報酬/目的指向行動の神経回路機構

• Project Area: Correspondence and Fusion of Artificial Intelligence and Brain Science
• Project/Area Number: 16H06568
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Osaka University (2018-2020); Kyoto University (2016-2017)
• Principal Investigator: 疋田 貴俊 大阪大学, 蛋白質研究所, 教授 (70421378)
• Co-Investigator(Kenkyū-buntansha): マクファーソン トム 大阪大学, 蛋白質研究所, 特任助教(常勤) (40821898) ; 小澤 貴明 大阪大学, 蛋白質研究所, 助教 (90625352) ; 山口 隆司 大阪大学, 蛋白質研究所, 助教 (40724258)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥87,230,000 (Direct Cost: ¥67,100,000、Indirect Cost: ¥20,130,000); Fiscal Year 2020: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
• Keywords: 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 / 大脳基底核 / 意思決定 / 大脳皮質 / 神経回路 / 腹側淡蒼球 / ドーパミン受容体 / 行動柔軟性

Outline of Annual Research Achievements

報酬/目的指向行動において大脳皮質内側前頭前野-側坐核-視床のループ回路が重要である。我々は側坐核の直接路と間接路が報酬/目的指向行動において異なる役割を担っていることを示してきた。しかしながら、側坐核の直接路と間接路による大脳皮質内側前頭前野-側坐核-視床のループ回路の制御機構は未解明の点が残っている。そこで、可逆的神経伝達遮断法を用いて側坐核の直接路あるいは間接路のそれぞれの神経伝達を特異的に遮断し、大脳皮質内側前頭前野の遺伝子発現の違いを調べた。RNAシークエンスによる遺伝子発現の定量後に、EdgeRとVoomの２種類の解析を行い、直接路遮断による変化遺伝子と間接路遮断による変化遺伝子を同定した。パスウエイ解析を行うと、直接路遮断により大脳皮質内側前頭前野で発現量が減少した遺伝子群と、間接路遮断により大脳皮質内側前頭前野で発現量が増加した遺伝子群に精神神経疾患関連遺伝子が含まれていた。大脳皮質内側前頭前野の変化遺伝子がどの細胞群に属するかを、TRAP法で同定されている細胞特異的遺伝子セットと比較することにより、5b層と6層の錐体細胞に含まれる遺伝子群は直接路遮断と間接路遮断の両方で発現量減少が見られるのに対して、5a層の錐体細胞に含まれる遺伝子群は直接路遮断で発言量増加、間接路遮断で発現量減少が見られた。これらの結果は側坐核の直接路と間接路がそれぞれ大脳皮質内側前頭前野の回路特異的に遺伝子発現を制御していることが明らかになった。
今後は引き続き、報酬/目的指向行動とその柔軟性における大脳基底核神経回路機構を解析するとともに、精神神経疾患の分子・回路病態を探る。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

報酬/目的指向行動における大脳皮質内側前頭前野-側坐核-視床のループ回路制御の分子機構を明らかにすることができ、論文発表を行うことができた。

Strategy for Future Research Activity

タッチスクリーン認知学習課題による報酬学習とその柔軟性の神経回路機構を明らかにする。報酬/目的指向行動下での脳内イメージングを行い、神経機構の解明を人工知能を応用しながら進めていく。

Research Products

• [Int'l Joint Research] ジョンズホプキンス大学/イリノイ大学(米国)
• [Int'l Joint Research] トロント大学(カナダ)
• [Int'l Joint Research] ジョンズホプキンス大学(米国)
• [Int'l Joint Research] トロント大学(カナダ)
• [Int'l Joint Research] ジョンズ・ホプキンス大学/イリノイ大学(アメリカ)
• [Int'l Joint Research] トロント大学(カナダ)
• [Int'l Joint Research] マックスプランク研究所(ドイツ)
• [Journal Article] Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex (2020)
  • Author(s): Hikida Takatoshi、Yao Shuhei、Macpherson Tom、Fukakusa Ayumi、Morita Makiko、Kimura Haruhide、Hirai Keisuke、Ando Tatsuya、Toyoshiba Hiroyoshi、Sawa Akira
  • Journal Title: Scientific Reports Volume: 10 Pages: 1838-1838
  • DOI: 10.1038/s41598-020-58711-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice (2020)
  • Author(s): Hikida Takatoshi、Morita Makiko、Kuroiwa Mahomi、Macpherson Tom、Shuto Takahide、Sotogaku Naoki、Niwa Minae、Sawa Akira、Nishi Akinori
  • Journal Title: Neuroscience Research Volume: in press Pages: 38-45
  • DOI: 10.1016/j.neures.2019.02.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids (2020)
  • Author(s): Wang Qiuyi、Shimizu Kimiko、Maehata Kanako、Pan Yue、Sakurai Koki、Hikida Takatoshi、Fukada Yoshitaka、Takao Toshifumi
  • Journal Title: Journal of Lipid Research Volume: 61 Pages: 570-579
  • DOI: 10.1194/jlr.d119000588
  • Peer Reviewed / Open Access
• [Journal Article] Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons (2019)
  • Author(s): Shioda Norifumi、Imai Yoshiki、Yabuki Yasushi、Sugimoto Wataru、Yamaguchi Kouya、Wang Yanyan、Hikida Takatoshi、Sasaoka Toshikuni、Mieda Michihiro、Fukunaga Kohji
  • Journal Title: J Neurosci Volume: 39 Pages: 7551-7563
  • DOI: 10.1523/jneurosci.0079-19.2019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders (2019)
  • Author(s): Macpherson Tom、Hikida Takatoshi
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 印刷中 Pages: 289-301
  • DOI: 10.1111/pcn.12830
  • Peer Reviewed / Open Access
• [Journal Article] Response to ‘Mood and Affect’ (2019)
  • Author(s): Macpherson Tom、Hikida Takatoshi
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 73 Pages: 347-347
  • DOI: 10.1111/pcn.12845
  • Open Access
• [Journal Article] 大脳基底核神経回路における腹側淡蒼球の役割解析 (2019)
  • Author(s): 疋田 貴俊
  • Journal Title: 日本生物学的精神医学会誌 Volume: 30 Pages: 105-107
• [Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation. (2019)
  • Author(s): Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
  • Journal Title: Scientific reports Volume: Mar 5;9(1) Pages: 3445-3445
  • DOI: 10.1038/s41598-019-38910-2
  • NAID: 120006579467
  • Peer Reviewed / Open Access
• [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. (2019)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
  • Journal Title: Neurochem Int Volume: 126 Pages: 11-18
  • DOI: 10.1016/j.neuint.2019.02.011
  • Peer Reviewed / Open Access
• [Journal Article] Opposing roles of dopamine receptor D1-and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice. (2019)
  • Author(s): Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
  • Journal Title: Front Behav Neurosci Volume: 13 Pages: 50-50
  • DOI: 10.3389/fnbeh.2019.00050
  • Peer Reviewed / Open Access
• [Journal Article] Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <b><i>Fez1</i></b>-Deficient Mice (2018)
  • Author(s): Sumitomo Akiko、Saka Ayumi、Ueta Keisho、Horike Kouta、Hirai Kazuko、Gamo Nao J.、Hikida Takatoshi、Nakayama Keiichi I.、Sawa Akira、Sakurai Takeshi、Tomoda Toshifumi
  • Journal Title: Molecular Neuropsychiatry Volume: 3 Pages: 223-233
  • DOI: 10.1159/000488081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice (2018)
  • Author(s): Macpherson Tom、Hikida Takatoshi
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 418-418
  • DOI: 10.3389/fnins.2018.00418
  • NAID: 120006491925
  • Peer Reviewed / Open Access
• [Journal Article] Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. (2018)
  • Author(s): Higashida Shu、Nagai Hirotaka、Nakayama Kazuki、Shinohara Ryota、Taniguchi Masayuki、Nagai Midori、Hikida Takatoshi、Yawata Satoshi、Ago Yukio、Kitaoka Shiho、Narumiya Shuh、Furuyashiki Tomoyuki
  • Journal Title: Scientific Reports Volume: 8 Pages: 10454-10454
  • DOI: 10.1038/s41598-018-28803-1
  • NAID: 120006501224
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons (2018)
  • Author(s): Sumitomo Akiko、Yukitake Hiroshi、Hirai Kazuko、Horike Kouta、Ueta Keisho、Chung Youjin、Warabi Eiji、Yanagawa Toru、Kitaoka Shiho、Furuyashiki Tomoyuki、Narumiya Shuh、Hirano Tomoo、Niwa Minae、Sibille Etienne、Hikida Takatoshi、Sakurai Takeshi、Ishizuka Koko、Sawa Akira、Tomoda Toshifumi
  • Journal Title: Hum Mol Genet. Volume: 27 Pages: 3165-3176
  • DOI: 10.1093/hmg/ddy219
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Homeostatic regulation of basal ganglia circuit for flexible behavior (2018)
  • Author(s): Hikida Takatoshi
  • Journal Title: Folia Pharmacol. Jpn. Volume: 152 Issue: 6 Pages: 295-298
  • DOI: 10.1254/fpj.152.295
  • NAID: 130007528439
  • ISSN: 0015-5691, 1347-8397
  • Open Access
• [Journal Article] Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression (2018)
  • Author(s): Yamaguchi Takashi、Lin Dayu
  • Journal Title: Current Opinion in Behavioral Sciences Volume: 24 Pages: 104-112
  • DOI: 10.1016/j.cobeha.2018.06.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics (2017)
  • Author(s): Tomoda Toshifumi、Hikida Takatoshi、Sakurai Takeshi
  • Journal Title: Neurotherapeutics Volume: 14 Pages: 623-629
  • DOI: 10.1007/s13311-017-0556-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vivo calcium imaging from dentate granule cells with wide-field fluorescence microscopy. (2017)
  • Author(s): Hayashi Yuichiro、Yawata Satoshi、Funabiki Kazuo、Hikida Takatoshi
  • Journal Title: PLoS One. Volume: 12
  • DOI: 10.1371/journal.pone.0180452
  • NAID: 120006539578
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior (2017)
  • Author(s): Miyajima M、Zhang B、Sugiura Y、Sonomura K、Guerrini MM、Tsutsui Y、Maruya M、Vogelzang A、Chamoto K、Honda K、Hikida T、Ito S、Qin H、Sanuki R、Suzuki K、Furukawa T、Ishihama Y、Matsuda F、Suematsu M、Honjo T、Fagarasan S
  • Journal Title: Nat Immunol Volume: 18 Pages: 1342-1352
  • DOI: 10.1038/ni.3867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 認知学習における大脳基底核神経回路機構 (2017)
  • Author(s): 疋田貴俊、森田真規子、Macpherson Tom
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Pages: 35-38
  • Peer Reviewed
• [Journal Article] 神経回路から精神疾患病態へ (2017)
  • Author(s): 疋田貴俊
  • Journal Title: 日本生物学的精神医学会誌 Volume: 28 Pages: 132-134
  • NAID: 130007630327
• [Journal Article] Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. (2017)
  • Author(s): Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabc M, Sasahara M, Fukunaga K
  • Journal Title: Molecular Psychiatry Volume: 印刷中 Issue: 8 Pages: 1205-1222
  • DOI: 10.1038/mp.2016.200
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits. (2017)
  • Author(s): Akiko Sumitomo, Keisho Ueta, Sayaka Mauchi, Kazuko Hirai, Kouta Horike, Takatoshi Hikida, Takeshi Sakurai, Akira Sawa, Toshifumi Tomoda
  • Journal Title: Neuroscience Research Volume: in press
  • DOI: 10.1016/j.neures.2016.12.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Role of leptin in conditioned place preference to high-fat diet in leptin-deficient ob/ob mice (2017)
  • Author(s): Shimizu Y, Son C, Aotani D, Nomura H, Hikida T, Hosoda K, Nakao K
  • Journal Title: Neuroscience letter Volume: 640 Pages: 60-63
  • DOI: 10.1016/j.neulet.2017.01.033
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] “Network mechanism of hippocampal laterality, place coding, and goal-directed navigation.” (2017)
  • Author(s): Kitanishi,T., Ito,H.T., Hayashi,Y., Shinohara,Y., Mizuseki,K., Hikida,T.
  • Journal Title: J. Physiol. Sci. Volume: 67 Pages: 247-258
  • DOI: 10.1007/s12576-016-0502-z
  • NAID: 40021113908
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. (2016)
  • Author(s): Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
  • Journal Title: Learning & Memory Volume: 23 Pages: 359-364
  • DOI: 10.1101/lm.042507.116
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dopamine D2L receptor is required for visual discrimination learning. (2016)
  • Author(s): Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
  • Journal Title: Molecular Neuropsychiatry Volume: 2 Pages: 124-132
  • DOI: 10.1159/000447970
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. (2016)
  • Author(s): Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A
  • Journal Title: Neuroscience Research Volume: 112 Pages: 63-69
  • DOI: 10.1016/j.neures.2016.06.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system. (2016)
  • Author(s): Aotani D, Son C, Shimizu Y, Nomura H, Hikida T, Kusakabe T, Tanaka T, Miyazawa T, Hosoda K, Nakao K
  • Journal Title: Neuroscience letter Volume: 633 Pages: 141-145
  • DOI: 10.1016/j.neulet.2016.09.014
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning. (2016)
  • Author(s): Hikida T, Morita M, Macpherson T
  • Journal Title: Neuroscience Research Volume: - Pages: 1-5
  • DOI: 10.1016/j.neures.2016.01.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 大脳基底核神経回路からみた薬物依存症の病態 (2016)
  • Author(s): 疋田貴俊
  • Journal Title: 精神科臨床Legato Volume: 2 Pages: 190-192
• [Presentation] 報酬・忌避行動と精神疾患病態における神経回路機構の解析 (2020)
  • Author(s): 疋田 貴俊
  • Organizer: 第5回包括的神経グリア研究会
  • Invited
• [Presentation] The role of the parallel pathways in the nucleus accumbens for reward and aversive learning (2020)
  • Author(s): 疋田 貴俊
  • Organizer: MACS International Symposium: COMPUTATIONAL PRINCIPLES IN ACTIVE PERCEPTION AND REINFORCEMENT LEARNING IN THE BRAIN
  • Int'l Joint Research / Invited
• [Presentation] A role for Enkephalin-expressing ventral pallidal neurons in controlling aversive Pavlovian Conditioning (2020)
  • Author(s): Macpherson Tom、Mizoguchi Hiroyuki 、Yamanaka Akihiro、Hikida Takatoshi
  • Organizer: 第97回日本生理学会大会
  • Invited
• [Presentation] 腹側淡蒼球の局所神経回路の解析 (2019)
  • Author(s): 疋田 貴俊
  • Organizer: 第13回脳表現型の分子メカニズム研究会
  • Invited
• [Presentation] 意思決定行動と精神疾患病態における神経回路機構の解析 (2019)
  • Author(s): 疋田 貴俊
  • Organizer: 鹿児島大学大学院セミナー
  • Invited
• [Presentation] 情動・認知学習の神経回路機構の研究から疾患横断的な精神疾患病態を考える (2019)
  • Author(s): 疋田 貴俊
  • Organizer: 第115回日本精神神経学会学術総会
  • Invited
• [Presentation] 食嗜好における大脳基底核神経回路機構の解析 (2019)
  • Author(s): 疋田 貴俊
  • Organizer: 生理学研究所研究会 第４回食欲・食嗜好の分子・神経基盤研究会
• [Presentation] 報酬・忌避学習における神経回路機構の解析 (2019)
  • Author(s): 疋田 貴俊
  • Organizer: 立命館大学システム視覚科学センターセミナー
  • Invited
• [Presentation] A role for nucleus accumbens D1-/D2-neuron pathways in controlling learning impaired in psychiatric disorders (2019)
  • Author(s): Macpherson Tom、Hikida Takatoshi
  • Organizer: 第42回日本神経科学学会
  • Invited
• [Presentation] 腹側淡蒼球の役割と回路機構の解析 (2018)
  • Author(s): 疋田貴俊
  • Organizer: 第11回脳表現型の分子メカニズム研究会
  • Invited
• [Presentation] Distinct roles of the direct and indirect striatal pathways in cognitive learning (2018)
  • Author(s): 疋田貴俊
  • Organizer: 第243回つくばブレインサイエンス・セミナー
  • Invited
• [Presentation] 蛋白質研究所での生物学的精神医学研究 (2018)
  • Author(s): 疋田貴俊
  • Organizer: 第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
  • Invited
• [Presentation] 大脳基底核における認知学習と精神疾患の制御機構 (2018)
  • Author(s): 疋田貴俊
  • Organizer: 第40回日本生物学的精神医学会 第61回日本神経化学会大会 合同年会
  • Invited
• [Presentation] 大脳基底核から情動の神経回路機構とその破綻を考える (2018)
  • Author(s): 疋田貴俊
  • Organizer: 平成30年度生理学研究所研究会「情動の神経回路機構とその破綻」
  • Invited
• [Presentation] 学習と意志決定における大脳基底核神経回路機構 (2018)
  • Author(s): 疋田貴俊
  • Organizer: 京阪・神経内科セミナー2018
  • Invited
• [Presentation] Enkephalin-Expressing Ventral Pallidal Neurons Control Aversive Learning. (2018)
  • Author(s): Hikida T, Macpherson T, Mizoguchi H, Yamanaka A.
  • Organizer: 57th Annual Meeting of the American College of Neuropsychopharmacology
  • Int'l Joint Research
• [Presentation] Ventral pallidum neurons control aversive learning. (2018)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
  • Organizer: The 48th Annual Meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Ventral pallidum neurons control aversive learning. (2018)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
  • Organizer: The 11th Meeting of the Federation of European Neuroscience Society
  • Int'l Joint Research
• [Presentation] Ventral pallidum neurons control aversive learning. (2018)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
  • Organizer: The 41th Annual Meeting of the Japan NeuroscienceSociety
• [Presentation] 柔軟な行動のための大脳基底核神経回路の恒常性維持機構とその破綻 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 第90回日本薬理学会シンポジウム
  • Place of Presentation: 長崎新聞文化ホール（長崎県・長崎市）
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] 神経細胞におけるp62発現上昇およびオートファジー減弱によるGABA受容体表面定時の低下と精神疾患の病態生理 (2017)
  • Author(s): 住友明子、植田啓公頁、堀家康太、北岡志保、古屋敷智之、疋田貴俊、櫻井武、澤明、友田利文、成宮周
  • Organizer: 第90回日本薬理学会シンポジウム
  • Place of Presentation: 長崎ブリックホール（長崎県・長崎市）
  • Year and Date: 2017-03-15
• [Presentation] 認知学習におけるドーパミンD2L受容体の役割解析 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 新潟脳神経研究会
  • Place of Presentation: 新潟大学脳研究所（新潟県・新潟市）
  • Year and Date: 2017-02-21
  • Invited
• [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて (2017)
  • Author(s): 疋田貴俊
  • Organizer: 大阪大学蛋白質研究所 蛋白研未来コロキウム
  • Place of Presentation: 大阪大学蛋白質研究所（大阪府・吹田市）
  • Year and Date: 2017-01-19
  • Invited
• [Presentation] 統合失調症病態における淡蒼球の役割解析 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 第９回脳表現型の分子メカニズム研究会
  • Invited
• [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて (2017)
  • Author(s): 疋田貴俊
  • Organizer: 第78回統合失調症研究勉強会
  • Invited
• [Presentation] D2L receptor-expressing striatal neurons control visual discrimination learning in a touchscreen operant system. (2017)
  • Author(s): Hikida T, Morita M, Macpherson T
  • Organizer: 26th Annual Meeting of the International Behavioral Neuroscience Society
  • Int'l Joint Research
• [Presentation] Basal ganglia circuit mechanisms for flexible behavior (2017)
  • Author(s): Hikida T
  • Organizer: 第40回日本神経科学大会
  • Invited
• [Presentation] Dual neural circuits in reward and aversive learning (2017)
  • Author(s): Hikida T
  • Organizer: 第27回神経回路学会シンポジウム
  • Invited
• [Presentation] 認知学習と精神疾患における神経回路機構 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 第47回日本神経精神薬理学会
  • Invited
• [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 第39回日本生物学的精神医学会
  • Invited
• [Presentation] 情動行動における大脳基底核神経回路機構とその破綻 (2017)
  • Author(s): 疋田貴俊
  • Organizer: 平成29年度生理学研究所研究会「先天的と後天的なメカニズムの融合による情動・行動の理解と制御」
  • Invited
• [Presentation] Neuronal circuit mechanisms in reward and aversive behavior. (2017)
  • Author(s): Hikida T
  • Organizer: National Tsing Hua University-Osaka University International Student Symposium 2017
  • Int'l Joint Research / Invited
• [Presentation] Basal ganglia network mechanisms in cognitive learning (2017)
  • Author(s): Hikida T
  • Organizer: 第12回研究所ネットワーク国際シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Nucleus accumbens D1 receptor expressing neurons control sutoshaping behavior. (2017)
  • Author(s): Hikida T
  • Organizer: 56th Annual Meeting of the American College of Neuropsychopharmacology
  • Int'l Joint Research
• [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control incentive salience to reward-predictive cues. (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: 26th Annual Meeting of the International Behavioral Neuroscience Society
  • Int'l Joint Research
• [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control attribution of incentive salience in an autoshaping task. (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: EBPS Biennial meeting 2017
  • Int'l Joint Research
• [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neuron control of Pavlovian associative learning. (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: 第40回日本神経科学大会
• [Presentation] Nucleus accumbens dopamine D1-receptor-expresing neurons control Pavlovian approach behaviour (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: The 44th Naito Conference, Decision Making in the Brain -Motivation, Prediction, and Learning
  • Int'l Joint Research
• [Presentation] Nucleus accumbens D1 receptor expressing neurons control sutoshaping behavior. (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Blockade of GAPDH nuclear translocation in the hippocampus contributes to anti-depressant-like action in stressed mice (2017)
  • Author(s): Nakajima H, Nakamura S, Kita A, Itakura M, Senami C, Kuwamura M, Hikida T, Azuma Y-T, Takeuchi T
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Dopamine D2L receptors control behavioral flexibility (2017)
  • Author(s): Macpherson T, Hikida T
  • Organizer: OU-ANU 2nd joint symposium Protein Structure and Function
  • Int'l Joint Research / Invited
• [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways. (2016)
  • Author(s): Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
  • Organizer: 55th Annual Meeting of the American College of Neuropsychopharmacology
  • Place of Presentation: フロリダ（アメリカ）
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task. (2016)
  • Author(s): Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
  • Organizer: Neuroscience 2016
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways. (2016)
  • Author(s): Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
  • Organizer: Neuroscience 2016
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Learning deficits involving nucleus accumbens D2-receptor expressing neurons in a DISC1 mouse model. (2016)
  • Author(s): Morita M, Macpherson T, Sawa A, Hikida T
  • Organizer: Neuroscience 2016
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] A novel therapeutic target for stroke by inhibition of GAPDH aggregation. (2016)
  • Author(s): Itakura M, Kubo T, Kaneshige A, Azuma Y, Hikida T, Takeuchi T, Nakajima H.
  • Organizer: Neuroscience 2016
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens neurons is necessary for behavioral flexibility in an IntelliCage place discrimination task. (2016)
  • Author(s): Tom Macpherson, Makiko Morita, Yanyan Wang, Toshikuni Sasaoka, Akira Sawa, Takatoshi Hikida
  • Organizer: 日本生理学会第109回近畿生理学談話会
  • Place of Presentation: 大阪市立大学医学研究科（大阪府・大阪市）
  • Year and Date: 2016-11-05
• [Presentation] 変異型DISC1トランスジェニックマウスは場所選好試験において海馬CA1場所細胞の報酬関連活動の低下を示す (2016)
  • Author(s): 疋田貴俊、林勇一郎、澤明
  • Organizer: 日本生理学会第109回近畿生理学談話会
  • Place of Presentation: 大阪市立大学医学研究科（大阪府・大阪市）
  • Year and Date: 2016-11-05
• [Presentation] ドパミンによる大脳基底核神経回路の制御機構 (2016)
  • Author(s): 疋田貴俊
  • Organizer: 平成28年度日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀（東京都）
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task. (2016)
  • Author(s): Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
  • Organizer: 第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-09-08
• [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構 (2016)
  • Author(s): 疋田貴俊
  • Organizer: 第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-09-08
• [Presentation] 神経回路から精神疾患病態へ (2016)
  • Author(s): 疋田貴俊
  • Organizer: 第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] 認知学習における大脳基底核神経回路機構 (2016)
  • Author(s): 疋田貴俊
  • Organizer: 第61回 脳の医学・生物学研究会
  • Place of Presentation: 名古屋大学医学部（愛知県・名古屋市）
  • Year and Date: 2016-08-20
  • Invited
• [Presentation] 側坐核直接路の活性化はリスク志向な行動選択に関与する (2016)
  • Author(s): 王 天、溝口博之、犬束 歩、片平健太郎、疋田貴俊、山中章弘、山田清文
  • Organizer: 第18回応用薬理シンポジウム
  • Place of Presentation: 名古屋大学医学部（愛知県・名古屋市）
  • Year and Date: 2016-08-05
• [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place learning task. (2016)
  • Author(s): Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task. (2016)
  • Author(s): Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioural flexibility in a place learning task in the IntelliCage. (2016)
  • Author(s): Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
  • Organizer: 10th FENS Forum of Neuroscience
  • Place of Presentation: コペンハーゲン（デンマーク）
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task. (2016)
  • Author(s): Hikida T
  • Organizer: International Symposium “Wiring and Functional Principles of Neural Circuits”
  • Place of Presentation: サンディエゴ（アメリカ）
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法 (2018)
  • Inventor(s): 岡正啓、疋田貴俊、他5名
  • Industrial Property Rights Holder: 岡正啓、疋田貴俊、他5名
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas
• [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法 (2017)
  • Inventor(s): 岡 正啓、（4名省略）、疋田 貴俊、森田 真規子
  • Industrial Property Rights Holder: 医薬基盤・健康・栄養研究所、京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-026027
  • Filing Date: 2017-02-15