Chemical signals of synthetic nutrient conjugates

• Project Area: Frontier research of chemical communications
• Project/Area Number: 17H06408
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: Uesugi Motonari 京都大学, 化学研究所, 教授 (10402926)
• Co-Investigator(Kenkyū-buntansha): 竹本 靖 京都大学, 化学研究所, 助教 (50453543)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000); Fiscal Year 2021: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
• Keywords: ケミカルバイオロジー / 化合物ライブラリー

Outline of Final Research Achievements

This study pioneered a new field of "artificial nutrient conjugates," which are intermediate between natural products and synthetic compounds. We chemically synthesized a library of such conjugates composed of multiple endogenous nutrients and screened it for biologically active chemical tools. We were able to delineate their underlying mechanisms of action and dissect the complex chemical communications of nutrients and metabolites.

Academic Significance and Societal Importance of the Research Achievements

本研究では、天然物と合成化合物の中間にあたる「人工栄養素結合体」という新しい分野を開拓した。例えば、血糖値を抑える栄養素結合体、ワクチンの機能を高める栄養素結合体を発見し、それらがどのようにして活性を発揮するのかを理解した。これらの成果は医薬品開発に新しい考え方を提供できるかもしれない。

Research Products

• [Int'l Joint Research] Tsinghua University/Fudan University(中国)
• [Int'l Joint Research] Fudan University(中国)
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• [Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite (2022)
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  • Journal Title: Cell Chem Biol. Volume: 29 Issue: 4 Pages: 660-669
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• [Journal Article] Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis (2021)
  • Author(s): Takemoto Yasushi、Kadota Shin、Minami Itsunari、Otsuka Shinya、Okuda Satoshi、Abo Masahiro、Punzalan Louvy Lynn、Shen Yan、Shiba Yuji、Uesugi Motonari
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• [Journal Article] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo (2021)
  • Author(s): Kawagoe, F., Mendoza, A., Hayata, Y., Asano, L., Kotake, K., Mototani, S., Kawamura, S., Kurosaki, S., Akagi, Y., Takemoto, Y., Nagasawa, K., Nakagawa, H., Uesugi, M., Kittaka, A.
  • Journal Title: J Med Chem. Volume: 64 Issue: 9 Pages: 5689-5709
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• [Journal Article] Light‐Controlled Tyrosine Nitration of Proteins (2021)
  • Author(s): Long, T., Liu, L., Tao, Y., Zhang, W., Quan, J., Zheng, J., Hegemann, JD., Uesugi, M., Yao, W., Tian, H., Wang, H.
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• [Journal Article] Differential diagnosis of vitamin D‐related hypercalcemia using serum vitamin D metabolite profiling (2021)
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  • Journal Title: JBMR Volume: 36 Issue: 7 Pages: 1340-1350
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• [Journal Article] ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts (2021)
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• [Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue (2021)
  • Author(s): Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M.
  • Journal Title: Chem Commun. Volume: 57 Issue: 12 Pages: 1470-1473
  • DOI: 10.1039/d0cc07171d
  • NAID: 120007002689
  • Peer Reviewed
• [Journal Article] Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants (2020)
  • Author(s): Jin Shuyu、Vu Hue Thi、Hioki Kou、Noda Naotaka、Yoshida Hiroki、Shimane Toru、Ishizuka Shigenari、Takashima Ippei、Mizuhata Yoshiyuki、Beverly Pe Kathleen、Ogawa Tetsuya、Nishimura Naoya、Packwood Daniel、Tokitoh Norihiro、Kurata Hiroki、Yamasaki Sho、Ishii Ken J.、Uesugi Motonari
  • Journal Title: Angewandte Chemie International Edition Volume: 60 Issue: 2 Pages: 961-969
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  • NAID: 120006958092
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• [Journal Article] Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor (2020)
  • Author(s): Ito Daishi、Kawazoe Yoshinori、Sato Ayato、Uesugi Motonari、Hirata Hiromi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-8
  • DOI: 10.1038/s41598-020-70983-2
  • Peer Reviewed / Open Access
• [Journal Article] Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library (2020)
  • Author(s): Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi
  • Journal Title: Cell Chemical Biology Volume: 27 Issue: 6 Pages: 708-718
  • DOI: 10.1016/j.chembiol.2020.04.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule. (2020)
  • Author(s): Zhang, X., Jiang, L., Huang, K., Fang, C., Li, J., Yang, J., Li, H., Ruan, X., Wang, P., Mo, M., Wu, O., Xu, Y., Peng, C., Uesugi, M., Ye, D.*, Yu, FX.*, Zhou, L.*
  • Journal Title: ACS Chem. Biol. Volume: 15 Issue: 3 Pages: 632-639
  • DOI: 10.1021/acschembio.9b00962
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of a Small-Molecule-Dependent Photolytic Peptide (2020)
  • Author(s): Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Goetze, Shin-ichi Sato, Motonari Uesugi
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 3 Pages: 1142-1146
  • DOI: 10.1021/jacs.9b09178
  • NAID: 120006813278
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ケミカルバイオロジーが切り開くビタミンD3の新機能 (2020)
  • Author(s): 竹本靖、上杉志成
  • Journal Title: 日本農芸化学会機関誌「化学と生物」 Volume: 58 Pages: 141-142
• [Journal Article] Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators (2019)
  • Author(s): Furuta Tomoyuki、Mizukami Yuya、Asano Lisa、Kotake Kenjiro、Ziegler Slava、Yoshida Hiroki、Watanabe Mizuki、Sato Shin-ichi、Waldmann Herbert、Nishikawa Makiya、Uesugi Motonari
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 9 Pages: 1860-1865
  • DOI: 10.1021/acschembio.9b00444
  • NAID: 120006769193
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment (2019)
  • Author(s): Takashima Ippei、Kusamori Kosuke、Hakariya Hayase、Takashima Megumi、Vu Thi Hue、Mizukami Yuya、Noda Naotaka、Takayama Yukiya、Katsuda Yousuke、Sato Shin-ichi、Takakura Yoshinobu、Nishikawa Makiya、Uesugi Motonari
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 4 Pages: 775-783
  • DOI: 10.1021/acschembio.9b00109
  • Peer Reviewed
• [Journal Article] Concise synthesis of 23-hydroxylated vitamin D ₃ metabolites (2019)
  • Author(s): Kawagoe Fumihiro、Sugiyama Toru、Yasuda Kaori、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: 186 Pages: 161
  • DOI: 10.1016/j.jsbmb.2018.10.010
  • Peer Reviewed
• [Journal Article] Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis (2019)
  • Author(s): Nishikawa Y、Kodama Y、Shiokawa M、Matsumori T、Marui S、Kuriyama K、Kuwada T、Sogabe Y、Kakiuchi N、Tomono T、Mima A、Morita T、Ueda T、Tsuda M、Yamauchi Y、Sakuma Y、Ota Y、Maruno T、Uza N、Uesugi M、Kageyama R、Chiba T、Seno H
  • Journal Title: Oncogene Volume: in press Issue: 22 Pages: 4283-4296
  • DOI: 10.1038/s41388-019-0718-5
  • Peer Reviewed / Open Access
• [Journal Article] Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity (2018)
  • Author(s): Ohkanda Junko,Kusumoto Atsushi,Punzalan Louvy,Masuda Ryoma,Wang Chenyu,Parvatkar Prakash,Akase Dai,Aida Misako,Uesugi Motonari,Higuchi Yusuke,Kato Nobuo
  • Journal Title: Chemistry - A European Journal Volume: 24 Issue: 60 Pages: 16066-16071
  • DOI: 10.1002/chem.201804428
  • Peer Reviewed
• [Journal Article] Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array (2018)
  • Author(s): Mashimo, Y., Yoshioka, M., Tokunaga, Y., Fockenberg, C., Terada, S., Koyama, Y., Shibata-Seki, T., Yoshimoto, K., Sakai, R., Hakariya, H., Liu, L., Akaike, T., Kobatake, E., How, SE., Uesugi, M., Chen, Y., Kamei, KI.
  • Journal Title: Journal of Visualized Experiments Volume: - Issue: 139
  • DOI: 10.3791/57377
  • Peer Reviewed
• [Journal Article] A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules (2018)
  • Author(s): Li, Q., Yoshimura, H., Komiya, M., Tajiri, K., Uesugi, M., Hata, Y., Ozawa, T.
  • Journal Title: The Analyst Volume: 143 Issue: 14 Pages: 3472-3480
  • DOI: 10.1039/c8an00285a
  • Peer Reviewed
• [Journal Article] Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics (2018)
  • Author(s): Yatsuzuka Kenji、Sato Shin-ichi、Pe Kathleen Beverly、Katsuda Yousuke、Takashima Ippei、Watanabe Mizuki、Uesugi Motonari
  • Journal Title: Chemical Communications Volume: 54 Issue: 52 Pages: 7151-7154
  • DOI: 10.1039/c8cc03805h
  • Peer Reviewed
• [Journal Article] Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. (2018)
  • Author(s): Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M.
  • Journal Title: J Biol Chem. Volume: 印刷中 Issue: 21 Pages: 8285-8294
  • DOI: 10.1074/jbc.ra118.002316
  • Peer Reviewed
• [Journal Article] Chemical decontamination of iPS cell-derived neural cell mixtures (2018)
  • Author(s): Mao Di、Chung Xie Khim Watson、Andoh-Noda Tomoko、Qin Ying、Sato Shin-ichi、Takemoto Yasushi、Akamatsu Wado、Okano Hideyuki、Uesugi Motonari
  • Journal Title: Chem Commun (Camb). 1355 Volume: 54 Issue: 11 Pages: 1355-1358
  • DOI: 10.1039/c7cc08686e
  • Peer Reviewed
• [Presentation] 光反応性プローブを用いた生理活性小分子化合物の標的同定 (2022)
  • Author(s): 竹本 靖
  • Organizer: JT講演会
  • Invited
• [Presentation] 栄養素結合体の化学コミュニケーション (2021)
  • Author(s): 上杉 志成
  • Organizer: 新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第8回公開シンポジウム
  • Invited
• [Presentation] 自己集合性ワクチンアジュバントの発見 (2021)
  • Author(s): 上杉 志成
  • Organizer: 第94回日本生化学会大会 創薬を志向したケミカルバイオロジー
  • Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2021)
  • Author(s): Motonari Uesugi
  • Organizer: Pacifichem2021: New Frontier of Chemical Probes Exploring Biology and Medicine
  • Int'l Joint Research / Invited
• [Presentation] Identification of Protein Targets of Lactone-Vitamin D3 (2021)
  • Author(s): Motonari Uesugi
  • Organizer: Pacifichem2021: Drug-Discovery Based on Natural Products Chemistry; Isolation, Synthesis, and Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2021)
  • Author(s): Motonari Uesugi
  • Organizer: ACBI 2021 Online Meeting
  • Int'l Joint Research / Invited
• [Presentation] 生理活性化合物の新しい世界 (2020)
  • Author(s): 上杉 志成
  • Organizer: 近畿化学協会合成部会 令和2年度第1回合成フォーラム
  • Invited
• [Presentation] Lipid Control by Vitamin D (2020)
  • Author(s): Motonari Uesugi
  • Organizer: The 8th Seoul Symposium on Bone Health (SSBH)
  • Int'l Joint Research / Invited
• [Presentation] 自己集合性ワクチンアジュバントの発見 (2020)
  • Author(s): 上杉 志成
  • Organizer: 化学コミュニ第2回領域リトリート
  • Int'l Joint Research
• [Presentation] New Directions of Chemical Biology: Self-Assembling Chemicals as New Vaccine Adjuvants (2020)
  • Author(s): Motonari Uesugi
  • Organizer: Fudan University International Academic Forum
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: Shanghai-Kyoto Chemistry Forum 2020
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2020)
  • Author(s): 上杉 志成
  • Organizer: 日本薬学会 北陸支部特別講演会
  • Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2020)
  • Author(s): 上杉 志成
  • Organizer: 神奈川大学講演会
  • Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: IIT Bombay Research Seminar
  • Int'l Joint Research / Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: CSIR-Indian Institute of Chemical Biology
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 8th Annual Conference of International Chemical Biology Society (ICBS-2019)
  • Int'l Joint Research / Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2019)
  • Author(s): Motonari Uesugi
  • Organizer: First Forum on Biomedical Research & Innovation by iCeMS, Kyoto University and Shenyang Pharmaceutical University
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2019)
  • Author(s): 上杉 志成
  • Organizer: 東京大学農学部講演会
  • Invited
• [Presentation] 人工ビタミン D3 の創出と応用 (2019)
  • Author(s): 竹本靖、上杉志成
  • Organizer: 新学術領域研究（研究領域提案型） 「化学コミュニケーションのフロンティア」 第5回公開シンポジウム
• [Presentation] 小分子化合物依存的な光分解性ペプチドの発見 (2019)
  • Author(s): 竹本靖、上杉志成
  • Organizer: 新学術領域研究（研究領域提案型） 「化学コミュニケーションのフロンティア」 第6回公開シンポジウム
• [Presentation] Small Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 2019 Queenstown Molecular Biology (QMB) Meetings in Shanghai
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2019)
  • Author(s): 上杉 志成
  • Organizer: 第42回白金シンポジウム
  • Invited
• [Presentation] Synthetic Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 2nd SPIRITS Symposium
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2019)
  • Author(s): Motonari Uesugi
  • Organizer: The 1st International Symposium on the Chemical Communications (ISCC2019)
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: Special Seminar, Nanjing University
  • Invited
• [Presentation] Nutrient-Oriented Peptide Library as a Source of Energy Metabolism Modulators (2018)
  • Author(s): Motonari Uesugi
  • Organizer: 10th International Peptide Symposium
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Energy Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: A3 Lecture, Zhejiang University
  • Int'l Joint Research / Invited
• [Presentation] エネルギー代謝を制御する小分子化合物 (2018)
  • Author(s): 上杉 志成
  • Organizer: 第4回Neo Vitamin D Workshop
  • Invited
• [Presentation] Synthetic Molecules for Cell Biology and Cell Therapy (2018)
  • Author(s): Motonari Uesugi
  • Organizer: BOSS XVI - 16th Belgian Organic Synthesis Symposium
  • Int'l Joint Research / Invited
• [Presentation] Small Molecules That Control Lipid Homeostasis (2018)
  • Author(s): Motonari Uesugi
  • Organizer: The 24th IUBMB and 15th FAOBMB Congress
  • Int'l Joint Research / Invited
• [Presentation] 25‐hydroxyvitamin D and Lipid Metabolism (2018)
  • Author(s): Motonari Uesugi
  • Organizer: The 21st Workshop on Vitamin D
  • Int'l Joint Research / Invited
• [Presentation] 脂質代謝ケミカルバイオロジー (2018)
  • Author(s): 上杉 志成
  • Organizer: 第91回 日本内分泌学会学術総会
  • Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2018)
  • Author(s): Motonari Uesugi
  • Organizer: POSTECH Seminar
  • Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology (2017)
  • Author(s): Uesugi, M.
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 6th Symposium
  • Int'l Joint Research / Invited
• [Presentation] 細胞を操る合成化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 第27回 万有福岡シンポジウム 革新的新薬・新物質の創製 今こそ有機化学の力を結集せよ
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Amgen Scholars Program Seminar
  • Invited
• [Presentation] ケミカルバイオロジーが拓く研究と教育の世界 (2017)
  • Author(s): 上杉 志成
  • Organizer: 長野県科学教育研究大会
  • Invited
• [Presentation] ビタミンＤによる脂質代謝調節 (2017)
  • Author(s): 上杉 志成
  • Organizer: 第６４回日本栄養改善学会学術集会 日本栄養改善学会・日本ビタミン学会合同シンポジウム 「ビタミン・ミネラル研究の最前線」
  • Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Special Lecture, UST Biochemistry
  • Int'l Joint Research / Invited
• [Presentation] Chemical Biology Research: Basics and Examples (2017)
  • Author(s): Uesugi, M.
  • Organizer: Special Lecture, University of the Philippines, Diliman
  • Int'l Joint Research / Invited
• [Presentation] 面白いの法則 (2017)
  • Author(s): 上杉 志成
  • Organizer: 早稲田大学講演
  • Invited
• [Presentation] 細胞を操る合成化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度秋季（後期）有機合成化学講習会
  • Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology and Cell Therapy (2017)
  • Author(s): Uesugi, M.
  • Organizer: AFPS2017 Integration, Improvement and Innovation toward Targeted Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Small-Molecule Tools for Cell Biology (2017)
  • Author(s): Uesugi, M.
  • Organizer: The Second A3 Roundtable Meeting on Asia Chemical Probe Research Hub
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells (2017)
  • Author(s): 上杉 志成
  • Organizer: 日本薬物動態学会第32回年会
  • Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2017)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度クラスター・概算合同シンポジウム
  • Invited
• [Presentation] 脂質合成を遮断する小分子化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 日本農芸化学会大会2018
  • Invited
• [Presentation] 「おもしろい」の３法則 (2017)
  • Author(s): 上杉 志成
  • Organizer: 平成29年度PRIME会議「画期的医薬品等の創出をめざす脂質の生理活性と機能の解明」研究開発領域
  • Invited
• [Presentation] 細胞を操る合成化合物 (2017)
  • Author(s): 上杉 志成
  • Organizer: 第5回 Medical Frontier Consortium beyond the Organcentric Dogma
  • Invited
• [Remarks] 京都大学化学研究所上杉研究室
  • URL: https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php
• [Remarks] 京都大学化学研究所・iCeMS上杉研究室
  • URL: http://www.scl.kyoto-u.ac.jp/~uesugi/
• [Patent(Industrial Property Rights)] Nutrient Conjugates (2019)
  • Inventor(s): 上杉志成、古田智行、西川元也
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-007537
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 免疫を賦活化する自己集合体 (2018)
  • Inventor(s): 上杉志成、フエ・ティ・ブー、吉田大樹、山崎晶、島根徹
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-161582
  • Filing Date: 2018