      後藤由季子
    • Organizer
      第136回奈良医学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞の運命制御、タイムシグナルと制御シンポジウム2016

    • Author(s)
      後藤由季子
    • Organizer
      筑波大学下田臨海実験センター
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 「ウイルス感染に対するI型インターフェロン産生と細胞死誘導の使い分け機構の解析 (特集 ウイルスに対する免疫反応)」臨床免疫・アレルギー科2017

    • Author(s)
      青山幸恵子、後藤由季子、岡崎朋彦
    • Publisher
      科学評論社
    • Related Report
      2017 Annual Research Report
  • [Book] 「神経幹細胞の運命制御におけるlncRNAの役割」CLINICAL CALCIUM2017

    • Author(s)
      木下隆太、岸雄介、後藤由季子
    • Publisher
      医薬ジャーナル
    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://molbio.f.u-tokyo.ac.jp

    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~molbio/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科分子生物学教室ホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~molbio/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2021-12-27  

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