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Neuronal circuit mechanisms of reward/goal-directed behavior

Planned

Project AreaCorrespondence and Fusion of Artificial Intelligence and Brain Science
Project/Area Number 16H06568
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionOsaka University (2018-2020)
Kyoto University (2016-2017)

Principal Investigator

HIKIDA Takatoshi  大阪大学, 蛋白質研究所, 教授 (70421378)

Co-Investigator(Kenkyū-buntansha) マクファーソン トム  大阪大学, 蛋白質研究所, 助教 (40821898)
小澤 貴明  大阪大学, 蛋白質研究所, 助教 (90625352)
山口 隆司  大阪大学, 蛋白質研究所, 助教 (40724258)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥87,230,000 (Direct Cost: ¥67,100,000、Indirect Cost: ¥20,130,000)
Fiscal Year 2020: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Keywords大脳基底核 / 神経回路 / 意思決定 / 強化学習 / 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 / 大脳皮質 / 腹側淡蒼球 / ドーパミン受容体 / 行動柔軟性
Outline of Final Research Achievements

Basal ganglia circit-specific reversible neurotransmission blocking revealed that the direct pathway of the nucleus accumbens is specifically involved in sign-tracking behavior in the reward/goal-directed behavioral task. In addition, the direct and indirect pathways of the nucleus accumbens regulate circuit-specific gene expression in the medial prefrontal cortex. The mutant DISC1 transgenic mouse model of psychiatric disorders showed molecular pathology specific in the indirect pathway in the nucleus accumbens, indicating a role for basal ganglia in the pathogenesis of psychiatric disorders.

Academic Significance and Societal Importance of the Research Achievements

本研究により、報酬/目的指向行動を適切にかつ柔軟性を持って遂行する機構として大脳基底核を中心とした神経回路の制御機構が明らかとなった。また精神疾患モデルマウスの解析により、精神疾患病態において大脳基底核神経回路の異常をもたらす分子病態が関与していることが明らかとなった。これらの研究成果は、脳科学に基づく新たな人工知能・ロボット制御・計算精神応用医学への応用につながるものである。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(121 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (7 results) Journal Article (35 results) (of which Int'l Joint Research: 18 results,  Peer Reviewed: 30 results,  Open Access: 31 results,  Acknowledgement Compliant: 7 results) Presentation (77 results) (of which Int'l Joint Research: 24 results,  Invited: 35 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] ジョンズホプキンス大学/イリノイ大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ジョンズホプキンス大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ジョンズ・ホプキンス大学/イリノイ大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex2020

    • Author(s)
      Saito Nae、Tainaka Kazuki、Macpherson Tom、Hikida Takatoshi、Yamaguchi Shun、Sasaoka Toshikuni
    • Journal Title

      Neurosci. Res.

      Volume: - Pages: 58-65

    • DOI

      10.1016/j.neures.2020.04.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system2020

    • Author(s)
      Anan Madoka、Higa Ryoko、Shikano Kenshiro、Shide Masahito、Soda Akinobu、Carrasco Apolinario Magdeline E.、Mori Kenji、Shin Toshitaka、Miyazato Mikiya、Mimata Hiromitsu、Hikida Takatoshi、Hanada Toshikatsu、Nakao Kazuwa、Kangawa Kenji、Hanada Reiko
    • Journal Title

      Heliyon

      Volume: 6

    • DOI

      10.1016/j.heliyon.2020.e03947

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice2020

    • Author(s)
      Nishioka Tadaaki、Hamaguchi Kosuke、Yawata Satoshi、Hikida Takatoshi、Watanabe Dai
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 14 Pages: 1-13

    • DOI

      10.3389/fnsys.2020.00038

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish2020

    • Author(s)
      Yatsuka Hiroyuki、Hada Kazumasa、Shiraishi Hiroshi、Umeda Ryohei、Morisaki Ikuko、Urushibata Hirotaro、Shimizu Nobuyuki、Sebastian Wulan Apridita、Hikida Takatoshi、Ishitani Tohru、Hanada Reiko、Shimada Tatsuo、Kimoto Kenichi、Kubota Toshiaki、Hanada Toshikatsu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 533 Pages: 1470-1476

    • DOI

      10.1016/j.bbrc.2020.10.044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex2020

    • Author(s)
      Hikida Takatoshi、Yao Shuhei、Macpherson Tom、Fukakusa Ayumi、Morita Makiko、Kimura Haruhide、Hirai Keisuke、Ando Tatsuya、Toyoshiba Hiroyoshi、Sawa Akira
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 1838-1838

    • DOI

      10.1038/s41598-020-58711-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice2020

    • Author(s)
      Hikida Takatoshi、Morita Makiko、Kuroiwa Mahomi、Macpherson Tom、Shuto Takahide、Sotogaku Naoki、Niwa Minae、Sawa Akira、Nishi Akinori
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 38-45

    • DOI

      10.1016/j.neures.2019.02.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids2020

    • Author(s)
      Wang Qiuyi、Shimizu Kimiko、Maehata Kanako、Pan Yue、Sakurai Koki、Hikida Takatoshi、Fukada Yoshitaka、Takao Toshifumi
    • Journal Title

      Journal of Lipid Research

      Volume: 61 Pages: 570-579

    • DOI

      10.1194/jlr.d119000588

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons2019

    • Author(s)
      Shioda Norifumi、Imai Yoshiki、Yabuki Yasushi、Sugimoto Wataru、Yamaguchi Kouya、Wang Yanyan、Hikida Takatoshi、Sasaoka Toshikuni、Mieda Michihiro、Fukunaga Kohji
    • Journal Title

      J Neurosci

      Volume: 39 Pages: 7551-7563

    • DOI

      10.1523/jneurosci.0079-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders2019

    • Author(s)
      Macpherson Tom、Hikida Takatoshi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 印刷中 Pages: 289-301

    • DOI

      10.1111/pcn.12830

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Response to ‘Mood and Affect’2019

    • Author(s)
      Macpherson Tom、Hikida Takatoshi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 73 Pages: 347-347

    • DOI

      10.1111/pcn.12845

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] 大脳基底核神経回路における腹側淡蒼球の役割解析2019

    • Author(s)
      疋田 貴俊
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 30 Pages: 105-107

    • Related Report
      2019 Annual Research Report
  • [Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation.2019

    • Author(s)
      Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
    • Journal Title

      Scientific reports

      Volume: Mar 5;9(1) Pages: 3445-3445

    • DOI

      10.1038/s41598-019-38910-2

    • NAID

      120006579467

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.2019

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Journal Title

      Neurochem Int

      Volume: 126 Pages: 11-18

    • DOI

      10.1016/j.neuint.2019.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opposing roles of dopamine receptor D1-and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.2019

    • Author(s)
      Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
    • Journal Title

      Front Behav Neurosci

      Volume: 13 Pages: 50-50

    • DOI

      10.3389/fnbeh.2019.00050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <b><i>Fez1</i></b>-Deficient Mice2018

    • Author(s)
      Sumitomo Akiko、Saka Ayumi、Ueta Keisho、Horike Kouta、Hirai Kazuko、Gamo Nao J.、Hikida Takatoshi、Nakayama Keiichi I.、Sawa Akira、Sakurai Takeshi、Tomoda Toshifumi
    • Journal Title

      Molecular Neuropsychiatry

      Volume: 3 Pages: 223-233

    • DOI

      10.1159/000488081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice2018

    • Author(s)
      Macpherson Tom、Hikida Takatoshi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 12 Pages: 418-418

    • DOI

      10.3389/fnins.2018.00418

    • NAID

      120006491925

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety2018

    • Author(s)
      Higashida Shu、Nagai Hirotaka、Nakayama Kazuki、Shinohara Ryota、Taniguchi Masayuki、Nagai Midori、Hikida Takatoshi、Yawata Satoshi、Ago Yukio、Kitaoka Shiho、Narumiya Shuh、Furuyashiki Tomoyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 10454-10454

    • DOI

      10.1038/s41598-018-28803-1

    • NAID

      120006517796

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ulk2 controls cortical excitatory?inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons2018

    • Author(s)
      Sumitomo Akiko、Yukitake Hiroshi、Hirai Kazuko、Horike Kouta、Ueta Keisho、Chung Youjin、Warabi Eiji、Yanagawa Toru、Kitaoka Shiho、Furuyashiki Tomoyuki、Narumiya Shuh、Hirano Tomoo、Niwa Minae、Sibille Etienne、Hikida Takatoshi、Sakurai Takeshi、Ishizuka Koko、Sawa Akira、Tomoda Toshifumi
    • Journal Title

      Hum Mol Genet.

      Volume: 27 Pages: 3165-3176

    • DOI

      10.1093/hmg/ddy219

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Homeostatic regulation of basal ganglia circuit for flexible behavior2018

    • Author(s)
      Hikida Takatoshi
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 152 Issue: 6 Pages: 295-298

    • DOI

      10.1254/fpj.152.295

    • NAID

      130007528439

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression2018

    • Author(s)
      Yamaguchi Takashi、Lin Dayu
    • Journal Title

      Current Opinion in Behavioral Sciences

      Volume: 24 Pages: 104-112

    • DOI

      10.1016/j.cobeha.2018.06.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics2017

    • Author(s)
      Tomoda Toshifumi、Hikida Takatoshi、Sakurai Takeshi
    • Journal Title

      Neurotherapeutics

      Volume: 14 Pages: 623-629

    • DOI

      10.1007/s13311-017-0556-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo calcium imaging from dentate granule cells with wide-field fluorescence microscopy2017

    • Author(s)
      Hayashi Yuichiro、Yawata Satoshi、Funabiki Kazuo、Hikida Takatoshi
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI

      10.1371/journal.pone.0180452

    • NAID

      120006539578

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior2017

    • Author(s)
      Miyajima M、Zhang B、Sugiura Y、Sonomura K、Guerrini MM、Tsutsui Y、Maruya M、Vogelzang A、Chamoto K、Honda K、Hikida T、Ito S、Qin H、Sanuki R、Suzuki K、Furukawa T、Ishihama Y、Matsuda F、Suematsu M、Honjo T、Fagarasan S
    • Journal Title

      Nat Immunol

      Volume: 18 Pages: 1342-1352

    • DOI

      10.1038/ni.3867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 認知学習における大脳基底核神経回路機構2017

    • Author(s)
      疋田貴俊、森田真規子、Macpherson Tom
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 37 Pages: 35-38

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経回路から精神疾患病態へ2017

    • Author(s)
      疋田貴俊
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 28 Pages: 132-134

    • NAID

      130007630327

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.2017

    • Author(s)
      Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabc M, Sasahara M, Fukunaga K
    • Journal Title

      Molecular Psychiatry

      Volume: 印刷中 Issue: 8 Pages: 1205-1222

    • DOI

      10.1038/mp.2016.200

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ulk1 protects against ethanol-induced neuronal stress and cognitive deficits in object discrimination.2017

    • Author(s)
      Akiko Sumitomo, Keisho Ueta, Sayaka Mauchi, Kazuko Hirai, Kouta Horike, Takatoshi Hikida, Takeshi Sakurai, Akira Sawa, Toshifumi Tomoda
    • Journal Title

      Neuroscience Research

      Volume: in press

    • DOI

      10.1016/j.neures.2016.12.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of leptin in conditioned place preference to high-fat diet in leptin-deficient ob/ob mice.2017

    • Author(s)
      Shimizu Y, Son C, Aotani D, Nomura H, Hikida T, Hosoda K, Nakao K
    • Journal Title

      Neuroscience letter

      Volume: 640 Pages: 60-63

    • DOI

      10.1016/j.neulet.2017.01.033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation.2017

    • Author(s)
      Kitanishi,T., Ito,H.T., Hayashi,Y., Shinohara,Y., Mizuseki,K., Hikida,T.
    • Journal Title

      J. Physiol. Sci.

      Volume: 67 Pages: 247-258

    • DOI

      10.1007/s12576-016-0502-z

    • NAID

      40021113908

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
    • Journal Title

      Learning & Memory

      Volume: 23 Pages: 359-364

    • DOI

      10.1101/lm.042507.116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
    • Journal Title

      Molecular Neuropsychiatry

      Volume: 2 Pages: 124-132

    • DOI

      10.1159/000447970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.2016

    • Author(s)
      Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A
    • Journal Title

      Neuroscience Research

      Volume: 112 Pages: 63-69

    • DOI

      10.1016/j.neures.2016.06.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system.2016

    • Author(s)
      Aotani D, Son C, Shimizu Y, Nomura H, Hikida T, Kusakabe T, Tanaka T, Miyazawa T, Hosoda K, Nakao K
    • Journal Title

      Neuroscience letter

      Volume: 633 Pages: 141-145

    • DOI

      10.1016/j.neulet.2016.09.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neural mechanism of the nucleus accumbens circuit in reward and aversive learning.2016

    • Author(s)
      Hikida T, Morita M, Macpherson T
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 1-5

    • DOI

      10.1016/j.neures.2016.01.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 大脳基底核神経回路からみた薬物依存症の病態2016

    • Author(s)
      疋田貴俊
    • Journal Title

      精神科臨床Legato

      Volume: 2 Pages: 190-192

    • Related Report
      2016 Annual Research Report
  • [Presentation] モデルマウスのドーパミン動態の解析2021

    • Author(s)
      疋田貴俊
    • Organizer
      第15回脳表現型の分子メカニズム研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Data-driven approach for elucidating the neural mechanism underlying conflict between reward and punishment2021

    • Author(s)
      Kohta Mizutani, Issei Nakagawa, Takaaki Ozawa, Takatoshi Hikida, Naoki Honda
    • Organizer
      第3回ExCELLS若手リトリート
    • Related Report
      2020 Annual Research Report
  • [Presentation] うま味物質の持つ塩味嗜好性増強効果における脳内報酬系の関与2021

    • Author(s)
      小澤貴明、疋田貴俊
    • Organizer
      大阪大学蛋白質研究所セミナー「食行動の脳内基盤と分子機構」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Choose a good option or avoid a bad option: D2-MSN in the NAc selectively contributes to the strategy to avoid a bad option under decision.2020

    • Author(s)
      Tadaaki Nishioka, Takatoshi Hikida
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex.2020

    • Author(s)
      Tom Macpherson, Shuhei Yao, Ayumi Fukakusa, Makiko Morita, Haruhide Kimura, Keisuke Hirai, Tatsuya Ando, Hiroyoshi Toyoshiba, Akira Sawa, Takatoshi Hikida
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of adolescent stress on the behavioral deficits in nucleus transport factor Kpna1 knockout mice.2020

    • Author(s)
      Koki Sakurai, Yoichi Miyamoto, Tetsuji Moriyama, Makiko Morita, Taichi Itou, Masahiro Oka, Takatoshi Hikida.
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Kpna1ノックアウトマウスは社会性ストレスに感受性を示す2020

    • Author(s)
      櫻井航輝、伊藤大一、森田真規子、盛山哲嗣、宮本洋一、岡正啓、疋田貴俊
    • Organizer
      NPBPPP2020合同年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 良い選択肢を選ぶのか、それとも悪い選択肢を回避するのか?意思決定において、側坐核のD2-MSNは悪い選択肢を回避するのに重要な役割を担っている2020

    • Author(s)
      西岡忠昭、疋田貴俊
    • Organizer
      NPBPPP2020合同年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 意思決定における側坐核ネットワークの制御機構2020

    • Author(s)
      疋田貴俊
    • Organizer
      生理学研究所研究会 意思決定研究の新展開-社会共感・主観価値の生成・葛藤に関わる神経メカニズム-
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] マウスにおける塩味とうま味の相乗作用2020

    • Author(s)
      小澤貴明、柴田智弘、疋田貴俊
    • Organizer
      生理学研究所研究会 第5回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Reinforcement learning model for osmoregulation2020

    • Author(s)
      Yuki Uchida, Takatoshi Hikida, Yuichi Yamashita
    • Organizer
      JSMB2020conference
    • Related Report
      2020 Annual Research Report
  • [Presentation] 報酬/罰となる食塩;浸透圧維持の強化学習モデル2020

    • Author(s)
      内田裕輝、疋田貴俊、山下祐一
    • Organizer
      第2回脳科学サロン「脳とAI」
    • Related Report
      2020 Annual Research Report
  • [Presentation] うま味物質の持つ塩味嗜好性増強効果-マウスにおける検討-2020

    • Author(s)
      柴田智弘、疋田貴俊、小澤貴明
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 適切な行動選択のための柔軟な脳のしくみ2020

    • Author(s)
      疋田貴俊
    • Organizer
      令和2年度国立大学附置研究所・センター会議 第2部会シンポジウム「コロナ新時代における蛋白質科学研究」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 人工的神経回路操作によるマウス食塩欲求の変化を強化学習モデルで再現する2020

    • Author(s)
      内田裕輝、山下祐一、疋田貴俊
    • Organizer
      第39回日本動物行動学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Data-drive approach for elucidating the neural mechanism underlying conflict between reward and punishment2020

    • Author(s)
      Kohta Mizutani, Issei Nakagawa, Takaaki Ozawa, Takatoshi Hikida, Naoki Honda
    • Organizer
      第3回ExCELLSシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Adolescent stress exacerbates behavioral deficits in Kpna1 knockout mice2020

    • Author(s)
      Koki Sakurai, Taichi Itou, Makiko Morita, Tetsuji Moriyama, Yoichi Miyamoto, Masahiro Oka, Takatoshi Hikida
    • Organizer
      FENS2020 Virtual Forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Choose a good option or avoid a bad option: D2-MSN in the NAc selectively contributes to the strategy to avoid a bad option under decision2020

    • Author(s)
      Tadaaki Nishioka, Takatoshi Hikida
    • Organizer
      International Symposium on Artificial Intelligence and Brain Science
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleus accumbens D2-receptor-expressing neurons regulate reversal learning in the Attentional Set Shifting Test2020

    • Author(s)
      Takatoshi Hikida, Jiyoon Kim, Tom Macpherson
    • Organizer
      59th Annual Meeting of the American College of Neuropsychopharmacology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 報酬・忌避行動と精神疾患病態における神経回路機構の解析2020

    • Author(s)
      疋田 貴俊
    • Organizer
      第5回包括的神経グリア研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The role of the parallel pathways in the nucleus accumbens for reward and aversive learning2020

    • Author(s)
      疋田 貴俊
    • Organizer
      MACS International Symposium: COMPUTATIONAL PRINCIPLES IN ACTIVE PERCEPTION AND REINFORCEMENT LEARNING IN THE BRAIN
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A role for Enkephalin-expressing ventral pallidal neurons in controlling aversive Pavlovian Conditioning2020

    • Author(s)
      Macpherson Tom、Mizoguchi Hiroyuki 、Yamanaka Akihiro、Hikida Takatoshi
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腹側淡蒼球の局所神経回路の解析2019

    • Author(s)
      疋田 貴俊
    • Organizer
      第13回脳表現型の分子メカニズム研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 意思決定行動と精神疾患病態における神経回路機構の解析2019

    • Author(s)
      疋田 貴俊
    • Organizer
      鹿児島大学大学院セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 情動・認知学習の神経回路機構の研究から疾患横断的な精神疾患病態を考える2019

    • Author(s)
      疋田 貴俊
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 食嗜好における大脳基底核神経回路機構の解析2019

    • Author(s)
      疋田 貴俊
    • Organizer
      生理学研究所研究会 第4回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 報酬・忌避学習における神経回路機構の解析2019

    • Author(s)
      疋田 貴俊
    • Organizer
      立命館大学システム視覚科学センターセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A role for nucleus accumbens D1-/D2-neuron pathways in controlling learning impaired in psychiatric disorders2019

    • Author(s)
      Macpherson Tom、Hikida Takatoshi
    • Organizer
      第42回日本神経科学学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腹側淡蒼球の役割と回路機構の解析2018

    • Author(s)
      疋田貴俊
    • Organizer
      第11回脳表現型の分子メカニズム研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Distinct roles of the direct and indirect striatal pathways in cognitive learning2018

    • Author(s)
      疋田貴俊
    • Organizer
      第243回つくばブレインサイエンス・セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 蛋白質研究所での生物学的精神医学研究2018

    • Author(s)
      疋田貴俊
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核における認知学習と精神疾患の制御機構2018

    • Author(s)
      疋田貴俊
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核から情動の神経回路機構とその破綻を考える2018

    • Author(s)
      疋田貴俊
    • Organizer
      平成30年度生理学研究所研究会「情動の神経回路機構とその破綻」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 学習と意志決定における大脳基底核神経回路機構2018

    • Author(s)
      疋田貴俊
    • Organizer
      京阪・神経内科セミナー2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Enkephalin-Expressing Ventral Pallidal Neurons Control Aversive Learning.2018

    • Author(s)
      Hikida T, Macpherson T, Mizoguchi H, Yamanaka A.
    • Organizer
      57th Annual Meeting of the American College of Neuropsychopharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ventral pallidum neurons control aversive learning.2018

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Organizer
      The 48th Annual Meeting of the Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ventral pallidum neurons control aversive learning.2018

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Organizer
      The 11th Meeting of the Federation of European Neuroscience Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ventral pallidum neurons control aversive learning.2018

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Organizer
      The 41th Annual Meeting of the Japan NeuroscienceSociety
    • Related Report
      2018 Annual Research Report
  • [Presentation] 柔軟な行動のための大脳基底核神経回路の恒常性維持機構とその破綻2017

    • Author(s)
      疋田貴俊
    • Organizer
      第90回日本薬理学会シンポジウム
    • Place of Presentation
      長崎新聞文化ホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経細胞におけるp62発現上昇およびオートファジー減弱によるGABA受容体表面定時の低下と精神疾患の病態生理2017

    • Author(s)
      住友明子、植田啓公頁、堀家康太、北岡志保、古屋敷智之、疋田貴俊、櫻井武、澤明、友田利文、成宮周
    • Organizer
      第90回日本薬理学会シンポジウム
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知学習におけるドーパミンD2L受容体の役割解析2017

    • Author(s)
      疋田貴俊
    • Organizer
      新潟脳神経研究会
    • Place of Presentation
      新潟大学脳研究所(新潟県・新潟市)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて2017

    • Author(s)
      疋田貴俊
    • Organizer
      大阪大学蛋白質研究所 蛋白研未来コロキウム
    • Place of Presentation
      大阪大学蛋白質研究所(大阪府・吹田市)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 統合失調症病態における淡蒼球の役割解析2017

    • Author(s)
      疋田貴俊
    • Organizer
      第9回脳表現型の分子メカニズム研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて2017

    • Author(s)
      疋田貴俊
    • Organizer
      第78回統合失調症研究勉強会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] D2L receptor-expressing striatal neurons control visual discrimination learning in a touchscreen operant system.2017

    • Author(s)
      Hikida T, Morita M, Macpherson T
    • Organizer
      26th Annual Meeting of the International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basal ganglia circuit mechanisms for flexible behavior2017

    • Author(s)
      Hikida T
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Dual neural circuits in reward and aversive learning2017

    • Author(s)
      Hikida T
    • Organizer
      第27回神経回路学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 認知学習と精神疾患における神経回路機構2017

    • Author(s)
      疋田貴俊
    • Organizer
      第47回日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構2017

    • Author(s)
      疋田貴俊
    • Organizer
      第39回日本生物学的精神医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 情動行動における大脳基底核神経回路機構とその破綻2017

    • Author(s)
      疋田貴俊
    • Organizer
      平成29年度生理学研究所研究会「先天的と後天的なメカニズムの融合による情動・行動の理解と制御」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neuronal circuit mechanisms in reward and aversive behavior.2017

    • Author(s)
      Hikida T
    • Organizer
      National Tsing Hua University-Osaka University International Student Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Basal ganglia network mechanisms in cognitive learning2017

    • Author(s)
      Hikida T
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nucleus accumbens D1 receptor expressing neurons control sutoshaping behavior.2017

    • Author(s)
      Hikida T
    • Organizer
      56th Annual Meeting of the American College of Neuropsychopharmacology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control incentive salience to reward-predictive cues.2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      26th Annual Meeting of the International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control attribution of incentive salience in an autoshaping task.2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      EBPS Biennial meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neuron control of Pavlovian associative learning.2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control Pavlovian approach behaviour2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      The 44th Naito Conference, Decision Making in the Brain -Motivation, Prediction, and Learning
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleus accumbens D1 receptor expressing neurons control sutoshaping behavior.2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blockade of GAPDH nuclear translocation in the hippocampus contributes to anti-depressant-like action in stressed mice2017

    • Author(s)
      Nakajima H, Nakamura S, Kita A, Itakura M, Senami C, Kuwamura M, Hikida T, Azuma Y-T, Takeuchi T
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dopamine D2L receptors control behavioral flexibility2017

    • Author(s)
      Macpherson T, Hikida T
    • Organizer
      OU-ANU 2nd joint symposium Protein Structure and Function
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways.2016

    • Author(s)
      Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
    • Organizer
      55th Annual Meeting of the American College of Neuropsychopharmacology
    • Place of Presentation
      フロリダ(アメリカ)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways.2016

    • Author(s)
      Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Learning deficits involving nucleus accumbens D2-receptor expressing neurons in a DISC1 mouse model.2016

    • Author(s)
      Morita M, Macpherson T, Sawa A, Hikida T
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel therapeutic target for stroke by inhibition of GAPDH aggregation.2016

    • Author(s)
      Itakura M, Kubo T, Kaneshige A, Azuma Y, Hikida T, Takeuchi T, Nakajima H.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens neurons is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Tom Macpherson, Makiko Morita, Yanyan Wang, Toshikuni Sasaoka, Akira Sawa, Takatoshi Hikida
    • Organizer
      日本生理学会第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学医学研究科(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 変異型DISC1トランスジェニックマウスは場所選好試験において海馬CA1場所細胞の報酬関連活動の低下を示す2016

    • Author(s)
      疋田貴俊、林勇一郎、澤明
    • Organizer
      日本生理学会第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学医学研究科(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドパミンによる大脳基底核神経回路の制御機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      平成28年度日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経回路から精神疾患病態へ2016

    • Author(s)
      疋田貴俊
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知学習における大脳基底核神経回路機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      第61回 脳の医学・生物学研究会
    • Place of Presentation
      名古屋大学医学部(愛知県・名古屋市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 側坐核直接路の活性化はリスク志向な行動選択に関与する2016

    • Author(s)
      王 天、溝口博之、犬束 歩、片平健太郎、疋田貴俊、山中章弘、山田清文
    • Organizer
      第18回応用薬理シンポジウム
    • Place of Presentation
      名古屋大学医学部(愛知県・名古屋市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place learning task.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioural flexibility in a place learning task in the IntelliCage.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      10th FENS Forum of Neuroscience
    • Place of Presentation
      コペンハーゲン(デンマーク)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Hikida T
    • Organizer
      International Symposium “Wiring and Functional Principles of Neural Circuits”
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法2018

    • Inventor(s)
      岡正啓、疋田貴俊、他5名
    • Industrial Property Rights Holder
      岡正啓、疋田貴俊、他5名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法2017

    • Inventor(s)
      岡 正啓、(4名省略)、疋田 貴俊、森田 真規子
    • Industrial Property Rights Holder
      医薬基盤・健康・栄養研究所、京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-026027
    • Filing Date
      2017-02-15
    • Related Report
      2016 Annual Research Report

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Published: 2016-07-04   Modified: 2022-01-28  

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