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Development of mimic biological systems for multimolecular crowding and functional materials working in cells

Planned

Project AreaChemical Approaches for Miscellaneous / Crowding Live Systems
Project/Area Number 17H06351
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKonan University

Principal Investigator

杉本 直己  甲南大学, 先端生命工学研究所, 教授 (60206430)

Co-Investigator(Kenkyū-buntansha) 三好 大輔  甲南大学, フロンティアサイエンス学部, 教授 (50388758)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥146,510,000 (Direct Cost: ¥112,700,000、Indirect Cost: ¥33,810,000)
Fiscal Year 2021: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2020: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2019: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2018: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2017: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Keywords分子夾雑 / 細胞模倣実験系 / 生体分子の定量的機能-環境定量相関 / 核酸構造 / 遺伝子発現制御 / 生体分子の機能-環境定量相関 / 遺伝子発制御 / 定量的解析 / 擬似細胞内環境 / 核酸 / セントラルドグマ / 遺伝子発現の制御 / 細胞内活性分子 / 核酸非標準構造 / 物理化学的解析
Outline of Annual Research Achievements

本研究では、生命の遺伝情報を担う核酸に着目し、(1) 細胞環境の核酸の挙動を物理化学的に解析できる「細胞模倣実験系を構築する研究」と (2) 「生体分子の定量的機能―環境定量相関(QFER)の解明する研究」を行う。さらに(1)の研究において得られた核酸の定量的パラメータを基に、セントラルドグマに関与する核酸の機能を合目的的に制御する研究を遂行する。
2020年度は、(1)の研究として、細胞内を模倣した分子夾雑環境下において、核酸構造の安定性を物理化学的手法により解析し、得られた知見をデータベース化し、細胞内に近い分子環境下においてRNA/DNAやDNA/DNAの構造安定性を予測できるエネルギー・パラメータを開発した(Proc. Natl. Acad. Sci. USA., 117, 14194-14201 (2020)、 Nucleic Acids Res., 48, 12042-12054 (2020))。
さらに、細胞内の核酸構造を予測する指針ができたことから、 (2)の研究として、細胞の分子環境変化に応答して変化する核酸構造の役割を解析した。例えば、分子夾雑環境下でのRNAプライマー伸長反応を詳細に検討して、ワトソン・クリック塩基対ルールとは異なる現象を見出した(RSC Adv., 10, 33052-33058 (2020))。また、神経変性疾患細胞において凝集体を形成すると細胞毒性を示すRNA配列は、溶液のカチオンの濃度に応じてRNAの構造を変化させ、液―液(または個体)相分離を引き起こすことを明らかにした(第14回バイオ関連化学シンポジウム等発表)。さらに、核酸構造とリガンドの相互作用を活用し、四重らせん構造を標的とした分子標的型光線力学療法を開発した(Genes, 11, 1340 (2020)など))。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究では、「細胞の分子夾雑環境」を化学的に理解し、核酸の非標準構造とその機能を制御する技術の開発を目的とし、 (1)「細胞模倣実験系を構築する研究」と (2) 「生体分子の定量的機能―環境定量相関(QFER)の解明する研究」を行う。
2020年度は、(1)の研究として、セントラルドグマに関わる生体反応に摂動を与える非二重らせん構造を物理化学的手法によって解析し、がん遺伝子上の四重らせん構造に及ぼす分子環境の効果や(Biochemistry, 59, 2640-2649 (2020)、Int. J. Mol. Sci. 22, 947(2021)など)、DNA/DNAおよびRNA/DNA二重らせん構造を細胞内で予測できるパラメータをデータベース化できた(Proc. Natl. Acad. Sci. USA., 117, 14194-14201 (2020)、 Nucleic Acids Res., 48, 12042-12054 (2020))。さらに、これらの知見を基に、遺伝子発現の制御を目的として核酸構造と天然アルカロイドなどの小分子の相互作用に関するエネルギーパラメータを収集した (第14回バイオ関連化学シンポジウムで発表)。さらに、核酸の機能を合目的的に制御する実験に関しても着手し、成果を挙げつつある(Molecules, 25, 4120 (2020) , Medical Science Digest.,46, 26-27 (2020)。そのため、本研究はおおむね順調に進展している。

Strategy for Future Research Activity

2020年度は、細胞内の分子夾雑環境で、核酸の構造や機能を熱力学的・速度論的に解析する方法も確立し、細胞内環境下における核酸構造や機能のデータベースを構築した。2021年度は、A02班の田中らと共同で分子動力学計算と開発したデータベースを用いて、細胞内の核酸構造の挙動を予測し、細胞内環境に応答した核酸構造変化が転写・翻訳・複製などの生体反応に及ぼす影響を定量的に解析する。さらに、細胞内の環境変動が機能性分子の状態や機能とどのように連動するかを体系的に明らかにし、細胞の機能―環境定量相関(QFER)という新たな概念を提唱する。また、生体反応は核酸構造によって大きく変化するため、QFERを活用し、セントラルドグマを制御する機能性分子の開発を行う。そのため種々の細胞模倣実験系において、天然の生理活性物質の化合物ライブラリーなどを用いて、四重鎖や三重鎖構造を特異的に安定化する低分子化合物をスクリーニングする。さらに、核酸構造を制御できる人工核酸やペプチドを開発し、遺伝子発現制御を試みる。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(247 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (13 results) Journal Article (46 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 43 results,  Open Access: 27 results) Presentation (178 results) (of which Int'l Joint Research: 69 results,  Invited: 68 results) Book (4 results) Remarks (5 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] 長春中医薬大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] National Institute of Chemistry(スロベニア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] KU Leuven(ベルギー)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Slovenian NMR Centre(スロベニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Calcutta(インド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Changchun Univ. of Chinese Medicine(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Institute of Chemistry(スロベニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Russian Academy of Sciences(ロシア連邦)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Chinese Academy of Sciences(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] POSTECH(韓国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Calcutta(インド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Cambridge/University of Reading(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Calcutta(インド)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes2021

    • Author(s)
      M. Tsuruta, Y. Sugitani, N. Sugimoto, and D. Miyoshi
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 22 Pages: 947-947

    • DOI

      10.3390/ijms22020947

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Insights into the Functions of Nucleic Acids Controlled by Cellular Microenvironments2021

    • Author(s)
      S. Matsumoto and N. Sugimoto
    • Journal Title

      Topics in Current Chemistry

      Volume: 379 Pages: 17-17

    • DOI

      10.1007/s41061-021-00329-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signaling Aptamer Optimization through Selection Using RNA-Capturing Microsphere Particles2020

    • Author(s)
      Endoh Tamaki、Sugimoto Naoki
    • Journal Title

      Anal. Chem.

      Volume: - Pages: 7955-7963

    • DOI

      10.1021/acs.analchem.0c01338

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nearest-neighbor parameters for predicting DNA duplex stability in diverse molecular crowding conditions2020

    • Author(s)
      S. Ghosh, S. Takahashi, T. Ohyama, T. Endoh, H. Tateishi-Karimata, and N. Sugimoto
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Pages: 14194-14201

    • DOI

      10.1073/pnas.1920886117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of morecular crowding on the stability of RNA G-quadruplexes with various numbers of quartets and lengths of loops2020

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, S. Takahashi, T. Ohyama, and N. Sugimoto
    • Journal Title

      Biochemistry

      Volume: 59 Pages: 2640-2649

    • DOI

      10.1021/acs.biochem.0c00346

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular crowding induces primer extension by RNA polymerase through base stacking beyond Watson-Crick rules2020

    • Author(s)
      S. Takahashi, H. Okura, P. Chilika, S. Ghosh, and N. Sugimoto
    • Journal Title

      RSC Advances

      Volume: 10 Pages: 33052-33058

    • DOI

      10.1039/d0ra06502a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Molecular Crowding on DNA Polymerase Reactions along Unnatural DNA Templates2020

    • Author(s)
      S. Takahashi, P. Herdwijn, and N. Sugimoto
    • Journal Title

      Molecules

      Volume: 25 Pages: 4120-4120

    • DOI

      10.3390/molecules25184120

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improved nearest-neighbor parameters for the stability of RNA/DNA hybrids under a physiological condition2020

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, S. Ghosh, T. Endoh, S. Takahashi, and N. Sugimoto
    • Journal Title

      Nucleic Acids Research

      Volume: 48 Pages: 12042-12054

    • DOI

      10.1093/nar/gkaa572

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RAS mRNAを狙った分子標的型光線力学療法2020

    • Author(s)
      杉本渉、川内敬子、三好大輔
    • Journal Title

      Medical Science Digest

      Volume: 46 Pages: 26-27

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA phase separation-mediated direction of molecular trafficking under conditions of molecular crowding2020

    • Author(s)
      Kohata Kazuki、Miyoshi Daisuke
    • Journal Title

      Biophys. Rev.

      Volume: - Pages: 669-676

    • DOI

      10.1007/s12551-020-00696-3

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Strategy of Photodynamic Therapy Targeting RAS mRNA with G-Quadruplex Ligands for Cancer Treatment?2020

    • Author(s)
      T. Torii, W. Sugimoto, K. Kawauchi, D. Miyoshi
    • Journal Title

      J Data Mining Genomics Proteomics

      Volume: 11 Pages: 1000226-1000226

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy2020

    • Author(s)
      K. Kawauchi, R. Urano, N. Kinoshita, S. Kuwamoto, T. Torii, Y. Hashimoto, S. Taniguchi, M. Tsuruta, D. Miyoshi
    • Journal Title

      Genes

      Volume: 11 Pages: 1340-1340

    • DOI

      10.3390/genes11111340

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications2020

    • Author(s)
      Takahashi Shuntaro、Bhattacharjee Snehasish、Ghosh Saptarshi、Sugimoto Naoki、Bhowmik Sudipta
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 2504-2504

    • DOI

      10.1038/s41598-020-59343-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Potassium Concentration on Triplex Stability under Molecular Crowding Conditions2020

    • Author(s)
      Teng Ye、Tateishi-Karimata Hisae、Ohyama Tatsuya、Sugimoto Naoki
    • Journal Title

      Molecules

      Volume: 25 Pages: 387-387

    • DOI

      10.3390/molecules25020387

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical biology of non-canonical structures of nucleic acids for therapeutic applications2020

    • Author(s)
      Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Chemical Communications

      Volume: 56 Pages: 2379-2390

    • DOI

      10.1039/c9cc09771f

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures2020

    • Author(s)
      Tateishi-Karimata Hisae、Ohyama Tatsuya、Muraoka Takahiro、Tanaka Shigenori、Kinbara Kazushi、Sugimoto Naoki
    • Journal Title

      Molecules

      Volume: 25 Pages: 705-705

    • DOI

      10.3390/molecules25030705

    • NAID

      120006811187

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA2020

    • Author(s)
      Tateishi-Karimata Hisae、Banerjee Dipanwita、Ohyama Tatsuya、Matsumoto Saki、Miyoshi Daisuke、Nakano Shu-ich、Sugimoto Naoki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 525 Pages: 177-183

    • DOI

      10.1016/j.bbrc.2020.02.045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides2020

    • Author(s)
      Kovacic Matic、Podbevsek Peter、Tateishi-Karimata Hisae、Takahashi Shuntaro、Sugimoto Naoki、Plavec Janez
    • Journal Title

      Nucleic Acids Res.

      Volume: 48 Pages: 3975-3986

    • DOI

      10.1093/nar/gkaa118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA G-Quadruplexes Facilitate RNA Accumulation in G-Rich Repeat Expansions2020

    • Author(s)
      Teng Ye、Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Biochemistry

      Volume: 59 Pages: 1972-1980

    • DOI

      10.1021/acs.biochem.0c00130

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conformational Dynamics of the RNA G-Quadruplex and its Effect on Translation Efficiency2019

    • Author(s)
      Endoh Tamaki、Sugimoto Naoki
    • Journal Title

      Molecules

      Volume: 24 Pages: 1613-1613

    • DOI

      10.3390/molecules24081613

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 平成の化学キーワード 核酸の多様性を生みだすもう一つの塩基対相互作用 フーグスティーン塩基対2019

    • Author(s)
      高橋俊太郎、杉本直己
    • Journal Title

      化学

      Volume: 74 Pages: 24-25

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Quantitative Analysis of Stall of Replicating DNA Polymerase by G-Quadruplex Formation2019

    • Author(s)
      Takahashi Shuntaro、Sugimoto Naoki
    • Journal Title

      Methods Mol. Biol.

      Volume: 2035 Pages: 257-274

    • DOI

      10.1007/978-1-4939-9666-7_15

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-Rich Sequence in a Non-Template DNA Strand Regulates Structure Change of G-Quadruplex in a Template Strand during Transcription2019

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 92 Issue: 3 Pages: 572-577

    • DOI

      10.1246/bcsj.20180298

    • NAID

      130007614869

    • ISSN
      0009-2673, 1348-0634
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Intracellular Crowding Environments with Topology-Based DNA Quadruplex Sensors2019

    • Author(s)
      Takahashi Shuntaro、Yamamoto Johtaro、Kitamura Akira、Kinjo Masataka、Sugimoto Naoki
    • Journal Title

      Analytical Chemistry

      Volume: 91 Pages: 2586-2590

    • DOI

      10.1021/acs.analchem.8b04177

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the nearest-neighbor model for Watson?Crick self-complementary DNA duplexes in molecular crowding condition2019

    • Author(s)
      Ghosh Saptarshi、Takahashi Shuntaro、Endoh Tamaki、Tateishi-Karimata Hisae、Hazra Soumitra、Sugimoto Naoki
    • Journal Title

      Nucleic Acids Research

      Volume: 47 Pages: 0-0

    • DOI

      10.1093/nar/gkz071

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bisubstrate Function of RNA Polymerases Triggered by Molecular Crowding Conditions2019

    • Author(s)
      Takahashi Shuntaro、Okura Hiromichi、Sugimoto Naoki
    • Journal Title

      Biochemistry

      Volume: 58 Pages: 1081-1093

    • DOI

      10.1021/acs.biochem.8b01204

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lighting up of thiazole orange on G-quadruplex DNA by high pressure2019

    • Author(s)
      Bhowmik Sudipta, Takahashi Shuntaro, Sugimoto Naoki
    • Journal Title

      ACS Omega

      Volume: 4 Pages: 0-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA-Capturing Microsphere Particles (R-CAMPs) for Optimization of Functional Aptamers2019

    • Author(s)
      Endoh Tamaki、Ohyama Tatsuya、Sugimoto Naoki
    • Journal Title

      Small

      Volume: 15 Pages: 1805062-1805062

    • DOI

      10.1002/smll.201805062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osmolyte-Enhanced Protein Synthesis Activity of a Reconstituted Translation System2019

    • Author(s)
      Moriizumi Y, Tabata KV, Miyoshi D, Noji H
    • Journal Title

      ACS Synth Biol

      Volume: 8 Pages: 557-567

    • DOI

      10.1021/acssynbio.8b00513

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞の分子夾雑環境における核酸構造と核酸構造リガンドの挙動 ~細胞内でも望みの機能を発現する分子の合理設計に向けて~2019

    • Author(s)
      三好 大輔
    • Journal Title

      生命化学研究レター

      Volume: 58 Pages: 17-21

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins2018

    • Author(s)
      Natan Eviatar、Endoh Tamaki、Haim-Vilmovsky Liora、Flock Tilman、Chalancon Guilhem、Hopper Jonathan T. S.、Kintses B、Horvath Peter、Daruka Lejla、Fekete Gergely、Pal Csaba、Papp B、Oszi Erika、Magyar Z、Marsh Joseph A.、Elcock Adrian H.、Babu M. Madan、Robinson Carol V.、Sugimoto Naoki、Teichmann Sarah A.
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 25 Pages: 279-288

    • DOI

      10.1038/s41594-018-0029-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations2018

    • Author(s)
      M. Trajkovski, T. Endoh, H. Tateishi-Karimata, T. Ohyama, S. Tanaka, J. Plavec, N. Sugimoto
    • Journal Title

      Nucl. Acids Res.

      Volume: 46 Pages: 4301-4315

    • DOI

      10.1093/nar/gky250

    • NAID

      120006473632

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recovery of the Formation and Function of Oxidized G-Quadruplexes by a Pyrene-Modified Guanine Tract2018

    • Author(s)
      Takahashi Shuntaro、Kim Ki Tae、Podbevsek Peter、Plavec Janez、Kim Byeang Hyean、Sugimoto Naoki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Pages: 5774-5783

    • DOI

      10.1021/jacs.8b01577

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crowding Shifts the FMN Recognition Mechanism of Riboswitch Aptamer from Conformational Selection to Induced Fit2018

    • Author(s)
      Rode Ambadas B.、Endoh Tamaki、Sugimoto Naoki
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Pages: 6868-6872

    • DOI

      10.1002/anie.201803052

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-Transcriptional Molecular Assembly Results in a Kinetically Controlled Irreversible RNA Conformational Switch2018

    • Author(s)
      Endoh Tamaki、Sugimoto Naoki
    • Journal Title

      Analytical Chemistry

      Volume: 90 Pages: 11193-11197

    • DOI

      10.1021/acs.analchem.8b03427

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mirror-Image Dependence: Targeting Enantiomeric G-Quadruplex DNA Using Triplex Metallohelices2018

    • Author(s)
      C. Zhao、H. Song、P. Scott、A. Zhao、H. Tateishi-Karimata、N. Sugimoto、J. Ren、X. Qu
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Pages: 15723-15727

    • DOI

      10.1002/anie.201809207

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Turn-On Detection of DNA Sequences by Means of Fluorescence of DNA-Templated Silver Nanoclusters via Unique Interactions of a Hydrated Ionic Liquid2018

    • Author(s)
      Y. Teng,H. Tateishi-Karimata、T. Tsuruoka, N. Sugimoto
    • Journal Title

      Molecules

      Volume: 23 Pages: 2889-2889

    • DOI

      10.3390/molecules23112889

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and Properties of Ligand-Conjugated Guanine Oligonucleotides for Recovery of Mutated G-Quadruplexes2018

    • Author(s)
      Takahashi Shuntaro、Chelobanov Boris、Kim Ki、Kim Byeang、Stetsenko Dmitry、Sugimoto Naoki
    • Journal Title

      Molecules

      Volume: 23 Pages: 3228-3228

    • DOI

      10.3390/molecules23123228

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] テトラエチレングリコールで修飾されたグアニン四重鎖の安定性の分子動力学計算による解析2018

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Journal Title

      日本核酸化学会誌

      Volume: 2 Pages: 3-10

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex2018

    • Author(s)
      K. Kawauchi, W. Sugimoto, T. Yasui, K. Murata, K. Itoh, K. Takagi, T. Tsuruoka, K. Akamatsu, H. Tateishi-Karimata, N. Sugimoto, and D. Miyoshi
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 2271-2271

    • DOI

      10.1038/s41467-018-04771-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription2018

    • Author(s)
      Tateishi-Karimata Hisae、Kawauchi Keiko、Sugimoto Naoki
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 140 Pages: 642-651

    • DOI

      10.1021/jacs.7b09449

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drastic stability change of X-X mismatch in d(CXG) trinucleotide repeat disorders under molecular crowding condition2018

    • Author(s)
      Teng Ye、Pramanik Smritimoy、Tateishi-Karimata Hisae、Ohyama Tatsuya、Sugimoto Naoki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 496 Pages: 601-607

    • DOI

      10.1016/j.bbrc.2018.01.083

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA2018

    • Author(s)
      Sato Norihiro、Takahashi Shuntaro、Tateishi-Karimata Hisae、Hazemi Madoka E.、Chikuni Tomoko、Onizuka Kazumitsu、Sugimoto Naoki、Nagatsugi Fumi
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 16 Pages: 1436-1441

    • DOI

      10.1039/c7ob03179c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase2017

    • Author(s)
      Takahashi Shuntaro、Brazier John A.、Sugimoto Naoki
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 114 Pages: 9605-9610

    • DOI

      10.1073/pnas.1704258114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA G-wire formation using an artificial peptide is controlled by protease activity2017

    • Author(s)
      Usui, K., Okada, A., Sakashita, S., Shimooka, M., Tsuruoka, T., Nakano, S., Miyoshi, D., Mashima, T., Katahira, M., Hamada, Y.
    • Journal Title

      Molecules

      Volume: 22 Pages: 1-12

    • DOI

      10.3390/molecules22111991

    • NAID

      120006501324

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞環境化学模倣実験系におけるDNAの構造とその熱力学的安定性2017

    • Author(s)
      三好 大輔
    • Journal Title

      日本核酸化学会誌

      Volume: 1 Pages: 13-19

    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学(65): ベルベリンによるRNAバルジ構造の認識および安定化の微視的解析2021

    • Author(s)
      遠藤玉樹 , SATPATHI Sagar, 大山達也, PODBEVSEK Peter, PLAVEC Janez, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学(66): 非天然DNAの複製反応に及ぼす分子クラウディングの影響2021

    • Author(s)
      高橋俊太郎, Herdwijn Piet, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学(67): DNA四重らせん構造と転写変異に及ぼすがんの悪性進行に伴う細胞内環境変化の影響2021

    • Author(s)
      建石寿枝, 川内敬子, 大山達也, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学(68): 老化における細胞内環境変化によるCpGアイランドのグアニン四重らせん構造のトポロジー制御2021

    • Author(s)
      松本咲, 大山達也, 杉本 直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ワトソン・クリックの核酸化学(69): 神経変性疾患に関連するRNA四重鎖ジペプチドリピートの分子シミュレーションによる相互作用の解析2021

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond Watson-Crick Double Helix (70): Prediction of DNA duplex stability having biased base composition under molecular crowding conditions2021

    • Author(s)
      Saptarshi Ghosh, Shuntaro Takahashi, Naoki Sugimoto
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nucleic Acid Chemistry beyond Watson-Crick Double Helix (71): I-motif stability prediction under molecular crowding conditions2021

    • Author(s)
      Pallavi Chilka, Shuntaro Takahashi, Naoki Sugimoto
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (72): Prediction of RNA/DNA hybrid stability under a physiological condition and verification of advantage in CRISPR-Cas92021

    • Author(s)
      Dipanwita Banerjee, Hisae Tateishi-Karimata, Tatsuya Ohyama, Marko Trajkovski, Maria Toplishek, Janez Plavec, Naoki Sugimoto
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フラボノイドによるi-motif DNAの配列選択的な構造変化2020

    • Author(s)
      高橋俊太郎, BHOWMIK Sudipta, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経変性疾患に関わるリピートRNAによる相分離機構の解析2020

    • Author(s)
      建石寿枝, Ye Teng, 大山達也, 田中成典, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] バルジを含むRNA二重鎖と天然アルカロイドとの相互作用解析2020

    • Author(s)
      遠藤 玉樹, SATPATHI Sagar, PODBEVSEK Peter, PLAVEC Janez, 杉本 直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 異なるGカルテット数とループ長を有するRNAグアニン四重らせんの安定性への分子クラウディングの効果2020

    • Author(s)
      松本咲, 建石寿枝, 高橋俊太郎, 大山達也, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Stability prediction of DNA duplexes available under diverse molecular crowding conditions2020

    • Author(s)
      GHOSH Saptarshi, 高橋俊太郎, 大山達也, 遠藤玉樹, 建石寿枝, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of the prediction method for stability of RNA/DNA hybrids under a physiological condition2020

    • Author(s)
      BANERJEE Dipanwita, 建石寿枝, 大山達也, GHOSH Saptarshi, 遠藤玉樹, 高橋俊太郎, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Empirical rule of i-motif stability regulated by different molecular crowding conditions2020

    • Author(s)
      PALLAVI Chilka, 高橋俊太郎,杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 局所的な細胞内環境における核酸構造の安定性を探る2020

    • Author(s)
      高橋俊太郎, GHOSH Saptarshi, 杉本直己
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] cMyc遺伝子のグアニン四重らせんに対する圧力効果とその生物学的意義2020

    • Author(s)
      高橋俊太郎, 杉本直己
    • Organizer
      第61回高圧討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (57): Parameters for prediction of DNA duplex stabilities under the crowding conditions2020

    • Author(s)
      S. Ghosh, S.Takahashi, T. Ohyama, T. Endoh, H. Tateishi-Karimata, N.Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (58): The effect of molecular crowding on the stability of RNA G-quadruplexes with various number of quartets and loops2020

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, S. Takahashi, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (59): Prediction method for the stability of RNA/DNA hybrid duplex under a physiological condition2020

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, M. Tranjkovski, M. Toplishek, S. Takahashi, T. Endoh, J. Plavec, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (60): Interaction analyses between natural alkaloids and RNAs with different structure motifs2020

    • Author(s)
      T. Endoh, S. Satpathi, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (61): Effect of neighboring base pairs of cytosine bulge on berberine Induced RNA stabilization2020

    • Author(s)
      S. Satpathi, T. Endoh, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (62): Transformation of selective i-motif DNAs induced by flavonoid2020

    • Author(s)
      S. Takahashi, S. Bhowmic, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (63):分子シュミレーションによるGGGGCCリピートのRNA四重鎖とジペプチドリピートの集積メカニズムの解析2020

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (64): Effects of malignant alteration in cancer cells on the DNA structures and transcript mutations2020

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chemistry of non-double helix nucleic acids in molecular crowding2020

    • Author(s)
      N. Sugimoto
    • Organizer
      日本化学会第100回春季年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 神経変性疾患に関与するRNA/ペプチドによるPhase separationの機構解析2019

    • Author(s)
      建石寿枝, Ye Teng, 大山達也, 田中成典, 杉本直己
    • Organizer
      第2回LLPS(液液相分離)研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Functions of Non-canonical Nucleic Acids (2)2019

    • Author(s)
      N. Sugimoto
    • Organizer
      International Workshop“Trends in Nucleic Acid (TINA) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞夾雑模倣系の構築と細胞内活性分子設計指針の構築(3)2019

    • Author(s)
      杉本直己
    • Organizer
      分子夾雑の生命化学 第3回領域会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] DNA四重らせん構造はがんの悪性化を制御しているのか2019

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      第22回生命化学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The Watson-Crick World Is Not Enough2019

    • Author(s)
      N. Sugimoto
    • Organizer
      Gordon Research Conference (Nucleosides, Nucleotides and Oligonucleotides)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] To B or Not to B : The Watson-Crick world is not enough2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The Commemorative International Symposium of Nucleic Acid Chemistry (CISNAC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nucleic Acids Chemistry under the Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      第29回バイオ・高分子シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経変性疾患に関わるRNAリピート配列とペプチドの相互作用解析2019

    • Author(s)
      建石 寿枝, Ye Teng, 大山 達也,田中 成典, 杉本 直己
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生理活性分子に結合する天然RNAの網羅的スクリーニング2019

    • Author(s)
      遠藤玉樹、杉本直己
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Adventures of Guanine-quadruplex in Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The 7th International Meeting on Quadruplex Nucleic Acids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role for G-quadruplexes of Nucleic Acids During Tumor Progression2019

    • Author(s)
      H. Tateishi-Karimata and N. Sugimoto
    • Organizer
      10th RSC-CSJ Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経変性疾患に関わるRNA・ペプチドの細胞内での相互作用解析2019

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      大阪大学蛋白研セミナー/第3回LLPS研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Effects of malignant alteration in cancer cells on the DNA G-quadruplex formation and transcript mutations2019

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi and N. Sugimoto
    • Organizer
      International Conference on Genomes and AI: From Packing to Regulation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子夾雑で遺伝子発現を制御する2019

    • Author(s)
      建石寿枝
    • Organizer
      第9会CSJ化学フェスタ文科省科研費新学術領域研究「分子夾雑の生命化学」特別企画:細胞の中身を化学する!
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Adventures of Nucleic Acids in the Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      Solvation Science Meets High Pressure Bioscience RESOLV ? 10th IMBP ? DFG FOR 1979
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] “To B or not to B” in Nucleic Acids Chemistry (3)2019

    • Author(s)
      N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids "ANNA2019"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of RNA structures on RNA and RNA/peptide accumulation in repeat-expansion disorders2019

    • Author(s)
      H. Tateihsi-Karimata and N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids "ANNA2019"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Conformational Dynamics of the RNA G-Quadruplex and its Effect on Gene Expressions2019

    • Author(s)
      T. Endoh and N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids "ANNA2019"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA グアニン四重鎖に結合する蛍光性リカ?ント?の高圧力による発光 増強効果2019

    • Author(s)
      高橋俊太郎, Bhowmik Sudipta, 杉本直己
    • Organizer
      第60回高圧討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prediction method for DNA duplex stability in molecular crowding conditions2019

    • Author(s)
      S. Ghosh, S. Takahashi, T. Ohyama, T. Endoh, H. Kateishi-Karimata, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topology-based DNA quadruplex sensors for characterization of intracellular crowding environments2019

    • Author(s)
      S. Takahashi, J. Yamamoto, A. Kitamura, M. Kinjo, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of transcriptomic RNAs that interact with thioflavin T derivative2019

    • Author(s)
      T. Endoh, M. Kuwahara, Y. Kataoka, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of RNA topology on phase separation of peptides and proteins in neurodegenerative diseases2019

    • Author(s)
      H. Tateishi-Karimata, Y. Teng, T. Ohyama, S. Tanaka, E. Chatani, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new prediction parameters for RNA/DNA hybrid duplex stability under a physiological buffer condition2019

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, T. Endoh, S. Takahashi, N. Sugimoto
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase separation of RNA G-quadruplexes induced bycationic peptides2019

    • Author(s)
      K. Kohata, W. Sugimoto, K. Kawauchi, N. Sugimoto, D. Miyoshi
    • Organizer
      第46回国際核酸化学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adventure on the World of Noncanonical Nucleic Acids2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The Symposium on Nucleic Acid Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sequence Optimization to Conditionally Regulate Functional RNAs for Biotechnological Applications2019

    • Author(s)
      T. Endoh, N. Sugimoto
    • Organizer
      13th Anniversary International Symposium on Nanomedicine (ISNM2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子夾雑環境に応答したDNAの構造変化が遺伝子発現機構に及ぼす影響を定量的に解析する2019

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      新学術領域「分子夾雑の生命化学」第2回関西地区シンポジウム, 第1回 CIBIC ワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders2019

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      Gordon Research Conference(RNA Nanotechnology)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functions of Nucleic Acids under Molecular Crowding Conditions2019

    • Author(s)
      N. Sugimto
    • Organizer
      The Lecture of Institute of Biophysics Czech Academy of Sciences
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Elucidation for mechanism of diseases caused by non-canonical structures of DNA and regulation for DNA function2019

    • Author(s)
      H. Tateishi-Karimata
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (48) :Imaging of crowding in cells by using guanine-quadruplex DNA2019

    • Author(s)
      S.Takahashi, J. Yamamoto, A. Kitamura, M. Kinjo, and N. Sugimoto
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (49): Validation of the nearest-neighbor model for self-complementary DNA duplex under molecular crowding2019

    • Author(s)
      S. Ghosh, S.Takahashi, T. Endoh, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix(50):Phase separation of RNA/peptides in neurodegenerative diseases is promoted by chemical environment changes in cell2019

    • Author(s)
      H. Tateishi-Karimata, Y. TENG, T.Ohyama, and N. Sugimoto
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (51): DNAとクラウディング分子の相互作用の分子動力学計算と電子状態計算による定量的解析2019

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (52) : Optimization of RNA conformational switch using RNA-capturing microsphere particle (R-CAMP)2019

    • Author(s)
      T. Endoh and N. Sugimoto
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (53): RNAグアニン四重らせん構造とカチオン性ペプチドによる特異的相分離現象2019

    • Author(s)
      小畠一起, 川内敬子, 杉本直己, 三好大輔
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (54):グアニン四重らせんおよびi-モチーフ選択的リガンドの開発2019

    • Author(s)
      今川佳樹, 小畠一起, 杉本直己, 三好大輔
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (55): DNA四重らせん選択的リガンドのワンポットスクリーニング2019

    • Author(s)
      長野香穂, 衣笠紫野, 萩原伸也, 佐藤綾人, 川内 敬子, 杉本直己, 三好大輔
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学(56): DNAの構造安定性に及ぼすメチル化と分子クラウディングの複合効果2019

    • Author(s)
      杉谷優衣, 造住有輝, 杉本直己, 三好大輔
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Adventures of Nucleic Acids in Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department Seminar of Sun Yat-sen University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] RNAs in Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The Seminar of Hong Kong RNA Club
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Adventures of Nucleic Acids in Molecular Crowding World2019

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department Seminar of City University of Hong Kong
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子夾雑環境における核酸の定量解析:核酸四重らせん構造に対する分子標的型光線力学療法の構築に向けて2019

    • Author(s)
      三好 大輔
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Rational design and development of photodynamic therapy targeting NRAS mRNA G-quadruplex2019

    • Author(s)
      三好 大輔
    • Organizer
      神戸大学工学部セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Functions of Non-canonical Nucleic Acids2018

    • Author(s)
      N. Sugimoto
    • Organizer
      International workshop“Trends in Nucleic Acid (TINA) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The world of non-canonical nucleic acids: To B or not to B2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The seminer of “The role of non-canonical structure of nucleic acids”
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞夾雑模倣系の構築と細胞内活性分子設計指針の構築2018

    • Author(s)
      杉本直己
    • Organizer
      分子夾雑の生命化学 第二回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry Beyond the Watson-Crick Double Helix:“To B or not to B”2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The Departmental seminar of College of Pharmacy
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nucleic Acids Chemistry Beyond the Watson-Crick Double Helix:“To B or not to B”2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Improved Efficiency of mRNA Sensing System by a Hydrated Ionic Liquid2018

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      Gordon Research Conference(Bioanalytical Sensors)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 核酸物理化学と核酸医薬の設計指針2018

    • Author(s)
      杉本直己
    • Organizer
      日本核酸医薬学会第4回年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がん細胞の悪性化に及ぼすDNA四重鎖構造の解離と転写変異の影響2018

    • Author(s)
      建石寿枝, 川内敬子, 杉本直己
    • Organizer
      日本核酸医薬学会第4回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分子クラウディング環境下におけるFMNリボスイッチ由来のアプタマードメインの分子挙動2018

    • Author(s)
      遠藤玉樹, Rode Anbadas, 杉本直己
    • Organizer
      第20回日本RNA学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stability and Function of Noncanonical Nucleic Acids2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The seminar of Institute of Chemical Biology and Fundamental Medicine
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nucleic Acids World under Molecular Crowding2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The 5th Asian Chemical Biology Conference (ACBC-5)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Noncanonical world of nucleic acids under molecular crowding:To B or not to B2018

    • Author(s)
      N. Sugimoto
    • Organizer
      XXIII International Roundtable of NucleosidesNucleotides and Nucleic Acids (IRT2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カリウムチャネルはがん遺伝子の転写活性をDNA四重鎖の形成によって制御しているのか?2018

    • Author(s)
      建石寿枝, 川内敬子, 大山達也, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物由来の天然代謝産物と核酸構造との相互作用解析2018

    • Author(s)
      遠藤玉樹, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] グアニン四重鎖リガンドのトポロジー依存的結合様式によるDNA複製反応の制御2018

    • Author(s)
      高橋俊太郎, Bhowmik Sudipta, Chang Ta-Cha, 佐藤しのぶ, 竹中繁織, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gelation of RNA repeats in ALS/FTD is promoted in crowding conditions2018

    • Author(s)
      Teng Ye, 建石寿枝, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ポリエチレングリコールにより誘起される分子クラウディング環境がDNA四重鎖の構造安定性に与える影響の分子シミュレーション解析2018

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] リガンド複合型核酸マテリアルによる塩基損傷を受けたグアニン四重鎖の機能回復2018

    • Author(s)
      高橋俊太郎, Kim Byeang Hyean, Stetsenko Dmitry, Plavec Janez,杉本直己
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Beyond the Watson-Crick Double Helix:Make New History of Nucleic Acids (6)2018

    • Author(s)
      N. Sugimoto
    • Organizer
      Asia 3 Roundtable on Nucleic Acids 2018 (A3RONA2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of structural dynamics of RNA aptamer using high pressure2018

    • Author(s)
      S. Takahashi, T. Endoh, A. B. Rode, N. Sugimoto
    • Organizer
      The 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Noncanonical world of nucleic acids under molecular crowding and high pressure2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Noncanonical world of nucleic acids under molecular crowding2018

    • Author(s)
      N. Suigmoto
    • Organizer
      The seminar of the department f Pharmacy University of Naples "Federico II"
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] To B or not to B” in Nucleic Acids Chemistry (2)2018

    • Author(s)
      N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids "ANNA2018"
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of noncanonical DNA structures on transcription2018

    • Author(s)
      N.Sugimto
    • Organizer
      The Third A3 Roundtable Meeting on Chemical Probe Research Hub
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimization of junction sequence between two aptamers for constructing signaling aptamer by using RNA library on microspheres2018

    • Author(s)
      T. Endoh, N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation for effects of polyethylene glycols on DNA structure and stability using molecular dynamics simulations2018

    • Author(s)
      T. Ohyama, H.Tateishi-Karimata, S. Tanaka, and N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase separation of repeated RNA with amyloid-like protein in neurodegenerative diseases is promoted by RNA G-quadruplexes2018

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of G-quadruplex stability and structure in the template DNA on transcript mutations in normal and cancer cells2018

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural Perspectives of the DNA binding properties of Ruthenium Polypyridyl Complexes2018

    • Author(s)
      K. McQuaid, J. Hall, H. Abell1, S. Takahashi, N. Sugimoto, D. Allan, D. Cardin, J. Brazier, and C. Cardin
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transformation of selective i-motif DNAs into hairpin-like structures induced by a flavonoid compound2018

    • Author(s)
      S. Takahashi, S. Bhowmik, S. Ghosh, and N. Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of molecular crowding on nearest-neighbor rules for Watson-Crick self-complementary DNA duplexes2018

    • Author(s)
      S. Ghosh, S. Takahashi, T. Endoh, H. Tateishi-Karimata, S. Hazra, and N, Sugimoto
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Noncanonical Nucleic Acids on Gene Expressions2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The 2nd International Symposium on “Functional Nucleic Acids: From Laboratory to Targeted Molecular Therapy”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functions “of Nucleic Acids with Non-canonical Structures:To B or not to B”2018

    • Author(s)
      N. Sugimoto
    • Organizer
      KONAN RESEARCH SUMMIT
    • Related Report
      2018 Annual Research Report
  • [Presentation] THE WORLD OF NON-CANONICAL NUCLEIC ACIDS2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The 9th Asian Biological Inorganic Chemistry “AsBIC9
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Crowding Effect on Functions of Nucleic Acids:2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department seminar, Korea Institute of Science and Technology (KIST)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Crowding Effect on Functions of Nucleic Acids:2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department seminar, Seoul National University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Crowding Effect on Functions of Nucleic Acids:2018

    • Author(s)
      N. Sugimoto
    • Organizer
      The Department seminar, Sungkyunkwan University School of Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子夾 雑環境における核酸構造リガンドの開発とその展開2018

    • Author(s)
      三好 大輔
    • Organizer
      新学術領域「分子夾雑の生命化学」水無月セミナー、蛋白質凝集と核酸
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子夾雑環境下における非二重らせん構造が遺伝子発現に及ぼす影響2018

    • Author(s)
      建石 寿枝
    • Organizer
      新学術領域「分子夾雑の生命化学」水無月セミナー、蛋白質凝集と核酸
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子夾雑効果の定量解析に基づいた機能分子の開発2018

    • Author(s)
      三好 大輔
    • Organizer
      日本学術振興会 分子ナノテクノロジー第174委員会 第62回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure and stability of nucleic acids under molecular crowding conditions with cationic polymers2018

    • Author(s)
      Daisuke Miyoshi
    • Organizer
      14th Japan; Belgium Symposium on Polymer Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子夾雑効果の定量解析に基づいた機能分子の開発2018

    • Author(s)
      三好 大輔、川内 敬子
    • Organizer
      名古屋大学医学部脳外科セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞の分子夾雑環境での核酸構造の定量解析とその応用2018

    • Author(s)
      三好 大輔
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] DNA I-motif 構造形成に伴う蛍光発光を用いた I-motif の新規検出法2018

    • Author(s)
      小畠 一起、杉本 直己、三好 大輔
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of DNA G-quadruplex and i-motif binding ligands by a fluorescent screening system2018

    • Author(s)
      Y. Imagawa, K. Kohata, N. Sugimoto, D. Miyoshi
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase separation of nucleic acids indced by cationic peptides and molecular crowding conditions2018

    • Author(s)
      K. Kohata, N. Sugimoto, D. Miyoshi
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increments in the thermal stability of G-quadruplexes with a long loop using bulky cations2018

    • Author(s)
      K. Tanabe, M. Horita, S. Morita, D. Miyoshi, N. Sugimoto, S. Nakano
    • Organizer
      第45回国際核酸化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん関連mRNAが形成する四重らせん構造に対する分子標的型光線力学療法2018

    • Author(s)
      三好 大輔
    • Organizer
      日経バイオテク プロフェッショナルセミナー 低分子薬で核酸を標的に
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Molecularly-targeted photodynamic therapy for NRAS mRNA G-quadruplex2018

    • Author(s)
      D. Miyoshi, K. Kawauchi, W. Sugimoto, K. Itoh, T. Tsuruoka, K. Akamatsu, H. Tateishi-Karimata, N. Sugimoto,
    • Organizer
      12th International Symposium on Nanomedicine (ISNM2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核酸構造安定性に及ぼす細胞の分子クラウディング効果の定量解析とその展開2018

    • Author(s)
      三好 大輔
    • Organizer
      東京大学大学院総合文化研究科 第192回 生命環境科学系セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Functions of Non-canonical Nucleic Acids2018

    • Author(s)
      N.Sugimoto
    • Organizer
      International workshop“Trends in Nucleic Acid (TINA) 2018”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topological impact of non-canonical DNA structures on the replication2018

    • Author(s)
      S. Takahashi, N. Sugimoto
    • Organizer
      Gordon Research Conference DNA Damage, Mutation and Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (38): Effects of malignant alteration in cancer cells on the G-quadruplex formation and transcript mutations2018

    • Author(s)
      H. Tateishi-Karimata, K. Kawaguchi, T, Ohyama, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 四重らせん構造による新規の転写制御機構:がん進行過程におけるノンコーディングDNAの役割2018

    • Author(s)
      建石寿枝
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (37): The formation of RNA foci in repeat expansion disorders is promoted in molecular crowding conditions2018

    • Author(s)
      Y. Teng, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (39) : Control of replication of G-quadruplex containing oxidative lesion2018

    • Author(s)
      S. Takahashi, P. Podbevsek, J. Plavec, B. H. Kim, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (40): Crowding Regulates the Riboswitch Aptamer-Ligand Recognition Mechanism in Bacterial Pathogenesis Mimic Condition2018

    • Author(s)
      A.B. Rode, T. Endoh, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (41): Construction of RNA display from DNAs immobilized on microsphere and its application for aptamer optimization2018

    • Author(s)
      T. Endoh, T. Ohyama, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (42): Quantitative analysis for effects of molecular network by crowding agents on the G-quadruplex stability2018

    • Author(s)
      T. Ohyama, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (43): G-quadruplex構造を安定化させるN-メチル化クロリン類の合成2018

    • Author(s)
      永野泰伸, 遠藤玉樹, 小笠原伸, 杉本直己, 民秋 均
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (44): DNAの構造安定性に及ぼすヒストン模倣高分子と分子クラウディング環境の複合効果2018

    • Author(s)
      造住有輝, 宮田貴史, 嶋田直彦, 杉本直己, 丸山厚, 三好大輔
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (45): ZnAPCによるグアニン四重らせん構造の選択的蛍光検出2018

    • Author(s)
      今川佳樹, 杉本直己, 三好大輔
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (46): Thioflavin Tを用いたDNA I-motifの配列特異的検出2018

    • Author(s)
      小畠一起, 赤山詩織, 杉本直己, 三好大輔
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (47): RNA四重らせん構造リガンドを用いた分子標的型光線力学療法の構築2018

    • Author(s)
      高木一樹, 安井貴俊, 伊藤功彦, 杉本渉, 川内敬子, 杉本直己, 三好大輔
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] What is the canonical structure of nucleic acids in cells?2018

    • Author(s)
      Daisuke Miyoshi
    • Organizer
      Institute Seminar, National Institute of Technology, Nagaland
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA and RNA G-quadruplexes under molecular crowding conditions2018

    • Author(s)
      Daisuke Miyoshi
    • Organizer
      IGIB seminar, Institute of Genomics & Integrative Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA and RNA G-quadruplexes: structure, function, and ligand under cell mimicking molecular crowding conditions2018

    • Author(s)
      Daisuke Miyoshi
    • Organizer
      International Conference on Current Trends in Materials Science and Engineering (CTMSE 2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of chemical environment change by malignant alteration in cancer cells on transcript productions from G-rich template DNAs2017

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, and N. Sugimoto
    • Organizer
      The 2nd International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-canonical DNA structures control DNA replication by topology-dependent manner2017

    • Author(s)
      S. Takahashi, J. A. Brazier, and N. Sugimoto
    • Organizer
      The 2nd International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Understanding of intracellular multimolecular crowding from interaction between RNA and small molecule2017

    • Author(s)
      T. Endoh. A. B. Rode, and N. Sugimoto
    • Organizer
      The 2nd International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 水和イオン液体中で機能するDNAセンサー2017

    • Author(s)
      建石寿枝, 杉本直己
    • Organizer
      第8回イオン液体討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of noncanonical DNA structures on DNA polymerase2017

    • Author(s)
      N.Sugimoto
    • Organizer
      The Second A3 Roundtable Meeting on Asia Chemical Probe Research Hub
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topological effect of non-canonical DNA structures on DNA replication2017

    • Author(s)
      S.Takahashi, J.A.Brazier, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of DNA structure and stability by combined effects of histone-mimicking polymers and osmolytes”2017

    • Author(s)
      Y.Zouzumi, N.Yamaguchi, N.Shimada, N.Sugimoto, A.Maruyama, D.Miyoshi
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The stabilization mechanism of cyclic naphthalene diimide binding with various topology of G-quadruplexes2017

    • Author(s)
      T.Ohyama, H.Tateishi-Karimata, S.Takahashi, S.Sato, S.Tanaka, S.Takenaka, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between malignant alteration in cancer cells and the transcript mutations by G-quadruplex formations in the template DNA2017

    • Author(s)
      H.Tateishi-Karimata, K.Kawauchi, T.Ohyama, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of RNA G-quadruplexes Formation in Normal and Cancer Cells Using Bicistronic IRES Vector2017

    • Author(s)
      A.B. Rode, T.Endoh, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does molecular crowding regulate C9orf72-related ALS/FTD diseases by RNA foci formation?2017

    • Author(s)
      Y.Teng, H.Tateishi-Karimata, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A fluorescence based screening system for ligands targeting non-canonical DNA structures2017

    • Author(s)
      J.Jana, T.Endoh, Y.Kataoka, S.Sato, S.Takenaka, M.Kuwahara, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] N-Methyl modification transforms a chlorophyll derivative into a G-quadruplex stabilizing ligand2017

    • Author(s)
      T.Endoh, Y.Nagano, S.Ogasawara, H.Tamiaki, N.Sugimoto
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Specific light-up system based on signal amplification by ternary initiation complexes2017

    • Author(s)
      H.Fujita, Y.Kataoka, Y.Nakajima, M.Yamada, N.Sugimoto, M.Kuwahara
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of interactions between DNA G-quadrplex and small biomolecules selected by high-throuput screenin2017

    • Author(s)
      K.Tanabe, D.Miyoshi, N.Sugimoto, S.Nakano
    • Organizer
      第44回国際核酸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 核酸化学における“To B or not to B”2017

    • Author(s)
      杉本直己
    • Organizer
      平成29年度生命融合科学教育学部シンポジウム“ライフサイエンスを開拓先導する分子科学”
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヘミン - グアニン四重鎖 DNA からなる DNAzyme の反応解析における高圧力の活用2017

    • Author(s)
      高橋 俊太郎, 杉本 直己
    • Organizer
      第58回高圧討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 核酸化学における“To B or not to B"2017

    • Author(s)
      杉本直己
    • Organizer
      第15回公開セミナー(Chemical Biology)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cell nucleus-mimicking system with synthetic cationic polymers2017

    • Author(s)
      Daisuke Miyoshi
    • Organizer
      1st Minisymposium on Material Biology
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] “To B or not to B” in Nucleic Acids Chemistry2017

    • Author(s)
      N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Transcriptional regulation by DNA structural changes responsive chemical environments in cells during tumor progression2017

    • Author(s)
      H. Tateishi-Kartimata, N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-canonical DNA and RNA in Gene Expressions, Pohang University of Science and Technology2017

    • Author(s)
      N. Sugimoto
    • Organizer
      Mini-Symposium on Nucleic Acid Chemistry
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Function of Non-canonical Nucleic Acids2017

    • Author(s)
      N. Sugimoto
    • Organizer
      2017 SKKU International Symposium on Molecular Medicine Current Progress in Nucleic Acid Research and Application
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA and RNA G-quadruplexes: Structure, Stability, Function, and Ligand under Cell-mimicking Molecular Crowding Conditions2017

    • Author(s)
      Daisuke Miyoshi, Yu-ki Zouzumi, Yoshiki Imagawa, Wataru Sugimoto, Takatoshi Yasui, and Keiko Kawauchi
    • Organizer
      A3 Foresight 9th Meeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 塩基損傷を受けたグアニン四重鎖DNAの検出と構造制御を誘導するリガンド複合型核酸マテリアルの創製2017

    • Author(s)
      高橋 俊太郎, Kim Byeang Hyean, 杉本 直己
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Beyond the Watson-Crick Double Helix: Make New History of Nucleic Acids (5)2017

    • Author(s)
      N. Sugimoto
    • Organizer
      Asia 3 Roundtable on Nucleic Acids 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞内模倣環境における核酸と蛋白質の非特異的な相互作用の評価2017

    • Author(s)
      堀田 政夫, 森本 隆太, 中井 大樹, 杉本 直己, 中野 修一
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ハイスループット解析による核酸と生体低分子の相互作用評価2017

    • Author(s)
      田辺 和也, 三好 大輔, 杉本 直己, 中野 修一
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストン模倣高分子のエピジェネティック修飾による DNA との結合親和性への影響2017

    • Author(s)
      造住 有輝, 山口 野乃花, 嶋田 直彦, 杉本 直己, 丸山 厚, 三好 大輔
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌関連遺伝子群の mRNA 上における転写反応と共役した二次構造と四重鎖構造の競合2017

    • Author(s)
      遠藤 玉樹, RODE Ambadas, 杉本 直己
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化損傷したクグアニン四重鎖の検出と四重鎖形成制御2017

    • Author(s)
      高橋 俊太郎, Kim Byeang Hyean, Podbevsek Peter, Plavec Janez, 杉本 直己
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん進行過程におけるノンコーディング領域のDNA四重らせん構造による転写制御機構2017

    • Author(s)
      建石寿枝、川内敬子、大山達也, 杉本 直己
    • Organizer
      第11回バイオ関連化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular Crowding Effect on the Stability, Topology and Function of Nucleic Acids:To B or not to B2017

    • Author(s)
      N. Sugimoto
    • Organizer
      The 7th Cambridge Symposium on Nucleic Acids Chemistry and Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞の分子クラウディング環境における核酸の四重らせん構造とそれを標的にした機能性分子の開発2017

    • Author(s)
      三好大輔
    • Organizer
      49th Seminer, Japanese Association of Scientists in Singapore
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Nanobioengineering of Non-canonical DNA and RNA2017

    • Author(s)
      N. Sugimoto
    • Organizer
      The 6th International Conference on DNA Nanotechnology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] "Non-canonical Nucleic Acids"2017

    • Author(s)
      N. Sugimoto
    • Organizer
      DNA assembly and nanotechnology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of Gene Expressions by Non-canonical DNA and RNA2017

    • Author(s)
      N. Sugimoto
    • Organizer
      First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核酸の高次構造を標的にする機能性分子の医療展開2017

    • Author(s)
      三好大輔
    • Organizer
      神戸医療産業都市クラスター交流会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Replication control by topologies of non-canonical DNA structures2017

    • Author(s)
      S. Takahashi, N. Sugimoto
    • Organizer
      FIBER国際核酸サミット2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] テトラエチレングリコール修飾核酸を活用した新しい逆転写制御法の開発2017

    • Author(s)
      建石 寿枝、大山 達也, 村岡 貴博, Peter Podbevsek、 Adam M. Wawro、田中 成典, 金原 数, Janez Plavec, 杉本 直己
    • Organizer
      日本核酸医薬学会第3回年会
    • Related Report
      2017 Annual Research Report
  • [Book] 核酸科学ハンドブック2020

    • Author(s)
      杉本直己
    • Total Pages
      565
    • Publisher
      講談社
    • ISBN
      9784065207864
    • Related Report
      2020 Annual Research Report
  • [Book] 現代化学2019

    • Author(s)
      高橋俊太郎, 杉本直己
    • Publisher
      化学同人
    • Related Report
      2018 Annual Research Report
  • [Book] CSJカレントレビュー「生命機能に迫る分子化学」2018

    • Author(s)
      建石寿枝、杉本直己
    • Publisher
      化学同人
    • Related Report
      2018 Annual Research Report
  • [Book] Biological and nanotechnological applications using interactions between ionic liquids and nucleic acids2018

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Publisher
      Biophysical Reviews (SpringerLink)
    • Related Report
      2018 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所 ホームページ

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2020 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所

    • URL

      http://www.konan-fiber.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2018 Annual Research Report
  • [Remarks] 分子夾雑の生命化学HP

    • URL

      http://www.bunshi-kyouzatsu.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所HP 研究業績

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] RNAアプタマーのスクリーニング方法2018

    • Inventor(s)
      杉本 直己、遠藤 玉樹
    • Industrial Property Rights Holder
      学校法人甲南学園
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2017-07-04   Modified: 2022-02-28  

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