| Budget Amount *help |
¥145,340,000 (Direct Cost: ¥111,800,000、Indirect Cost: ¥33,540,000)
Fiscal Year 2021: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2020: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2018: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2017: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
|
|---|
| Outline of Final Research Achievements |
Biological systems flexibly change their phenotypes in response to environmental changes. In order to quantitatively analyze the characteristics of adaptive evolution of the phenotype, we carried out a systematic evolution experiment of Escherichia coli under various environments and analyzed the phenotypic and genotypic changes of the evolved strain. The results indicate that the possible phenotypic changes in E. coli are restricted to a low-dimension phenotype space. Furthermore, the magnitude of the phenotypic changes correlates with the magnitude of the phenotypic fluctuations independent of the genotype changes. These results are in good agreement with theoretical predictions and suggest that evolution can be predicted and controlled in short generations.
|
