Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum

• Project Area: Toward an integrative understanding of functional zones in organelles
• Project/Area Number: 17H06419
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Mori Kazutoshi 京都大学, 理学研究科, 教授 (70182194)
• Co-Investigator(Kenkyū-buntansha): 尾野 雅哉 国立研究開発法人国立がん研究センター, 研究所, 研究員 (00270900) ; 西頭 英起 宮崎大学, 医学部, 教授 (00332627) ; 片桐 豊雅 徳島大学, 先端酵素学研究所, 教授 (60291895) ; 名黒 功 東京大学, 大学院薬学系研究科(薬学部), 准教授 (80401222) ; 蜷川 暁 神戸大学, バイオシグナル総合研究センター, 助教 (80647991)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥234,520,000 (Direct Cost: ¥180,400,000、Indirect Cost: ¥54,120,000); Fiscal Year 2021: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2020: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2019: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2018: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2017: ¥54,600,000 (Direct Cost: ¥42,000,000、Indirect Cost: ¥12,600,000)
• Keywords: オルガネラ / オルガネラ・ゾーン / 小胞体 / 輸送 / タンパク質分解 / 小胞体ストレス / 超解像顕微鏡 / ゴルジ体 / 小胞輸送 / 選別 / 応答

Outline of Final Research Achievements

In this study, the following results were obtained for three organelle zones. Sorting zone: we visualized the intracellular transport of the endoplasmic reticulum (ER) stress sensors ATF6 and IRE1 and identified their regulators. Degradation zone: our analysis revealed that Derlin1 and Derlin2 can form different complexes that play different roles in protein degradation in the ER. We also found that Derlin1 and Derlin2 are essential for neurite outgrowth in the central nervous system and that TXNDC11 is essential for mannose trimming in glycoprotein degradation. Mitochondria-ER communication zone: we found that an ER-resident protein PERK is indispensable for mitochondrial biogenesis during brown adipocyte differentiation.

Academic Significance and Societal Importance of the Research Achievements

小胞体におけるタンパク質の合成と品質管理は、細胞の生命活動をささえる根幹システムの１つである。本研究により、それを制御する小胞体ストレスセンサーの新たな活性化機構や活性化シグナルが明らかとなった。また、タンパク質分解機構についても、分解経路の多様性や新たな生理的意義が見出された。タンパク質品質管理の制御破綻は、がんや糖尿病を初めとする種々の疾患との関連が指摘されており、本研究の成果は、小胞体機能の学術的理解に貢献するとともに、関連疾患の発症や治療戦略の研究にも資すると期待される。

Research Products

• [Int'l Joint Research] MIT Whitehead Institute(米国)
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  • Author(s): 門脇 寿枝、西頭 英起
  • Journal Title: 生化学 Volume: 94 Issue: 1 Pages: 97-101
  • DOI: 10.14952/SEIKAGAKU.2022.940097
  • ISSN: 0037-1017
  • Year and Date: 2022-02-25
• [Journal Article] Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD (2021)
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• [Journal Article] The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity (2021)
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• [Journal Article] Endoplasmic Reticulum-Associated Degradation Controls Virus Protein Homeostasis, Which Is Required for Flavivirus Propagation (2021)
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  • Journal Title: Journal of Virology Volume: 95 Issue: 15 Pages: 02234-20
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• [Journal Article] ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function (2021)
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• [Journal Article] Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins. (2021)
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  • Journal Title: 「臨床免疫・アレルギー科」科学評論社 Volume: 75 Pages: 226-232
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  • Journal Title: Cancer Research Volume: 81 Issue: 2 Pages: 414-425
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• [Journal Article] EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD (2020)
  • Author(s): George Ginto、Ninagawa Satoshi、Yagi Hirokazu、Saito Taiki、Ishikawa Tokiro、Sakuma Tetsushi、Yamamoto Takashi、Imami Koshi、Ishihama Yasushi、Kato Koichi、Okada Tetsuya、Mori Kazutoshi
  • Journal Title: eLife Volume: 9
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• [Journal Article] Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer. (2020)
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• [Journal Article] The GALNT6-LGALS3BP axis promotes breast cancer cell growth (2020)
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• [Journal Article] ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. (2020)
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• [Journal Article] ASK1 promotes uterine inflammation leading to pathological preterm birth (2020)
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• [Journal Article] Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase. (2020)
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• [Journal Article] Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population (2019)
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• [Journal Article] High Serum Levels of Interleukin-18 Are Associated With Worse Outcomes in Patients With Breast Cancer. (2019)
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• [Journal Article] Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction. (2019)
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  • Journal Title: Biochem Biophys Res Commun. Volume: 518 Issue: 1 Pages: 183-189
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• [Journal Article] Endoplasmic reticulum quality control by garbage disposal. (2019)
  • Author(s): Kadowaki H, Nishitoh H
  • Journal Title: The FEBS Journal Volume: 286 Issue: 2 Pages: 232-240
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• [Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells. (2019)
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• [Journal Article] Monitoring lipid droplet dynamics in living cells by using fluorescent probes (2019)
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• [Journal Article] In situ single-cell western blot on adherent cell culture. (2019)
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• [Journal Article] Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases. (2019)
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• [Journal Article] Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph. (2019)
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• [Journal Article] Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2(low) ATL and various cancer cells. (2019)
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• [Journal Article] NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression. (2019)
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• [Journal Article] Species-Specific Quantitative Proteomics Profiles of Sarcoma Patient-Derived Models Closely Reflect Their Primary Tumors. (2019)
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• [Journal Article] Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins (2019)
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• [Journal Article] Paradigm shift from ‘Compartment’ to ‘Zone’ in the understanding of organelles (2018)
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• [Journal Article] Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1 (2018)
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• [Journal Article] Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage. (2018)
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• [Journal Article] A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer (2018)
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• [Journal Article] Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer (2018)
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• [Journal Article] Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish (2017)
  • Author(s): Tokiro Ishikawa, Makoto Kashima, Atsushi J Nagano, Tomoko Ishikawa-Fujiwara, Yasuhiro Kamei, Takeshi Todo, Kazutoshi Mori
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  • DOI: 10.7554/elife.26845
  • NAID: 120006358815
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• [Journal Article] Role of the unfolded protein response in the development of central nervous system (2017)
  • Author(s): Murao Naoya、Nishitoh Hideki
  • Journal Title: The Journal of Biochemistry Volume: 162 Issue: 3 Pages: 155-162
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  • NAID: 40021326021
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• [Presentation] 乳がん治療刷新を目指した新たな創薬開発研究 (2022)
  • Author(s): 片桐豊雅
  • Organizer: 第137回日本病理学会中国四国支部学術集会
  • Invited
• [Presentation] 小胞体の予防的品質管理における新規合成タンパク質の翻訳制御機構 (2021)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: 第73回日本細胞生物学会大会
• [Presentation] 小胞体膜分子 Derlin-1の成体海馬ニューロン新生における役割 (2021)
  • Author(s): 村尾直哉、西頭英起
  • Organizer: 第73回日本細胞生物学会大会
• [Presentation] 小胞体プロテオスタシスを介した脳内コレステロール生合成の制御 (2021)
  • Author(s): 西頭英起
  • Organizer: 第64回 日本神経化学会大会
  • Invited
• [Presentation] 小胞体プロテオスタシスを介した脳内コレステロール生合成の制御 (2021)
  • Author(s): 西頭英起、杉山崇史、村尾直哉
  • Organizer: 第15回日本臨床ストレス応答学会大会
• [Presentation] 小胞体予防的品質管理システムの破綻による細胞質プロテオスタシスの低下 (2021)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: 第15回日本臨床ストレス応答学会大会
• [Presentation] Derlin familyの欠損による脳の発達障害は脳内コレステロール合成低下に起因する (2021)
  • Author(s): 杉山崇史、村尾直哉、西頭英起
  • Organizer: 第94回日本生化学会大会
• [Presentation] 小胞体膜上での翻訳時分解の分子機構 (2021)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: 第44回日本分子生物学会年会
  • Invited
• [Presentation] トリプルネガティブ乳癌細胞においてBIG3-PHB2複合体は癌病態ミトコンドリアを安定制御する (2021)
  • Author(s): 相原仁, 吉丸哲郎, 片桐豊雅
  • Organizer: 第25回日本がん分子標的治療学会学術集会
• [Presentation] Genetic and epigenetic alterations of SALL3 contributes to chemoresistance in triple-negative breast cancer (2021)
  • Author(s): Toyomasa Katagiri, Yosuke Matsushita
  • Organizer: ISPCM Annual Meeting online Virtual meeting
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリアBIG3-PHB2複合体の脆弱性を標的にしたトリプルネガティブ乳癌治療法の可能性考察 (2021)
  • Author(s): 相原仁, 吉丸哲郎, 尾野雅哉, 笹三徳, 三好康雄, 片桐豊雅
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Super-resolution live cell imaging of endoplasmic reticulum stress-induced transport of the membrane-bound transcription factor ATF6. (2020)
  • Author(s): Tetsuya Okada and Kazutoshi Mori
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] 抗精神病薬オランザピンは、副作用としてプロインスリンのミスフォールディングとその分解を惹起する (2020)
  • Author(s): 蜷川暁
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] EDEM2酵素活性発揮には、TXNDC11とのジスルフィド結合形成が必要である (2020)
  • Author(s): 蜷川暁、Ginto George、矢木宏和、斎藤泰輝、住友嘉樹、石川時郎、佐久間哲史、山本卓、今見考志、石濱泰、加藤晃一、岡田徹也、森和俊
  • Organizer: 第39回 日本糖質学会年会
• [Presentation] 小胞体膜結合性転写因子ATF6の活性化を制御する選別輸送ゾーンの解析 (2020)
  • Author(s): 岡田徹也、村上奈々、森和俊
  • Organizer: 第72回日本細胞生物学会大会
• [Presentation] 抗精神病薬オランザピンによって , プロインスリンは分子間ジスルフィド結合を介した構造異常が誘発され , 小胞体関連分解によって処理される (2020)
  • Author(s): 蜷川暁、多田誠一郎、奥村正樹、井ノ口健太、木下岬、金村進吾、今見考志、梅沢元、石川時郎、岡田徹也、Robert Mackin、鳥居征司、石濱泰、稲葉謙次、穴澤貴行、長嶺敬彦、森和俊
  • Organizer: 第72回日本細胞生物学会大会
• [Presentation] ER-resident sensor PERK-mediated regulation of mitochondrial function in brown adipose tissue (2020)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: 第93回日本生化学会大会
• [Presentation] BIG3 phosphatase inactivates tumor suppressor PHB2 via tis dephosphorylation to contribute to the breast carcinogenesis (2020)
  • Author(s): Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagiri
  • Organizer: The 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] ミトコンドリア局在BIG3-PHB2複合体の抑制は骨肉腫細胞の悪性化を阻害する (2020)
  • Author(s): 土岐 俊一, 吉丸 哲郎, 相原 仁, 松下 洋輔, 片桐 豊雅
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] トリプルネガティブ乳癌細胞のミトコンドリア構造・機能制御におけるBIG3-PHB2複合体の病態生理的役割と創薬開発 (2020)
  • Author(s): 相原 仁, 吉丸 哲郎, 片桐 豊雅
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] BIG3-PHB2標的治療薬によるトラスツズマブ耐性HER2陽性乳がんの克服 (2020)
  • Author(s): 吉丸 哲郎, 松下 洋輔, 片桐 豊雅
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] 乳がん治療耐性克服を目指した抑制因子活性化誘導PPI阻害ペプチドの開発 (2020)
  • Author(s): 片桐 豊雅, 吉丸 哲郎, 松下 洋輔
  • Organizer: 第24回日本がん分子標的治療学会学術集会
  • Invited
• [Presentation] トリプルネガティブ乳癌細胞のミトコンドリア構造・機能制御におけるBIG3-PHB2複合体の病態生理的役割と創薬開発 (2020)
  • Author(s): 相原 仁, 吉丸 哲郎, 尾野 雅哉, 笹 三徳 , 三好 康雄, 片桐 豊雅
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] BIG3-PHB2複合体の形成が，HER2陽性乳癌のトラスツズマブ耐性獲得を誘導する (2020)
  • Author(s): 吉丸 哲郎, 松下 洋輔, 尾野 雅哉, 笹 三徳, 三好 康雄, 片桐 豊雅
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] ミトコンドリアBIG3-PHB2複合体阻害は骨肉腫の悪性化を抑制する (2020)
  • Author(s): 土岐 俊一, 吉丸 哲郎, 相原 仁, 松下 洋輔, 尾野 雅哉, 片桐 豊雅
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] がん抑制因子活性化を利用した新規乳がん内分泌療戦略 (2020)
  • Author(s): 片桐 豊雅
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 新規Aキナーゼアンカータンパク質BIG3による乳がん関連シグナル制御機構の解明 (2020)
  • Author(s): 片桐 豊雅
  • Organizer: 第93回日本生化学会大会
• [Presentation] 超解像イメージングによる小胞体ストレスセンサーATF6選別輸送ゾーンの解析 (2019)
  • Author(s): 岡田徹也 森和俊
  • Organizer: 第３回オルガネラ・ゾーン研究会
• [Presentation] Multiple organelle zones present in the endoplasmic reticulum (2019)
  • Author(s): Kazutoshi Mori
  • Organizer: International symposium on organelle zones: opening a new era of cell biology
  • Int'l Joint Research / Invited
• [Presentation] 乳がん細胞におけるO結合型糖鎖修飾を介した小胞体ストレス応答活性化機構の解明 (2019)
  • Author(s): 片桐 豊雅
  • Organizer: 第38回日本糖質学会年会
• [Presentation] 無償な癌抑制因子を利用した新たなホルモン依存性乳癌治療薬の開発 (2019)
  • Author(s): 片桐 豊雅
  • Organizer: 第20回ホルモンと癌研究会
  • Invited
• [Presentation] Regulation of brown adipocyte function through the crosstalk signaling between mitochondria and the endoplasmic reticulum (2019)
  • Author(s): 西頭英起
  • Organizer: 第57回日本生物物理学会年会
• [Presentation] ER stress sensor PERK is essential for mitochondrial biogenesis and thermogenesis in brown adipose tissue (2019)
  • Author(s): Hideki Nishitoh
  • Organizer: EMBO Workshop “Proteostasis：From organelles to organisms”
  • Int'l Joint Research
• [Presentation] 哺乳類細胞における浸透圧ストレスシグナリングの解明とその役 (2019)
  • Author(s): 名黒 功、一條 秀憲
  • Organizer: 第92回日本生化学会大会
• [Presentation] 小胞体の機能と制御のダイナミクス (2018)
  • Author(s): 森 和俊
  • Organizer: 第９１回日本生化学会大会・特別講演
  • Invited
• [Presentation] Crosstalk signaling between mitochondria and endoplasmic reticulum is essential for brown adipocyte function (2018)
  • Author(s): Hideki Nishitoh
  • Organizer: Keystone Symposia conference“Mitochondrial Biology”
  • Int'l Joint Research
• [Presentation] Novel therapeutic strategy for breast cancer utilizing activation of tumor suppressor PHB2 (2018)
  • Author(s): Toyomasa Katagiri
  • Organizer: The 34th Radiation Biology Center International Symposium
  • Int'l Joint Research / Invited
• [Presentation] プロテアソーム依存的なASK3の不活性化による高浸透圧ストレス応答の制御 (2018)
  • Author(s): 周 翔宇、渡邊 謙吾、森下 和浩、名黒 功、一條 秀憲
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] トリプリネガティブ乳がんにおけるRHBDL2の役割解明と抗体創薬の可能性 (2018)
  • Author(s): 奥村 和正, 松下 洋輔, 小松 正人, 木村 竜一朗, 吉丸 哲郎, 尾野 雅哉, 三好 康雄, 本田 純子, 笹 三徳, 丹黒 章, 片桐 豊雅
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Dynamics of Function and Regulation of the Endoplasmic Reticulum (2018)
  • Author(s): Kazutoshi Mori
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] Mechanistic analysis of mammalian ER-associated degradation (2018)
  • Author(s): Kazutoshi Mori
  • Organizer: International Symposium on ER stress, glycosylation, homeostasis and diseases
  • Int'l Joint Research / Invited
• [Presentation] タンパク質の品質管理を担う小胞体内オルガネラ・ゾーン (2018)
  • Author(s): 岡田徹也 森和俊
  • Organizer: 日本薬学会第138年会(金沢)
  • Invited
• [Presentation] Stapled BIG3 helical peptide ERAP potentiates anti-tumor activity for breast cancer therapeutics (2018)
  • Author(s): 片桐豊雅
  • Organizer: International Society of Precision Cancer Medicine Annual Meeting 2018
• [Presentation] ミトコンドリア－小胞体間クロストークを介した褐色脂肪細胞機能制御 (2018)
  • Author(s): 加藤裕紀、西頭英起
  • Organizer: 第3回口腔医科学フロンティア研究会
• [Presentation] The unfolded protein response : to mammals and beyond (2017)
  • Author(s): Kazutoshi Mori
  • Organizer: Endoplasmic Reticulum Functions in Physiology and Pathology
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanism of neurodegenerative diseases triggered by the dysfunction of ER quality control (2017)
  • Author(s): 西頭英起
  • Organizer: 第60回日本神経化学会大会
• [Presentation] 褐色脂肪細胞における小胞体センサーPERKを介したミトコンドリア機能制御 (2017)
  • Author(s): 西頭英起
  • Organizer: 第160回日本獣医学会学術集会
  • Invited
• [Presentation] 小胞体の予防的品質管理における新規合成タンパク質の分解機構 (2017)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: 第12回小胞体ストレス研究会
• [Presentation] 記憶学習における小胞体品質管理機構の役割の解明 (2017)
  • Author(s): 村尾直哉、西頭英起
  • Organizer: 第12回小胞体ストレス研究会
• [Presentation] PERKを介したミトコンドリアストレス応答機構の解明 (2017)
  • Author(s): 加藤裕紀、西頭英起
  • Organizer: 第12回小胞体ストレス研究会
• [Presentation] 中枢神経組織における小胞体品質機構の破綻に起因する運動障害のメカニズム (2017)
  • Author(s): 杉山崇史、村尾直哉、西頭英起
  • Organizer: 第12回小胞体ストレス研究会
• [Presentation] 成体ニューロン新生を介した記憶学習制御における小胞体品質管理機構の役割(Role of endoplasmic reticulum (ER) quality control in learning and memory via adult hippocampal neurogenesis) (2017)
  • Author(s): 村尾直哉、西頭英起
  • Organizer: 第13回成体脳のニューロン新生懇談会
• [Presentation] ミトコンドリア-小胞体間のオルガネラ連携による細胞機能制御（Regulation of cell function by organelle cross-talk between mitochondria and ER） (2017)
  • Author(s): 西頭英起
  • Organizer: ConBio2017生命科学系学会合同年次大会
• [Presentation] 小胞体の予防的品質管理における新規合成タンパク質の分解機構 (Molecular mechanism of newly synthesized protein degradation in ER stress-induced preemptive quality control) (2017)
  • Author(s): 門脇寿枝、西頭英起
  • Organizer: ConBio2017生命科学系学会合同年次大会
• [Presentation] 記憶学習における小胞体品質管理機構の役割 (The role of ER quality control system in learning and memory.) (2017)
  • Author(s): 村尾直哉、西頭英起
  • Organizer: ConBio2017生命科学系学会合同年次大会
• [Presentation] 褐色脂肪細胞のミトコンドリア機能制御における小胞体センサーPERKの新規役割 (Novel role of ER stress receptor PERK for the regulation of mitochondrial function in brown adipocyte.) (2017)
  • Author(s): 加藤裕紀、西頭英起
  • Organizer: ConBio2017生命科学系学会合同年次大会
• [Presentation] 中枢神経組織における小胞体品質機構の破綻に起因する運動障害のメカニズム (Mechanisms of motor dysfunction caused by the disturbance of endoplasmic reticulum quality control system in central nervous system) (2017)
  • Author(s): 杉山崇史、村尾直哉、西頭英起
  • Organizer: ConBio2017生命科学系学会合同年次大会
• [Book] ヒトゲノム事典 (2022)
  • Author(s): 西頭英起
  • Total Pages: 1
  • Publisher: 一色出版
  • ISBN: 9784910389127
• [Book] ミトコンドリアダイナミクス (2021)
  • Author(s): 西田卓人, 西頭英起
  • Total Pages: 11
  • Publisher: エヌ・ティー・エス
  • ISBN: 9784860437466
• [Book] 生体の化学「タンパク質・核酸の分子修飾」 (2018)
  • Author(s): 加藤裕紀、西頭英起
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] Precision Medicine (2018)
  • Author(s): 吉丸哲郎、片桐豊雅
  • Publisher: 北隆館 ニューサイエンス社
• [Remarks] 細胞機能を司るオルガネラ・ゾーンの解読
  • URL: http://organellezone.org
• [Patent(Industrial Property Rights)] BIG3-PHB2相互作用阻害PHB2由来ペプチドによる乳がん治療薬 (2019)
  • Inventor(s): 片桐豊雅, 吉丸哲郎, 大高章, 宮本貴史, 岡本康秀
  • Industrial Property Rights Holder: 片桐豊雅, 吉丸哲郎, 大高章, 宮本貴史, 岡本康秀
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] プローブ、ミトコンドリアの状態判定用キット、ミトコンドリアの状態判定方法及びミトコンドリア機能改善剤のスクリーニング方法 (2019)
  • Inventor(s): 西頭英起、加藤裕紀
  • Industrial Property Rights Holder: 西頭英起、加藤裕紀
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-234295
  • Filing Date: 2019