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Chemical signals of synthetic nutrient conjugates

Planned Research

Project AreaFrontier research of chemical communications
Project/Area Number 17H06408
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

Uesugi Motonari  京都大学, 化学研究所, 教授 (10402926)

Co-Investigator(Kenkyū-buntansha) 竹本 靖  京都大学, 化学研究所, 助教 (50453543)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2021: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywordsケミカルバイオロジー / 化合物ライブラリー
Outline of Final Research Achievements

This study pioneered a new field of "artificial nutrient conjugates," which are intermediate between natural products and synthetic compounds. We chemically synthesized a library of such conjugates composed of multiple endogenous nutrients and screened it for biologically active chemical tools. We were able to delineate their underlying mechanisms of action and dissect the complex chemical communications of nutrients and metabolites.

Academic Significance and Societal Importance of the Research Achievements

本研究では、天然物と合成化合物の中間にあたる「人工栄養素結合体」という新しい分野を開拓した。例えば、血糖値を抑える栄養素結合体、ワクチンの機能を高める栄養素結合体を発見し、それらがどのようにして活性を発揮するのかを理解した。これらの成果は医薬品開発に新しい考え方を提供できるかもしれない。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (80 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (25 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 24 results,  Open Access: 2 results) Presentation (49 results) (of which Int'l Joint Research: 24 results,  Invited: 46 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Tsinghua University/Fudan University(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Fudan University(中国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Glucose as a Protein-Condensing Cellular Solute2022

    • Author(s)
      Noda, N., Jung, Y., Ado, G., Mizuhata, Y., Higuchi, M., Ogawa, T., Ishidate, F., Sato, S., Kurata, H., Tokitoh, N., Uesugi, M.
    • Journal Title

      ACS Chem. Biol.

      Volume: 17 Issue: 3 Pages: 567-575

    • DOI

      10.1021/acschembio.1c00849

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe2022

    • Author(s)
      Jung, Y., Noda, N., Takaya, J., Abo, M., Toh, K., Tajiri, K., Cui, C., Zhou, L., Sato, S., Uesugi, M.
    • Journal Title

      ACS Chem. Biol.

      Volume: 17 Issue: 2 Pages: 340-347

    • DOI

      10.1021/acschembio.1c00824

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite2022

    • Author(s)
      Mendoza, A., Takemoto, Y., Cruzado, KT., Masoud, SS., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M.
    • Journal Title

      Cell Chem Biol.

      Volume: 29 Issue: 4 Pages: 660-669

    • DOI

      10.1016/j.chembiol.2021.08.008

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis2021

    • Author(s)
      Takemoto Yasushi、Kadota Shin、Minami Itsunari、Otsuka Shinya、Okuda Satoshi、Abo Masahiro、Punzalan Louvy Lynn、Shen Yan、Shiba Yuji、Uesugi Motonari
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 40 Pages: 21824-21831

    • DOI

      10.1002/anie.202100523

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo2021

    • Author(s)
      Kawagoe, F., Mendoza, A., Hayata, Y., Asano, L., Kotake, K., Mototani, S., Kawamura, S., Kurosaki, S., Akagi, Y., Takemoto, Y., Nagasawa, K., Nakagawa, H., Uesugi, M., Kittaka, A.
    • Journal Title

      J Med Chem.

      Volume: 64 Issue: 9 Pages: 5689-5709

    • DOI

      10.1021/acs.jmedchem.0c02179

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Light‐Controlled Tyrosine Nitration of Proteins2021

    • Author(s)
      Long, T., Liu, L., Tao, Y., Zhang, W., Quan, J., Zheng, J., Hegemann, JD., Uesugi, M., Yao, W., Tian, H., Wang, H.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 60 Issue: 24 Pages: 13414-13422

    • DOI

      10.1002/anie.202102287

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differential diagnosis of vitamin D‐related hypercalcemia using serum vitamin D metabolite profiling2021

    • Author(s)
      Kaufmann, M., Schlingmann, K-P., Berezin, L., Molin, A., Sheftel, J., Vig, M., Gallagher, JC., Nagata, A., Masoud, SS., Sakamoto, R., Nagasawa, K., Uesugi, M., Kottler, ML., Konrad, M., Jones, G.
    • Journal Title

      JBMR

      Volume: 36 Issue: 7 Pages: 1340-1350

    • DOI

      10.1002/jbmr.4306

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts2021

    • Author(s)
      Li, Q., Meissner, TB., Wang, F., Du, Z., Ma, S., Kshirsagar, S., Tilburgs, T., Buenrostro, JD., Uesugi, M., Strominger, JL.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 118 Issue: 9

    • DOI

      10.1073/pnas.2025512118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue2021

    • Author(s)
      Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M.
    • Journal Title

      Chem Commun.

      Volume: 57 Issue: 12 Pages: 1470-1473

    • DOI

      10.1039/d0cc07171d

    • NAID

      120007002689

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants2020

    • Author(s)
      Jin Shuyu、Vu Hue Thi、Hioki Kou、Noda Naotaka、Yoshida Hiroki、Shimane Toru、Ishizuka Shigenari、Takashima Ippei、Mizuhata Yoshiyuki、Beverly Pe Kathleen、Ogawa Tetsuya、Nishimura Naoya、Packwood Daniel、Tokitoh Norihiro、Kurata Hiroki、Yamasaki Sho、Ishii Ken J.、Uesugi Motonari
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 2 Pages: 961-969

    • DOI

      10.1002/anie.202011604

    • NAID

      120006958092

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor2020

    • Author(s)
      Ito Daishi、Kawazoe Yoshinori、Sato Ayato、Uesugi Motonari、Hirata Hiromi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41598-020-70983-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library2020

    • Author(s)
      Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi
    • Journal Title

      Cell Chemical Biology

      Volume: 27 Issue: 6 Pages: 708-718

    • DOI

      10.1016/j.chembiol.2020.04.007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule.2020

    • Author(s)
      Zhang, X., Jiang, L., Huang, K., Fang, C., Li, J., Yang, J., Li, H., Ruan, X., Wang, P., Mo, M., Wu, O., Xu, Y., Peng, C., Uesugi, M., Ye, D.*, Yu, FX.*, Zhou, L.*
    • Journal Title

      ACS Chem. Biol.

      Volume: 15 Issue: 3 Pages: 632-639

    • DOI

      10.1021/acschembio.9b00962

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of a Small-Molecule-Dependent Photolytic Peptide2020

    • Author(s)
      Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Goetze, Shin-ichi Sato, Motonari Uesugi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 3 Pages: 1142-1146

    • DOI

      10.1021/jacs.9b09178

    • NAID

      120006813278

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ケミカルバイオロジーが切り開くビタミンD3の新機能2020

    • Author(s)
      竹本靖、上杉志成
    • Journal Title

      日本農芸化学会機関誌「化学と生物」

      Volume: 58 Pages: 141-142

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators2019

    • Author(s)
      Furuta Tomoyuki、Mizukami Yuya、Asano Lisa、Kotake Kenjiro、Ziegler Slava、Yoshida Hiroki、Watanabe Mizuki、Sato Shin-ichi、Waldmann Herbert、Nishikawa Makiya、Uesugi Motonari
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Issue: 9 Pages: 1860-1865

    • DOI

      10.1021/acschembio.9b00444

    • NAID

      120006769193

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment2019

    • Author(s)
      Takashima Ippei、Kusamori Kosuke、Hakariya Hayase、Takashima Megumi、Vu Thi Hue、Mizukami Yuya、Noda Naotaka、Takayama Yukiya、Katsuda Yousuke、Sato Shin-ichi、Takakura Yoshinobu、Nishikawa Makiya、Uesugi Motonari
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Issue: 4 Pages: 775-783

    • DOI

      10.1021/acschembio.9b00109

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis of 23-hydroxylated vitamin D3 metabolites2019

    • Author(s)
      Kawagoe Fumihiro、Sugiyama Toru、Yasuda Kaori、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: 186 Pages: 161-168

    • DOI

      10.1016/j.jsbmb.2018.10.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis2019

    • Author(s)
      Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
    • Journal Title

      Oncogene

      Volume: in press Issue: 22 Pages: 4283-4296

    • DOI

      10.1038/s41388-019-0718-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity2018

    • Author(s)
      Ohkanda Junko,Kusumoto Atsushi,Punzalan Louvy,Masuda Ryoma,Wang Chenyu,Parvatkar Prakash,Akase Dai,Aida Misako,Uesugi Motonari,Higuchi Yusuke,Kato Nobuo
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 60 Pages: 16066-16071

    • DOI

      10.1002/chem.201804428

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array2018

    • Author(s)
      Mashimo, Y., Yoshioka, M., Tokunaga, Y., Fockenberg, C., Terada, S., Koyama, Y., Shibata-Seki, T., Yoshimoto, K., Sakai, R., Hakariya, H., Liu, L., Akaike, T., Kobatake, E., How, SE., Uesugi, M., Chen, Y., Kamei, KI.
    • Journal Title

      Journal of Visualized Experiments

      Volume: - Issue: 139

    • DOI

      10.3791/57377

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules2018

    • Author(s)
      Li, Q., Yoshimura, H., Komiya, M., Tajiri, K., Uesugi, M., Hata, Y., Ozawa, T.
    • Journal Title

      The Analyst

      Volume: 143 Issue: 14 Pages: 3472-3480

    • DOI

      10.1039/c8an00285a

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics2018

    • Author(s)
      Yatsuzuka Kenji、Sato Shin-ichi、Pe Kathleen Beverly、Katsuda Yousuke、Takashima Ippei、Watanabe Mizuki、Uesugi Motonari
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 52 Pages: 7151-7154

    • DOI

      10.1039/c8cc03805h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.2018

    • Author(s)
      Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M.
    • Journal Title

      J Biol Chem.

      Volume: 印刷中 Issue: 21 Pages: 8285-8294

    • DOI

      10.1074/jbc.ra118.002316

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical decontamination of iPS cell-derived neural cell mixtures2018

    • Author(s)
      Mao Di、Chung Xie Khim Watson、Andoh-Noda Tomoko、Qin Ying、Sato Shin-ichi、Takemoto Yasushi、Akamatsu Wado、Okano Hideyuki、Uesugi Motonari
    • Journal Title

      Chem Commun (Camb). 1355

      Volume: 54 Issue: 11 Pages: 1355-1358

    • DOI

      10.1039/c7cc08686e

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 光反応性プローブを用いた生理活性小分子化合物の標的同定2022

    • Author(s)
      竹本 靖
    • Organizer
      JT講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 栄養素結合体の化学コミュニケーション2021

    • Author(s)
      上杉 志成
    • Organizer
      新学術領域研究(研究領域提案型)「化学コミュニケーションのフロンティア」第8回公開シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 自己集合性ワクチンアジュバントの発見2021

    • Author(s)
      上杉 志成
    • Organizer
      第94回日本生化学会大会 創薬を志向したケミカルバイオロジー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Self-Assembling Bioactive Small Molecules2021

    • Author(s)
      Motonari Uesugi
    • Organizer
      Pacifichem2021: New Frontier of Chemical Probes Exploring Biology and Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of Protein Targets of Lactone-Vitamin D32021

    • Author(s)
      Motonari Uesugi
    • Organizer
      Pacifichem2021: Drug-Discovery Based on Natural Products Chemistry; Isolation, Synthesis, and Biosynthesis
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-Assembling Bioactive Small Molecules2021

    • Author(s)
      Motonari Uesugi
    • Organizer
      ACBI 2021 Online Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生理活性化合物の新しい世界2020

    • Author(s)
      上杉 志成
    • Organizer
      近畿化学協会合成部会 令和2年度第1回合成フォーラム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Lipid Control by Vitamin D2020

    • Author(s)
      Motonari Uesugi
    • Organizer
      The 8th Seoul Symposium on Bone Health (SSBH)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自己集合性ワクチンアジュバントの発見2020

    • Author(s)
      上杉 志成
    • Organizer
      化学コミュニ第2回領域リトリート
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New Directions of Chemical Biology: Self-Assembling Chemicals as New Vaccine Adjuvants2020

    • Author(s)
      Motonari Uesugi
    • Organizer
      Fudan University International Academic Forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-Assembling Bioactive Small Molecules2020

    • Author(s)
      Motonari Uesugi
    • Organizer
      Shanghai-Kyoto Chemistry Forum 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生理活性合成化合物の新しい世界2020

    • Author(s)
      上杉 志成
    • Organizer
      日本薬学会 北陸支部特別講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生理活性合成化合物の新しい世界2020

    • Author(s)
      上杉 志成
    • Organizer
      神奈川大学講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] New Opportunities of Synthetic Bioactive Molecules2020

    • Author(s)
      Motonari Uesugi
    • Organizer
      IIT Bombay Research Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Opportunities of Synthetic Bioactive Molecules2020

    • Author(s)
      Motonari Uesugi
    • Organizer
      CSIR-Indian Institute of Chemical Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Small Molecules That Control Energy Metabolism2019

    • Author(s)
      Motonari Uesugi
    • Organizer
      8th Annual Conference of International Chemical Biology Society (ICBS-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Opportunities of Synthetic Bioactive Molecules2019

    • Author(s)
      Motonari Uesugi
    • Organizer
      First Forum on Biomedical Research & Innovation by iCeMS, Kyoto University and Shenyang Pharmaceutical University
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生理活性合成化合物の新しい世界2019

    • Author(s)
      上杉 志成
    • Organizer
      東京大学農学部講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 人工ビタミン D3 の創出と応用2019

    • Author(s)
      竹本靖、上杉志成
    • Organizer
      新学術領域研究(研究領域提案型) 「化学コミュニケーションのフロンティア」 第5回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 小分子化合物依存的な光分解性ペプチドの発見2019

    • Author(s)
      竹本靖、上杉志成
    • Organizer
      新学術領域研究(研究領域提案型) 「化学コミュニケーションのフロンティア」 第6回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Small Molecules That Control Energy Metabolism2019

    • Author(s)
      Motonari Uesugi
    • Organizer
      2019 Queenstown Molecular Biology (QMB) Meetings in Shanghai
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生理活性合成化合物の新しい世界2019

    • Author(s)
      上杉 志成
    • Organizer
      第42回白金シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthetic Molecules That Control Energy Metabolism2019

    • Author(s)
      Motonari Uesugi
    • Organizer
      2nd SPIRITS Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Small Molecules That Control Energy Metabolism2019

    • Author(s)
      Motonari Uesugi
    • Organizer
      The 1st International Symposium on the Chemical Communications (ISCC2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Small Molecules That Control Energy Metabolism2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      Special Seminar, Nanjing University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nutrient-Oriented Peptide Library as a Source of Energy Metabolism Modulators2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Small Molecules That Control Energy Metabolism2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      A3 Lecture, Zhejiang University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エネルギー代謝を制御する小分子化合物2018

    • Author(s)
      上杉 志成
    • Organizer
      第4回Neo Vitamin D Workshop
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      BOSS XVI - 16th Belgian Organic Synthesis Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Small Molecules That Control Lipid Homeostasis2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      The 24th IUBMB and 15th FAOBMB Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 25‐hydroxyvitamin D and Lipid Metabolism2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      The 21st Workshop on Vitamin D
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂質代謝ケミカルバイオロジー2018

    • Author(s)
      上杉 志成
    • Organizer
      第91回 日本内分泌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] New Opportunities of Synthetic Bioactive Molecules2018

    • Author(s)
      Motonari Uesugi
    • Organizer
      POSTECH Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthetic Small-Molecule Tools for Cell Biology2017

    • Author(s)
      Uesugi, M.
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 6th Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞を操る合成化合物2017

    • Author(s)
      上杉 志成
    • Organizer
      第27回 万有福岡シンポジウム 革新的新薬・新物質の創製 今こそ有機化学の力を結集せよ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chemical Biology Research: Basics and Examples2017

    • Author(s)
      Uesugi, M.
    • Organizer
      Amgen Scholars Program Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ケミカルバイオロジーが拓く研究と教育の世界2017

    • Author(s)
      上杉 志成
    • Organizer
      長野県科学教育研究大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ビタミンDによる脂質代謝調節2017

    • Author(s)
      上杉 志成
    • Organizer
      第64回日本栄養改善学会学術集会 日本栄養改善学会・日本ビタミン学会合同シンポジウム 「ビタミン・ミネラル研究の最前線」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chemical Biology Research: Basics and Examples2017

    • Author(s)
      Uesugi, M.
    • Organizer
      Special Lecture, UST Biochemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Biology Research: Basics and Examples2017

    • Author(s)
      Uesugi, M.
    • Organizer
      Special Lecture, University of the Philippines, Diliman
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 面白いの法則2017

    • Author(s)
      上杉 志成
    • Organizer
      早稲田大学講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 細胞を操る合成化合物2017

    • Author(s)
      上杉 志成
    • Organizer
      平成29年度秋季(後期)有機合成化学講習会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Synthetic Small-Molecule Tools for Cell Biology and Cell Therapy2017

    • Author(s)
      Uesugi, M.
    • Organizer
      AFPS2017 Integration, Improvement and Innovation toward Targeted Drug Discovery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthetic Small-Molecule Tools for Cell Biology2017

    • Author(s)
      Uesugi, M.
    • Organizer
      The Second A3 Roundtable Meeting on Asia Chemical Probe Research Hub
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells2017

    • Author(s)
      上杉 志成
    • Organizer
      日本薬物動態学会第32回年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生理活性合成化合物の新しい世界2017

    • Author(s)
      上杉 志成
    • Organizer
      平成29年度クラスター・概算合同シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脂質合成を遮断する小分子化合物2017

    • Author(s)
      上杉 志成
    • Organizer
      日本農芸化学会大会2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 「おもしろい」の3法則2017

    • Author(s)
      上杉 志成
    • Organizer
      平成29年度PRIME会議「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」研究開発領域
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 細胞を操る合成化合物2017

    • Author(s)
      上杉 志成
    • Organizer
      第5回 Medical Frontier Consortium beyond the Organcentric Dogma
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Remarks] 京都大学化学研究所上杉研究室

    • URL

      https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 京都大学化学研究所・iCeMS上杉研究室

    • URL

      http://www.scl.kyoto-u.ac.jp/~uesugi/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] Nutrient Conjugates2019

    • Inventor(s)
      上杉志成、古田智行、西川元也
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-007537
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫を賦活化する自己集合体2018

    • Inventor(s)
      上杉志成、フエ・ティ・ブー、吉田大樹、山崎晶、島根徹
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-161582
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-07-04   Modified: 2023-01-30  

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