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Model construction and theorization of intercell interactions

Planned Research

Project AreaIntegrated analysis and regulation of cellular diversity
Project/Area Number 17H06330
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionIwate University

Principal Investigator

Kawasaki Shuji  岩手大学, 理工学部, 准教授 (10282922)

Co-Investigator(Kenkyū-buntansha) 富田 浩史  岩手大学, 理工学部, 教授 (40302088)
菅野 江里子  岩手大学, 理工学部, 准教授 (70375210)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥79,560,000 (Direct Cost: ¥61,200,000、Indirect Cost: ¥18,360,000)
Fiscal Year 2021: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2020: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2019: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2018: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2017: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywords遺伝子的メカニズムのパターン相図 / 1細胞解析 / 発現量ベクトルの相互作用 / オプトジェネティクス / 光感受性 / チャネルロドプシン / 卵巣がん / 遺伝子的メカニズム / 網膜色素変性症 / 光受容クロライドチャネル遺伝子 / ComV1遺伝子 / 遺伝子発現量 / 多変量解析 / 遺伝子発現パターン相図 / 一細胞解析 / TGF-beta / 主成分分析 / 局所相関 / 擬似時間 / 卵巣癌 / 主成分固有値 / がん / 遺伝子 / 細胞クラスタ間相互作用 / 数理モデル / クラスタリング / 連鎖関係 / 分子経路ネットワーク / 確率モデル / 相転移 / 弾性と塑性 / 細胞分化スイッチング
Outline of Final Research Achievements

To gene expression vectors in Ovarian carcinoma, we have defined two statistics. Then, it turned out that plotting the statistics along two axes like a scatter plot, we could be able to present a pattern of interactions of the vectors. By this, we have clarified that genetic interactions by streamlines as each of the controls quantitatively and visually, and thus constructed a fundamental framework to understand the movement or genetic mechanism of the cancer formation.
Also, by an alnalysis with th next generation sequencer, we have recognized that the promotion of expression of a gene that is important for the functional expression of a light receiving channel gene and that it resides in Muler cells in retina by an immune tissue chemistry. We have found that a gene introduced cells remain there a long period without being inhibited, by the measurement of cell numbers.

Academic Significance and Societal Importance of the Research Achievements

がん形成の遺伝子的メカニズムの数理的側面からの解析において,従来主流であった細胞系譜過程の推定という問題に対し,遺伝子系譜過程の推定とも言うべき新しい観点をもたらした.それはある統計量に基づく遺伝子発現量ベクトルのパターン図を作成する事であり,Ad Hoc でない解析法の基礎を与えた.それにより1つの基盤的手法となるフレームワークを提案する事が出来た.
また,失明に対する視覚再建治療として、オプトジェネティック遺伝子治療技術について、次世代シーケンサーを用いて網羅的に遺伝子発現を調べることによって、それらの一端を明らかすることができ、遺伝子治療の実用化への重要な知見が得られた。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (63 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (23 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 22 results) Presentation (30 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Immortalization of cells derived from domestic dogs through expressing mutant cyclin-dependent kinase 4, cyclin D1, and telomerase reverse transcriptase.2022

    • Author(s)
      Munirah I, Ozaki T, Sekine A, Morimoto M, Sugawara M, Takada H, Sugano E, Tomita H, Kiyono T, Fukuda T.
    • Journal Title

      Cytotechnology.

      Volume: 74(1) Issue: 1 Pages: 181-192

    • DOI

      10.1007/s10616-021-00504-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detailed chromosome analysis of wild-type, immortalized fibroblasts with SV40T, E6E7, combinational introduction of cyclin dependent kinase 4, cyclin D1, telomerase reverse transcriptase.2021

    • Author(s)
      Takada H, Miura T, Fujibayashi S, Sasaki N, Takahashi K, Sugano E, Tomita H, Ozaki T, Kiyono T, Yoshida MA, Fukuda T.
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: 57(10) Issue: 10 Pages: 998-1005

    • DOI

      10.1007/s11626-021-00631-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zinc mediates the interaction between ceruloplasmin and apo-transferrin for the efficient transfer of Fe(III) ions.2021

    • Author(s)
      Sakajiri T, Nakatsuji M, Teraoka Y, Furuta K, Ikuta K, Shibusa K, Sugano E, Tomita H, Inui T, Yamamura T.
    • Journal Title

      Metallomics.

      Volume: 13(12) Issue: 12

    • DOI

      10.1093/mtomcs/mfab065

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells.2021

    • Author(s)
      Furuya K, Fujibayashi S, Wu T, Takahashi K, Takase S, Orimoto A, Sugano E, Tomita H, Kashiwagi S, Kiyono T, Ishii T, Fukuda T.
    • Journal Title

      BMC Genom Data.

      Volume: 23(1) Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12863-021-01018-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.2021

    • Author(s)
      Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H.
    • Journal Title

      NPJ Regen Med.

      Volume: 6(1) Issue: 1 Pages: 64-64

    • DOI

      10.1038/s41536-021-00177-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene.2021

    • Author(s)
      Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H.
    • Journal Title

      Int J Mol Sci.

      Volume: 22(13) Issue: 13 Pages: 6732-6732

    • DOI

      10.3390/ijms22136732

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The transcriptome of wild-type and immortalized corneal epithelial cells.2021

    • Author(s)
      Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T.
    • Journal Title

      Sci Data.

      Volume: 8(1) Issue: 1 Pages: 126-126

    • DOI

      10.1038/s41597-021-00908-9

    • NAID

      120007175170

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Data on mitochondrial ultrastructure of photoreceptors in pig, rabbit, and mouse retinas2021

    • Author(s)
      Ozaki Taku、Utsumi Shinto、Iwamoto Takeshi、Tanaka Makoto、Tomita Hiroshi、Sugano Eriko、Ishiyama Eri、Ishida Kinji
    • Journal Title

      Data in Brief

      Volume: 24 Pages: 105544-105544

    • DOI

      10.1016/j.dib.2020.105544

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells2021

    • Author(s)
      Fukuda Tomokazu、Furuya Kai、Takahashi Kouhei、Orimoto Ai、Sugano Eriko、Tomita Hiroshi、Kashiwagi Sayo、Kiyono Tohru、Ishii Tsuyoshi
    • Journal Title

      iScience

      Volume: 24 Issue: 1 Pages: 101929-101929

    • DOI

      10.1016/j.isci.2020.101929

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of mitochondrial calpain-52021

    • Author(s)
      Chukai Yusaku、Iwamoto Takeshi、Itoh Ken、Tomita Hiroshi、Ozaki Taku
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1868 Issue: 5 Pages: 118989-118989

    • DOI

      10.1016/j.bbamcr.2021.118989

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetics-Mediated Gene Therapy for Retinal Diseases2021

    • Author(s)
      Tomita Hiroshi、Sugano Eriko
    • Journal Title

      Adv Exp Med Biol.

      Volume: 1293 Pages: 535-43

    • DOI

      10.1007/978-981-15-8763-4_37

    • ISBN
      9789811587627, 9789811587634
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of ES1 homolog in the mitochondrial intermembrane space of porcine retinal cells2020

    • Author(s)
      Utsumi Shinto、Sakamoto Kimitoshi、Yamashita Tetsuro、Tomita Hiroshi、Sugano Eriko、Ishida Kinji、Ishiyama Eri、Ozaki Taku
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Issue: 3 Pages: 542-48

    • DOI

      10.1016/j.bbrc.2020.01.127

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geranylgeranyl acetone prevents glutamate-induced cell death in HT-22?cells by increasing mitochondrial membrane potential2020

    • Author(s)
      Sugano Eriko、Endo Yuka、Sugai Akihisa、Kikuchi Yuki、Tabata Kitako、Ozaki Taku、Kurose Takahiro、Takai Yoshihiro、Mitsuguchi Yoko、Honma Yoichi、Tomita Hiroshi
    • Journal Title

      European Journal of Pharmacology

      Volume: 883 Pages: 173193-173193

    • DOI

      10.1016/j.ejphar.2020.173193

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mathematical Analysis of Gefitinib Resistance Caused by MET Amplification2019

    • Author(s)
      T. Ito, Y. Kumagai, K. Itano, T. Maruyama, K. Tamura, S. Kawasaki, T. Suzuki and Y. Murakami
    • Journal Title

      Biochem. Biophys. Res. Comm.

      Volume: 9:511(3) Pages: 544-550

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing2019

    • Author(s)
      Fukuda T, Gouko R, Eitsuka T, Suzuki R, Takahashi K, Nakagawa K, Sugano E1 Tomita H, Kiyono
    • Journal Title

      Front. Genet.

      Volume: 10 Pages: 587-587

    • DOI

      10.3389/fgene.2019.00587

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina2019

    • Author(s)
      Kurose T, Sugano E, Sugai A, Shiraiwa R, Kato M, Mitsuguchi Y, Takai Y, Tabata K, Honma Y, Tomita H
    • Journal Title

      International Journal of Ophthalmology

      Volume: 12 Issue: 8 Pages: 1231-1237

    • DOI

      10.18240/ijo.2019.08.01

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of acid-Ceramidase (ASAH1) Protects Retinal Cells (ARPE19) from Oxidative Stress2019

    • Author(s)
      Sugano E, Edwards G, Saha S, Wilmott LA, Grambergs RC, Mondal K, Qi H, Stiles M, Tomita H, Manda N
    • Journal Title

      J Lipid Res

      Volume: 60(1) Issue: 1 Pages: 30-43

    • DOI

      10.1194/jlr.m082198

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] N-methyl-N-nitrosourea-induced photoreceptor degeneration is inhibited by nicotinamide via the blockade of upstream events before the phosphorylation of signaling proteins.2019

    • Author(s)
      Sugano E, Tabata K, Takezawa T, Shiraiwa R, Muraoka H, Metoki T, Kudo A, Nakazawa M, Tomita H, Iwama Y
    • Journal Title

      BioMed Research International

      Volume: 2019 Pages: 1-10

    • DOI

      10.1155/2019/3238719

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Data analytic study of the homothermal maintenance mechanism of <i>Skunk Cabbage</i>: Capturing pre-equilibrium characteristics using extended poisson model2018

    • Author(s)
      Kawasaki Shuji、Ito Kikukatsu
    • Journal Title

      Biophysics and Physicobiology

      Volume: 15 Issue: 0 Pages: 235-250

    • DOI

      10.2142/biophysico.15.0_235

    • NAID

      130007506150

    • ISSN
      2189-4779
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mathematical modeling and analysis of ErbB3 and EGFR dimerization process for the gefitinib resistance2018

    • Author(s)
      Itano Keiko, Ito Takeshi, Kawasaki Shuji, Murakami Yoshinori, Suzuki Takashi
    • Journal Title

      JSIAM Letters

      Volume: 10 Issue: 0 Pages: 33-36

    • DOI

      10.14495/jsiaml.10.33

    • NAID

      130007431148

    • ISSN
      1883-0609, 1883-0617
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The poly-cistronic expression of four transcriptional factors (CRX, RAX, NEURO-D, OTX2) in fibroblasts via retro- or lentivirus causes partial reprogramming into photoreceptor cells2018

    • Author(s)
      Fukuda T, Ishizawa Y, Donai K, Sugano E, Tomita H.
    • Journal Title

      Cell Biol Int.

      Volume: - Issue: 5 Pages: 608-614

    • DOI

      10.1002/cbin.10942

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kinetic profiles of photocurrents in cells expressing two types of channelrhodopsin genes.2018

    • Author(s)
      Watanabe Y, Sugano E, Tabata K, Ozaki T, Saito T, Tamai M, Tomita H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 12;496(3) Issue: 3 Pages: 814-819

    • DOI

      10.1016/j.bbrc.2018.01.149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Natronomonas pharaonis halorhodopsin Ser81 plays a role in maintaining chloride ions near the Schiff base2018

    • Author(s)
      Sakajiri Yuko、Sugano Eriko、Watanabe Yoshito、Sakajiri Tetsuya、Tabata Kitako、Kikuchi Takeshi、Tomita Hiroshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 4 Pages: 2326-2332

    • DOI

      10.1016/j.bbrc.2018.06.156

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Characterizing Asymptotic Distribution in Martingale Convergence of Supercritical Branching Processes2022

    • Author(s)
      Bat-Erdene B, Kawasaki, S
    • Organizer
      第16回日本統計学会春季集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Erdos-Renyiランダムグラフの臨界近傍における最大クラスターサイズの確率評価について2022

    • Author(s)
      佐々木俊一、川崎秀二
    • Organizer
      第16回日本統計学会春季集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 安定分布の複合Poisson級数近似における概収束のノルム評価について2022

    • Author(s)
      赤羽淳弥、川崎秀二
    • Organizer
      第16回日本統計学会春季集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オプトジェネティクスを用いた網膜神経細胞保護2022

    • Author(s)
      菊地由樹、菅野江里子、田端希多子、冨田浩史
    • Organizer
      新学術領域研究 第4回 若手ワークショップ
    • Related Report
      2021 Annual Research Report
  • [Presentation] オプトジェネティクスによる視覚再生後の視覚野の可塑性2022

    • Author(s)
      佐渡愛、菅野江里子、田端希多子、冨田浩史
    • Organizer
      新学術領域研究 第4回 若手ワークショップ
    • Related Report
      2021 Annual Research Report
  • [Presentation] オプトジェネティクスによるパーキンソン病モデルラットの行動評価2022

    • Author(s)
      新林史悠、菅野江里子、田端希多子、冨田浩史
    • Organizer
      新学術領域研究 第4回 若手ワークショップ
    • Related Report
      2021 Annual Research Report
  • [Presentation] 日常光レベルの光に応答する高感度チャネルロドプシンの開発2022

    • Author(s)
      畠山暁斗、菅野江里子、田端希多子、冨田浩史
    • Organizer
      新学術領域研究 第4回 若手ワークショップ
    • Related Report
      2021 Annual Research Report
  • [Presentation] マーモセット自閉症モデル前頭前皮質 樹状突起スパインと軸索ブトンのin vivo 2光子顕微鏡観察による解析2021

    • Author(s)
      野口潤、磯田李紗、渡辺恵、中垣慶子、菅野江里子、冨田浩史、渡我部昭哉、山森哲雄、水上 浩明、一戸紀孝
    • Organizer
      神経科学学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロワットオーダーの光に応答する高感度型チャネルロドプシンの開発2021

    • Author(s)
      畠山暁斗、渡邊義人、菅野江里子、田端希多子、佐山達樹、冨田浩史
    • Organizer
      日本光医学・光生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規ステップ関数型オプシンによる網膜神経細胞保護2021

    • Author(s)
      菊地由樹、菅野江里子、田端希多子、冨田浩史
    • Organizer
      眼薬理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 遺伝子治療による視覚再生後の脳の可塑性2021

    • Author(s)
      佐渡愛、菅野江里子、田端希多子、新林史悠、小野口玲奈、冨田 浩史
    • Organizer
      眼薬理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 遺伝子治療による視覚再生技術とその視覚持続性2021

    • Author(s)
      冨田 浩史
    • Organizer
      第64回数理医学研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 私の研究紹介2020

    • Author(s)
      川崎秀二
    • Organizer
      細胞社会ダイバーシティーの統合的解明と制御 領域シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 視覚再生後の網膜、視覚野の機能変化2020

    • Author(s)
      菅野江里子、冨田浩史、田端希多子
    • Organizer
      細胞社会ダイバーシティーの統合的解明と制御 領域シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 卵巣がん遺伝子発現量データの主成分に基づく遺伝子ネットワーク解析2020

    • Author(s)
      S. Kawasaki
    • Organizer
      細胞ダイバース第5回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Testing the Limit Cycle Behavior in Homothermal Maintenance of Skunk Cabbage2019

    • Author(s)
      E. Turtgtokh and S. Kawasaki
    • Organizer
      Int. Conf. Appl. Phys. Math.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On the Limit Cycle Behavior in Homothermal Maintenance of Skunk Cabbage2019

    • Author(s)
      E. Turtgtokh and S. Kawasaki
    • Organizer
      日本応用数理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 卵巣がん遺伝子発現量ベクトルにおけるEMT関連主成分と近接する他遺伝子群の抽出について2019

    • Author(s)
      S. Kawasaki
    • Organizer
      細胞ダイバース第4回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gene Therapy using our developed mVChR1 gene for Retinitis Pigmentosa2019

    • Author(s)
      E. Sugano
    • Organizer
      第123m回日本眼科学会総会International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 視覚再生のための遺伝子治療2019

    • Author(s)
      冨田浩史、田端希多子、菅野江里子
    • Organizer
      第123m回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 遺伝子治療による視覚再建2019

    • Author(s)
      冨田浩史、田端希多子、菅野江里子
    • Organizer
      第354回岩手県眼科医会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 視覚再建のための遺伝子治療ー臨床試験に向けて2019

    • Author(s)
      冨田浩史、田端希多子、菅野江里子
    • Organizer
      群馬県網膜色素変性症協会(JRPS群馬)記念医療講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 視覚経路の再建により誘導される神経栄養因子の網羅的解析2019

    • Author(s)
      冨田浩史、田端希多子、菅野江里子
    • Organizer
      細胞ダイバース第5回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規ステップ機能型チャネルロドプシンの特性解析2019

    • Author(s)
      渡邊義人、アリアルアシーらるび、菅野江里子、冨田浩史
    • Organizer
      日本動物学会東北支部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 認知症モデルラットに対する保護薬の効果検討2019

    • Author(s)
      熊谷俊哉, 田端希多子, 菅野江里子, 冨田浩史
    • Organizer
      日本動物学会東北支部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マーモセット自閉症モデル大脳皮質樹状突起スパインのin vivo2光子顕微鏡観察2019

    • Author(s)
      野口 潤、渡辺 恵、三嶋 晶、中垣 慶子、磯田 李紗、境 和久、菅野 江里子、冨田 浩史、渡我部 昭哉、山森 哲雄、水上 浩、一戸 紀孝
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 遺伝子治療による視機能再建2019

    • Author(s)
      冨田浩史、田端希多子, 菅野江里子
    • Organizer
      日本眼薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経細胞の再活性化によるRNAパターンの網羅的解析2019

    • Author(s)
      菅野江里子,田端希多子,熊谷俊哉,冨田浩史
    • Organizer
      細胞ダイバース第5回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] On the Chaotic Dynamics in Homothermal Maintenance of Skunk Cabbage2018

    • Author(s)
      E. Turtogtokh and S. Kawasaki
    • Organizer
      日本応用数理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ザゼンソウ温度制御メカニズムのデータ解析的考察2018

    • Author(s)
      川崎秀二、梅川結、伊藤菊一
    • Organizer
      RIMS共同研究「数理農学の基盤作りに向けて」
    • Related Report
      2018 Annual Research Report
  • [Book] Data Analytic Study of the Genetic Mechanism of Ovarian Carcinoma Using Single-Cell RNA-Seq Data2022

    • Author(s)
      Kawasaki S, Hayasi H, Tominaga Y
    • Total Pages
      12
    • Publisher
      Springer
    • ISBN
      9789811648656
    • Related Report
      2021 Annual Research Report
  • [Book] ダイレクトリプログラミング--再生医療の新展開(分担執筆)2020

    • Author(s)
      川崎秀二、林寛敦、冨永陽子
    • Total Pages
      270
    • Publisher
      NTS出版
    • ISBN
      9784860436711
    • Related Report
      2020 Annual Research Report
  • [Remarks] 岩手大学 視覚神経科学研究室

    • URL

      http://web.cc.iwate-u.ac.jp/~htomita/vis-neurosci/

    • Related Report
      2021 Annual Research Report 2019 Annual Research Report
  • [Remarks] NEW VISION

    • URL

      https://www.jig-saw.com/news/20161226/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 失明者の視覚再建

    • URL

      https://www.crieto.hosp.tohoku.ac.jp/seedlist/seed23.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「生物・細胞」をソフトウェア制御する「再生医療」に着手

    • URL

      https://www.jig-saw.com/news/20161226/

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 改変チャネルロドプシン2020

    • Inventor(s)
      冨田浩史、菅野江里子
    • Industrial Property Rights Holder
      冨田浩史、菅野江里子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 改変光受容クロライドチャネル2020

    • Inventor(s)
      冨田浩史、菅野江里子
    • Industrial Property Rights Holder
      冨田浩史、菅野江里子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 改変チャネルロドプシン2020

    • Inventor(s)
      冨田浩史、菅野江里子
    • Industrial Property Rights Holder
      岩手大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 改変光受容クロライドチャネル2020

    • Inventor(s)
      冨田浩史、菅野江里子
    • Industrial Property Rights Holder
      岩手大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report

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Published: 2017-07-04   Modified: 2023-01-30  

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