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Cortical local circuits for multi-area interconnectivity and parallel processing

Planned Research

Project AreaBrain information dynamics underlying multi-area interconnectivity and parallel processing
Project/Area Number 17H06311
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTamagawa University (2019-2021)
National Institute for Physiological Sciences (2017-2018)

Principal Investigator

川口 泰雄  玉川大学, 脳科学研究所, 研究員 (40169694)

Co-Investigator(Kenkyū-buntansha) 大塚 岳  生理学研究所, 脳機能計測・支援センター, 助教 (10390692)
高田 美絵子 (森島美絵子)  東京慈恵会医科大学, 医学部, 講師 (30435531)
孫 在隣  生理学研究所, 脳機能計測・支援センター, 特任研究員 (40780333)
窪田 芳之  生理学研究所, 基盤神経科学研究領域, 准教授 (90192567)
倉本 恵梨子  鹿児島大学, 医歯学域歯学系, 助教 (60467470)
植田 禎史  東京女子医科大学, 医学部, 助教 (00511015)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥113,750,000 (Direct Cost: ¥87,500,000、Indirect Cost: ¥26,250,000)
Fiscal Year 2021: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2018: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywords前頭皮質 / 錐体細胞 / 局所回路 / 皮質線条体投射 / 皮質間投射 / ソマトスタチン細胞 / FS細胞 / 振動 / ソマトスタチン / 電子顕微鏡
Outline of Annual Research Achievements

前頭皮質局所サブネットワーク形成の機能的意義の理解と、前頭皮質固有の回路則の解明を目指して、以下の実験・解析を進めた。
(1) 5層終脳内投射錐体細胞(IT細胞)の投射多様性: 前頭皮質5層のIT細胞が電気的・生理的には多様であるが、投射する皮質領野との関係は不明である。この点を明らかにするために、Janelia Research Campusの公開データベースにある、単一IT細胞の皮質内軸索分布を定量解析した。その結果、5層IT細胞の中で、複数の皮質領野を支配するものは1層支配が強く、特定の領野だけを支配するものは1層に軸索をあまり出さないことが分かった。これらの皮質間投射細胞サブタイプの分子発現特異性と結合選択性を解析している。
(2) 前頭皮質ソマトスタチン(SOM)細胞の多様性: 前頭皮質のSOM細胞の機能はあまり解明されていない。新皮質2/3層の主要な投射先は、他の皮質領野である。本研究では前頭皮質2/3層で、発火・形態特性を同定したSOM細胞と皮質間投射錐体細胞の結合関係を調べることで、SOM細胞の機能的多様化と、前頭皮質2/3層興奮・抑制回路の結合原理を明らかにする。そのために、2/3層SOM細胞や皮質間投射錐体細胞の生理特性・分子発現・形態の解明を進めている。この解析に導入したSOM細胞にCreを発現するマウスで、SOM発現特異性を免疫組織化学の手法で調べた。前頭皮質2/3層では5/6層とは異なり、Creがソマトスタチン細胞選択的に発現することを確認した。次に、2/3層SOM細胞からホールセル記録することで、これらが電気生理学的に多様であることが分かった。この生理的多様性と、SOM細胞に発現する複数の分子マーカーとの関係を、記録細胞の免疫組織化学で検索した。電気生理的な性質及び分子マーカー発現が異なる細胞の樹状突起・軸索形態を定量的に比較している。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

新皮質局所サブネットワーク理解の為に明らかにしてきた5層興奮性局所回路と、前頭皮質の機能発現に重要な皮質間トップダウン投射の多様化とを結びつける端緒を掴むことができた。また、2/3層興奮性サブネットワークの抑制性制御を理解するのに必要と考えられるソマトスタチン細胞の多様性を明らかにすることができた。

Strategy for Future Research Activity

これまでに明らかにした前頭皮質2/3層と5層の興奮性局所サブネットワークについて、それらの皮質間投射との関係や抑制性制御を明らかにすることで、前頭皮質の基本回路構造(標準)を明らかにしていきたい。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(92 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (21 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 15 results,  Acknowledgement Compliant: 1 results) Presentation (69 results) (of which Int'l Joint Research: 25 results,  Invited: 10 results) Remarks (1 results)

  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Deep learning-based point-scanning super-resolution imaging2021

    • Author(s)
      Fang L, Monroe F, Novak SW, Kirk L, Schiavon CR, Yu SB, Zhang T, Wu M, Kastner K, Latif AA, Lin Z, Shaw A, Kubota Y, Mendenhall J, Zhang Z, Pekkurnaz G, Harris K, Howard J, Manor U
    • Journal Title

      Nat Methods

      Volume: 18 Pages: 406-416

    • DOI

      10.1038/s41592-021-01080-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice2021

    • Author(s)
      Dhar A, Kuramoto E, Fukushima M, Iwai H, Yamanaka A, Goto T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 54 Issue: 1 Pages: 11-19

    • DOI

      10.1267/ahc.20-00036

    • NAID

      130007991342

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurodegeneration of trigeminal mesencephalic neurons by the tooth loss triggers the progression of Alzheimer's disease in 3xTg-AD model mice.2020

    • Author(s)
      Goto T, Kuramoto E, Dhar A, Wang RP-H, Seki H, Iwai H, Yamanaka A, Matsumoto S, Hara H, Michikawa M, Ohyagi Y, Leung WK, Chang RC-C
    • Journal Title

      J Alzheimer’s Dis

      Volume: 76 Pages: 1443-1459

    • DOI

      10.3233/jad-200257

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ipsi- and contralateral corticocortical projection-dependent subcircuits in layer 2 of the rat frontal cortex2019

    • Author(s)
      Ueta Yoshifumi、Sohn Jaerin、Agahari Fransiscus Adrian、Im Sanghun、Hirai Yasuharu、Miyata Mariko、Kawaguchi Yasuo
    • Journal Title

      J Neurophysiol

      Volume: 122 Pages: 1461-1472

    • DOI

      10.1152/jn.00333.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 6A?Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons2019

    • Author(s)
      Hatanaka Yumiko、Kawasaki Takahiko、Abe Takaya、Shioi Go、Kohno Takao、Hattori Mitsuharu、Sakakibara Akira、Kawaguchi Yasuo、Hirata Tatsumi
    • Journal Title

      iScience

      Volume: 21 Pages: 359-374

    • DOI

      10.1016/j.isci.2019.10.034

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential Striatal Axonal Arborizations of the Intratelencephalic and Pyramidal-Tract Neurons: Analysis of the Data in the MouseLight Database2019

    • Author(s)
      Kenji Morita, Sanghun Im, Yasuo Kawaguchi
    • Journal Title

      Front Neural Circuits

      Volume: 13 Pages: 71-71

    • DOI

      10.3389/fncir.2019.00071

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UNI-EM: An Environment for Deep Neural Network-Based Automated Segmentation of Neuronal Electron Microscopic Images2019

    • Author(s)
      Urakubo Hidetoshi、Bullmann Torsten、Kubota Yoshiyuki、Oba Shigeyuki、Ishii Shin
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 19413-19413

    • DOI

      10.1038/s41598-019-55431-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Control of excitatory hierarchical circuits by parvalbumin-FS basket cells in layer 5 of the frontal cortex: insights for cortical oscillations2019

    • Author(s)
      Kawaguchi Y, Otsuka T, Morishima M, Ushimaru M, Kubota Y
    • Journal Title

      J Neurophysiol

      Volume: 121 Pages: 2222-2236

    • DOI

      10.1152/jn.00778.2018

    • NAID

      120006649569

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Method for Labeling and Reconstruction of Single Neurons Using Sindbis Virus Vectors2019

    • Author(s)
      Eriko Kuramoto
    • Journal Title

      J Chem Neuroanat

      Volume: 100 Pages: 101648-101648

    • DOI

      10.1016/j.jchemneu.2019.05.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Dual Role Hypothesis of the Cortico-Basal-Ganglia Pathways: Opponency and Temporal Difference Through Dopamine and Adenosine2019

    • Author(s)
      Kenji Morita, Yasuo Kawaguchi
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 12 Pages: 111-111

    • DOI

      10.3389/fncir.2018.00111

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • NAID

      120006869035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning2018

    • Author(s)
      Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Kondo Masashi、Terada Shin-Ichiro、Kawaguchi Yasuo、Matsuzaki Masanori
    • Journal Title

      Neuron

      Volume: 100 Pages: 244-258

    • DOI

      10.1016/j.neuron.2018.08.016

    • NAID

      40021939701

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration2018

    • Author(s)
      Kaneko N., Herranz-Perez V., Otsuka T., Sano H., Ohno N., Omata T., Nguyen H. B., Thai T. Q., Nambu A., Kawaguchi Y., Garcia-Verdugo J. M., Sawamoto K.
    • Journal Title

      Science Advances

      Volume: 4 Pages: 0618-0618

    • DOI

      10.1126/sciadv.aav0618

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large Volume Electron Microscopy and Neural Microcircuit Analysis2018

    • Author(s)
      Kubota Yoshiyuki、Sohn Jaerin、Kawaguchi Yasuo
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 12 Pages: 98-98

    • DOI

      10.3389/fncir.2018.00098

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 電子顕微鏡を使った革新的脳組織解析法 ― コネクトーム研究2018

    • Author(s)
      窪田芳之, 川口泰雄
    • Journal Title

      実験医学

      Volume: 36 Pages: 158-164

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure2018

    • Author(s)
      Kubota Y, Sohn J, Hatada S, Schurr M, StraehleJ, Gour A, Neujahr R, MikiT, Mikula S, Kawaguchi Y
    • Journal Title

      Nature Commun

      Volume: 9 Pages: 437-437

    • DOI

      10.1038/s41467-017-02768-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Segregated Excitatory?Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex2017

    • Author(s)
      Morishima Mieko、Kobayashi Kenta、Kato Shigeki、Kobayashi Kazuto、Kawaguchi Yasuo
    • Journal Title

      Cereb. Cortex

      Volume: 27 Pages: 5846-5857

    • DOI

      10.1093/cercor/bhx276

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pyramidal cell subtypes and their synaptic connections in layer 5 of rat frontal cortex2017

    • Author(s)
      Kawaguchi Y
    • Journal Title

      Cereb Cortex

      Volume: 27 Pages: 5755-5771

    • DOI

      10.1093/cercor/bhx252

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大脳皮質局所回路:古典的競合選択モデルの実験的検証と混合選択性細胞2017

    • Author(s)
      森田賢治, 川口泰雄
    • Journal Title

      生体の科学

      Volume: 68 Pages: 43-47

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors2017

    • Author(s)
      Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka Y, Furuta T, Hioki H, Goto T
    • Journal Title

      J Comp Neurol

      Volume: 525 Pages: 3821-3839

    • DOI

      10.1002/cne.12646

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individual Mediodorsal Thalamic Neurons Project to Multiple Areas of the Rat Prefrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors.2017

    • Author(s)
      Kuramoto E, Pan SX, Furuta T, Tanaka YR, Iwai H, Yamanaka A, Ohno S, Kaneko T, Goto T, Hioki H.
    • Journal Title

      The Journal of comparative neurology

      Volume: 525 Pages: 166-185

    • DOI

      10.1002/cne.24054

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Synaptic reconfiguration in motor cortex underlies acquisition of proficient motor skill2021

    • Author(s)
      Sohn J, Suzuki M, Mohammed Y, Hatada S, Larkum ME, Kawaguchi Y, Kubota Y
    • Organizer
      第10回 生理研-霊長研-新潟脳研合同シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] ラットの大脳皮質細胞へのシナプス入力特性2021

    • Author(s)
      窪田芳之, 川口泰雄
    • Organizer
      第126回日本解剖学会総会・全国学術集会/第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 運動学習時の皮質-皮質間連絡・視床-皮質投射の神経回路再編成2021

    • Author(s)
      孫在隣, 川口泰雄, 窪田芳之
    • Organizer
      第126回日本解剖学会総会・全国学術集会/第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 皮質-皮質間連絡・視床-皮質投射の入力依存的な運動学習時回路動態2020

    • Author(s)
      孫在隣, Mohammed Y, 川口泰雄, 窪田芳之
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大容量電顕データセットを使った視床-大脳皮質神経終末のシナプスターゲット解析2020

    • Author(s)
      窪田芳之, 孫在隣, 倉本恵梨子, Mohammed Y, 日置寛之, 川口泰雄
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 導電性カーボンナノチューブコートPETテープに乗せた神経組織の高解像度電子顕微鏡撮影とその解析法2020

    • Author(s)
      窪田芳之
    • Organizer
      第59回 フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 非錐体細胞の樹状突起へのシナプス入力特性2020

    • Author(s)
      窪田芳之, 川口泰雄
    • Organizer
      第10 回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy2020

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sublayer dependent excitatory and inhibitory circuits in the layer 5 of rat frontal cortex2020

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Input-dependent spine dynamics in motor cortex during motor learning2020

    • Author(s)
      Sohn J, Youssef M, Hatada S, Kawaguchi Y, Kubota Y
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Connection selectivity of somatostatin cell subtypes in layer 2/3 of frontal cortex2020

    • Author(s)
      Agahari FA, Kawaguchi Y
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Layer 1 projection diversity of layer 5 pyramidal cells in the frontal cortex2020

    • Author(s)
      Im S, Morishima M, Kawaguchi Y
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Local circuits in the frontal cortex drive diverse corticocortical projections2020

    • Author(s)
      Kawaguchi Y, Ueta Y, Agahari FA, Im S
    • Organizer
      The Eighth International Neural Microcircuit Conference- Synaptic Specificity to Circuit Dynamics -
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] スパインと電気結合:濱先生と私2020

    • Author(s)
      川口泰雄
    • Organizer
      ABiS Symposium Forefront and Future of Electron Microscopic Imaging
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy2020

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
    • Organizer
      ABiS Symposium Forefront and Future of Electron Microscopic Imaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Network plastic changes in the primary motor cortex as the basis of a new motor skill acquisition2020

    • Author(s)
      Kubota Y, Sohn J, Suzuki M, Hatada S, Youssef M, Larkum ME, Kawaguchi Y
    • Organizer
      2020 Gordon Research Conference, Thamamocortiacl Interaction
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct functional and morphological properties of the frontal and parietal layer 5 corticothalamic pathways2020

    • Author(s)
      Kuramoto E, Bokor H, Hadinger N, Bosz E, Toth B, David C, Komlosi G, Shepherd G, Yamawaki N, Goto T, Acsady L
    • Organizer
      2020 Gordon Research Conference, Thamamocortiacl Interactions
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動学習中の大脳皮質入出力の層特異的な神経活動ダイナミクス2020

    • Author(s)
      田中康裕、田中康代、正水芳人、川口泰雄、松崎政紀
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮質-皮質間連絡・視床-皮質投射の入力依存的な運動学習時回路動態2020

    • Author(s)
      孫在隣、窪田芳之、川口泰雄
    • Organizer
      日本顕微鏡学会第75回学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラットの前頭皮質における視床前腹側核VA由来神経終末のシナプスターゲット構造-ATUM-SEM法による解析-2020

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Hioki H, Kawaguchi Y
    • Organizer
      日本顕微鏡学会第75回学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Thalamo-cortical synaptic network in motor cortex analyzed with large volume electron microscopy2019

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
    • Organizer
      2019 Gordon Research Conference Dendrites: Molecules, Structure and Function
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An electrodeposited copper tape for serial-section electron microscopy of neural ultrastructure with ATUM-SEM2019

    • Author(s)
      Kubota Y, Kawaguchi Y
    • Organizer
      日本顕微鏡学会第75回学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The role of cortical pyramidal cell subtype dependent oscillatory activities in motor learning2019

    • Author(s)
      Otsuka T, Kawaguchi Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrophysiological, morphological, and connection characteristics of layer 2/3 somatostatin cells in mouse frontal cortex2019

    • Author(s)
      Agahari FA, Kawaguchi Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Sublayer-dependent excitatory and inhibitory circuits in layer 5 of the rat frontal cortex2019

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Corticocortical and thalamocortical remodeling in the cortical microcircuit during motor learning2019

    • Author(s)
      Sohn J, Kubota Y, Kawaguchi Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] An electrodeposited copper foil tape for serial-section electron microscopy of brain ultrastructure with ATUM-SEM2019

    • Author(s)
      Kubota Y, Kawaguchi Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Coactosin functions as a morphological determinant in developing cortical interneurons2019

    • Author(s)
      Hou X, Morishima M, Matohara N, Sugi J, Sakimura K, Kawaguchi Y, Sugiyama S
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular mechanism of KCNQ channels for reward behavior2019

    • Author(s)
      Tsuboi D, Nishioka T, Shimomura T, Otsuka T, Kubo Y, Kawaguchi Y, Kaibuchi K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cortical oscillatory activities regulate motor learning formation2019

    • Author(s)
      Otsuka T, Kawaguchi Y
    • Organizer
      第11回光操作研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮質オシレーション活動による運動学習形成の制御2019

    • Author(s)
      大塚岳、川口泰雄
    • Organizer
      第9回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Connection selectivity of somatostatin cell subtypes in layer 2/3 of frontal cortex2019

    • Author(s)
      Agahari FA, Kawaguchi Y
    • Organizer
      第9回 名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Circuit remodeling in the motor cortex during motor learning2019

    • Author(s)
      Sohn J, Kubota Y, Kawaguchi Y
    • Organizer
      49th annual meeting of the Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thalamo cortical synaptic network in motor cortex analyzed with large volume electron microscopy2019

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
    • Organizer
      49th annual meeting of the Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mapping learning-dependent structural changes in thalamocortical synapses2019

    • Author(s)
      Kawaguchi Y
    • Organizer
      The 9th Okazaki-Tuebingen-Beijing Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Network plastic changes in the primary motor cortex as the basis of a new motor skill acquisition2019

    • Author(s)
      Sohn J, Kubota Y, Kawaguchi Y
    • Organizer
      The 9th Okazaki-Tuebingen-Beijing Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経組織の大容量電顕データセット作成とオートセグメンテーションによる3次元再構築2019

    • Author(s)
      窪田芳之, 川口泰雄
    • Organizer
      日本顕微鏡学会第62回シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Sublayer- dependent inhibitory-excitatory connections in the layer 5 of rat frontal cortex2019

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第8回生理研-霊長研-新潟脳研合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sublayer- dependent inhibitory-excitatory connections in the layer 5 of rat frontal cortex2019

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      The 9th BRI International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thalamo-cortical target analysis in cortical motor cortex using large volume electron microscopy2019

    • Author(s)
      Kubota Y, Sohn J, Kuramoto E, Kawaguchi Y
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Large volume electron microscopy and neural microcircuitanalysis2019

    • Author(s)
      Kubota Y, Sohn J, Kawaguchi Y
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Layer 5 sublayer-dependent excitatory-inhibitory connections in the rat frontal cortex2019

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thalamocortical axon activity in motor cortex exhibits layer-specific dynamics during motor learning2019

    • Author(s)
      Tanaka YR, Tanaka YH, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
    • Organizer
      9th FAOPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sublayer-dependent interaction between GABAergic and pyramidal cells in layer 5 of the rat frontal cortex2018

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第10回光操作研究会・第2回脳情報動態合同国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Layer 5a and 5b dependent inhibitory connections in the rat frontal cortex2018

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Emerging dynamics of thalamocortical ensemble activity through learning of self-initiated lever pull2018

    • Author(s)
      Tanaka YH, Tanaka YR, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SemaphorinA6 on radial glia cell and PlexinA2/A4 on neuron are required for proper positioning of superficial layer neurons in the cerebral cortex2018

    • Author(s)
      Hatanaka Y, Kawasaki T, KohnoT, Hattori M, Sakakibara A, Kawaguchi Y, Hirata T
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum2018

    • Author(s)
      Nonomura S, Kato S, Iguchi Y, Nishizawa K, Sakai Y, Kawaguchi Y, Nambu A, Watanabe M, Kobayashi K, Isomura Y, Kimura M
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cortical neuron types and their synaptic connections2018

    • Author(s)
      Kawaguchi Y
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新皮質パルブアルブミン細胞とソマトスタチン細胞のシナプス構築2018

    • Author(s)
      川口泰雄
    • Organizer
      第8回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure2018

    • Author(s)
      Kubota Y, Sohn J, Kawaguchi Y
    • Organizer
      第8回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Local recurrent subnetworks correlated with long-distance projections in frontal cortex2018

    • Author(s)
      Kawaguchi Y
    • Organizer
      International symposium on Brain Information Dynamics 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ipsilateral and contralateral corticocortical projection-dependent subcircuits in layer 2/3 of rat frontal cortex2018

    • Author(s)
      Ueta Y, Kawaguchi Y
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dynamics of thalamocortical activities during motor execution and learning2018

    • Author(s)
      Tanaka YH, Tanaka YR, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Local connections of excitatory neurons to parvalbumin-containing interneurons in motor-associated cortical areas of mice2018

    • Author(s)
      Kuramoto E
    • Organizer
      Gordon Research Conference Thalamocortical Interaction
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATUMtome 用の新開発テープと高解像画像用組織処理法2017

    • Author(s)
      窪田芳之, 孫在隣, 畑田小百合, 川口泰雄
    • Organizer
      第73回日本顕微鏡学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Differential involvement of direct- and indirect-pathway spiny projection neurons in action valuation and update in the dorsomedial striatum2017

    • Author(s)
      Kimura M, Nonomura S, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Yamanaka K, Isomura Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel tape for ATUMtome and high resolution electron microscopy2017

    • Author(s)
      Kubota Y, Sohn J, Hatada S, Kawaguchi Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Labeling of neurons derived from intermediate neuronal progenitors in the mouse cerebral cortex2017

    • Author(s)
      Hatanaka Y, Hirata T, Kawaguchi Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cortical pyramidal cell-subtype dependent motor learning and oscillatory activities2017

    • Author(s)
      Otsuka T, Kawaguchi Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thalamocortical dynamics mediate learning and execution of self-initiated movement2017

    • Author(s)
      Tanaka YH, Tanaka YR, Hira R, Kondo M, Terada S, Kawaguchi Y, Matsuzaki M
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activity of direct- and indirect-pathway striatal projection neurons identified by optogenetics during adaptive choice task with probabilistic reward2017

    • Author(s)
      Nonomura S, Yamanaka K, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Isomura Y, Kimura M
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pyramidal cell subtype-dependent inhibitory innervations in layer 5 of the rat frontal cortex2017

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 前頭皮質のニューロン構成と標準回路2017

    • Author(s)
      川口泰雄
    • Organizer
      新学術領域研究「脳情報動態を規定する多領野連関と並列処理(脳情報動態)」領域公募説明会&特別講演会「コネクトミクスからAIへ」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Action-specific reinforcement and update by direct- and indirect- pathway striatal projection neurons2017

    • Author(s)
      Nonomura S, Nishizawa K, Kobayashi K, Sakai Y, Kawaguchi Y, Nambu A, Yamanaka K, Enomoto K, Isomura Y, Kimura M
    • Organizer
      47th annual meeting of the Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A conductive novel tape material and a new staining protocol for volume electron microscopy applications2017

    • Author(s)
      Kubota Y, Sohn J, Hatada S, Schurr M , Straehle J, Gour A. G, Neujahr R, Mikula S, Kawaguchi Y
    • Organizer
      47th annual meeting of the Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Innervation differences of layer 5a and 5b Martinotti cells in frontal cortex2017

    • Author(s)
      Kawaguchi Y, Morishima M
    • Organizer
      47th annual meeting of the Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 前頭皮質ニューロンと再帰的結合の多様性2017

    • Author(s)
      川口泰雄
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Local connections of excitatory neurons to parvalbumin-containing interneurons in motor-associated cortical areas of mice2017

    • Author(s)
      Kuramoto E, Hiokii H, Tanaka Y, Iwai H, Yamanaka A, Goto T, Kaneko T
    • Organizer
      FENS regional meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 生理学研究所大脳神経回路論研究部門

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2022-12-28  

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