| Budget Amount *help |
¥169,520,000 (Direct Cost: ¥130,400,000、Indirect Cost: ¥39,120,000)
Fiscal Year 2020: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2018: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2017: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2016: ¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
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| Outline of Final Research Achievements |
In the developing cortex, different types of cells are generated from neural stem/progenitor cells depending on the “developmental clock”, and move toward their final destinations. The aim of this study was to clarify how the neuronal migration and differentiation are regulated through interactions with the surrounding cellular environment. As the results, we found that the migrating neurons receive an extracellular signal in the marginal zone to achieve the layer formation through interacting with multiple receptors, one for the termination of migration and another for enabling cellular aggregation. We also found that the neuronal identity in the cerebral cortex is not completely determined just by when the cells are born but also by the cellular environment that they find themselves in. It is thus thought that the cortex is formed through interplay between the cellular clock and the microenvironment.
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