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Inflammation and related molecular preventive medicine in kidney diseases

Planned

Project AreaPreventive medicine through inflammation cellular sociology
Project/Area Number 17H06394
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionKanazawa University

Principal Investigator

和田 隆志  金沢大学, その他部局等, その他 (40334784)

Co-Investigator(Kenkyū-buntansha) 古市 賢吾  金沢医科大学, 医学部, 教授 (50432125)
坂井 宣彦  金沢大学, 附属病院, 准教授 (60377421)
岩田 恭宜  金沢大学, 附属病院, 特任教授 (90432137)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥91,520,000 (Direct Cost: ¥70,400,000、Indirect Cost: ¥21,120,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywords腎臓病 / 慢性炎症 / 感染症 / 細菌 / ゲノム / シングルセル
Outline of Annual Research Achievements

超高齢社会を迎えた本邦では、感染症対策とその病態解明は喫緊の課題である。感染症の重症度に関わる因子として、宿主の免疫状態などの宿主側因子と、菌自体の毒性などの菌体側因子が考えられる。また、感染症の経過中、急性腎障害を併発することも多く、生命予後の悪化と深くかかわっている。しかしながら、細菌自身の表現型や遺伝子型ならびにそこに立脚するタンパクが、重症感染症や急性腎障害の発症にかかわる病態との関連は、ほとんど明らかになってはいない。そこで、本研究では感染症を生じる細菌、ことに臨床上問題となる多剤耐性菌と感染に伴う炎症、常在する細菌叢の撹乱とその病態、腎臓病を中心とする病気の予防、発症、進展との関連を炎症・細胞生物学から明らかとすることを目指している。我々はこれまで、メチシリン耐性黄色ブドウ球菌(MRSA)の網羅的遺伝子解析を通して、血流感染症や急性腎障害の発症に関わる候補遺伝子の変異を同定した。特定の変異を有するMRSAは急性腎障害など臨床的に腎病変と関連することを確認した。これら変異遺伝子及び変異タンパクが感染症や急性腎障害の病態に及ぼす意義について検討する。菌株を投与し、未病、発症モデルを確立し、さらに腎臓をシングルセル化し、網羅的遺伝子解析を展開する。このMRSAによる急性腎障害の未病―発症モデルを中心に、病態解明に向けた検討を施行している。さらに、細菌叢由来の代謝産物に着目し、腎障害との関連も検討している。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

当初の計画通り、MRSAによるマウス急性腎障害の未病―発症モデルを確立し、検討を進めている。菌量により、病理学的所見、腎機能および腎障害マーカーに差を認めた。比較的投与菌量が少ない群による未病モデルを確立した。これを用いて、本研究の主課題である未病から発症に至る病態解明を進めている。これらのモデル作成ならびに腎臓所見は再現性が高く、モデルとして適切であることを確認した。また、このモデルより腎を摘出し、シングルセル化した。シングルセル化した検体は、フローサイトメトリーで確認し、死細胞は十分除去され、腎固有細胞、浸潤細胞がクラスターを形成していることを確認した。遺伝子の抽出も量・質ともに十分であり、質の高い遺伝子発現解析を施行しえている。以上から、本研究課題は概ね順調に進展し、さらに新たな知見を得ている。

Strategy for Future Research Activity

今後も、腎臓を炎症の場とした、細菌感染に伴う急性腎障害において、腎固有細胞や、免疫担当細胞とのクロストーク、細胞単位の炎症の記憶と遷延化などを、シングルセルトランスクリプトームの手法を用いて解析を進める。また、進行性腎障害の回復と、進展を分ける責任細胞、責任因子を、炎症細胞社会の包括的な視点で取らえることで、キーとなる細胞、分子に特化した創薬基盤や、新規バイオマーカーの創出を目指す。
また、近年、腸内をはじめとする細菌叢とその代謝産物の変化が、感染症をはじめとする全身性疾患の病態に関与していることが明らかとなっている。このモデルにおいても、細菌叢由来の代謝産物に着目し、感染症、特に感染症関連の急性腎障害に与える影響を検討したい。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(64 results)

All 2021 2020 2019 2018 2017

All Journal Article (27 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 26 results,  Open Access: 26 results) Presentation (33 results) (of which Int'l Joint Research: 2 results,  Invited: 15 results) Book (4 results)

  • [Journal Article] D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus2021

    • Author(s)
      Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 22 Pages: 50-56

    • DOI

      10.1016/j.bbrc.2020.12.078

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients2020

    • Author(s)
      Iwata Y、Sakai N、Yoneda I、Satou K、Furuichi K、Senda Y、Sakai-Takemori Y、Wada T、Fujita S、Ogura H、Sato K、Minami T、Yamaguchi K、Kitajima S、Toyama T、Yamamura Y、Miyagawa T、Hara A、Shimizu M、Sakai Y、Ikeo K、Shichino S、Ueha S、Nakajima T、Matsushima K、Wada T
    • Journal Title

      J Infect Chemother

      Volume: 26 Pages: 604-610

    • DOI

      10.1016/j.jiac.2020.01.016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.2020

    • Author(s)
      Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, et al.
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 91 Pages: 22-31

    • DOI

      10.1016/j.ijid.2019.11.003

    • NAID

      120006842044

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenicity Characterization of Prevalent-Type Streptococcus dysgalactiae subsp. equisimilis Strains2020

    • Author(s)
      Matsue Miki、Ogura Kohei、Sugiyama Hironori、Miyoshi-Akiyama Tohru、Takemori-Sakai Yukiko、Iwata Yasunori、Wada Takashi、Okamoto Shigefumi
    • Journal Title

      Front Microbiol.

      Volume: 11 Pages: 97-97

    • DOI

      10.3389/fmicb.2020.00097

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細菌由来D-アミノ酸を介した新たな腎腸連関機序2020

    • Author(s)
      中出祐介・岩田恭宜・和田隆志
    • Journal Title

      D-アミノ酸学会誌

      Volume: 8 Pages: 1-8

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2019

    • Author(s)
      Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
    • Journal Title

      Nat Commun.

      Volume: 10 Pages: 1385-1385

    • DOI

      10.1038/s41467-019-09735-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between the recurrence period of acute kidney injury and mortality: a single-centre retrospective observational study in Japan2019

    • Author(s)
      Sako Keisuke、Furuichi Kengo、Yamamura Yuta、Oshima Megumi、Toyama Tadashi、Kaneko Shuichi、Wada Takashi
    • Journal Title

      BMJ Open

      Volume: 9

    • DOI

      10.1136/bmjopen-2018-023259

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Erythropoietin signal protected HUVEC from high glucose induced injury2019

    • Author(s)
      Yasuda Haruka、Iwata Yasunori、Nakajima Satoshi、Furuichi Kengo、Miyake Taito、Sakai Norihiko、Kitajima Shinji、Toyama Tadashi、Shinozaki Yasuyuki、Sagara Akihiro、Miyagawa Taro、Hara Akinori、Shimizu Miho、Kamikawa Yasutaka、Sato Kouichi、Oshima Megumi、Yoneda-Nakagawa Shiori、Kaneko Shuichi、Wada Takashi
    • Journal Title

      Nephrology (Carlton)

      Volume: in press Pages: 767-774

    • DOI

      10.1111/nep.13518

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta‐analysis2019

    • Author(s)
      Toyama Tadashi、Neuen Brendon L.、Jun Min、Ohkuma Toshiaki、Neal Bruce、Jardine Meg J.、Heerspink Hiddo L.、Wong Muh Geot、Ninomiya Toshiharu、Wada Takashi、Perkovic Vlado
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 21 Pages: 1237-1250

    • DOI

      10.1111/dom.13648

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells2019

    • Author(s)
      Sakai Yoshio、Honda Masao、Matsui Shigeyuki、Komori Osamu、Murayama Toshinori、Fujiwara Tadami、Mizuno Masaaki、Imai Yasuhito、Yoshimura Kenichi、Nasti Alessandro、Wada Takashi、Iida Noriho、Kitahara Masaaki、Horii Rika、Toshikatsu Tamai、Nishikawa Masashi、Okafuji Hirofumi、Mizukoshi Eishiro、et al
    • Journal Title

      Cancer Sci.

      Volume: 110 Pages: 1364-1388

    • DOI

      10.1111/cas.13971

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipose tissue‐derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL‐17‐mediated inflammation2019

    • Author(s)
      Yamato Masatoshi、Sakai Yoshio、Mochida Hatsune、Kawaguchi Kazunori、Takamura Masayuki、Usui Soichiro、Seki Akihiro、Mizukoshi Eishiro、Yamashita Taro、Yamashita Tatsuya、Ishida Kousuke、Nasti Alessandro、Tuyen Ho Thuy Bich、Komura Takuya、Yoshida Keiko、Wada Takashi、Honda Masao、Kaneko Shuichi
    • Journal Title

      J Gastroenterol Hepatol

      Volume: - Pages: 1432-1440

    • DOI

      10.1111/jgh.14647

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score-Matched Analysis of a Nationwide, Biopsy-Based Cohort Study.2019

    • Author(s)
      Yamanouchi M, Furuichi K, Hoshino J, Toyama T, Hara A, Shimizu M, Kinowaki K, Fujii T, Ohashi K, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Mise K, Makino H, Matsuo S, Ubara Y, Wada T.
    • Journal Title

      Diabetes Care

      Volume: - Pages: 891-902

    • DOI

      10.2337/dc18-1320

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS.2018

    • Author(s)
      Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima K, Matsui M, Yamauchi H, Gohda T, Fukami K et al
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Pages: 377-387

    • DOI

      10.1007/s10157-017-1467-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy2018

    • Author(s)
      Furuichi Kengo、Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Wada Takashi et al.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: - Pages: 570-582

    • DOI

      10.1007/s10157-017-1485-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis2018

    • Author(s)
      Furuichi Kengo、Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Wada Takashi et al.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: - Pages: 629-637

    • DOI

      10.1007/s10157-017-1496-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study2018

    • Author(s)
      Hara Akinori、Wada Takashi、Sada Ken-ei、Amano Koichi、Dobashi Hiroaki、Harigai Masayoshi、Takasaki Yoshinari、Yamada Hidehiro、Hasegawa Hitoshi、Hayashi Taichi、Fujimoto Shouichi、Muso Eri、Kawakami Tamihiro、Homma Sakae、Yoshida Masaharu、Hirahashi Junichi、et al
    • Journal Title

      The Journal of Rheumatology

      Volume: 45 Pages: 521-528

    • DOI

      10.3899/jrheum.170508

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study)2018

    • Author(s)
      Wada Takashi、Hosoya Tatsuo、Honda Daisuke、Sakamoto Ryusuke、Narita Kazutaka、Sasaki Tomomitsu、Okui Daisuke、Kimura Kenjiro
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Pages: 860-870

    • DOI

      10.1007/s10157-018-1530-1

    • NAID

      120006490099

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinico-pathological features of kidney disease in diabetic cases2018

    • Author(s)
      Furuichi Kengo、Shimizu Miho、Okada Hirokazu、Narita Ichiei、Wada Takashi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: - Pages: 1046-1051

    • DOI

      10.1007/s10157-018-1556-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study2018

    • Author(s)
      Yamanouchi Masayuki、Hoshino Junichi、Ubara Yoshifumi、Takaichi Kenmei、Kinowaki Keiichi、Fujii Takeshi、Ohashi Kenichi、Mise Koki、Toyama Tadashi、Hara Akinori、Shimizu Miho、Furuichi Kengo、Wada Takashi
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: -

    • DOI

      10.1093/ndt/gfy121

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.2018

    • Author(s)
      Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y.
    • Journal Title

      PLOS ONE

      Volume: 13

    • DOI

      10.1371/journal.pone.0197604

    • NAID

      120006605152

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood.2018

    • Author(s)
      Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y.
    • Journal Title

      Canadian Journal of Gastroenterology and Hepatology

      Volume: 7436205 Pages: 7436205-7436205

    • DOI

      10.1155/2018/7436205

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota-derived D-serine protects against acute kidney injury2018

    • Author(s)
      Yusuke Nakade, Yasunori Iwata, Takashi Wada, et al.
    • Journal Title

      JCI Insight.

      Volume: 18;3(20) Pages: 97957-97957

    • DOI

      10.1172/jci.insight.97957

    • NAID

      120006733372

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients2018

    • Author(s)
      Kamikawa Yasutaka、Sakai Norihiko、Miyake Taito、Sagara Akihiro、Shinozaki Yasuyuki、Kitajima Shinji、Toyama Tadashi、Hara Akinori、Iwata Yasunori、Shimizu Miho、Furuichi Kengo、Imamura Ryu、Suda Takashi、Kaneko Shuichi、Wada Takashi
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: - Pages: 345-354

    • DOI

      10.1111/1744-9987.12651

    • NAID

      120006498382

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral Blood Plasmacytosis in Severe Fever with Thrombocytopenia Syndrome2017

    • Author(s)
      Wada T, Iwata Y, Kamikawa Y, Wada T, Yachie A.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: - Issue: 4 Pages: 470-471

    • DOI

      10.7883/yoken.jjid.2016.575

      10.7883/yoken.JJID.2016.575

    • NAID

      130005851926

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impairment of the carnitine/organic cation transporter 1?ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease2017

    • Author(s)
      Shinozaki Yasuyuki、Furuichi Kengo、Toyama Tadashi、Kitajima Shinji、Hara Akinori、Iwata Yasunori、Sakai Norihiko、Shimizu Miho、Kaneko Shuichi、Isozumi Noriyoshi、Nagamori Shushi、Kanai Yoshikatsu、Sugiura Tomoko、Kato Yukio、Wada Takashi
    • Journal Title

      Kidney Int.

      Volume: 92 Pages: 1356-1369

    • DOI

      10.1016/j.kint.2017.04.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Down-regulation of the two-component system and cell-wall biosynthesis-related genes was associated with the reversion to daptomycin susceptibility in daptomycin non-susceptible methicillin-resistant Staphylococcus aureus2017

    • Author(s)
      Iwata Y.、Satou K.、Tsuzuku H.、Furuichi K.、Senda Y.、Sakai-Takemori Y.、Wada T.、Fujita S.、Miyake T.、Yasuda H.、Sakai N.、Kitajima S.、Toyama T.、Shinozaki Y.、Sagara A.、Miyagawa T.、Hara A.、Shimizu M.、Kamikawa Y.、Kaneko S.、Wada T.
    • Journal Title

      Eur J Clin Microbiol Infect Dis.

      Volume: 36 Pages: 1839-1845

    • DOI

      10.1007/s10096-017-2999-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis2017

    • Author(s)
      Sakai Norihiko、Nakamura Miki、Lipson Kenneth E.、Miyake Taito、Kamikawa Yasutaka、Sagara Akihiro、Shinozaki Yasuyuki、Kitajima Shinji、Toyama Tadashi、Hara Akinori、Iwata Yasunori、Shimizu Miho、Furuichi Kengo、Kaneko Shuichi、Tager Andrew M.、Wada Takashi
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 5392-5392

    • DOI

      10.1038/s41598-017-05624-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The gut-kidney axis in diabetic kidney disease2020

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性腎臓病と糖尿病性腎臓病:病態と最新治療2020

    • Author(s)
      和田隆志
    • Organizer
      第65回日本透析医学会学術集会・総会(WEB開催)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 急性腎障害における線維化,リモデリング機序と新規治療の可能性2019

    • Author(s)
      古市賢吾・和田隆志
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 細菌叢と腎臓を繋ぐD-アミノ酸2019

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The involvement of cytoskeleton-dependent signaling pathway mediated by bioactive substances in the pathogenesis of organ fibrosis.2019

    • Author(s)
      坂井宣彦・和田隆志
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腎腸連関機構の解明とその制御2019

    • Author(s)
      和田隆志
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The involvement of cytoskeleton-dependent signaling pathway mediated by bioactive substances in the pathogenesis of organ fibrosis.2019

    • Author(s)
      Norihiko Sakai, Takashi Wada
    • Organizer
      The 62nd Annual Meeting of the Japanese Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Kidney diseases and related organ-cross talk - pathogenesis, therapy and biomarkers-2019

    • Author(s)
      Takashi Wada
    • Organizer
      Kick-Off Symposium of the Double Degree Programs Between Hanoi Medical University and Kanazawa University
    • Related Report
      2018 Annual Research Report
  • [Presentation] ANCA関連血管炎における抗エリスロポエチン受容体抗体の臨床的意義2018

    • Author(s)
      原章規・北川清樹・北島信治・遠山直志・岩田恭宜・坂井宣彦・清水美保・古市賢吾・和田隆志
    • Organizer
      第62回日本リウマチ学会総会・学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クラスター解析を用いたANCA関連血管炎の分類と重症度に関する検討2018

    • Author(s)
      佐田憲映・原章規・和田隆志・本間栄・針谷正祥
    • Organizer
      第62回日本リウマチ学会総会・学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ANCA関連腎炎の臨床病理所見および予後の変遷2018

    • Author(s)
      北川清樹・安藤舞・相良明宏・古市賢吾・和田隆志
    • Organizer
      第62回日本リウマチ学会総会・学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病性腎症の進展マーカー候補としての抗エリスロポエチン受容体抗体2018

    • Author(s)
      原章規・古市賢吾・和田隆志
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キラルアミノ酸の可能性2018

    • Author(s)
      中出祐介・岩田恭宜・和田隆志
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病性腎臓病と糖尿病性腎症:腎病変の不均一性と病態2018

    • Author(s)
      和田隆志・清水美保・遠山直志・原章規・湯澤由紀夫・古市賢吾
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 成人領域の腎コロボーマ症候群と病態2018

    • Author(s)
      山村雄太・古市賢吾・和田隆志
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病腎生検コホートの最新知見2018

    • Author(s)
      古市賢吾・和田隆志
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細菌遺伝子情報の病態への関与2018

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎臓病におけるバイオマーカー2018

    • Author(s)
      和田隆志
    • Organizer
      第58 回日本臨床化学会年次学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] DKD・高血圧性腎硬化症の病理と臨床2018

    • Author(s)
      遠山直志・原章規・清水美保・古市賢吾・和田隆志
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DKDにおける臨床と病理の相互理解2018

    • Author(s)
      清水美保・古市賢吾・和田隆志
    • Organizer
      第48回日本腎臓学会西部学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病性腎臓病update2018

    • Author(s)
      和田隆志
    • Organizer
      第59回日本内科学会 信越支部主催生涯教育講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症・糖尿病性腎臓病の病態と治療2018

    • Author(s)
      和田隆志
    • Organizer
      第33回日本糖尿病合併症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症に対するLDLアフェレシス療法2018

    • Author(s)
      北島信二・原章規・古市賢吾・和田隆志
    • Organizer
      第39回日本アフェレシス学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Long-term outcome of biopsy-proven lupus nephritis and novel insight of autoantibodies to erythropoietin receptor for prognosis.2018

    • Author(s)
      Takashi Wada
    • Organizer
      The 62nd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diabetic Kidney Diseases with Type 2 Diabetes.2018

    • Author(s)
      Takashi Wada
    • Organizer
      CSN Annual General Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nationwide Clinicopathological Study & Related Biomarkers in Diabetic Nephropathy.2018

    • Author(s)
      Takashi Wada
    • Organizer
      Dynamo Townhall
    • Related Report
      2018 Annual Research Report
  • [Presentation] Diabeticnephropathy and diabetic kidney disease: Clinicopathological aspects and biomarkers.2018

    • Author(s)
      Takashi Wada
    • Organizer
      Advanced Course on Renal Pathology and Nephrology
    • Related Report
      2018 Annual Research Report
  • [Presentation] 進行性腎障害における炎症細胞社会と分子標的2018

    • Author(s)
      和田隆志
    • Organizer
      平成29~33年度文部科学省新学術領域研究 予防を科学する炎症細胞社会学 第1回公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性腎臓病における腸腎連関 ― トランスポーターの観点から ―2018

    • Author(s)
      和田隆志
    • Organizer
      日本薬学会第138年会(金沢)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腎腸連関とマイクロバイオーム2017

    • Author(s)
      和田隆志
    • Organizer
      第52回日本小児腎臓病学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] CKDと新たな検査2017

    • Author(s)
      遠山直志・北島信治・古市賢吾・和田隆志
    • Organizer
      日本臨床検査自動化学会第49回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス腹膜線維化モデルにおけるトレハロースの線維化抑制効果の検討2017

    • Author(s)
      三宅泰人・坂井宣彦・古市賢吾・和田隆志
    • Organizer
      第23回日本腹膜透析学会学術集会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腎不全における臓器連関破綻~腸・腎連関~2017

    • Author(s)
      古市賢吾・和田隆志
    • Organizer
      2017年度生命科学系学会合同年次大会 ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] ヒトマイクロバイオーム Vol.22020

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Total Pages
      624
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436599
    • Related Report
      2020 Annual Research Report
  • [Book] 知っておきたい臨床検査値 第2版2019

    • Author(s)
      和田隆志、日本薬学会(編集)
    • Total Pages
      264
    • Publisher
      東京化学同人(編集)
    • ISBN
      4807909541
    • Related Report
      2018 Annual Research Report
  • [Book] 糖尿病性腎臓病の診かた、考えかた2018

    • Author(s)
      和田 隆志、柏原 直樹
    • Total Pages
      224
    • Publisher
      中外医学社
    • ISBN
      9784498224360
    • Related Report
      2018 Annual Research Report
  • [Book] AKI急性腎障害治療の実際2018

    • Author(s)
      迫恵輔、和田隆志、阿部 雅紀(編集)
    • Total Pages
      262
    • Publisher
      日本医事新報社
    • ISBN
      9784784944873
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2021-12-27  

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