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プロテオミクスをベースにした化学シグナル解析技術開発

Planned Research

Project AreaFrontier research of chemical communications
Project/Area Number 17H06412
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

長田 裕之  国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80160836)

Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2021: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywordsプロテオーム / 阻害剤 / 生物活性リガンド / プロテオミクス / 生理活性物質 / 標的同定 / proteome analysis / chemicalbiology / drug target
Outline of Annual Research Achievements

「ChemProteoBaseの拡充化・高度化、並びに、改変CETSAの開発」:昨年度に引き続きChemProteoBaseのデータベース拡充を行った。がん細胞の増殖阻害を指標にNPDepoライブラリーより探索された化合物の中から、ChemProteoBase、ならびに、細胞の形態を指標としたMorphoBaseを用いた統合表現型プロファイリング法を用いて、新規作用が予測される化合物NPD9055を見出した。MSを用いたケミカルプロテオミクスを用いて結合タンパク質の解析を行い、 NPD9055が3量体Giタンパク質に結合し、調節化合物として働くことが明らかになった(Biosci. Biotechnol. Biochem. 84: 2484-2490, 2020)。また、昨年度開発した2DE-CETSAついては、さらに解析系の改良を行うとともに、班員との共同研究を通して、新規化合物の解析をおこなった。
「有用生物活性リガンドの開発」:班員との共同研究で、光親和型固定化法で調製した化合物ビーズによる結合タンパク質の解析法を用いてMiclxinの標的分子の解析を行った。その結果、Miclxin はMIC60の阻害剤であること、β-カテニン変異がん細胞にミトコンドリアストレスを介してアポトーシスを誘導することが明らかになった(ACS Chem. Biol. 15:2195-2204, 2020)。また、シロイヌナズナとイネの塩耐性を増強する化合物FSL0260が複合体Iに結合することが明らかとなった(Sci. Rep. 10:8691, 2020)。さらに、かび毒であるテヌアゾン酸の研究の過程で、生合成酵素のケト合成酵素ドメインの立体構造を明らかにし、テヌアゾン酸の生合成反応メカニズムを解明した(J. Biol. Chem. 295: 11602-11612,2020)。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

作用標的の明らかな既知物質を用いたChemProteoBaseのデータベースの拡張やシステムの開発は順調に進んでおり、様々な標的に対応する可能性を高めている。これらの解析系を用いて生理活性物質を解析することや、それに関連したプロテオミクス の手法を用いた解析によって、共同研究を含む幾つかの成果に結びついた(Ikeda H et al, ACS Chem. Biol. 15:2195-2204, 2020, Sako K et al, Sci. Rep.10:8691, 2020, Sophonnithiprasert T et al, Heliyon 6:e05200 2020)。
昨年度構築した2-D DIGEを利用した新しい解析系2DE-CETSAを利用して、新規化合物の解析に取りかかれたことは、予想以上に計画が進んでいることを示している。さらに、解析系の最適化を進め、今までのChemProteoBaseと組み合わせることによって、より多様な標的に対応した解析が可能となることが期待される。

Strategy for Future Research Activity

1)引き続きChemProteoBaseの拡張のための既知化合物の解析を行うほか、スポットの同定情報を考慮した解析法を改良することによって、システムの改良を行う。
2)構築された2DE-CETSAの解析系については、さらに良い解析系にしていくために系の最適化を行なっていく。新規化合物の解析に応用することによって、化合物の標的タンパク質を明らかにすることを通して、解析系の有用性を示す。
3)有用生物活性リガンドの開発のために、化合物アレイによる標的ベース探索・細胞表現型に基づくセルベース探索を行い、そこで得られた化合物について、ChemProteoBase解析や2DE-CETSAの解析系を適用し、解析系の有用性を示すほか、新規化合物の標的を解析する。領域内の、慶応大学・榊原教授、理研・Dr. Boone、順天堂大学・井本教授、公募班の松本博士らと共同研究を進めているが、さらに、プロジェクト内の新規化合物の解析を行うことによって、プロジェクトに貢献する。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(125 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (16 results) Journal Article (67 results) (of which Int'l Joint Research: 28 results,  Peer Reviewed: 65 results,  Open Access: 30 results,  Acknowledgement Compliant: 3 results) Presentation (29 results) (of which Int'l Joint Research: 17 results,  Invited: 29 results) Book (7 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] マックス・プランク研究所/ザールランド大学(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 韓国生命工学研院(KRIBB)(韓国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 浙江大学/曁南大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] マレーシア科学大学(USM)(マレーシア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] マックス・プランク研究所/ザールランド大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 韓国生命工学研院(KRIBB)(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 浙江大学/曁南大学(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マレーシア科学大学(USM)(マレーシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マックス・プランク研究所/ザールランド大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 韓国生命工学研院(KRIBB)(韓国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マレーシア科学大学(USM)(マレーシア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 浙江大学/東北師範大学/曁南大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マックス・プランク研究所/ザールランド大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 韓国生命工学研院(KRIBB)(韓国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] マレーシア科学大学(USM)(マレーシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 浙江大学(中国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H6472021

    • Author(s)
      Lopez Julius Adam V.、Nogawa Toshihiko、Futamura Yushi、Aono Harumi、Hashizume Daisuke、Osada Hiroyuki
    • Journal Title

      J Antibiot

      Volume: ahead of online

    • DOI

      10.1038/s41429-021-00420-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus2021

    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 1290-1293

    • DOI

      10.1093/bbb/zbab021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?2021

    • Author(s)
      Kako S, Tabuchi M, Miyazawa K, Tanaka M, Minamoto C, Asano Y, Kimura F, Aoki Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.
    • Journal Title

      European Journal of Orthodontics

      Volume: - Pages: 658-664

    • DOI

      10.1093/ejo/cjaa067

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.2021

    • Author(s)
      Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wunsch B, Artacho-Cordon A, Nieto FR, Watanabe N, Osada H, Ziegler S, Waldmann H.
    • Journal Title

      Cell Chemical Biology

      Volume: - Pages: 1-7

    • DOI

      10.1016/j.chembiol.2021.01.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.2021

    • Author(s)
      Keiichiro Watanabe、Ariunzaya Bat-Erdene、Hirofumi Tenshin、Qu Cui、Jumpei Teramachi、Masahiro Hiasa、Asuka Oda、Takeshi Harada、Hirokazu Miki、Kimiko Sogabe、Masahiro Oura、Ryohei Sumitani、Yukari Mitsui、Itsuro Endo、Eiji Tanaka、Makoto Kawatani、Hiroyuki Osada、Toshio Matsumoto、Masahiro Abe
    • Journal Title

      Haematologica

      Volume: 106 Pages: 1172-1177

    • DOI

      10.3324/haematol.2019.244418

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator.2021

    • Author(s)
      Takao R, Sakai K, Koshino H, Osada H, Takahashi S.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Pages: 714-721

    • DOI

      10.1093/bbb/zbaa082

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase2021

    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Kiyota Hiromasa、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 126-133

    • DOI

      10.1093/bbb/zbaa035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening2021

    • Author(s)
      Rawa Mira Syahfriena Amir、Nogawa Toshihiko、Okano Akiko、Futamura Yushi、Nakamura Takemichi、Wahab Habibah A、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 69-76

    • DOI

      10.1093/bbb/zbaa051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dutomycin induces autophagy and apoptosis by targeting the serine protease Inhibitor SERPINB6.2021

    • Author(s)
      Jang M, Hara S, Kim GH, Kim SM, Son S, Kwon M, Ryoo IJ, Seo H, Kim MJ, Kim ND, Soung NK, Kwon YT, Kim BY, Osada H, Jang JH, Ko SK, Ahn JS.
    • Journal Title

      ACS Chem Biol

      Volume: 16 Pages: 360-370

    • DOI

      10.1021/acschembio.0c00889

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.2021

    • Author(s)
      Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.
    • Journal Title

      Nature Chemical Biology

      Volume: 17 Pages: 335-343

    • DOI

      10.1038/s41589-020-00676-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of 3-cinnamamido-N-substituted benzamides as potential antimalarial agents.2020

    • Author(s)
      Liu H, Futamura Y, Wu H, Ishiyama A, Zhang T, Shi T, Zheng Q, Iwatsuki M, Omura S, Zou H, Osada H.
    • Journal Title

      Med Chem

      Volume: -

    • DOI

      10.2174/1573406416666200817160708

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of a selective RelA inhibitor based on DSE-FRET screening methods.2020

    • Author(s)
      Shiroma Y, Fujita G, Yamamoto T, Takahashi RU, Kumar A, Zhang KYJ, Ito A, Osada H, Yoshida M, Tahara H.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 21 Pages: 9150-9150

    • DOI

      10.3390/ijms21239150

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues2020

    • Author(s)
      Nogawa Toshihiko、Terai Atsutaka、Amagai Keita、Hashimoto Junko、Futamura Yushi、Okano Akiko、Fujie Manabu、Satoh Noriyuki、Ikeda Haruo、Shin-ya Kazuo、Osada Hiroyuki、Takahashi Shunji
    • Journal Title

      J Nat Prod

      Volume: 83 Pages: 3598-3605

    • DOI

      10.1021/acs.jnatprod.0c00755

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.2020

    • Author(s)
      Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    • Journal Title

      Environmental Pollution

      Volume: 266 Pages: 115179-115179

    • DOI

      10.1016/j.envpol.2020.115179

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress2020

    • Author(s)
      Sophonnithiparasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R
    • Journal Title

      Heliyon

      Volume: 6

    • DOI

      10.1016/j.heliyon.2020.e05200

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics2020

    • Author(s)
      16)Kawamura, T., Futamura, Y., Shang, E., Muroi, M., Janning, P., Ueno, M., Wilke, J., Takeda, S., Kondoh, Y., Ziegler, S., Watanabe, N., Waldmann, H., Osada, H.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Pages: 2484-2490

    • DOI

      10.1080/09168451.2020.1812375

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.2020

    • Author(s)
      Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 84 Pages: 2113-2120

    • DOI

      10.1080/09168451.2020.1789445

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete2020

    • Author(s)
      Asai Shihori、Tsunematsu Yuta、Masuya Takahiro、Otaka Junnosuke、Osada Hiroyuki、Watanabe Kenji
    • Journal Title

      J Antibiot

      Volume: 73 Pages: 721-728

    • DOI

      10.1038/s41429-020-0355-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis.2020

    • Author(s)
      Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J
    • Journal Title

      Aging (Albany NY)

      Volume: 12 Pages: 13991-14018

    • DOI

      10.18632/aging.103521

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.2020

    • Author(s)
      Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M
    • Journal Title

      ACS Chem. Biol

      Volume: 15 Pages: 2195-2204

    • DOI

      10.1021/acschembio.0c00381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique features of the ketosynthase domain in a nonribosomal peptide synthetase?polyketide synthase hybrid enzyme, tenuazonic acid synthetase 12020

    • Author(s)
      Yun Choong-Soo、Nishimoto Kazuki、Motoyama Takayuki、Shimizu Takeshi、Hino Tomoya、Dohmae Naoshi、Nagano Shingo、Osada Hiroyuki
    • Journal Title

      J Biol Chem

      Volume: 295 Pages: 11602-11612

    • DOI

      10.1074/jbc.ra120.013105

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.2020

    • Author(s)
      Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 10230-10230

    • DOI

      10.1038/s41598-020-66974-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana2020

    • Author(s)
      Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 8691-8691

    • DOI

      10.1038/s41598-020-65614-9

    • NAID

      120006876594

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene2020

    • Author(s)
      Kato Sho、Motoyama Takayuki、Uramoto Masakazu、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      J Antibiot

      Volume: - Pages: 475-479

    • DOI

      10.1038/s41429-020-0295-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-942020

    • Author(s)
      Kato Sho、Motoyama Takayuki、Futamura Yushi、Uramoto Masakazu、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Tanaka Akira、Takahashi-Ando Naoko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 84 Pages: 1303-1307

    • DOI

      10.1080/09168451.2020.1725419

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes2020

    • Author(s)
      Tabuchi Akiko、Fukushima-Sakuno Emi、Osaki-Oka Kumiko、Futamura Yushi、Motoyama Takayuki、Osada Hiroyuki、Ishikawa Noemia Kazue、Nagasawa Eiji、Tokimoto Keisuke
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 84 Pages: 876-886

    • DOI

      10.1080/09168451.2020.1714421

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells.2020

    • Author(s)
      Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang JH, Ahn JS.
    • Journal Title

      J Microbiol Biotechnol

      Volume: 30 Pages: 31-37

    • DOI

      10.4014/jmb.1908.08043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Measurement of ATPase Activity of Valosin-containing Protein/p972020

    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Osada Hiroyuki、Watanabe Nobumoto
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3516

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry2020

    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Watanabe Nobumoto、Osada Hiroyuki
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3517

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.2020

    • Author(s)
      Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
    • Journal Title

      Cell Chemical Biology

      Volume: 27 Pages: 1-11

    • DOI

      10.1016/j.chembiol.2019.11.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of tooth movement by reveromycin A in OPG KO mice2020

    • Author(s)
      Minamoto C., Miyazawa K., Tabuchi M., Tanaka H., Mizuno M., Yoshizako M., Torii Y., Tamaoka Y., Asano Y., Kawatani M., Osada H., Maeda H., and Goto S.
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 157 Pages: 680-689

    • DOI

      10.1016/j.ajodo.2019.04.037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ゲノム創薬の潮流2020

    • Author(s)
      長田 裕之
    • Journal Title

      腫瘍内科

      Volume: 25 Pages: 2-8

    • Related Report
      2019 Annual Research Report
  • [Journal Article] An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s2019

    • Author(s)
      Kanoh Naoki, Kawamata-Asano Ayano, Suzuki Kana, Takahashi Yusuke, Miyazawa Takeshi, Nakamura Takemichi, Moriya Takashi, Hirano Hiroyuki, Osada Hiroyuki, Iwabuchi Yoshiharu, Takahashi Shunji
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 18023-18023

    • DOI

      10.1038/s41598-019-54473-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.2019

    • Author(s)
      Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
    • Journal Title

      Journal of Microbiological Methods

      Volume: 167 Pages: 105743-105743

    • DOI

      10.1016/j.mimet.2019.105743

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001.2019

    • Author(s)
      Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 986-990

    • DOI

      10.1038/s41429-019-0239-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647.2019

    • Author(s)
      Lopez JAV, Nogawa T, Futamura Y, Shimizu T, Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 991-995

    • DOI

      10.1038/s41429-019-0217-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and biological activity of metarhizin C, a new stereoisomer of BR-050 from a fungus Tolypocladium album RK17-F00072019

    • Author(s)
      Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 996-1000

    • DOI

      10.1038/s41429-019-0229-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.2019

    • Author(s)
      Forster T, Shang E, Shimizu K, Sanada E, Scholermann B, Huebecker B, Hahne G, Lopez-Alberca MP, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H, Waldmann H.
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2019 Pages: 5486-5496

    • DOI

      10.1002/ejoc.201900586

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stereocomplementary chemoenzymatic Pictet-Spengler reactions for formation of rare azepino-indole frameworks: Discovery of antimalarial compounds.2019

    • Author(s)
      Cai Y, Shao N, Xie H, Futamura Y, Panjikar S, Liu H, Zhu H, Osada H, Zou H.
    • Journal Title

      ACS Catal

      Volume: 9 Pages: 7443-7448

    • DOI

      10.1021/acscatal.9b01628

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies2019

    • Author(s)
      Yoshida Kazuko、Kondoh Yasumitsu、Iwahashi Fukumatsu、Nakano Takeshi、Honda Kaori、Nagano Eiki、Osada Hiroyuki
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1964-1971

    • DOI

      10.1021/acschembio.9b00453

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure2019

    • Author(s)
      Takase Shohei、Kurokawa Rumi、Kondoh Yasumitsu、Honda Kaori、Suzuki Takehiro、Kawahara Teppei、Ikeda Haruo、Dohmae Naoshi、Osada Hiroyuki、Shin-ya Kazuo、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1819-1828

    • DOI

      10.1021/acschembio.9b00410

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.2019

    • Author(s)
      Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.
    • Journal Title

      J Cell Mol Med

      Volume: 23 Pages: 6283-6294

    • DOI

      10.1111/jcmm.14514

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay2019

    • Author(s)
      Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
    • Journal Title

      J. Biochem.

      Volume: - Pages: 1-10

    • DOI

      10.1093/jb/mvz007

    • NAID

      40021952184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure characterization and action mechanism of an antiaging new compound from Gastrodia elata Blume.2019

    • Author(s)
      Farooq U, Pan Y, Lin Y, Wang Y, Osada H, Xiang L, Qi J.
    • Journal Title

      J Cell Mol Med

      Volume: 2019 Pages: 5459862-5459862

    • DOI

      10.1155/2019/5459862

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.2019

    • Author(s)
      Panthee S., Takahashi S.*, Hayashi T., Shimizu T, and Osada H.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 5802-5802

    • DOI

      10.1038/s41598-019-42268-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery and applications of nucleoside antibiotics beyond polyoxin.2019

    • Author(s)
      Osada H.
    • Journal Title

      J Antibiot

      Volume: 72 Pages: 853-854

    • DOI

      10.1038/s41429-019-0237-1

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.2019

    • Author(s)
      Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.
    • Journal Title

      FEBS Letters

      Volume: 593 Pages: 763-776

    • DOI

      10.1002/1873-3468.13361

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense-induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signaling pathways.2019

    • Author(s)
      Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J
    • Journal Title

      Mol Pharm

      Volume: 16 Pages: 1423-1432

    • DOI

      10.1021/acs.molpharmaceut.8b00939

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.2019

    • Author(s)
      Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Pages: 2988-2996

    • DOI

      10.1074/jbc.ra118.004741

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments2019

    • Author(s)
      Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      Nat. Protoc.

      Volume: 14 Pages: 415-440

    • DOI

      10.1038/s41596-018-0099-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of Nectriapyrone Biosynthesis in the Rice Blast Fungus Pyricularia oryzae by Disturbance of the Two-Component Signal Transduction System2019

    • Author(s)
      Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Osada Hiroyuki
    • Journal Title

      Chembiochem

      Volume: 20 Pages: 693-700

    • DOI

      10.1002/cbic.201800620

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a potato fraction library for the investigation of functional secondary metabolites2019

    • Author(s)
      Nogawa T, Futamura Y, Okano A, Suto M, Nakamura J, Ishihara K, Osada H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 83 Pages: 65-75

    • DOI

      10.1080/09168451.2018.1525273

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.2019

    • Author(s)
      Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: 1867 Pages: 28-37

    • DOI

      10.1016/j.bbapap.2018.06.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catenulisporolides, glycosylated triene macrolides from the chemically underexploited actinomycete Catenulispora species.2018

    • Author(s)
      Son S., Hong Y.S., Futamura Y., Jang M., Lee J.K., Heo K.T., Ko S.K., Lee J.S., Takahashi S., Osada H., Jang J.H., Ahn J.S.
    • Journal Title

      Org Lett

      Volume: 20 Pages: 7234-7238

    • DOI

      10.1021/acs.orglett.8b03160

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions2018

    • Author(s)
      Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      PLoS Comput. Biol.

      Volume: 14

    • DOI

      10.1371/journal.pcbi.1006532

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structures and synthesis of hitoyopodins: bioactive aromatic sesquiterpenoids produced by the mushroom Coprinopsis cinerea.2018

    • Author(s)
      Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 6294-6297

    • DOI

      10.1021/acs.orglett.8b02788

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic enantioselective synthesis of a pyrrolizidine-alkaloid-inspired compound collection with antiplasmodial activity.2018

    • Author(s)
      Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.
    • Journal Title

      J Org Chem

      Volume: 83 Pages: 7033-7041

    • DOI

      10.1021/acs.joc.7b03202

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs.2018

    • Author(s)
      Jang JP, Han JM, Jung HJ, Osada H, Jang JH, Ahn JS.
    • Journal Title

      J Microbiol Biotechnol

      Volume: 28 Pages: 1332-1338

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium.2018

    • Author(s)
      Jianhua Qi, Lihong Cheng, Yujuan Sun, Yushi Hirata, Naoki Ushida, Zhonghua Ma, Hiroyuki Osada, Toshio Nishikawa, Lan Xiang.
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Pages: 8100-8104

    • DOI

      10.1002/anie.201803329

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion2018

    • Author(s)
      Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.
    • Journal Title

      Bioorg Med Chem

      Volume: 26 Pages: 1453-1461

    • DOI

      10.1016/j.bmc.2017.11.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pentaminomycins A and B, hydroxyarginine-containing cyclic pentapeptides from Streptomyces sp. RK88-1441.2018

    • Author(s)
      Jang J.-P., Hwang G.J., Kwon M.C., Ryoo I.-J., Jang M., Takahashi S., Ko S.K., Osada H., Jang J.H., and Ahn J.S.
    • Journal Title

      J Nat Prod

      Volume: 81 Pages: 806-810

    • DOI

      10.1021/acs.jnatprod.7b00882

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a terpenoid-production platform in streptomyces reveromyceticus SN-593.2017

    • Author(s)
      Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S
    • Journal Title

      ACS Synthctic Biology

      Volume: 6 Issue: 12 Pages: 233-2349

    • DOI

      10.1021/acssynbio.7b00249

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.2017

    • Author(s)
      Robke I., Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 28 Pages: 8153-8157

    • DOI

      10.1002/anie.201703738

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Allantopyrone a activates Keapl-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.2017

    • Author(s)
      Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Issue: 4 Pages: 429-434

    • DOI

      10.1038/ja.2016.99

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure-activity relationships of terpendole E and its natural derivatives.2017

    • Author(s)
      Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T
    • Journal Title

      ChemistrySelect

      Volume: 2 Pages: 1533-1536

    • DOI

      10.1002/slct.201602015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.2017

    • Author(s)
      Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
    • Journal Title

      Chem. Biol. Drug Des.

      Volume: - Pages: 862-869

    • DOI

      10.1111/cbdd.12909

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Functional annotation of chemical libraries across diverse biological processes.2017

    • Author(s)
      Piotrowski JS, Li SC, Deshpande R.......Shirahige K,......Boone C.
    • Journal Title

      Nat. Chem. Biol.

      Volume: 13 Pages: 1286-1286

    • DOI

      10.1038/nchembio.2436

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 天然物創薬に適した表現系スクリーニング2021

    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会東北支部 第155回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Target identification of NPD10084, a novel inhibitor of cancer metabolism.2020

    • Author(s)
      Osada, H.
    • Organizer
      Symposium on Convergent technologies for biomedical impact.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of new antifungal antibiotics using artificial intelligence.2019

    • Author(s)
      Osada, H.
    • Organizer
      日中分野別ハイレベル研究者交流会2019:医薬・健康領域
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target identification of small molecule compounds.2019

    • Author(s)
      Osada, H
    • Organizer
      浙江大学薬学院明徳弘薬セミナー
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Morphology-based screening of antitumor and antifungal compounds.2019

    • Author(s)
      Osada, H.
    • Organizer
      8th Annual Conference ICBS-2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biosynthesis of tenuazonic acid in Pyricularia oryzae.2019

    • Author(s)
      Osada, H
    • Organizer
      The Cold Spring Harbor Asia conference on Chemical Biology and Drug Discovery.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of new antifungal compounds based on morphological change of fungi.2019

    • Author(s)
      Osada, H
    • Organizer
      The 2nd International Symposium on Natural Resources-based Drug Development.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アカデミア創薬の難しさ2019

    • Author(s)
      長田裕之
    • Organizer
      第14回 日本がん分子標的治療学会 TRワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ring formation in biosynthesis of specialized microbial metabolites2019

    • Author(s)
      Hiroyuki Osada
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ケミカルバイオロジー基盤を活用した創薬シードの探索2018

    • Author(s)
      長田裕之
    • Organizer
      講演会「化学が先導するライフ・イノベーション ~医療・創薬研究の最前線~」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マルチオミックス基盤を活用したがん代謝阻害剤の探索2018

    • Author(s)
      長田裕之
    • Organizer
      化学コミュニケーションのフロンティア 第3回公開シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がん代謝阻害剤の探索2018

    • Author(s)
      長田裕之
    • Organizer
      愛媛大学大学医学部付属病院先端医療創生センターTRCシリーズセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Timing of the mycotoxin, tenuazonic acid, produciton at the infection of plant pathogenic fungi2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Japanese-German Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target identification of compounds isolated from a fraction library of fungal broths2018

    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Yushi Futamura, Makoto Muroi, Naoki Kato
    • Organizer
      3rd European Conference on Natural Products 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 破骨細胞を標的とするリベロマイシンA:生物活性研究から生合成研究への展開2018

    • Author(s)
      長田 裕之
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開(微生物創薬研究の温故知新)2018

    • Author(s)
      長田 裕之
    • Organizer
      日本技術士会化学部会 2月度 講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Systematic isolation of microbial metabolites and the target identification2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anti-osteoclastic agent, reveromycin A (biological activity and biosynthesis)2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Department of Chemistry Bicoastal Lecture Series, The Scripps Research Institute
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical synthesis or biosynthesis:It is the question for reveromycin production2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Mona Symposium 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がん代謝を標的とする小分子阻害剤の探索2017

    • Author(s)
      長田 裕之、二村 友史、室井 誠
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 破骨細胞を標的とするreveromycin Aの研究2017

    • Author(s)
      長田 裕之
    • Organizer
      筑波大学WPIセミナー「有機化学・創薬化学セミナー」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開(微生物創薬研究の温故知新)2017

    • Author(s)
      長田 裕之
    • Organizer
      ライフサイエンス技術部会・反応分科会 講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 的を射る難しさ2017

    • Author(s)
      長田 裕之
    • Organizer
      第52回 天然物化学談話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ケミカルバイオロジーの威力2017

    • Author(s)
      長田 裕之
    • Organizer
      関西学院大学化学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Chemical array screening, a powerful approach for exploring small molecule inhibitors against proteins2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium “Systems Glycobiology and Beyond”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening and target identification of small molecules affecting cancer metabolism2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      ICBS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Activation of the sleeping gene cluster of microbial secondary metabolites2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      9th US-Japan Seminar on the Biosynthesis of Natural Products
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of inhibitors against cancer stem cells from natural products depository (NPDepo)2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      18th International Symposium on the Biology of Actinomycetes (ISBA18)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Screening of small molecule inhibitors of human pirin2017

    • Author(s)
      Hiroyuki Osada
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] マウス・ラットモデル作製・解析プロフェッショナル2021

    • Author(s)
      先端モデル動物支援プラットフォーム(AdAMS)
    • Total Pages
      320
    • Publisher
      羊土社
    • ISBN
      9784758121125
    • Related Report
      2020 Annual Research Report
  • [Book] Protein-protein Interaction regulators. Drug discovery series No. 782021

    • Author(s)
      Roy S. and Fu H (eds.)
    • Total Pages
      380
    • Publisher
      Royal society of chemistry
    • ISBN
      9781788011877
    • Related Report
      2020 Annual Research Report
  • [Book] Comprehensive natural products III: chemistry and biology. vol. 72020

    • Author(s)
      Liu HB and Begley TP (eds.)
    • Total Pages
      553
    • Publisher
      Elsevier
    • ISBN
      9780081026915
    • Related Report
      2020 Annual Research Report
  • [Book] 医薬品開発におけるオミクス解析技術 ~ゲノム・トランスクリプトーム・プロテオーム・メタボローム~2020

    • Author(s)
      鎌田 真由美, 奥野 恭史, 山田 弘, 森田 英利, 田丸 浩, 伊藤 昌可, 林崎 良英, 飯塚 朋代, 小林 巧, 池尾 一穂, 中岡 慎治, 松田 史生, 室井 誠, 小川 直子, 長田 裕之, 三浦 信明, 杉本 昌弘, 中山 泰宗, 三枝 淳, 松本 光晴, 久保田 浩行, 金井 弥栄, 津田 昇, 鈴木 孝昌
    • Total Pages
      181
    • Publisher
      情報機構
    • ISBN
      9784865021844
    • Related Report
      2019 Annual Research Report
  • [Book] Systems Chemical Biology, Methods and Protocols, Methods in Molecular Biology2019

    • Author(s)
      Slava Ziegler and Herbert Waldmann
    • Total Pages
      315
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Book] ケミカルバイオロジー化合物集 -研究展開のヒント -2018

    • Author(s)
      日本学術振興会ケミカルバイオロジー第189委員会」編  編集長:長田 裕之
    • Publisher
      株式会社 オーム社
    • Related Report
      2018 Annual Research Report
  • [Book] Bioprobes2017

    • Author(s)
      Osada, Hiroyuki (Ed.)
    • Total Pages
      384
    • Publisher
      Springer Japan
    • ISBN
      9784431565277
    • Related Report
      2017 Annual Research Report
  • [Remarks] 理化学研究所 環境資源科学研究センター ケミカルバイオロジー研究グループ

    • URL

      http://www.cbrg.riken.jp/csrs/ja/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 理化学研究所 環境資源科学研究センター ケミカルバイオロジーグループ

    • URL

      http://www.cbrg.riken.jp/csrs/ja/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 理化学研究所 環境資源科学研究センター ケミカルバイオロジー グループ

    • URL

      http://www.cbrg.riken.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 理化学研究所 環境資源科学研究センター ケミカルバイオロジー グループ

    • URL

      http://www.cbrg.riken.jp/csrs/ja/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] イネいもち病防除薬剤2019

    • Inventor(s)
      長田裕之, 本山高幸, 清水猛, 近藤恭光
    • Industrial Property Rights Holder
      理研
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] 新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム The 1st International Symposium on Chemical Communication (ISCC2019)2019

    • Related Report
      2018 Annual Research Report

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Published: 2017-07-04   Modified: 2021-12-27  

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