Cortical local circuits for multi-area interconnectivity and parallel processing

• Project Area: Brain information dynamics underlying multi-area interconnectivity and parallel processing
• Project/Area Number: 17H06311
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tamagawa University (2019-2021); National Institute for Physiological Sciences (2017-2018)
• Principal Investigator: 川口 泰雄 玉川大学, 脳科学研究所, 研究員 (40169694)
• Co-Investigator(Kenkyū-buntansha): 大塚 岳 生理学研究所, 脳機能計測・支援センター, 助教 (10390692) ; 高田 美絵子 (森島美絵子) 東京慈恵会医科大学, 医学部, 講師 (30435531) ; 孫 在隣 生理学研究所, 脳機能計測・支援センター, 特任研究員 (40780333) ; 窪田 芳之 生理学研究所, 基盤神経科学研究領域, 准教授 (90192567) ; 倉本 恵梨子 鹿児島大学, 医歯学域歯学系, 助教 (60467470) ; 植田 禎史 東京女子医科大学, 医学部, 助教 (00511015)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥113,750,000 (Direct Cost: ¥87,500,000、Indirect Cost: ¥26,250,000); Fiscal Year 2021: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000); Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2019: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000); Fiscal Year 2018: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000); Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
• Keywords: 前頭皮質 / 錐体細胞 / 局所回路 / 皮質線条体投射 / 皮質間投射 / FS細胞 / 振動 / ソマトスタチン / 電子顕微鏡

Outline of Annual Research Achievements

前頭皮質固有の回路則の解明と局所サブネットワーク機能の理解を目指して、以下の提案と実験解析を行った。
(1) 前頭皮質FS細胞による5層興奮性サブネットワークの同期制御
前頭皮質5層の錐体細胞には、対側線条体へ投射するcrossed corticostriatal (CCS)細胞と、同側橋核へ投射するcorticopontine (CPn)細胞という二つのサブタイプがある。サブタイプ間の結合がCCS細胞からCPn細胞への一方向性であり、階層が異なる二つの興奮性サブネットワークが作られている。これらのサブタイプの結合様式・伝達特性の解析結果から、CPn細胞とGABA作動性FS細胞間の結合がガンマ振動生成において重要であると推測した。更に、FS細胞の電気シナプスに関連した結合選択性も取り入れて、一部のFS細胞と5層下流のCPn細胞がガンマ振動で同期し、その活動が5層上流のCCS細胞へ逆行性に伝搬することで、同時に活動するCCS細胞とCPn細胞のサブグループが作られることを提唱した。
(2) 前頭皮質2層の両側・片側興奮投射系の局所回路
二次運動野の主要な皮質出力先である対側M2および同側嗅周皮質への投射様式を、細胞構築・分子発現から区分した2層、3層、5層上部で比較した。3層と5層上部では2つの出力先に分枝して、同時に投射する細胞が多く見られたのに対して、2層の細胞は出力先ごとに異なる細胞グループを形成していた。さらに樹状突起の形態と電気的性質も異なっていた。2層の興奮性シナプス結合は同種・異種サブタイプ間で作られていたが、異種間での結合は対側二次運動野に投射するサブタイプから、同側嗅周皮質に投射するサブタイプへの一方向性結合であった。5層と同じく、2 層でも両側投射細胞から片側投射細胞への一方向性結合があると考えられた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

新皮質局所サブネットワーク理解の為に明らかにしてきたニューロンサブタイプと結合選択性を、振動現象の回路理解に結びつけることができた。5層だけでなく、2/3層の興奮性サブネットワークを明らかにできた。

Strategy for Future Research Activity

2/3層と5層の興奮性局所サブネットワークをかなり同定できたので、これらに共通した主要な出力である皮質間投射の構造と機能を明らかにする解析を進めることで、局所サブネットワークごとの機能的意義を明らかにしていきたい。

Research Products

• [Int'l Joint Research] マックスプランク研究所(ドイツ)
• [Journal Article] Ipsi- and contralateral corticocortical projection-dependent subcircuits in layer 2 of the rat frontal cortex (2019)
  • Author(s): Ueta Yoshifumi、Sohn Jaerin、Agahari Fransiscus Adrian、Im Sanghun、Hirai Yasuharu、Miyata Mariko、Kawaguchi Yasuo
  • Journal Title: J Neurophysiol Volume: 122 Pages: 1461-1472
  • DOI: 10.1152/jn.00333.2019
  • Peer Reviewed
• [Journal Article] Semaphorin 6A?Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons (2019)
  • Author(s): Hatanaka Yumiko、Kawasaki Takahiko、Abe Takaya、Shioi Go、Kohno Takao、Hattori Mitsuharu、Sakakibara Akira、Kawaguchi Yasuo、Hirata Tatsumi
  • Journal Title: iScience Volume: 21 Pages: 359-374
  • DOI: 10.1016/j.isci.2019.10.034
  • Peer Reviewed / Open Access
• [Journal Article] Differential Striatal Axonal Arborizations of the Intratelencephalic and Pyramidal-Tract Neurons: Analysis of the Data in the MouseLight Database (2019)
  • Author(s): Kenji Morita, Sanghun Im, Yasuo Kawaguchi
  • Journal Title: Front Neural Circuits Volume: 13 Pages: 71-71
  • DOI: 10.3389/fncir.2019.00071
  • Peer Reviewed / Open Access
• [Journal Article] UNI-EM: An Environment for Deep Neural Network-Based Automated Segmentation of Neuronal Electron Microscopic Images (2019)
  • Author(s): Urakubo Hidetoshi、Bullmann Torsten、Kubota Yoshiyuki、Oba Shigeyuki、Ishii Shin
  • Journal Title: Sci Rep Volume: 9 Pages: 19413-19413
  • DOI: 10.1038/s41598-019-55431-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Control of excitatory hierarchical circuits by parvalbumin-FS basket cells in layer 5 of the frontal cortex: insights for cortical oscillations (2019)
  • Author(s): Kawaguchi Y, Otsuka T, Morishima M, Ushimaru M, Kubota Y
  • Journal Title: J Neurophysiol Volume: 121 Pages: 2222-2236
  • DOI: 10.1152/jn.00778.2018
  • NAID: 120006649569
  • Peer Reviewed / Open Access
• [Journal Article] Method for Labeling and Reconstruction of Single Neurons Using Sindbis Virus Vectors (2019)
  • Author(s): Eriko Kuramoto
  • Journal Title: J Chem Neuroanat Volume: 100 Pages: 101648-101648
  • DOI: 10.1016/j.jchemneu.2019.05.002
  • Peer Reviewed
• [Journal Article] A Dual Role Hypothesis of the Cortico-Basal-Ganglia Pathways: Opponency and Temporal Difference Through Dopamine and Adenosine (2019)
  • Author(s): Kenji Morita, Yasuo Kawaguchi
  • Journal Title: Frontiers in Neural Circuits Volume: 12 Pages: 111-111
  • DOI: 10.3389/fncir.2018.00111
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways (2018)
  • Author(s): Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
  • Journal Title: Neuron Volume: 99(6) Issue: 6 Pages: 1302-1314
  • DOI: 10.1016/j.neuron.2018.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning (2018)
  • Author(s): Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Kondo Masashi、Terada Shin-Ichiro、Kawaguchi Yasuo、Matsuzaki Masanori
  • Journal Title: Neuron Volume: 100 Pages: 244-258
  • DOI: 10.1016/j.neuron.2018.08.016
  • NAID: 40021939701
  • Peer Reviewed / Open Access
• [Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration (2018)
  • Author(s): Kaneko N., Herranz-Perez V., Otsuka T., Sano H., Ohno N., Omata T., Nguyen H. B., Thai T. Q., Nambu A., Kawaguchi Y., Garcia-Verdugo J. M., Sawamoto K.
  • Journal Title: Science Advances Volume: 4 Pages: 0618-0618
  • DOI: 10.1126/sciadv.aav0618
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large Volume Electron Microscopy and Neural Microcircuit Analysis (2018)
  • Author(s): Kubota Yoshiyuki、Sohn Jaerin、Kawaguchi Yasuo
  • Journal Title: Frontiers in Neural Circuits Volume: 12 Pages: 98-98
  • DOI: 10.3389/fncir.2018.00098
  • Peer Reviewed / Open Access
• [Journal Article] 電子顕微鏡を使った革新的脳組織解析法 ― コネクトーム研究 (2018)
  • Author(s): 窪田芳之, 川口泰雄
  • Journal Title: 実験医学 Volume: 36 Pages: 158-164
• [Journal Article] A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure (2018)
  • Author(s): Kubota Y, Sohn J, Hatada S, Schurr M, StraehleJ, Gour A, Neujahr R, MikiT, Mikula S, Kawaguchi Y
  • Journal Title: Nature Commun Volume: 9 Pages: 437-437
  • DOI: 10.1038/s41467-017-02768-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Segregated Excitatory?Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex (2017)
  • Author(s): Morishima Mieko、Kobayashi Kenta、Kato Shigeki、Kobayashi Kazuto、Kawaguchi Yasuo
  • Journal Title: Cereb. Cortex Volume: 27 Pages: 5846-5857
  • DOI: 10.1093/cercor/bhx276
  • Peer Reviewed / Open Access
• [Journal Article] Pyramidal cell subtypes and their synaptic connections in layer 5 of rat frontal cortex (2017)
  • Author(s): Kawaguchi Y
  • Journal Title: Cereb Cortex Volume: 27 Pages: 5755-5771
  • DOI: 10.1093/cercor/bhx252
  • Peer Reviewed / Open Access
• [Journal Article] 大脳皮質局所回路：古典的競合選択モデルの実験的検証と混合選択性細胞 (2017)
  • Author(s): 森田賢治, 川口泰雄
  • Journal Title: 生体の科学 Volume: 68 Pages: 43-47
• [Journal Article] Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors (2017)
  • Author(s): Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka Y, Furuta T, Hioki H, Goto T
  • Journal Title: J Comp Neurol Volume: 525 Pages: 3821-3839
  • DOI: 10.1002/cne.12646
  • Peer Reviewed
• [Journal Article] Individual Mediodorsal Thalamic Neurons Project to Multiple Areas of the Rat Prefrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors. (2017)
  • Author(s): Kuramoto E, Pan SX, Furuta T, Tanaka YR, Iwai H, Yamanaka A, Ohno S, Kaneko T, Goto T, Hioki H.
  • Journal Title: The Journal of comparative neurology Volume: 525 Pages: 166-185
  • DOI: 10.1002/cne.24054
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy (2020)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research
• [Presentation] Sublayer dependent excitatory and inhibitory circuits in the layer 5 of rat frontal cortex (2020)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research
• [Presentation] Input-dependent spine dynamics in motor cortex during motor learning (2020)
  • Author(s): Sohn J, Youssef M, Hatada S, Kawaguchi Y, Kubota Y
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research
• [Presentation] Connection selectivity of somatostatin cell subtypes in layer 2/3 of frontal cortex (2020)
  • Author(s): Agahari FA, Kawaguchi Y
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research
• [Presentation] Layer 1 projection diversity of layer 5 pyramidal cells in the frontal cortex (2020)
  • Author(s): Im S, Morishima M, Kawaguchi Y
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research
• [Presentation] Local circuits in the frontal cortex drive diverse corticocortical projections (2020)
  • Author(s): Kawaguchi Y, Ueta Y, Agahari FA, Im S
  • Organizer: The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
  • Int'l Joint Research / Invited
• [Presentation] スパインと電気結合：濱先生と私 (2020)
  • Author(s): 川口泰雄
  • Organizer: ABiS Symposium Forefront and Future of Electron Microscopic Imaging
  • Invited
• [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy (2020)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
  • Organizer: ABiS Symposium Forefront and Future of Electron Microscopic Imaging
  • Int'l Joint Research
• [Presentation] Network plastic changes in the primary motor cortex as the basis of a new motor skill acquisition (2020)
  • Author(s): Kubota Y, Sohn J, Suzuki M, Hatada S, Youssef M, Larkum ME, Kawaguchi Y
  • Organizer: 2020 Gordon Research Conference, Thamamocortiacl Interaction
  • Int'l Joint Research
• [Presentation] Distinct functional and morphological properties of the frontal and parietal layer 5 corticothalamic pathways (2020)
  • Author(s): Kuramoto E, Bokor H, Hadinger N, Bosz E, Toth B, David C, Komlosi G, Shepherd G, Yamawaki N, Goto T, Acsady L
  • Organizer: 2020 Gordon Research Conference, Thamamocortiacl Interactions
  • Int'l Joint Research
• [Presentation] 運動学習中の大脳皮質入出力の層特異的な神経活動ダイナミクス (2020)
  • Author(s): 田中康裕、田中康代、正水芳人、川口泰雄、松崎政紀
  • Organizer: 第125回日本解剖学会総会・全国学術集会
• [Presentation] 皮質－皮質間連絡・視床－皮質投射の入力依存的な運動学習時回路動態 (2020)
  • Author(s): 孫在隣、窪田芳之、川口泰雄
  • Organizer: 日本顕微鏡学会第75回学術講演会
• [Presentation] ラットの前頭皮質における視床前腹側核VA由来神経終末のシナプスターゲット構造－ATUM-SEM法による解析－ (2020)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Hioki H, Kawaguchi Y
  • Organizer: 日本顕微鏡学会第75回学術講演会
• [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy (2019)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
  • Organizer: 2019 Gordon Research Conference Dendrites: Molecules, Structure and Function
  • Int'l Joint Research
• [Presentation] An electrodeposited copper tape for serial-section electron microscopy of neural ultrastructure with ATUM-SEM (2019)
  • Author(s): Kubota Y, Kawaguchi Y
  • Organizer: 日本顕微鏡学会第75回学術講演会
• [Presentation] The role of cortical pyramidal cell subtype dependent oscillatory activities in motor learning (2019)
  • Author(s): Otsuka T, Kawaguchi Y
  • Organizer: 第42回日本神経科学大会
• [Presentation] Electrophysiological, morphological, and connection characteristics of layer 2/3 somatostatin cells in mouse frontal cortex (2019)
  • Author(s): Agahari FA, Kawaguchi Y
  • Organizer: 第42回日本神経科学大会
• [Presentation] Sublayer-dependent excitatory and inhibitory circuits in layer 5 of the rat frontal cortex (2019)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 第42回日本神経科学大会
• [Presentation] Corticocortical and thalamocortical remodeling in the cortical microcircuit during motor learning (2019)
  • Author(s): Sohn J, Kubota Y, Kawaguchi Y
  • Organizer: 第42回日本神経科学大会
• [Presentation] An electrodeposited copper foil tape for serial-section electron microscopy of brain ultrastructure with ATUM-SEM (2019)
  • Author(s): Kubota Y, Kawaguchi Y
  • Organizer: 第42回日本神経科学大会
• [Presentation] Coactosin functions as a morphological determinant in developing cortical interneurons (2019)
  • Author(s): Hou X, Morishima M, Matohara N, Sugi J, Sakimura K, Kawaguchi Y, Sugiyama S
  • Organizer: 第42回日本神経科学大会
• [Presentation] Molecular mechanism of KCNQ channels for reward behavior (2019)
  • Author(s): Tsuboi D, Nishioka T, Shimomura T, Otsuka T, Kubo Y, Kawaguchi Y, Kaibuchi K
  • Organizer: 第42回日本神経科学大会
• [Presentation] Cortical oscillatory activities regulate motor learning formation (2019)
  • Author(s): Otsuka T, Kawaguchi Y
  • Organizer: 第11回光操作研究会
• [Presentation] 皮質オシレーション活動による運動学習形成の制御 (2019)
  • Author(s): 大塚岳、川口泰雄
  • Organizer: 第9回名古屋大学医学系研究科・生理学研究所合同シンポジウム
• [Presentation] Connection selectivity of somatostatin cell subtypes in layer 2/3 of frontal cortex (2019)
  • Author(s): Agahari FA, Kawaguchi Y
  • Organizer: 第9回 名古屋大学医学系研究科・生理学研究所合同シンポジウム
• [Presentation] Circuit remodeling in the motor cortex during motor learning (2019)
  • Author(s): Sohn J, Kubota Y, Kawaguchi Y
  • Organizer: 49th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Thalamo cortical synaptic network in motor cortex analyzed with large volume electron microscopy (2019)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
  • Organizer: 49th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Mapping learning-dependent structural changes in thalamocortical synapses (2019)
  • Author(s): Kawaguchi Y
  • Organizer: The 9th Okazaki-Tuebingen-Beijing Joint Symposium
  • Int'l Joint Research
• [Presentation] Network plastic changes in the primary motor cortex as the basis of a new motor skill acquisition (2019)
  • Author(s): Sohn J, Kubota Y, Kawaguchi Y
  • Organizer: The 9th Okazaki-Tuebingen-Beijing Joint Symposium
  • Int'l Joint Research
• [Presentation] 神経組織の大容量電顕データセット作成とオートセグメンテーションによる３次元再構築 (2019)
  • Author(s): 窪田芳之, 川口泰雄
  • Organizer: 日本顕微鏡学会第62回シンポジウム
• [Presentation] Sublayer- dependent inhibitory-excitatory connections in the layer 5 of rat frontal cortex (2019)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 第8回生理研-霊長研-新潟脳研合同シンポジウム
• [Presentation] Sublayer- dependent inhibitory-excitatory connections in the layer 5 of rat frontal cortex (2019)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: The 9th BRI International Symposium
  • Int'l Joint Research
• [Presentation] Thalamo-cortical target analysis in cortical motor cortex using large volume electron microscopy (2019)
  • Author(s): Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
  • Organizer: 第124回日本解剖学会総会・全国学術集会
  • Invited
• [Presentation] Large volume electron microscopy and neural microcircuitanalysis (2019)
  • Author(s): Kubota Y, Sohn J, Kawaguchi Y
  • Organizer: 9th FAOPS
  • Int'l Joint Research
• [Presentation] Layer 5 sublayer-dependent excitatory-inhibitory connections in the rat frontal cortex (2019)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 9th FAOPS
  • Int'l Joint Research
• [Presentation] Thalamocortical axon activity in motor cortex exhibits layer-specific dynamics during motor learning (2019)
  • Author(s): Tanaka YR, Tanaka YH, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
  • Organizer: 9th FAOPS
  • Int'l Joint Research
• [Presentation] Sublayer-dependent interaction between GABAergic and pyramidal cells in layer 5 of the rat frontal cortex (2018)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 第10回光操作研究会・第２回脳情報動態合同国際シンポジウム
  • Int'l Joint Research
• [Presentation] Layer 5a and 5b dependent inhibitory connections in the rat frontal cortex (2018)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 第41回日本神経科学大会
• [Presentation] Emerging dynamics of thalamocortical ensemble activity through learning of self-initiated lever pull (2018)
  • Author(s): Tanaka YH, Tanaka YR, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
  • Organizer: 第41回日本神経科学大会
• [Presentation] SemaphorinA6 on radial glia cell and PlexinA2/A4 on neuron are required for proper positioning of superficial layer neurons in the cerebral cortex (2018)
  • Author(s): Hatanaka Y, Kawasaki T, KohnoT, Hattori M, Sakakibara A, Kawaguchi Y, Hirata T
  • Organizer: 第41回日本神経科学大会
• [Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum (2018)
  • Author(s): Nonomura S, Kato S, Iguchi Y, Nishizawa K, Sakai Y, Kawaguchi Y, Nambu A, Watanabe M, Kobayashi K, Isomura Y, Kimura M
  • Organizer: 第41回日本神経科学大会
• [Presentation] Cortical neuron types and their synaptic connections (2018)
  • Author(s): Kawaguchi Y
  • Organizer: 第41回日本神経科学大会
  • Invited
• [Presentation] 新皮質パルブアルブミン細胞とソマトスタチン細胞のシナプス構築 (2018)
  • Author(s): 川口泰雄
  • Organizer: 第8回名古屋大学医学系研究科・生理学研究所合同シンポジウム
  • Invited
• [Presentation] A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure (2018)
  • Author(s): Kubota Y, Sohn J, Kawaguchi Y
  • Organizer: 第8回名古屋大学医学系研究科・生理学研究所合同シンポジウム
• [Presentation] Local recurrent subnetworks correlated with long-distance projections in frontal cortex (2018)
  • Author(s): Kawaguchi Y
  • Organizer: International symposium on Brain Information Dynamics 2018
  • Int'l Joint Research / Invited
• [Presentation] Ipsilateral and contralateral corticocortical projection-dependent subcircuits in layer 2/3 of rat frontal cortex (2018)
  • Author(s): Ueta Y, Kawaguchi Y
  • Organizer: 第95回日本生理学会大会
• [Presentation] Dynamics of thalamocortical activities during motor execution and learning (2018)
  • Author(s): Tanaka YH, Tanaka YR, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
  • Organizer: 第95回日本生理学会大会
• [Presentation] Local connections of excitatory neurons to parvalbumin-containing interneurons in motor-associated cortical areas of mice (2018)
  • Author(s): Kuramoto E
  • Organizer: Gordon Research Conference Thalamocortical Interaction
  • Int'l Joint Research
• [Presentation] ATUMtome 用の新開発テープと高解像画像用組織処理法 (2017)
  • Author(s): 窪田芳之, 孫在隣, 畑田小百合, 川口泰雄
  • Organizer: 第73回日本顕微鏡学会学術講演会
  • Invited
• [Presentation] Differential involvement of direct- and indirect-pathway spiny projection neurons in action valuation and update in the dorsomedial striatum (2017)
  • Author(s): Kimura M, Nonomura S, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Yamanaka K, Isomura Y
  • Organizer: 第40回日本神経科学大会
• [Presentation] A novel tape for ATUMtome and high resolution electron microscopy (2017)
  • Author(s): Kubota Y, Sohn J, Hatada S, Kawaguchi Y
  • Organizer: 第40回日本神経科学大会
• [Presentation] Labeling of neurons derived from intermediate neuronal progenitors in the mouse cerebral cortex (2017)
  • Author(s): Hatanaka Y, Hirata T, Kawaguchi Y
  • Organizer: 第40回日本神経科学大会
• [Presentation] Cortical pyramidal cell-subtype dependent motor learning and oscillatory activities (2017)
  • Author(s): Otsuka T, Kawaguchi Y
  • Organizer: 第40回日本神経科学大会
• [Presentation] Thalamocortical dynamics mediate learning and execution of self-initiated movement (2017)
  • Author(s): Tanaka YH, Tanaka YR, Hira R, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Activity of direct- and indirect-pathway striatal projection neurons identified by optogenetics during adaptive choice task with probabilistic reward (2017)
  • Author(s): Nonomura S, Yamanaka K, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Isomura Y, Kimura M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Pyramidal cell subtype-dependent inhibitory innervations in layer 5 of the rat frontal cortex (2017)
  • Author(s): Morishima M, Kawaguchi Y
  • Organizer: 第40回日本神経科学大会
• [Presentation] 前頭皮質のニューロン構成と標準回路 (2017)
  • Author(s): 川口泰雄
  • Organizer: 新学術領域研究「脳情報動態を規定する多領野連関と並列処理（脳情報動態）」領域公募説明会＆特別講演会「コネクトミクスからAIへ」
  • Invited
• [Presentation] Action-specific reinforcement and update by direct- and indirect- pathway striatal projection neurons (2017)
  • Author(s): Nonomura S, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Yamanaka K, Enomoto K, Isomura Y, Kimura M
  • Organizer: 47th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] A conductive novel tape material and a new staining protocol for volume electron microscopy applications (2017)
  • Author(s): Kubota Y, Sohn J, Hatada S, Schurr M , Straehle J, Gour A. G, Neujahr R, Mikula S, Kawaguchi Y
  • Organizer: 47th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Innervation differences of layer 5a and 5b Martinotti cells in frontal cortex (2017)
  • Author(s): Kawaguchi Y, Morishima M
  • Organizer: 47th annual meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 前頭皮質ニューロンと再帰的結合の多様性 (2017)
  • Author(s): 川口泰雄
  • Organizer: 次世代脳プロジェクト冬のシンポジウム2017
  • Invited
• [Presentation] Local connections of excitatory neurons to parvalbumin-containing interneurons in motor-associated cortical areas of mice (2017)
  • Author(s): Kuramoto E, Hiokii H, Tanaka Y, Iwai H, Yamanaka A, Goto T, Kaneko T
  • Organizer: FENS regional meeting
  • Int'l Joint Research
• [Remarks] 生理学研究所大脳神経回路論研究部門
  • URL: http://www.nips.ac.jp/circuit/