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Dynamic conformation and domain structure of lipid molecules in model biomembranes

Planned Research

Project AreaFrontier research of chemical communications
Project/Area Number 17H06406
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionOsaka University

Principal Investigator

Murata Michio  大阪大学, 理学研究科, 教授 (40183652)

Co-Investigator(Kenkyū-buntansha) 土川 博史  大分大学, 医学部, 特任講師 (30460992)
此木 敬一  東北大学, 農学研究科, 准教授 (40292825)
山下 まり  東北大学, 農学研究科, 教授 (50192430)
西川 俊夫  名古屋大学, 生命農学研究科, 教授 (90208158)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2021: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywords天然物リガンド / 化学コミュニケーション / イオンチャネル / 脂質二重膜 / 細胞膜作動性リガンド / 膜貫通ドメイン / ATPアーゼ阻害剤 / ATPアーゼ / ATPアーゼ
Outline of Final Research Achievements

In this study, the interactions between membrane proteins and natural product ligands were elucidated by physicochemical and structural biology methods. Many marine natural products are known to act specifically on ion channels, etc. We aimed to elucidate the biological significance of these natural products, biosynthesis, structure-activity relationships, and, for biotoxins, mechanisms of action, and achieved our objectives by using exploration, isolation, structure determination, chemical biology, and electrophysiological methods. We were able to achieve our objectives through exploration, isolation, structure determination, chemical biology, and electrophysiological methods. The structure of amphotericin B, a historically known example of a natural product that forms ion channels by self-association in lipid bilayers, was determined at atomic resolution.

Academic Significance and Societal Importance of the Research Achievements

天然リガンドの作用機構の解明や構造生物学的知見は、歴史的にも大変重要視されてきた。特に、海洋性生物毒が示す強力で特異的な阻害機構によって、幾多の画期的成果が生化学分野にもたらされている。一例を挙げると、フグ毒テトロドトキシンや下痢性貝毒オカダ酸によって、ナトリウムチャネルやタンパク質リン酸加水分解酵素の研究が進むことによって生物学や医薬学の進展が図られたように大きな波及効果を生む。従って、本研究で取り上げたイオンチャネルなどの膜タンパク質に結合する天然リガンドの研究成果は、特に創薬において有用な基礎的情報となる可能性がある。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(234 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (7 results) Journal Article (70 results) (of which Int'l Joint Research: 19 results,  Peer Reviewed: 69 results,  Open Access: 17 results,  Acknowledgement Compliant: 2 results) Presentation (148 results) (of which Int'l Joint Research: 12 results,  Invited: 33 results) Book (5 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] フランクフルト大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Pacific Adventist University(パプアニューギニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Abo Akademi University(フィンランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Stony Brook University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Pacific Adventist University(ソロモン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] フランクフルト大学/Trier University(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Convergent Synthesis of the WXYZA′B′C′D′E′F′ Ring Segment of Maitotoxin2022

    • Author(s)
      Keitaro Umeno , Hisaaki Onoue , Keiichi Konoki , Kohei Torikai , Yoko Yasuno , Masayuki Satake , Tohru Oishi
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 95 Issue: 2 Pages: 325-330

    • DOI

      10.1246/bcsj.20210397

    • ISSN
      0009-2673, 1348-0634
    • Year and Date
      2022-02-15
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Green spotted puffers can detect an almost nontoxic TTX analog odor using crypt olfactory sensory neurons.2022

    • Author(s)
      Suzuki, T., Nakahigashi, R., Adachi, M., Nishikawa, T., Abe, H.
    • Journal Title

      Chemical Senses

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of the eight-membered carbocycle of brachialactone by intramolecular Mizoroki-Heck reaction.2022

    • Author(s)
      Hirata, Y., Nakazaki, A., Nishikawa, T.
    • Journal Title

      Tetrahedron Lett.

      Volume: 90 Pages: 153608-153608

    • DOI

      10.1016/j.tetlet.2021.153608

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local Differences in the Toxin Amount and Composition of Tetrodotoxin and Related Compounds in Pufferfish (Chelonodon patoca) and Toxic Goby (Yongeichthys criniger) Juveniles.2022

    • Author(s)
      Ito, M., Furukawa, R., Yasukawa, S., Sato, M., Oyama, H., Okabe, T., Suo, R., Sugita, H., Takatani, T., Arakawa, O., Adachi, M., Nishikawa, T., Itoi, S.
    • Journal Title

      Toxins

      Volume: 14 Issue: 2 Pages: 150-150

    • DOI

      10.3390/toxins14020150

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First Identification of 12β-Deoxygonyautoxin 5 (12α-Gonyautoxinol 5) in the Cyanobacterium Dolichospermum circinale (TA04) and 12β-Deoxysaxitoxin (12α-Saxitoxinol) in D. circinale (TA04) and the Dinoflagellate Alexandrium pacificum (Group IV) (120518KureAC)2022

    • Author(s)
      Akamatsu Michiru、Hirozumi Ryosuke、Cho Yuko、Kudo Yuta、Konoki Keiichi、Oshima Yasukatsu、Yotsu-Yamashita Mari
    • Journal Title

      Marine Drugs

      Volume: 20 Issue: 3 Pages: 166-166

    • DOI

      10.3390/md20030166

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production2022

    • Author(s)
      Taylor S. Steele, John K. Brunson, Yukari Maeno, Ryuta Terada, Andrew E. Allen, Mari Yotsu-Yamashita, Jonathan, R. Chekan*, Bradley S. Moore*
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 119 Issue: 6

    • DOI

      10.1073/pnas.2117407119

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A study on the genetic population structure and the tetrodotoxin content of rough-skinned newts, Taricha granulosa (Salamandridae), from their northern range of distribution2022

    • Author(s)
      Dietrich Mebs,* Julio V. Schneider, Oskar Schroder, Mari Yotsu-Yamashita, John R. Harley, Linda Mogk, Gunther Kohler
    • Journal Title

      Toxicon

      Volume: 206 Pages: 28-41

    • DOI

      10.1016/j.toxicon.2021.12.010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Synthesis of simplified analogues of crambescin B carboxylic acid and their inhibitory activity of voltage-gated sodium channels: new aspects of atructure-activity relationships.2022

    • Author(s)
      Nakazaki, A., Mouri, S., Nakane, Y., Ishikawa, Y., Yamashira,M., Nishikawa, T.
    • Journal Title

      Heterocycles

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of domoic acid analogues using a bioconversion system, and their toxicity in mice2021

    • Author(s)
      Maeno Yukari、Kotaki Yuichi、Terada Ryuta、Hidaka Masafumi、Cho Yuko、Konoki Keiichi、Yotsu-Yamashita Mari
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 19 Issue: 36 Pages: 7894-7902

    • DOI

      10.1039/d1ob01378e

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquiring toxicity of a newt, Cynops orientalis2021

    • Author(s)
      Dietrich Mebs* and Mari Yotsu-Yamashita
    • Journal Title

      Toxicon

      Volume: 198 Pages: 32-35

    • DOI

      10.1016/j.toxicon.2021.04.025

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of Tricyclic Guanidino Compounds from the Tetrodotoxin-Bearing Newt Taricha granulosa, .2021

    • Author(s)
      Yuta Kudo, Charles T. Hanifin, and Mari Yotsu-Yamashita.
    • Journal Title

      Org. Lett.

      Volume: 23 Issue: 9 Pages: 3513-3517

    • DOI

      10.1021/acs.orglett.1c00916

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol.2021

    • Author(s)
      Ondevilla, J. C., Hanashima, S., Mukogawa, A., Umegawa, Y., Murata, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 36 Pages: 127816-127816

    • DOI

      10.1016/j.bmcl.2021.127816

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin.2021

    • Author(s)
      Miyasaka, T., Adachi, M., Nishikawa, T.
    • Journal Title

      Org. Lett.

      Volume: 23 Issue: 23 Pages: 9232-9236

    • DOI

      10.1021/acs.orglett.1c03565

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis and biological evaluation of oscillatoxin D, E, and F2021

    • Author(s)
      Yusuke Araki, Yusuke Hanaki, Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, Toshio Nishikawa
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: in press Issue: 6 Pages: 1371-1382

    • DOI

      10.1093/bbb/zbab042

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the <i>in vitro</i> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions2021

    • Author(s)
      Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 8 Issue: 3 Pages: 69-73

    • DOI

      10.2131/fts.8.69

    • NAID

      130008052793

    • ISSN
      2189-115X
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines.2021

    • Author(s)
      Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
    • Journal Title

      Heterocycles

      Volume: 102 Issue: 12 Pages: 2353-2362

    • DOI

      10.3987/com-21-14538

    • NAID

      40022762966

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions2021

    • Author(s)
      Hanashima Shinya、Fukuda Nanami、Malabed Raymond、Murata Michio、Kinoshita Msanao、Greimel Peter、Hirabayashi Yoshio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1863 Issue: 2 Pages: 183496-183496

    • DOI

      10.1016/j.bbamem.2020.183496

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomimetic Synthesis of the CDE Ring Moiety of Physalins, Complex 13,14-Secosteroids2021

    • Author(s)
      Yusuke Araki, Atsuo Nakazaki, Toshio Nishikawa
    • Journal Title

      Org. Lett.

      Volume: 23 Issue: 3 Pages: 989-994

    • DOI

      10.1021/acs.orglett.0c04198

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First Detection of Tetrodotoxins in the Cotylean Flatworm Prosthiostomum trilineatum2021

    • Author(s)
      Suo Rei、Kashitani Maho、Oyama Hikaru、Adachi Masaatsu、Nakahigashi Ryota、Sakakibara Ryo、Nishikawa Toshio、Sugita Haruo、Itoi Shiro
    • Journal Title

      Marine Drugs

      Volume: 19 Issue: 1 Pages: 40-40

    • DOI

      10.3390/md19010040

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes.2021

    • Author(s)
      Uenoyama, R.; Miyazaki, T.; Hurst, J.; Beynon, R.; Asachi, M.; Murooka, T.; Onoda, I.; Miyazawa, Y.; Katayama, T.; Yamashita, T.; Kaneko, S.; Nishikawa, T.; Miyazaki, M.
    • Journal Title

      Sci. Adv.

      Volume: 7 Issue: 4 Pages: 1-14

    • DOI

      10.1126/sciadv.abd9135

    • NAID

      120006952777

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Total Synthesis of the Cardiotonic Steroid (+)-Cannogenol2021

    • Author(s)
      Shogo Watanabe, Toshio Nishikawa, Atsuo Nakazaki
    • Journal Title

      J. Org. Chem.

      Volume: 86 Issue: 4 Pages: 3605-3614

    • DOI

      10.1021/acs.joc.0c02966

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two new skeletal analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic shellfish toxins2021

    • Author(s)
      Numano Satoshi、Kudo Yuta、Cho Yuko、Konoki Keiichi、Kaga Yoshimasa、Nagasawa Kazuo、Yotsu-Yamashita Mari
    • Journal Title

      Chemosphere

      Volume: 278 Pages: 130224-130224

    • DOI

      10.1016/j.chemosphere.2021.130224

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tetrodotoxin Framework Construction from Linear Substrates Utilizing a Hg(OTf)2-Catalyzed Cycloisomerization Reaction: Synthesis of the Unnatural Analogue 11-nor-6,7,8-Trideoxytetrodotoxin2021

    • Author(s)
      Keisuke Nishikawa, Takayuki Noguchi, Seiho Kikuchi, Takahiro Maruyama, Yusuke Araki, Mari Yotsu-Yamashita, and Yoshiki Morimoto
    • Journal Title

      Org. Lett.

      Volume: 23 Issue: 5 Pages: 1703-1708

    • DOI

      10.1021/acs.orglett.1c00125

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SxtA localizes to chloroplasts and changes to its 3′UTR may reduce toxin biosynthesis in non-toxic Alexandrium catenella (Group I)?2021

    • Author(s)
      Cho Yuko、Hidema Shizu、Omura Takuo、Koike Kazuhiko、Koike Kanae、Oikawa Hiroshi、Konoki Keiichi、Oshima Yasukatsu、Yotsu-Yamashita Mari
    • Journal Title

      Harmful Algae

      Volume: 101 Pages: 101972-101972

    • DOI

      10.1016/j.hal.2020.101972

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Synthetic Method for Efficient Synthesis of Bioactive Natural Products —Biomimetic Synthesis of Chaxines—2020

    • Author(s)
      西川俊夫
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 78 Issue: 6 Pages: 566-574

    • DOI

      10.5059/yukigoseikyokaishi.78.566

    • NAID

      130007853933

    • ISSN
      0037-9980, 1883-6526
    • Year and Date
      2020-06-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine.2020

    • Author(s)
      Hiroshi Tsuchikawa, Takuya Ono, Masaki Yamagami, Yuichi Umegawa, Wataru Shinoda, Michio Murata
    • Journal Title

      Biochemistry

      Volume: 59 Issue: 40 Pages: 3929-3938

    • DOI

      10.1021/acs.biochem.0c00589

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains2020

    • Author(s)
      Yano Yo、Hanashima Shinya、Tsuchikawa Hiroshi、Yasuda Tomokazu、Slotte J. Peter、London Erwin、Murata Michio
    • Journal Title

      Biophysical Journal

      Volume: 119 Issue: 3 Pages: 539-552

    • DOI

      10.1016/j.bpj.2020.06.028

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin.2020

    • Author(s)
      Raymond Malabed, Shinya Hanashima, Michio Murata, Kaori Sakurai
    • Journal Title

      Langmuir

      Volume: 36 Issue: 13 Pages: 3600-3610

    • DOI

      10.1021/acs.langmuir.9b03957

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A biomimetic synthesis of chaxine and its related compounds2020

    • Author(s)
      Niki, M., Hirata, Y., Nakazaki, A., Wu, J., Kawagishi, H., Nishikawa, T.
    • Journal Title

      J. Org. Chem.

      Volume: 85 Issue: 7 Pages: 4848-4860

    • DOI

      10.1021/acs.joc.9b03482

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies toward the Synthesis of Chartelline C2020

    • Author(s)
      Yoshiki Nakane, Atsuo Nakazaki, Toshio Nishikawa
    • Journal Title

      J. Org. Chem.

      Volume: 85 Issue: 11 Pages: 7534-7542

    • DOI

      10.1021/acs.joc.0c00643

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton2020

    • Author(s)
      Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa, Chengwei Liu, Jun-ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiyama, Atsushi Minami, Hideaki Oikawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 59 Issue: 41 Pages: 17996-18002

    • DOI

      10.1002/anie.202007280

    • NAID

      120007160289

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures of N-Hydroxy-Type Tetrodotoxin Analogues and Bicyclic Guanidinium Compounds Found in Toxic Newts2020

    • Author(s)
      Yuta Kudo, Charles T. Hanifin, Yuichi Kotaki, Mari Yotsu-Yamashita*
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 9 Pages: 2706-2717

    • DOI

      10.1021/acs.jnatprod.0c00623

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Revisited - Failure of tetrodotoxin to protect red-spotted newts, Notophthalmus viridescens, from endoparasites2020

    • Author(s)
      Dietrich Mebs *, Mari Yotsu-Yamashita, Katharina Hartmann , Christine Elbert ,Richard Zehner, Stefan W. Toennes
    • Journal Title

      Toxicon

      Volume: 178 Pages: 77-81

    • DOI

      10.1016/j.toxicon.2020.02.026

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polypedates Leucomystax (White-lipped Tree Frog) Toxicity.2020

    • Author(s)
      Mari Yotsu-Yamashita, Gunther Kohler, Dietrich Mebs.
    • Journal Title

      Herpetol. Rev.

      Volume: 51 Pages: 822-823

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage‐gated sodium channels.2020

    • Author(s)
      Adachi, K., Yamada, T., Ishizuka, H., Oki, M., Tsunogae, S., Shimada, N., Chiba, O., Orihara, T., Hidaka, M., Hirokawa, T., Odagi, M., Konoki, K., Yotsu-Yamashita, M., Nagasawa, K.
    • Journal Title

      Chem. Eur. J.

      Volume: 26 Issue: 9 Pages: 2025-2033

    • DOI

      10.1002/chem.201904184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycinA1 and its desmethyl derivative bearing 19F-labeling.2019

    • Author(s)
      Tatsuru Hayashi, Hiroshi Tsuchikawa, Yuichi Umegawa, Michio Murata.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 27 Issue: 8 Pages: 1677-1682

    • DOI

      10.1016/j.bmc.2019.03.017

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 7,6-Spirocyclic Imine with Butenolide Ring Provides Evidence for the Relative Configuration of Marine Toxin 13-desMe Spirolide C.2019

    • Author(s)
      Kou Minamino, Michio Murata, Hiroshi Tsuchikawa.
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 22 Pages: 8970-8975

    • DOI

      10.1021/acs.orglett.9b03373

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Synthesis of the Aromatic Fragment of Sespendole.2019

    • Author(s)
      Ono, Y.; Nakazaki, A.; Ueki, K.; Higuchi, K.; Sriphana, U.; Adachi, M.; Nishikawa, T.
    • Journal Title

      J. Org. Chem.

      Volume: 84 Issue: 15 Pages: 9750-9757

    • DOI

      10.1021/acs.joc.9b01597

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Oxy-Functionalized Steroidal Skeletons via Mizoroki-Heck and Intramolecular Diels-Alder Reactions.2019

    • Author(s)
      Watanabe, S., Nishikawa, T., Nakazaki, A.
    • Journal Title

      Org. Lett.,

      Volume: 21 Issue: 18 Pages: 7410-7414

    • DOI

      10.1021/acs.orglett.9b02716

    • NAID

      120006777538

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Novel Saxitoxin Analogue, 12β-Deoxygonyautoxin 3, in the Cyanobacterium, Anabaena circinalis (TA04)2019

    • Author(s)
      Minowa T.、Cho Y.、Oshima Y. 、Konoki K.、Yotsu-Yamashita M.
    • Journal Title

      Toxins

      Volume: 11 Issue: 9 Pages: 539-539

    • DOI

      10.3390/toxins11090539

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Average Conformation of Branched Chain Lipid PGP-Me That Accounts for the Thermal Stability and High-Salinity Resistance of Archaeal Membranes.2019

    • Author(s)
      Yamagami, M., Tsuchikawa, H., Cui, J., Umegawa, Y., Miyazaki, Y., Seo, S., Shinoda, W., Murata, M.
    • Journal Title

      Biochemistry

      Volume: 58 Issue: 37 Pages: 3869-3879

    • DOI

      10.1021/acs.biochem.9b00469

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible Biosynthetic Products and Metabolites of Kainic Acid from the Red Alga Digenea simplex and Their Biological Activity2019

    • Author(s)
      Maeno Yukari、Terada Ryuta、Kotaki Yuichi、Cho Yuko、Konoki Keiichi、Yotsu-Yamashita Mari
    • Journal Title

      Journal of Natural Products

      Volume: 82 Issue: 6 Pages: 1627-1633

    • DOI

      10.1021/acs.jnatprod.9b00128

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and biological activity of 8-epitetrodotoxin and the structure of a possible biosynthetic shunt product of tetrodotoxin, Cep-226A, from the newt, Cynops ensicauda popei2019

    • Author(s)
      Yuta Kudo and Mari Yotsu-Yamashita*
    • Journal Title

      Journal of Natural Products

      Volume: 82 Issue: 6 Pages: 1656-1663

    • DOI

      10.1021/acs.jnatprod.9b00178

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal Variation of the Profile and Concentrations of Paralytic Shellfish Toxins and Tetrodotoxin in the Scallop, Patinopecten yessoensis, Cultured in a Bay of East Japan2019

    • Author(s)
      Numano Satoshi、Kudo Yuta、Cho Yuko、Konoki Keiichi、Yotsu-Yamashita Mari
    • Journal Title

      Marine Drugs

      Volume: 17 Issue: 12 Pages: 653-653

    • DOI

      10.3390/md17120653

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitation of Tetrodotoxin and Its Analogues with a Combination of Liquid Chromatography-Tandem Mass Spectrometry and Quantitative 1H_NMR Spectroscopy2019

    • Author(s)
      Ryuichi Watanabe, Masato Tanioka, Hajime Uchida, Ryoji Matsushima, Hiroshi Oikawa,Masahiro Matsumiya, Mari Yotsu-Yamashita, and Toshiyuki Suzuki*
    • Journal Title

      J. Agric. Food Chem.

      Volume: 67 Issue: 46 Pages: 12911-12917

    • DOI

      10.1021/acs.jafc.9b06380

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol2019

    • Author(s)
      Cornelio Kimberly、Espiritu Rafael Atillo、Hanashima Shinya、Todokoro Yasuto、Malabed Raymond、Kinoshita Masanao、Matsumori Nobuaki、Murata Michio、Nishimura Shinichi、Kakeya Hideaki、Yoshida Minoru、Matsunaga Shigeki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1861 Issue: 1 Pages: 228-235

    • DOI

      10.1016/j.bbamem.2018.07.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt.2019

    • Author(s)
      Masaatsu Adachi,Tadachika Miyasaka, Yuta Kudo, Keita Sugimoto, Mari Yotsu-Yamashita, Toshio Nishikawa.
    • Journal Title

      Org. Lett.

      Volume: 21 Issue: 3 Pages: 780-784

    • DOI

      10.1021/acs.orglett.8b04043

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic study of saxitoxin analogues and biosynthetic intermediates in dinoflagellates using 15N-labelled sodium nitrate as a nitrogen source2019

    • Author(s)
      1.Cho, Y., Tsuchiya, S., Omura, T., Koike, K., Oikawa, H., Konoki, K., Oshima, Y., Yotsu-Yamashita, M.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 3460-3460

    • DOI

      10.1038/s41598-019-39708-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tetrodotoxin content of rough-skinned newts, Taricha granulosa (Salamandridae), from their northern distribution range, British Columbia, Canada, and Southeast-Alaska, USA.2019

    • Author(s)
      Dietrich Mebs, Mari Yotsu-Yamashita, Stefan W. Toennes.
    • Journal Title

      Salamandra

      Volume: 55

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A concise synthesis of peramine, a metabolite of endophytic fungi.2018

    • Author(s)
      Shinsaku Ito, Yuta Yamamoto, Toshio Nishikawa.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 82 Issue: 12 Pages: 2053-2058

    • DOI

      10.1080/09168451.2018.1511966

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium.2018

    • Author(s)
      Jianhua Qi, Lihong Cheng, Yujuan Sun, Yushi Hirata, Naoki Ushida, Zhonghua Ma, Hiroyuki Osada, Toshio Nishikawa, Lan Xiang.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 57 Issue: 27 Pages: 8100-8104

    • DOI

      10.1002/anie.201803329

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives.2018

    • Author(s)
      Linglin Bian, Shining Cao, Lihong Cheng, Atsuo Nakazaki, Toshio Nishikawa, jianhua Qi.
    • Journal Title

      ChemMedChem

      Volume: 13 Issue: 18 Pages: 1972-1977

    • DOI

      10.1002/cmdc.201800352

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel compound, “FA-1” isolated from Prunus mume, protects human bronchial epithelial cells and keratinocytes from cigarette Smoke extract-induced damage.2018

    • Author(s)
      Andrew J. Jang, Ji-Hyeok Lee, Mari Yotsu-Yamashita, Joodong Park, Steve Kye, Raymond L. Benza, Michael J. Passineau, You-Jin Jeon, Toru Nyunoya.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 11504-11504

    • DOI

      10.1038/s41598-018-29701-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lack of alkaloids and tetrodotoxin in the neotropical frogs Allobates spp. (Aromobatidae) and Silverstoneia flotator (Dendrobatidae).2018

    • Author(s)
      Dietrich Mebs, Mari Yotsu-Yamashita, Werner Pogoda, Joseph Vargas Alvarez, Raffael Ernst, Gunther Kohler, Stefan W. Toennes.
    • Journal Title

      Toxicon

      Volume: 152 Pages: 103-105

    • DOI

      10.1016/j.toxicon.2018.07.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pufferfish Saxitoxin and Tetrodotoxin Binding Protein (PSTBP) Analogues in the Blood Plasma of the Pufferfish Arothron nigropunctatus, A. hispidus, A. manilensis, and Chelonodon patoca2018

    • Author(s)
      2.Yotsu-Yamashita, M., Nagaoka, Y., Muramoto, K., Cho, Y., Konoki, K.
    • Journal Title

      Mar. Drugs

      Volume: 16 Issue: 7 Pages: 224-224

    • DOI

      10.3390/md16070224

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation and structure determination of lysiformine from bacteria associated with marine sponge Halichondria okadai2018

    • Author(s)
      3.Kikuchi, S., Okada, K., Cho, Y., Yoshida, S., Kwon, E., Yotsu-Yamashita, M., *Konoki, K.
    • Journal Title

      Tetrahedron

      Volume: 74 Issue: 27 Pages: 3742-3747

    • DOI

      10.1016/j.tet.2018.05.049

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geographic range expansion of tetrodotoxin in amphibians - First record in Atelopus hoogmoedi from the Guiana Shield.2018

    • Author(s)
      Dietrich Mebs, Max Lorentz, Mari Yotsu-Yamashita, Daniela C. Robler, Raffael Ernst, Stefan Lotters.
    • Journal Title

      Toxicon

      Volume: 150 Pages: 175-179

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spiro Bicyclic Guanidino Compounds from Pufferfish, Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments2018

    • Author(s)
      Ueyama Nozomi、Sugimoto Keita、Kudo Yuta、Onodera Ken-ichi、Cho Yuko、Konoki Keiichi、Nishikawa Toshio、Yotsu-Yamashita Mari
    • Journal Title

      Chem. Eur. J.

      Volume: 印刷中 Issue: 28 Pages: 7250-7258

    • DOI

      10.1002/chem.201801006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Six domoic acid related compounds from the red alga, Chondria armata, and domoic acid biosynthesis by the diatom, Pseudo-nitzschia multiseries2018

    • Author(s)
      Maeno Yukari、Kotaki Yuichi、Terada Ryuta、Cho Yuko、Konoki Keiichi、Yotsu-Yamashita Mari
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 356-356

    • DOI

      10.1038/s41598-017-18651-w

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis of Dibromo Compounds Containing 2,6-Dioxabicyclo[3.1.1]heptane Similar to Core Moiety of Thromboxane A22018

    • Author(s)
      Nishikawa Toshio、Nakazaki Atsuo、Nokura Yoshihiko
    • Journal Title

      HETEROCYCLES

      Volume: 96 Issue: 1 Pages: 127-127

    • DOI

      10.3987/com-17-13814

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor.2017

    • Author(s)
      Futoshi Hasegawa, Kazushi Kawamura, Hiroshi Tsuchikawa, Michio Murata.
    • Journal Title

      Bioorg. Med Chem.

      Volume: 25 Issue: 16 Pages: 4056-4511

    • DOI

      10.1016/j.bmc.2017.06.042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient access to functionalized bicyclic pharmacophore of spirolide C via selective Diels-Alder reaction.2017

    • Author(s)
      Hiroshi Tsuchikawa, Kou Minamino, Sho Hayashi, Michio Murata.
    • Journal Title

      Asian J. Org. Chem.

      Volume: 6 Issue: 9 Pages: 1322-1327

    • DOI

      10.1002/ajoc.201700164

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster2017

    • Author(s)
      Kudo Yuta、Chiba Chikafumi、Konoki Keiichi、Cho Yuko、Yotsu-Yamashita Mari
    • Journal Title

      Toxicon

      Volume: 137 Pages: 78-82

    • DOI

      10.1016/j.toxicon.2017.07.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetrodotoxin in Asian newts (Salamandridae)2017

    • Author(s)
      Yotsu-Yamashita, M., Toennes, S.W., Mebs, D.
    • Journal Title

      Toxicon

      Volume: 134 Pages: 14-17

    • DOI

      10.1016/j.toxicon.2017.05.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis and identification of key biosynthetic intermediates for formation of the tricyclic skeleton of saxitoxin2017

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Renpei Yoshioka, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, and Mari Yotsu-Yamashita
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Issue: 19 Pages: 1-6

    • DOI

      10.1002/anie.201612461

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands2017

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, and Mari Yotsu-Yamashita*
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 2 Pages: 222-225

    • DOI

      10.1080/09168451.2016.1246172

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of Polycavernosides A and B, Two Lethal Toxins from Red Alga.2017

    • Author(s)
      Kotaro Iwasaki, Satori Sasaki, Yusuke Kasai, Yuki Kawashima, Shohei Sasaki, Takanori Ito, Mari Yotsu-Yamashita, Makoto Sasaki.
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Issue: 24 Pages: 13201-13219

    • DOI

      10.1021/acs.joc.7b02293

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 貝毒、魚毒、腔腸動物の毒、神経毒とNeuroscience2017

    • Author(s)
      山下まり、此木敬一
    • Journal Title

      月刊 臨床神経科学、Clinical Neuroscience

      Volume: 35 Pages: 1443-1448

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav1.1 to Nav1.7)2017

    • Author(s)
      Tsukamoto Tadaaki、Chiba Yukie、Wakamori Minoru、Yamada Tomoshi、Tsunogae Shunsuke、Cho Yuko、Sakakibara Ryo、Imazu Takuya、Tokoro Shouta、Satake Yoshiki、Adachi Masaatsu、Nishikawa Toshio、Yotsu-Yamashita Mari、Konoki Keiichi
    • Journal Title

      Br. J. Pharmacol.

      Volume: 174 Issue: 21 Pages: 3881-3892

    • DOI

      10.1111/bph.13985

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B,2017

    • Author(s)
      Tadaaki Tsukamoto, Yukie Chiba, Atsuo Nakazaki, Yuki Ishikawa, Yoshiki Nakane, Yuko Cho, Mari Yotsu-Yamashita, Toshio Nishikawa, Minoru Wakamori, and Keiichi Konoki,*
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 5 Pages: 1247-1251

    • DOI

      10.1016/j.bmcl.2017.01.054

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] アンフォテリシンB会合体と構造化したリン脂質の相互作用の解明2022

    • Author(s)
      片山 綾人、梅川雄一、篠田渉、村田道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞質型ホスホリパーゼA2活性化に寄与するセラミド1-リン酸の膜動態解析2022

    • Author(s)
      植浦 大貴、中込 まどか、花島 慎弥、安田 智一、村田 道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 固体NMRを用いた脂質膜環境におけるガングリオシドGM3糖鎖の立体構造解析2022

    • Author(s)
      佐々木 克聡、梅川 雄一、村田 道雄、花島 慎弥
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 極長鎖脂肪酸が脂質二重膜へ与える影響の解析を目指した新規蛍光プローブの合成と評価2022

    • Author(s)
      福永 志穂、梅川 雄一、村田 道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 固体31P NMR測定を用いたp24タンパク質膜貫通ドメインとリン脂質の相互作用の解析2022

    • Author(s)
      赤岩 大樹、梅川 雄一、村田 道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 2H-13C二重標識体を用いた固体NMRによる飽和リン脂質sn-1、sn-2アシル鎖の配座配向解析2022

    • Author(s)
      齋藤 宣樹、梅川 雄一、篠田 渉、村田 道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生体モデル膜における内葉脂質フォスファチジルエタノールアミンの動的挙動解析2022

    • Author(s)
      西 直也、安田 智一、花島 慎弥、村田 道雄
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Synthesis of CF3-attached lactosylceramide probe for 19F solid-state NMR to investigate interactions with glycans on lipid bilayers.2022

    • Author(s)
      Kang、W, J., Michio, M., Hanashima, S.
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 古くて新しい天然物化学の課題:ネコのマタタビ 反応の謎に挑戦する。中長期テーマシンポジウム 「生物現象鍵物質の研究展開」2022

    • Author(s)
      西川俊夫
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] テトロドトキシンの推定生合成中間体Tb-210B、Tb-226、Tb-242C、Tb-258の全合成。2022

    • Author(s)
      西海眞史、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発。2022

    • Author(s)
      波田航平、新木悠介、野倉吉彦、花木祐輔、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] FAS 遺伝子群が作り出す新奇サイトカイニンに関する研究。2022

    • Author(s)
      宮田和輝、Surjana, A., 小嶋美紀子、幸木謙典、西川俊夫、榊原均
    • Organizer
      第63回日本植物生理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 植物病原Rhodococcus fascians が作り出す新奇サイトカイニンの構造と機能の解明。2022

    • Author(s)
      吉野実花、Surjana, A., 小嶋美紀子, 幸木謙典, 西川俊夫, 榊原均
    • Organizer
      第63回日本植物生理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オオツノヒラムシにおけるテトロドトキシンの生産と細菌の寄与。2022

    • Author(s)
      米澤遼、林健太朗、吉武和敏、JDM Senevirathna、スミス梨花、満山進、木下滋晴、尾山輝、上田紘之、周防玲、杉田治男、安立昌篤、西川俊夫、モリテツシ、糸井史朗、浅川修一
    • Organizer
      令和4年日本水産学会春季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ツムギハゼおよびオキナワフグの毒化機構の種差に関する研究。2022

    • Author(s)
      伊藤正晟、古川理紗子、安川詩乃、佐藤雅哉、尾山 輝、岡部泰基、周防 玲、杉田治男、高谷智裕、荒川 修、安立昌篤、西川俊夫、糸井史朗
    • Organizer
      令和4年日本水産学会春季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] テトロドトキシン含有イモリ由来の新規三環性骨格を持つ2種のグアニジノ化合物2022

    • Author(s)
      工藤 雄大, Hanifin, C, T., 長 由扶子, 此木 敬一, 山下 まり
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] サキシトキシンの推定生合成中間体の合成と有毒淡水産藍藻における同定2022

    • Author(s)
      袴田 真有, 東海林 千容, 長 由扶子, 安達 栞菜, 石塚 颯, 工藤 雄大, 此木 敬一, 大島 泰克, 長澤 和夫, 山下 まり
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 異種発現環化酵素を用いた新規カイニン酸類縁体の調製2022

    • Author(s)
      山田 基生, 前野 優香理, 小瀧 裕一, 寺田 竜太, 工藤 雄大, 長 由扶子, 此木 敬一, 山下 まり
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 渦鞭毛藻におけるサキシトキシン生合成酵素SxtG活性の解析と細胞内局在2022

    • Author(s)
      長 由扶子, 日出間 志寿, 大村 卓朗, 土屋 成輝, 小池一彦, 此木 敬一, 大島 泰克, 山下 まり
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗テトロドトキシンモノクローナル抗体の 主要テトロドトキシン類縁体に対する交差反応性評価2022

    • Author(s)
      八巻慶汰, 佐藤恭佳, 工藤雄大, 川津健太郎, 荒川修, 高谷智裕, 長由扶子, 此木敬一, 山下まり
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] クロイソカイメンより単離したアラキドン酸と各種脂肪酸による電位依存性ナトリウムチャネルの阻害作用2022

    • Author(s)
      千葉 修, 島田 紀子, 工藤 雄大, 長 由扶子, 山下 まり, 此木 敬一
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 陸上テトロドトキシンの生合成解明を目指した有毒イモリ由来の新規化合物の探索2022

    • Author(s)
      工藤雄大, 山下まり
    • Organizer
      日本農芸化学会2022年度大会シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] STX骨格C11位への第三級水酸基導入法の開発および新規STX誘導体の合成2022

    • Author(s)
      濡木絢斗, 高柳優夏, 星 美波, 石塚 颯, 千葉 修, 広川貴次, 此木敬一, 山下まり, 長澤和夫
    • Organizer
      日本化学会第102春季大会(2022)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 12β-deoxysaxitoxinの藍藻Dolichospermum circinale (TA04) および渦鞭毛藻_Alexandrium pacificum (Group IV)からの同定2022

    • Author(s)
      山下まり, 赤松みちる, 長 由扶子, 此木敬一, 工藤雄大, 大島泰克
    • Organizer
      令和4年度日本水産学会春季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 渦鞭毛藻における麻痺性貝毒の生合成2022

    • Author(s)
      長 由扶子, 日出間 志寿, 大村 卓朗, 土屋 成輝, 小池 一彦, 小池 香苗, 及川 寛, 此木 敬一, 大島 泰克, 山下 まり
    • Organizer
      令和4年度日本水産学会春季大会ミニシンポジウム フグ毒と麻痺性貝毒の産生と動態に 関する研究の現状と展望
    • Related Report
      2021 Annual Research Report
  • [Presentation] 渦鞭毛藻細胞における麻痺性貝毒成分の蛍光標識アプタマーによる可視化法の検討2022

    • Author(s)
      長 由扶子, 大村 卓朗, 小池一彦, 此木 敬一, 大島 泰克, 山下 まり
    • Organizer
      令和4年度日本水産学会春季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Studies on Biosynthesis of Marine Toxins Based on The Chemical Structures2022

    • Author(s)
      Yotsu-Yamashita*, M.
    • Organizer
      日本化学会第102春季大会(2022)The Nakanishi Symposium on Natural Products & Bioorganic Chemistry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フグ毒テトロドトキシンの生合成経路の推定2022

    • Author(s)
      山下まり, 工藤雄大, 上山 望, Hanifin, C, T., 沼野 聡, 長 由扶子, 此木敬一
    • Organizer
      令和4年度日本水産学会春季大会ミニシンポジウム フグ毒と麻痺性貝毒の産生と動態に 関する研究の現状と展望
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヤマイモサポニン・Diosgenin 配糖体のモデル膜における膜脂質との相互作用2021

    • Author(s)
      Ondevilla, J, C., 花島 慎弥、Garza, D, L., 土川 博史、梅川 雄一、村田 道雄
    • Organizer
      第63回天然有機化合物討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Marine and Freshwater Toxins, Detection, Structure, and Pharmacology, Possible mode of action of polycavernosides, and Nav blocking activities of highly purified tetrodotoxin analogues2021

    • Author(s)
      Yotsu-Yamashita*, M., Doi, Y., Iwasaki, K., Sasaki, S., Kawashima, Y., Shimada, N., Chiba, O., Sato, K., Kudo, Y., Cho, Y., Konoki, K., Sasaki, M.
    • Organizer
      PACIFICHEM 2021, Symposium #32, Marine and Freshwater Toxins, Detection
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prediction of biosynthetic pathway towards tetrodotoxin based on the structures of its natural analogues2021

    • Author(s)
      Yotsu-Yamashita*, M., Kudo, Y., Yaegashi, Y., Numano, S., Ueyama, N., Hanifin, C., Cho, Y., Konoki, K.
    • Organizer
      PACIFICHEM 2021 Symposium #51 Biosynthesis of Natural Products
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新規三環性骨格を有するグアニジノ化合物の構造解析2021

    • Author(s)
      工藤雄大, Charles T. Hanifin, 山下まり
    • Organizer
      第32 回万有仙台シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイトトキシンの標的分子探索2021

    • Author(s)
      此木敬一, 角替俊輔, 八代田陽子, 松本健, Hanifin, C, T., A., Tong, Y., Kamaldeep, Kaur Aulakh, Habsid, A., 山下まり, Moffat, J., Boone, C., 吉田稔, 村田道雄
    • Organizer
      化学コミュニケーションのフロンティア第8回公開シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Maitotoxin による細胞膜の Blebbing の機構解明2021

    • Author(s)
      田端滉樹, 角替俊輔, 後藤萌香, 吉尾柊太郎, 長 由扶子, 村田道雄, 山下まり, 此木敬一
    • Organizer
      2021年度日本農芸化学会東北支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] テトロドトキシン含有サメハダイモリより得られた新規三環性骨格を有するグアニジノ化合物の構造解析2021

    • Author(s)
      工藤雄大, Hanifin, C, T., 長 由扶子, 此木敬一, 山下まり
    • Organizer
      第63回 天然有機化合物討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 二次元NMR long range-HSQMBCを用いた構造解析の有用性の検証2021

    • Author(s)
      工藤雄大, 海原大輔, Hanifin, C, T., 長 由扶子, 此木敬一, 山下まり
    • Organizer
      第156回 農芸化学会東北支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生合成酵素を用いたドウモイ酸類縁体の調製と構造活性相関2021

    • Author(s)
      前野優香理, 小瀧裕一, 寺田竜太, 日高將文, 長 由扶子, 此木敬一, 山下まり
    • Organizer
      2021年度日本農芸化学会東北支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Hemiaminal type saxitoxin analogues found in the scallop, Patinopecten yessoensis2021

    • Author(s)
      Yotsu-Yamashita*, M., Numano, S., Kudo, Y., Cho, Y., Konoki, K., Kaga, Y., Nagasawa, K.
    • Organizer
      9th International Conference on Harmful Algae.
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] C11位に第三級水酸基を有するSTX誘導体の合成と活性評価2021

    • Author(s)
      濡木絢斗, 高柳優夏, 石塚颯, 広川貴次, 千葉修, 此木敬一, 山下まり, 長澤和夫
    • Organizer
      第81回有機合成化学協会関東支部シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生物機能の解明を目指した天然有機化合物の網羅的合成2021

    • Author(s)
      西川俊夫
    • Organizer
      第37回有機合成化学セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Unified synthesis of aplysiatoxin/ocillatoxins, Hawaiian marine natural products. New Frontier of chemical probes exploring biology and medicine.2021

    • Author(s)
      Nishikawa, N.
    • Organizer
      The international chemical congress of PACIFIC BASIN SOCIETIES 2021
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 琉球列島におけるフグ毒保有魚の稚魚期の毒性に関する研究。2021

    • Author(s)
      伊藤正晟、古川理紗子、尾山輝、佐藤雅哉、周防玲、杉田治男、中東亮太、榊原良、安立昌篤、西川俊夫、高谷智裕、荒川修、糸井史朗
    • Organizer
      第21回マリンバイオテクノロジー学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] フグ毒保有生物オオツノヒラムシの産卵生態に及ぼす水温の影響。2021

    • Author(s)
      尾山輝、岡部泰基、周防玲、杉田治男、安立昌篤、西川俊夫、糸井史郎
    • Organizer
      令和3年度日本水産学会秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ステロイド系天然物フィサリン類の合成研究-CDE環の生合成類似合成-。2021

    • Author(s)
      新木悠介、中崎敦夫、西川俊夫
    • Organizer
      第63回天然有機化合物討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マタタビ反応中のネコが葉を舐め噛む行動は葉から防蚊活性物質の放出を促進する。2021

    • Author(s)
      上野山怜子、宮崎珠子、安立正篤、西川俊夫、宮崎雅雄
    • Organizer
      2021年度日本味と匂学会第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 植物病原菌が作り出す新奇サイトカイニンの構造と機能の解明。2021

    • Author(s)
      吉野実花、Surjana, A., 小嶋美紀子、西川俊夫、榊原均
    • Organizer
      第31回イソプレノイド研究会例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] テトロドトキシンの推定生合成中間体Tb-242Cの全合成。2021

    • Author(s)
      西海眞史、安立昌篤、西川俊夫
    • Organizer
      第50回複素環化学討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 4,9-アンヒドロ-10-ヘミケタール-5-デオキシテトロドトキシンの合成研究。2021

    • Author(s)
      宮坂忠親、安立昌篤、西川俊夫
    • Organizer
      第52回 中部化学関係学協会支部連合秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発。2021

    • Author(s)
      波田航平、新木悠介、花木祐輔、野倉吉彦、西川俊夫
    • Organizer
      第119回有機合成シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] テトロドトキシン推定生合成中間体4,9-アンヒドロ-10-ヘミケタール-5-デオキシテトロドトキシンの8-デオキシアナログの合成。2021

    • Author(s)
      宮坂忠親、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生命分子の形と働きー構造決定後の天然物化学ー2021

    • Author(s)
      村田 道雄
    • Organizer
      日本化学会 第101春季年会(2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Membrane interaction and disrupting activity of the triterpenoid saponin ginsenoside Rh2 to cholesterol and sphingomyelin-containing liposomes2021

    • Author(s)
      Darcy Lacanilao Garza, Michio Murata, Shinya Hanashima
    • Organizer
      日本化学会 第101春季年会(2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Diosgenin-Induced Physicochemical Effects on Phospholipid Bilayers in Comparison with Cholesterol2021

    • Author(s)
      Joan Candice Ondevilla, Shinya Hanashima, Yuichi Umegawa, Michio Murata
    • Organizer
      日本化学会 第101春季年会(2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Stereochemical determination of marine toxin spirolide homologues based on efficient synthesis of the 7,6-spirocyclic imine moiety.2020

    • Author(s)
      Kou Minamino, Sho Hayashi, Michio Murata, Noriko Shimada, Keiichi Konoki, Hiroshi Tsuchikawa.
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prediction of biosynthetic pathways of tetrodotoxin and saxitoxin on the basis of the structures of their intermediates.2020

    • Author(s)
      Mari Yotsu-Yamashita
    • Organizer
      American Society of Pharmacognosy, the Natural Product Science Webinars
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Efficient Synthesis of 7,6-Spirocyclic Imine and Stereochemical Determination of Marine Toxin Spirolide Homologues.2020

    • Author(s)
      MINAMINO, Kou; TSUCHIKAWA, Hiroshi; MURATA, Michio; SHIMADA, Noriko; KONOKI, Keiichi
    • Organizer
      日本化学会 第100春季年会 (2020)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthesis and Biological activities of Aplysiatozin/Oscillatoxin Marine Natural Products.2019

    • Author(s)
      Toshio Nishikawa
    • Organizer
      Marine biotechnology Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemistry-based approach to lipid-protein interactions.2019

    • Author(s)
      Murata, M., Yano, Y., Yasuda, T., Umegawa, U., Tsuchikawa, H., Hanashima, S.
    • Organizer
      ICBL
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] テトロドトキシン類縁体の電位依存性Naチャネル阻害活性と生合成経路の推定2019

    • Author(s)
      山下まり
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中間体に基づく海洋生物毒の生合成研究2019

    • Author(s)
      山下まり
    • Organizer
      東京大学大学院薬学系研究科天然物化学教室セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 海洋天然毒の作用機序解明2019

    • Author(s)
      此木敬一
    • Organizer
      生物有機化学講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 天然物の網羅的合成による新たな生物機能の解明を目指して2019

    • Author(s)
      西川俊夫
    • Organizer
      第54回天然物化学談話会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新たな生物活性の発見を目指した天然物の網羅的合成2019

    • Author(s)
      西川俊夫
    • Organizer
      神奈川大学上村大輔特別招聘教授を囲む会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新たな生物活性の発見を目指した天然物の網羅的合成2019

    • Author(s)
      西川俊夫
    • Organizer
      日本薬学会関東支部第44回学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 古細菌脂質 PGP-Me が形成する二重膜の構造解析による特徴的な膜物性の解明2019

    • Author(s)
      土川博史
    • Organizer
      第 3 回 生体膜と生体モデル膜セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 天然物リガンドの合成を基盤とした脂質二重膜および膜タンパク質との相互作用解析2019

    • Author(s)
      土川博史
    • Organizer
      理工学部講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 膜脂質の構造・動態および膜タンパク質との相互作用2019

    • Author(s)
      村田道雄
    • Organizer
      日本学術振興会回折構造生物第169委員会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Analysis of Inhibitory Mechanism of Bafilomycin against Vacuolar-type ATPase by Solid-state NMR.2019

    • Author(s)
      Hiroshi Tsuchikawa
    • Organizer
      GRC-Osaka U Bilateral Symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] メチル分岐アシル基含有リン脂質DPhPCが示す二重膜の安定性を担う分子配向・配座の解明2019

    • Author(s)
      斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄、篠田渉
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アミロイドペプチドへの結合モチーフとしての各種梯子状ポリエーテル化合物の評価と相互作用についての考察2019

    • Author(s)
      Xiong Weiqi・土川 博史・原 利明・村田 道雄・佐竹 真幸
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スピロイミン環を有する海洋天然物の生物活性中心構造の合成とそのニコチン性アセチルコリン受容体阻害能の評価2019

    • Author(s)
      南野 宏・土川 博史・村田 道雄・此木 敬一
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chemical Communication between Lipids and Proteins in Archaeal Membrane.2019

    • Author(s)
      Hiroshi Tsuchikawa, Masaki Yamagami, Yuichi Umegawa, Sho Kato, Jin Cui, Satoshi Kawatake, Shigeru Matsuoka, Sangjae Seo, Wataru Shinoda, Michio Murata.
    • Organizer
      新学術領域研究(研究領域提案型)「化学コミュニケーションのフロンティア」第1回国際シンポジウム(ISCC2019)(第4回公開シンポジウム)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chartelline Cの全合成研究2019

    • Author(s)
      中根嘉祈、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テトロドトキシンの推定生合成中間体の全合成と絶対立体配置の決定2019

    • Author(s)
      宮坂忠親、安立昌篤、工藤雄大、杉本敬太、山下まり、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RCAI-56のα-カルバガラクトース部分の新規合成法2019

    • Author(s)
      牛田直輝、永井伸和、石井保之、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クランベシンB単純化アナログの合成研究2019

    • Author(s)
      毛利春輔、山下まり、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chaxine類とその類縁体の合成研究2019

    • Author(s)
      二木美咲、平田裕嗣、中崎敦夫、呉 静、河岸洋和、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ジャガイモシスト線虫孵化促進物質ソラノエクレピンA左側部分の合成研究2019

    • Author(s)
      立松怜史、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 天然物の網羅的合成と新生物機能の解明2019

    • Author(s)
      西川俊夫、中崎敦夫、安立昌篤
    • Organizer
      日本農芸化学会2019年度大会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 高純度テトロドトキシン類縁体の調製2019

    • Author(s)
      山下まり, 佐藤恭佳, 工藤雄大, 長由扶子, 此木敬一
    • Organizer
      平成31年度公益社団法人日本水産学会春季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 渦鞭毛藻の麻痺性貝毒生合成に対する 5-ethynyl-2’-deoxyuridine の影響と作用点2019

    • Author(s)
      長由扶子, 土屋成輝, 大村卓朗, 小池一彦, 此木敬一, 大島泰克, 山下まり
    • Organizer
      平成31年度公益社団法人日本水産学会春季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホタテガイ中腸腺のオカダ酸アシル化酵素の探索に向けた活性測定法の開発2019

    • Author(s)
      寺内将斗, 古用幸愛, 長由扶子, 山下まり, 此木敬一
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するサキシトキシン誘導体の阻害活性評価2019

    • Author(s)
      山田智士, 安達栞菜, 長由扶子, 山下まり, 此木敬一, 長澤和夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ソロモン諸島産の海洋生物中のNav阻害活性物質の探索2019

    • Author(s)
      春日政人, Clyde Gorapava Puilingi, 角替俊輔, 中崎敦夫, 長由扶子, 西川俊夫, 此木 敬一, 山下 まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するサキシトキシン誘導体の阻害活性評価2019

    • Author(s)
      山田智士, 安達栞菜, 長由扶子, 山下まり, 此木敬一, 長澤 和夫
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カイニン酸新規類縁体の探索及び生合成経路の推定2019

    • Author(s)
      前野優香理, 寺田竜太, 小瀧裕一, 長由扶子, 此木敬一, 山下まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 東日本で養殖したホタテガイ中のLC-MS/MSによる麻痺性貝毒分析2019

    • Author(s)
      沼野聡, 工藤雄大, 長由扶子, 此木敬一, 山下まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 渦鞭毛藻におけるサキシトキシン生合成の15N同位体標識硝酸ナトリウムを用いたメタボロミクス解析2019

    • Author(s)
      長由扶子, 土屋成輝, 大村卓朗, 小池一彦, 及川寛, 此木敬一, 大島泰克, 山下まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 陸上由来のテトロドトキシン新規類縁体、生合成関連化合物の構造と生理活性2019

    • Author(s)
      工藤雄大, 山下まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テトロドトキシン推定生合成中間体のテトロドトキシン含有生物への投与2019

    • Author(s)
      杉本敬太, 工藤雄大, 宮坂忠親, 安立昌篤, 長由扶子, 此木敬一, 千葉親文, 西川俊夫, 山下まり
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1,3-双極子付加環化反応を用いたゼテキトキシン ABのC11位-C15位構造の構築2019

    • Author(s)
      安達栞菜, 石塚颯, 星美波, 山下まり, 長澤和夫
    • Organizer
      日本化学会第99春季年会2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] C11位に着目した新規サキシトキシン誘導体の合成及びパッチクランプ法を用いたNaチャネル阻害活性評価2019

    • Author(s)
      星美波, 安達栞菜, 山田智士, 大木麻菜, 石塚颯, 此木敬一, 山下まり, 長澤和夫
    • Organizer
      日本化学会第99春季年会2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sensitivity of the voltage-gated sodium channel subtypes, Nav1.1 to Nav1.7, against guanidine-containing natural products and their analogues.2019

    • Author(s)
      Tadaaki Tsukamoto, Yukie Chiba, Shunsuke Tsunogae, Tomoshi Yamada, Yuko Cho, Ryo Sakakibara, Takuya Imazu, Shouta Tokoro, Yoshiki Satake, Yuki Ishikawa, Yoshiki Nakane, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Minoru Wakamori, Mari Yotsu-Yamashita, Keiichi Konoki.
    • Organizer
      新学術領域研究(研究領域提案型)「化学コミュニケーションのフロンティア」第1回国際シンポジウム(ISCC2019)(第4回公開シンポジウム)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Collective Synthesis of Chaxines, Novel Steroidal Natural Products Isolated from Chinese Edible Mushroom.2018

    • Author(s)
      Toshio Nishikawa, Misaki Niki, Yushi Hirata, Atsuo Nakazaki, Hidenori Kawagishi.
    • Organizer
      The 14th International Kyoto Conference on New Aspect of Organic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物の網羅的合成と生物機能の解明2018

    • Author(s)
      西川俊夫
    • Organizer
      第5回ケミカルバイオロジーセミナーin信州大学農学部
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] クランベシンB脱炭酸体アナログの合成研究2018

    • Author(s)
      毛利春輔、中崎敦夫、西川俊夫
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ぺラミンの効率的合成法の開発2018

    • Author(s)
      伊藤晋作、山本雄太、西川俊夫
    • Organizer
      日本農芸化学会中部支部第183回支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chaxine類とその類縁体の合成研究2018

    • Author(s)
      二木美咲、平田裕嗣、中崎敦夫、呉静、河岸洋和、西川俊夫
    • Organizer
      日本農芸化学会中部支部第183回支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RCAI-56のα-カルバガラクトース部分の新規合成法2018

    • Author(s)
      牛田直輝、永井伸和、石井保之、西川俊夫
    • Organizer
      日本プロセス化学会 2018 サマーシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 天然物の効率的合成のための新合成方法論の開発2018

    • Author(s)
      西川俊夫
    • Organizer
      平成30年度有機合成セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] テトロドトキシン推定生合成中間体の合成研究2018

    • Author(s)
      宮坂忠親、安立昌篤、杉本敬太、山下まり、西川俊夫
    • Organizer
      第113回有機合成シンポジウム2018年
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホタテガイ中腸腺に存在するオカダ酸アシル化酵素の探索法の開発2018

    • Author(s)
      寺内将斗, 古用幸愛, 長由扶子, 山下まり, 此木敬一
    • Organizer
      日本農芸化学会東北・北海道合同支部大会(東北支部第153回大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイトトキシンの膜透過性亢進作用の機構解明に向けた電気生理学的アプローチ2018

    • Author(s)
      山田智士, 岩本真幸, 長由扶子, 老木成稔, 村田道雄, 山下まり, 此木敬一
    • Organizer
      日本農芸化学会東北・北海道合同支部大会(東北支部第153回大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイトトキシンの膜透過性亢進作用の機構解明に向けた電気生理学的アプローチ2018

    • Author(s)
      寺内将斗, 古用幸愛, 長由扶子, 山下まり, 此木敬一
    • Organizer
      日本農芸化学会東北・北海道合同支部大会(東北支部第153回大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] テトロドトキシン類縁体に対する電位依存性ナトリウムチャネルの感受性評価2018

    • Author(s)
      塚本匡顕, 千葉雪絵, 若森実, 日高將文, 山田智士, 角替俊輔, 長由扶子, 榊原良, 今津拓也, 所聖太, 佐竹佳樹, 安立昌篤, 西川俊夫, 山下まり, 此木敬一
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bioconversion of putative biosynthetic intermediates of amnesic shellfish toxin, domoic acid, in the diatom Pseudo-nitzschia multiseries.2018

    • Author(s)
      Yukari Maeno, Yuichi Kotaki, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita.
    • Organizer
      Tohoku University's Chemistry Summer School
    • Related Report
      2018 Annual Research Report
  • [Presentation] Screening for bioactive compounds in marine organisms collected in the Solomon Islands.2018

    • Author(s)
      Masato Kasuga, Clyde Gorapava Puilingi, Atsuo Nakazaki, Shunsuke Tsunogae, Yuko Cho, Keiichi Konoki, Toshio Nishikawa, Mari Yotsu-Yamashita.
    • Organizer
      Tohoku University's Chemistry Summer School
    • Related Report
      2018 Annual Research Report
  • [Presentation] 記憶喪失性貝毒ドウモイ酸の新規生合成中間体の同定と生合成経路の解明2018

    • Author(s)
      前野優香理, 小瀧裕一, 寺田竜太, 長由扶子, 此木敬一, 山下まり
    • Organizer
      第29回 万有仙台シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of seven possible biosynthetic intermediates of tetrodotoxin in marine environments isolated from pufferfish.2018

    • Author(s)
      Mari Yotsu-Yamashita*, Nozomi Ueyama, Keita Sugimoto, Yuji Yaegashi, Yuta Kudo, Ken-ichi Onodera, Yuko Cho, Keiichi Konoki, Toshio Nishikawa.
    • Organizer
      18th International conference on Harmful Algae, Nantes, France
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Usefulness of column switching HILIC-MS and 15N-labeled inorganic nitrogen for the study of STX biosynthesis in dinoflagellates.2018

    • Author(s)
      Yuko Cho, Shigeki Tsuchiya, Takuo Omura, Kazuhiko Koike, Hiroshi Oikawa, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita.
    • Organizer
      18th International conference on Harmful Algae, Nantes, France
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中間体を基盤とした海産毒の生合成研究2018

    • Author(s)
      山下まり
    • Organizer
      「第22回天然薬物の開発と応用シンポジウム」日本薬学会生薬天然物部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学的手法による海産毒の生合成経路の推定2018

    • Author(s)
      山下まり
    • Organizer
      2018年度農芸化学会東北支部シンポジウム 天然有機化合物が拓く新研究展開
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthesis and biological evaluation of natural product-mimicking 7,6-spirocyclic imine compounds toward a specific inhibitor of neuronal nicotinic acetylcholine receptor.2018

    • Author(s)
      MINAMINO, Kou; TSUCHIKAWA, Hiroshi; MURATA, Michio; KONOKI, Keiichi.
    • Organizer
      日本化学会第98春季年会(2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stereoselective construction of spiroacetal framework and evaluation of its thermodynamic/kinetic stability.2018

    • Author(s)
      YASUKAWA, Yoshifumi; TSUCHIKAWA, Hiroshi; MURATA, Michio.
    • Organizer
      日本化学会第98春季年会(2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Elucidation of Bafilomycin-Vacuolar-type ATPase interaction based on solid-state NMR.2018

    • Author(s)
      HAYASHI, Tatsuru; TSUCHIKAWA, Hiroshi; UMEGAWA, Yuichi; MURATA, Michio; NAGUMO, Yoko; USUI, Takeo.
    • Organizer
      日本化学会第98春季年会(2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質FABP7の選択的阻害剤の開発を目指した環状脂肪酸誘導体の合成と親和性評価2018

    • Author(s)
      永安 麻優・土川 博史・杉山 成・松岡 茂・原 利明・村田 道雄・島本 知英・吉川 武男
    • Organizer
      日本化学会第98春季年会(2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 梯子状ポリエーテル化合物のアミロイドβ凝集阻害活性および相互作用の評価2018

    • Author(s)
      Xiong Weiqi・原 利明・土川 博史・村田 道雄・佐竹 真幸
    • Organizer
      日本化学会第98春季年会(2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 網羅合成を目指した連続反応による天然物合成2018

    • Author(s)
      西川俊夫
    • Organizer
      有機合成2月セミナー“有機合成のニュートレンド2018”
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Oscillatoxin DとAplysiatoxinの統一的合成法の開発2018

    • Author(s)
      新木悠介、野倉吉彦、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] セスペンドールの合成研究2018

    • Author(s)
      小野義貴、植木佳織、Jittra Suthiwong、西川俊夫
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] テトロドトキシンのフグ誘引活性の解明を目的とした類縁体の合成研究2018

    • Author(s)
      中東亮太、安立昌篤、野口能寿、山本直之、阿部秀樹、西川俊夫
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クランベシン類縁体の合成研究2018

    • Author(s)
      毛利春輔、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クサフグ(Takifugu niphobles)におけるフグ毒類縁体に対する嗅覚感知機構2018

    • Author(s)
      野口能寿、榊原良、佐竹佳樹、安立昌篤、西川俊夫、山本直之、阿部秀樹
    • Organizer
      平成30年度日本水産学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 紅藻ハナヤナギ(Chondria armata)から同定したドウモイ酸の推定生合成中間体のLC-MS分析法の検討2018

    • Author(s)
      前野優香理,山下まり,長由扶子,此木敬一,小瀧裕一,寺田竜太
    • Organizer
      平成30年度日本水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 海洋生物における新規テトロドトキシン関連化合物の探索2018

    • Author(s)
      上山望,杉本敬太,長由扶子,此木敬一,山下まり
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロイソカイメン共生菌が生産する新規有毒二次代謝産物の構造決定2018

    • Author(s)
      菊池颯、岡田華弥、長由扶子、吉田慎一朗、權 垠相、山下まり、此木敬一
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 記憶喪失性貝毒ドウモイ酸の生合成経路に関する研究2018

    • Author(s)
      前野優香理,小瀧裕一,長由扶子,此木敬一,山下まり
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 15N同位体標識培地による渦鞭毛藻の麻痺性貝毒及び生合成中間体への15N取り込み挙動の解析2018

    • Author(s)
      長由扶子,土屋成輝,此木敬一,大島泰克,山下まり
    • Organizer
      平成30年度日本水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis of Natural Products in Bioagricultural Sciences.2017

    • Author(s)
      Toshio Nishikawa
    • Organizer
      Joint Degree Conference on “ Science and Technology Cooperation relationshio in Agriculture for Next generation”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Syntheses of Biologically Active Natural Products by Means of Cascade Reactions.2017

    • Author(s)
      Toshio Nishikawa
    • Organizer
      Seminar at CRI
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カスケード反応による天然物合成2017

    • Author(s)
      西川俊夫
    • Organizer
      九州大学公開講演会 最新化学談話シリーズ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Inagami-Tamura EDLF(内因性ジギタリス様物質)の候補化合物の化学合成2017

    • Author(s)
      中崎敦夫、橋本圭古、池田藍、柴田貴広、西川俊夫
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛍光デキストランを利用した匂い刺激に応答するクサフグ嗅上皮細胞の同定2017

    • Author(s)
      野口能寿、榊原良、佐竹佳樹、安立昌篤、西川俊夫、山本直之、阿部秀樹
    • Organizer
      日本動物学会第88回富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フグ毒テトロドトキシンの推定生合成中間体の化学合成研究2017

    • Author(s)
      宮坂忠親、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会中部支部180回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oscillatoxin D類の新規合成法の開発2017

    • Author(s)
      新木悠介、野倉吉彦、中崎敦夫、西川俊夫
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oscillatoxin DとAplysiatoxinの網羅的合成法の開発2017

    • Author(s)
      新木悠介、野倉吉彦、中崎敦夫、西川俊夫
    • Organizer
      ITbM/IGER Chemistry Workshop 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Concise Synthesis of Oscillatoxin D and its analogues.2017

    • Author(s)
      Toshio Nishikawa
    • Organizer
      The Second A3 Roundtable Meeting on Chemical Probe Research Hub
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カスケード型環化反応によるグアニジン系天然物の合成2017

    • Author(s)
      西川俊夫
    • Organizer
      東北大学天然物生命化学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フグ毒の生合成経路解明へのアプローチ2017

    • Author(s)
      山下まり
    • Organizer
      日本農芸化学会創立100周年に向けたシンポジウム、Visionary農芸化学100シンポジウム、天然物化学領域 第一回 生命現象に介在する天然物の化学
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 化学的手法による天然毒の生合成研究2017

    • Author(s)
      山下まり
    • Organizer
      第34回有機合成化学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 食中毒を引き起こす海洋生物毒と対応策の進展2017

    • Author(s)
      山下まり
    • Organizer
      5大学共同開催フォーラム第7回食の安全研究ホットトピックス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Prediction of Biosynthetic Pathways of Tetrodotoxin and Saxitoxin Based on the Structures of Intermediates.2017

    • Author(s)
      Mari Yotsu-Yamashita
    • Organizer
      The 5th Tohoku University (TU)-Dalian University of Technology (DUT) Joint Symposium on Chemistry.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Biosynthetic pathway of saxitoxin based on the structures of its intermediate.2017

    • Author(s)
      Mari Yotsu-Yamashita
    • Organizer
      The JSFS 85th Anniversary-Commemorative International Symposium “Fisheries Science for Future Generations”
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 化学的手法による天然毒の生合成研究2017

    • Author(s)
      山下まり
    • Organizer
      名古屋大学大学院生命農学研究科セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フグのテトロドトキシン関連化合物の構造と推定生合成経路2017

    • Author(s)
      上山望、杉本敬太、西川俊夫、長由扶子、此木敬一、山下まり
    • Organizer
      第28回万有仙台シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] フグの新規スピロ環状グアニジノ化合物の単離,構造決定と海産テトロドトキシンの生合成経路の推定2017

    • Author(s)
      前野優香理,山下まり,長由扶子,此木敬一,小瀧裕一,寺田竜太
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フグ由来のテトロドトキシン関連化合物の合成2017

    • Author(s)
      杉本敬太,上山望,長由扶子,此木敬一,西川俊夫,山下まり
    • Organizer
      日本農芸化学会東北支部第152回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Screening of biosynthetic intermediates of domoic acid, the causative toxin of amnesic shellfish poisoning.2017

    • Author(s)
      Yukari Ebine, Yuichi Kotaki, Ryuta Terada, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
    • Organizer
      Tohoku University's Chemistry Summer School 2017
    • Related Report
      2017 Annual Research Report
  • [Book] 古くて新しい天然物化学の課題 ネコのマタタビ反応の謎を解く。2021

    • Author(s)
      西川俊夫、上野山怜子、宮崎雅雄
    • Publisher
      現代化学
    • Related Report
      2021 Annual Research Report
  • [Book] ネコがマタタビに反応する生物学的意義の解明 マタタビ への顔の擦り付けは蚊への化学防除を可能にする。2021

    • Author(s)
      上野山怜子、西川俊夫、宮崎雅雄
    • Publisher
      化学と生物
    • Related Report
      2021 Annual Research Report
  • [Book] ネコのマタタビに対する特異的な反応は蚊に対する化学防御効果を有する。2021

    • Author(s)
      上野山怜子、西川俊夫、宮崎雅雄
    • Publisher
      AROMA RESEARCH
    • Related Report
      2021 Annual Research Report
  • [Book] 5.1 貝毒, シリーズ 水産の科学 3,カキ・ホタテガイの科学, 良永智義総編集, 尾定誠編著2019

    • Author(s)
      山下まり, 此木敬一
    • Publisher
      朝倉書店
    • ISBN
      9784254485035
    • Related Report
      2019 Annual Research Report
  • [Book] キノコから見つかった天然物チャキシンの合成. 天然物の化学II -自然からの贈り物-(上村大輔編)(科学のとびら64)2018

    • Author(s)
      西川俊夫
    • Total Pages
      186
    • Publisher
      東京化学同人
    • Related Report
      2018 Annual Research Report
  • [Remarks] 大阪大学大学院理学研究科生体分子化学研究室(村田研究室)

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 村田研究室HP

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 村田研究室・研究紹介(日本語)

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/research.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Patent(Industrial Property Rights)] α-カルバガラクトース化合物の製造方法2018

    • Inventor(s)
      牛田直樹, 西川俊夫
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2023-01-30  

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