| Budget Amount *help |
¥112,840,000 (Direct Cost: ¥86,800,000、Indirect Cost: ¥26,040,000)
Fiscal Year 2021: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2020: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2019: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2018: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2017: ¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
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| Outline of Final Research Achievements |
Organelles are involved in cellular activities that are fundamental to life, and each plays a highly specialized role. Organelles have sites for their function, and these sites are defined as organelle zones. In this study, we analyzed host defense responses from the viewpoint of organelle zones and made the following five findings. (1) The zone on the Golgi apparatus is involved in interferon production against DNA viruses. (2) The zone on the plasma membrane is involved in the inflammatory response induced by phagosome damage. (3) The molecule that recognizes zones of membrane damage caused by bacterial infection is involved in xenophagy. (4) The degradation zone in the virus replication organelle is involved in flavivirus replication. (5) The mitochondria - virus replication organelle contact zone is involved in viral replication.
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