Identification of molecules targeting cancers and neurons based on molecular tracing

• Project Area: Chemical Approaches for Miscellaneous / Crowding Live Systems
• Project/Area Number: 17H06356
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Nagoya University
• Principal Investigator: 夏目 敦至 名古屋大学, 医学系研究科, 准教授 (30362255)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥104,650,000 (Direct Cost: ¥80,500,000、Indirect Cost: ¥24,150,000); Fiscal Year 2021: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2020: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2019: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2018: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2017: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
• Keywords: スーパーエンハンサー / エピゲノム / 創薬 / 脳腫瘍 / 次世代シーケンス / がん / ゲノム / 神経再生 / ナノテクノロジー / 検診 / 尿 / リキッドバイオプシー / 神経科学 / 分子イメージング / エンハンサー

Outline of Annual Research Achievements

脳腫瘍の診断と治療において、最も重要なのは、腫瘍の進展や悪性化の頻度を考慮にいれて、最善のタイミングに最善の治療を施すことである。腫瘍のひとつひとつの細胞の増殖率、悪性化率（遺伝子変異率）を算出することで、個体の腫瘍の増殖曲線と変異確率を提示できる。これまで、「積極的治療を今おこなわなくても、しばらく経過観察でよい」とされていた腫瘍は、この治療法で本当に良いのだろうか。これを数理モデルで明らかにした。その場合でも早期発見は予後良好に資するところが大きい。早期発見は勘弁な検査で達成できるようになった。尿１mLに含まれる遺伝子の解析により脳腫瘍や他のがん種を早期診断できる画期的な技術を開発した。日本の10施設で治療された276例の低悪性度IDH変異神経膠腫のMRIから算出した腫瘍体積と治療歴を含む時系列データを用いて、治療による影響を加味した腫瘍増殖に関する数理モデルを構築し、さらに網羅的な遺伝子変異解析を行うことで、各治療が腫瘍の増殖および悪性化に与える影響を推定し、各症例おいて悪性化を防ぐ最適な治療戦略を明らかにすることを目指した。具体的には１）腫瘍細胞が遺伝子変異などの「悪性化に関わるイベント」を稀に獲得し、これが一定数蓄積された段階でその細胞は悪性化すると仮定し、２）化学療法や放射線治療は、これらの治療を受けていない腫瘍細胞に比べ「悪性化に関わるイベント」を獲得する確率を変化させると仮定して、各症例の経過中の悪性化リスクを計算した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

論文を今年度は10本以上公表した。

Strategy for Future Research Activity

本数理モデルによって、低悪性度IDH変異神経膠腫の各患者さんにとって、悪性化を防ぎ、結果として生存率を向上させる治療が提示できる。また、本解析アプローチは、新たな治療法や他の悪性腫瘍にも応用可能な汎用性の高いものである。また、尿による本ナノワイヤ診断技術は、肺がん等の他のがんも尿で高精度に診断できる可能性が高い。それを達成することで、わずかな尿を使用し、脳腫瘍だけではなく、多種類のがんを同時に発見できる可能性がある。

Research Products

• [Int'l Joint Research] UCSF(米国)
• [Int'l Joint Research] Sick Kidds(カナダ)
• [Int'l Joint Research] Bach Mai Hospital(ベトナム)
• [Int'l Joint Research] ソウル大学(韓国)
• [Journal Article] Importance of Hydrostatic Pressure and Irrigation for Hemostasis in Neuroendoscopic Surgery (2021)
  • Author(s): ISHIKAWA Takayuki、TAKEUCHI Kazuhito、YAMAMOTO Taiki、NAGATA Yuichi、NATSUME Atsushi
  • Journal Title: Neurologia medico-chirurgica Volume: 61 Issue: 2 Pages: 117-123
  • DOI: 10.2176/nmc.oa.2020-0278
  • NAID: 130007986449
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma? (2021)
  • Author(s): Kanamori M, Takami H, Kijima N, Terashima K, Ichimura K, Nishikawa R, et al,
  • Journal Title: Neuro-Oncology Volume: 23 Issue: 2 Pages: 295-303
  • DOI: 10.1093/neuonc/noaa199
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2) (2020)
  • Author(s): Naito Y, Aburatani H, Amano T, Baba E, Furukawa T, Hayashida T, Hiyama E, Ikeda S, Kanai M, Kato M, Kinoshita I, Kiyota N, Kohno T, Kohsaka S, et al.
  • Journal Title: Int J Clin Oncol Volume: － Issue: 2 Pages: 233-283
  • DOI: 10.1007/s10147-020-01831-6
  • Peer Reviewed / Open Access
• [Journal Article] Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study (2020)
  • Author(s): Shimizu Hiroyuki、Motomura Kazuya、Ohka Fumiharu、Aoki Kosuke、Tanahashi Kuniaki、Hirano Masaki、Chalise Lushun、Nishikawa Tomohide、Yamaguchi Junya、Yoshida Jun、Natsume Atsushi、Wakabayashi Toshihiko
  • Journal Title: Journal of Neurosurgery Volume: － Pages: 1-9
  • DOI: 10.3171/2020.6.jns20638
  • Peer Reviewed
• [Journal Article] Multiple metastases to the bone and bone marrow from a 1p/19q-codeleted and IDH2-mutant anaplastic oligodendroglioma: a case report and literature review (2020)
  • Author(s): Shimizu Hiroyuki、Motomura Kazuya、Ohka Fumiharu、Aoki Kosuke、Tanahashi Kuniaki、Hirano Masaki、Chalise Lushun、Nishikawa Tomohide、Yamaguchi Junya、Wakabayashi Toshihiko、Natsume Atsushi
  • Journal Title: Neuro-Oncology Advances Volume: 2 Issue: 1 Pages: 1-9
  • DOI: 10.1093/noajnl/vdaa101
  • Peer Reviewed / Open Access
• [Journal Article] Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan (2020)
  • Author(s): Shoichi Deguchi, Yoko Nakasu, Tsukasa Sakaida, Jiro Akimoto, Kuniaki Tanahashi, Atsushi Natsume, Masamichi Takahashi, Takeshi Okuda, Hirofumi Asakura, Koichi Mitsuya, Nakamasa Hayashi, Yoshitaka Narita
  • Journal Title: International journal of clinical oncology Volume: 25 Issue: 11 Pages: 1995-2005
  • DOI: 10.1007/s10147-020-01740-8
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma (2019)
  • Author(s): Ranjit Melissa、Hirano Masaki、Aoki Kosuke、Okuno Yusuke、Ohka Fumiharu、Yamamichi Akane、Kato Akira、Maeda Sachi、Motomura Kazuya、Matsuo Keitaro、Enomoto Atsushi、Ino Yasushi、Todo Tomoki、Takahashi Masahide、Wakabayashi Toshihiko、Kato Takuya、Natsume Atsushi
  • Journal Title: Cell Reports Volume: 26 Issue: 9 Pages: 2274-2281
  • DOI: 10.1016/j.celrep.2019.01.109
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors. (2019)
  • Author(s): Matsumura N, Nobusawa S, Ito J, Kakita A, Suzuki H, Fujii Y, Fukuda M, Iwasaki M, Nakasato N, Tominaga T, Natsume A, Mikami Y, Shinojima N, Yamazaki T, Nakazato Y, Hirato J, Yokoo H.
  • Journal Title: J Neurooncol. Volume: 143 Issue: 1 Pages: 27-33
  • DOI: 10.1007/s11060-019-03138-7
  • Peer Reviewed
• [Journal Article] Posterior Cerebral Artery Reconstruction by In-Situ Bypass with Superior Cerebellar Artery via Occipital Transtentorial Approach (2019)
  • Author(s): Tanahashi Kuniaki、Araki Yoshio、Uda Kenji、Muraoka Shinsuke、Motomura Kazuya、Lushun Chalise、Wakabayashi Toshihiko、Natsume Atsushi
  • Journal Title: World Neurosurgery Volume: 126 Pages: 24-29
  • DOI: 10.1016/j.wneu.2019.02.127
  • Peer Reviewed
• [Journal Article] Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping. (2019)
  • Author(s): Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A.
  • Journal Title: J Neurosurg. Volume: 17 Issue: 6 Pages: 1-9
  • DOI: 10.3171/2019.3.jns19211
  • Peer Reviewed
• [Journal Article] Anterior insular cortex stimulation and its effects on emotion recognition. (2019)
  • Author(s): Motomura K, Terasawa Y, Natsume A, Iijima K, Chalise L, Sugiura J, Yamamoto H, Koyama K, Wakabayashi T, Umeda S.
  • Journal Title: Brain Struct Funct. Volume: 224(6) Issue: 6 Pages: 2167-2181
  • DOI: 10.1007/s00429-019-01895-9
  • Peer Reviewed
• [Journal Article] Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review. (2019)
  • Author(s): Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A.
  • Journal Title: World Neurosurg Volume: 130 Pages: 400-404
  • DOI: 10.1016/j.wneu.2019.07.052
  • Peer Reviewed
• [Journal Article] Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas (2019)
  • Author(s): Ohka Fumiharu、Shinjo Keiko、Deguchi Shoichi、Matsui Yusuke et al.
  • Journal Title: Cancer Research Volume: 79 Issue: 19 Pages: 4814-4827
  • DOI: 10.1158/0008-5472.can-19-1272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma. (2019)
  • Author(s): Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A.
  • Journal Title: Molecules Volume: 24(17) Issue: 17 Pages: 3046-3046
  • DOI: 10.3390/molecules24173046
  • Peer Reviewed / Open Access
• [Journal Article] A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma. (2018)
  • Author(s): Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.
  • Journal Title: Neuro Oncol. Volume: 21 Issue: 3 Pages: 348-359
  • DOI: 10.1093/neuonc/noy200
  • Peer Reviewed / Open Access
• [Journal Article] Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study. (2018)
  • Author(s): Wee CW, Kim IH, Park CK, Kim JW, Dho YS, Ohka F, Aoki K, Motomura K, Natsume A, Kim N, Suh CO, Chang JH, Kim SH, Cho WK, Lim DH, Nam DH, Choi JW, Kim IA, Kim CY, Oh YT, Cho O, Chung WK, Kim SH, Kim E.
  • Journal Title: Radiother Oncol. Volume: 129(2) Issue: 2 Pages: 347-351
  • DOI: 10.1016/j.radonc.2018.09.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells. (2018)
  • Author(s): Murakami T, Nakazawa T(equally contribution), Natsume A, Nishimura F, Nakamura M, Matsuda R, Omoto K, Tanaka Y, Shida Y, Park YS, Motoyama Y, Nakagawa I, Yamada S, Tamura K, Takeshima Y, Takamura Y,
  • Journal Title: Anticancer Res Volume: 38 Issue: 9 Pages: 5049-5056
  • DOI: 10.21873/anticanres.12824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of Intraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors (2018)
  • Author(s): Motomura Kazuya、Sumita Kayo、Chalise Lushun、Nishikawa Tomohide、Tanahashi Kuniaki、Ohka Fumiharu、Aoki Kosuke、Hirano Masaki、Nakamura Tomohiko、Matsushita Tadashi、Wakabayashi Toshihiko、Natsume Atsushi
  • Journal Title: World Neurosurgery Volume: 119 Pages: e1052-e1059
  • DOI: 10.1016/j.wneu.2018.08.039
  • NAID: 120006554488
  • Peer Reviewed
• [Journal Article] Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions (2018)
  • Author(s): Motomura Kazuya、Chalise Lushun、Ohka Fumiharu、Aoki Kosuke、Tanahashi Kuniaki、Hirano Masaki、Nishikawa Tomohide、Wakabayashi Toshihiko、Natsume Atsushi
  • Journal Title: World Neurosurgery Volume: 119 Pages: 30-39
  • DOI: 10.1016/j.wneu.2018.07.193
  • NAID: 120006554487
  • Peer Reviewed
• [Journal Article] Inflammation Flare and Radiation Necrosis Around a Stereotactic Radiotherapy-Pretreated Brain Metastasis Site After Nivolumab Treatment (2018)
  • Author(s): Furuta Hiromi、Yoshida Tatsuya、Natsume Atsushi、Hida Toyoaki、Yatabe Yasushi
  • Journal Title: Journal of Thoracic Oncology Volume: 13 Issue: 12 Pages: 1975-1978
  • DOI: 10.1016/j.jtho.2018.07.005
  • Peer Reviewed
• [Journal Article] Cytokine Therapy of Gliomas (2018)
  • Author(s): Iwami Kenichiro、Natsume Atsushi、Wakabayashi Toshihiko
  • Journal Title: Prog Neurol Surg Volume: ー Pages: 79-89
  • DOI: 10.1159/000469682
  • Peer Reviewed
• [Journal Article] Neuro-endoscopic cylinder surgery and 5-aminolevulinic acid (5-ALA) photodynamic diagnosis of deep-seated intracranial lesions. (2018)
  • Author(s): Choo J, Takeuchi K, Nagata Y, Ohka F, Kishida Y, Watanabe T, Satoh Y, Nagatani T, Kato K, Wakabayashi T, Natsume A.
  • Journal Title: World Neurosurg. Volume: 印刷中 Pages: e35-e41
  • DOI: 10.1016/j.wneu.2018.03.112
  • Peer Reviewed
• [Journal Article] Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion (2018)
  • Author(s): Yamamichi Akane、Ohka Fumiharu、Aoki Kosuke、Suzuki Hiromichi、Kato Akira、Hirano Masaki、Motomura Kazuya、Tanahashi Kuniaki、Chalise Lushun、Maeda Sachi、Wakabayashi Toshihiko、Kato Yukinari、Natsume Atsushi
  • Journal Title: Brain Tumor Pathology Volume: - Issue: 2 Pages: 106-113
  • DOI: 10.1007/s10014-018-0312-5
  • NAID: 120006496406
  • Peer Reviewed
• [Journal Article] A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR (2018)
  • Author(s): Hirano Masaki、Ohka Fumiharu、Maeda Sachi、Chalise Lushun、Yamamichi Akane、Aoki Kosuke、Kato Akira、Tanahashi Kuniaki、Motomura Kazuya、Nishimura Yusuke、Hara Masahito、Shinjo Keiko、Kondo Yutaka、Wakabayashi Toshihiko、Natsume Atsushi
  • Journal Title: Brain Tumor Pathology Volume: - Issue: 2 Pages: 97-105
  • DOI: 10.1007/s10014-018-0310-7
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric-type follicular lymphoma in the dura: a case report and literature review. (2018)
  • Author(s): Yamaguchi J, Kato S, Iwata E, Aoki K, Kabeya R, Natsume A, Wakabayashi T.
  • Journal Title: World Neurosurg. Volume: 印刷中 Pages: 176-180
  • DOI: 10.1016/j.wneu.2018.04.053
  • Peer Reviewed
• [Journal Article] Podoplanin - an emerging cancer biomarker and therapeutic target. (2018)
  • Author(s): Krishnan H, Rayes J, Miyashita T, Ishii G, Retzbach EP, Sheehan SA, Takemoto A, Chang YW, Yoneda K, Asai J, Jensen L, Chalise L, Natsume A, Goldberg GS.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 5 Pages: 1292-1299
  • DOI: 10.1111/cas.13580
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack (2017)
  • Author(s): Yoshida Y, Wang H, Hiwasa T, Machida T, Takiguchi M, Iwadate Y, et al.
  • Journal Title: Oncotarget Volume: 9 Issue: 3 Pages: 8836-8848
  • DOI: 10.1007/s11060-018-2831-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Molecular and genetic classification of brain tumors (2019)
  • Author(s): Atsushi Natsume
  • Organizer: The WFNS Educational Course
  • Int'l Joint Research / Invited
• [Presentation] Brain functional mapping and awake craniotomy for brain tumors (2019)
  • Author(s): Atsushi Natsume
  • Organizer: The WFNS Educational Course
  • Invited
• [Presentation] Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas (2019)
  • Author(s): Atsushi Natsume（発表者）, Hiroshi Tsubouchi（17人中17番目）
  • Organizer: ASCO
  • Int'l Joint Research
• [Presentation] 11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine (2019)
  • Author(s): Kosuke Aoki（17人中1番目）, Atsushi Natsume (演者：17人中17番目）
  • Organizer: 11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
  • Int'l Joint Research
• [Presentation] Neurofibromatosis 1と神経膠腫のゲノム解明とNF1変異動物モデルの表現型 (2019)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: 第10回日本レックリングハウゼン病学会
  • Invited
• [Presentation] immune-cold”と言われる脳腫瘍に対する免疫治療を考える (2019)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: 第５回名古屋大学がん免疫フォーラム
  • Invited
• [Presentation] Mathematical prediction for precision medicine of CNS glial tumors (2019)
  • Author(s): Atsushi Natsume
  • Organizer: AACR-JCA joint meeting
  • Int'l Joint Research
• [Presentation] グリオーマでのクローン進化を数理モデル (2018)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: 第10回 がんゲノム・エピゲノム、数理統計解析についての勉強会
  • Invited
• [Presentation] State of art treatment for brain cancer using single cell atlas and artificial intelligence (2018)
  • Author(s): Atsushi Natsume
  • Organizer: 日越国交45周年記念祝賀会
  • Int'l Joint Research / Invited
• [Presentation] Lower-grade gliomaの遺伝子不均一性獲得の数理シミュレーション (2018)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: 日本脳腫瘍学会
• [Presentation] 日本発のキメラ抗原受容体遺伝子導入T細胞の臨床治験 (2018)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: 第77回日本脳神経脳神経外科学会学術総会
• [Presentation] ゲノム時代におけるグリオーマの治療戦略ー手術、化学療法、放射線治療のタイミングー (2018)
  • Author(s): 夏目敦至、大岡史治、若林俊彦、近藤 豊
  • Organizer: Glioma Update Seminar
  • Invited
• [Presentation] Molecular classificationn of gliomas (2018)
  • Author(s): Atsushi Natsume
  • Organizer: International Society of Brain Tumor Pathology
  • Int'l Joint Research / Invited
• [Presentation] 悪性神経膠腫薬物療法における現状の今後の展望 (2018)
  • Author(s): 夏目敦至、青木恒介、若林俊彦
  • Organizer: 第10回東海脳腫瘍手術手技研究会
  • Invited
• [Presentation] シングル細胞レベルのCell AtlasとAIを用いた脳腫瘍治療への展望 (2018)
  • Author(s): 夏目敦至、若林俊彦
  • Organizer: 日本脳神経外科コングレス2018
  • Int'l Joint Research / Invited
• [Presentation] ゲノム時代におけるグリオーマの治療戦略 (2018)
  • Author(s): 夏目敦至
  • Organizer: 第22回北海道脳腫瘍懇話会
  • Invited
• [Presentation] Genome-based Precision Medicine in Brain Tumors (2018)
  • Author(s): Atsushi Natsume
  • Organizer: First Joint US-Japan Clinical Cancer Genomics and Personalized Medicine Symposium
  • Int'l Joint Research / Invited
• [Presentation] Mutational landscape and clonal architecture (2017)
  • Author(s): Atsushi Natsume
  • Organizer: Chemistry of Molecular Crowding
  • Int'l Joint Research / Invited
• [Book] 最新主要文献でみる脳神経外科学レビュー (2019)
  • Author(s): 夏目敦至
  • Total Pages: 373
  • Publisher: 総合医学社
• [Remarks] 名古屋大学大学院医学系研究科 脳神経外科 脳腫瘍グループ
  • URL: https://med-nagoya-neurosurgery.jp/intro/group/group1
• [Patent(Industrial Property Rights)] 脳腫瘍を検査する方法 (2019)
  • Inventor(s): 夏目敦至、安井隆雄、馬場 嘉信
  • Industrial Property Rights Holder: 夏目敦至、安井隆雄、馬場 嘉信
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-177615
  • Filing Date: 2019