• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism and function of posttranslational modification zones

Planned Research

Project AreaToward an integrative understanding of functional zones in organelles
Project/Area Number 17H06421
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionRikkyo University

Principal Investigator

後藤 聡  立教大学, 理学部, 教授 (60280575)

Co-Investigator(Kenkyū-buntansha) 石川 裕之  千葉大学, 大学院理学研究院, 准教授 (00398819)
金川 基  愛媛大学, 医学系研究科, 教授 (00448044)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥128,570,000 (Direct Cost: ¥98,900,000、Indirect Cost: ¥29,670,000)
Fiscal Year 2021: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2020: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2018: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Keywordsゴルジ体 / 小胞体 / 糖鎖修飾 / リン酸修飾 / 筋ジストロフィー / 修飾ゾーン / GPI / ゴルジキナーゼ / リビトールリン酸 / オルガネラ・ゾーン / ゾーン形成因子 / ゴルジ体キナーゼ / ジストログリカン / 翻訳後修飾
Outline of Annual Research Achievements

(1)GPI修飾ゾーン内の核膜ゾーンに局在するPIGBについて解析を進めた。昨年度までにPIGBが核膜ゾーンに局在することがGPI修飾に必要であることを証明したが、本年度は、このPIGBの新たな機能を見出した。すなわち、核内膜直下の核ラミナ(ラミンが主要因子)に均一な分布にPIGBが必要であることがわかった。この機能にはGPI合成酵素の活性は必要ないことを見出した。(後藤)
(2)本年度は、RNAiによりリン酸修飾ゾーンが減少した遺伝子であるflf1のショウジョウバエ変異体を作出し、flf1変異体においてもリン酸修飾ゾーンが減少することを確かめた。一方で、flf1変異体の成虫翅において顕著な表現型は観察されなかった。以上の結果は、flf1はリン酸修飾ゾーン形成に必要ではあるが、ショウジョウバエの正常発生には必要ではない可能性を示唆している。(石川)
(3)ジストログリカンのリビトールリン酸修飾の特異性を決定する因子の探索をすすめ、リビトールリン酸修飾のドナー基質をゴルジ内腔へ輸送するトランスポーターとリビトールリン酸修飾酵素が近傍に位置していることを見出した。更に、トランスポーターとリビトールリン酸修飾酵素のいずれにも結合する分子を同定した。この分子を欠損させるとリビトールリン酸修飾に異常が生じた。以上から、酵素・基質輸送体が複合体(ゾーン)を形成し、リビトールリン酸修飾を制御している可能性が浮上してきた。
また、ジストログリカン糖鎖異常症(リビトールリン酸異常型)のモデル動物を作出した。このモデルにおいては、リビトールリン酸修飾ゾーンは形成されているものの、基質がないため機能を発揮できないタイプといえる。このモデルのリビトールリン酸不全を解消し、筋ジストロフィー治療効果をもつ化合物を開発した。(金川)

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

GPI修飾ゾーンとしての核膜ゾーンを同定し、その機能と形成機構を明らかにしたことに加え、核膜ゾーンの新たな役割を見出した。リン酸化ゾーンについてもその形成機構に関与する分子を同定することができた。またリビトールリン酸修飾ゾーンについては、その形成機構が明らかになりつつあることに加え、このゾーンの異常によって引き起こされるシストログリカン異常症(筋ジストロフィー)の治療薬候補を得ることもできた。

Strategy for Future Research Activity

(1)核膜ゾーンの新たな機能を明らかにする必要がある。核ラミナの機能として、核膜の強度、核内外の選択的輸送、染色体の核内配置などが正常に維持されているか検討する。
(2)ショウジョウバエのゲノム中には、flf1のパラログと予測されるflf2が存在することを見出した。そこで今後は、flf1とflf2が冗長性をもって機能する可能性を考慮して、flf1だけでなくflf2に関しても解析を進める必要がある。
(3)酵素・基質輸送体複合体からなるリビトールリン酸修飾ゾーンを、イメージング技術などを応用して実証する。リビトールリン酸異常型筋ジストロフィーモデルマウスの治療研究を進める。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(50 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (23 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 23 results,  Open Access: 22 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila2021

    • Author(s)
      Kawaguchi Kohei、Yamamoto‐Hino Miki、Matsuyama Nina、Suzuki Emiko、Goto Satoshi
    • Journal Title

      FEBS Letters

      Volume: 595 Issue: 7 Pages: 960-968

    • DOI

      10.1002/1873-3468.14048

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex2021

    • Author(s)
      Kawaguchi Kohei、Yamamoto-Hino Miki、Murakami Yoshiko、Kinoshita Taroh、Goto Satoshi
    • Journal Title

      Cell Structure and Function

      Volume: 46 Issue: 2 Pages: 65-71

    • DOI

      10.1247/csf.21019

    • NAID

      130008083701

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy2020

    • Author(s)
      Morioka Shigefumi、Sakaguchi Hirofumi、Mohri Hiroaki、Taniguchi-Ikeda Mariko、Kanagawa Motoi、Suzuki Toshiaki、Miyagoe-Suzuki Yuko、Toda Tatsushi、Saito Naoaki、Ueyama Takehiko
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 5 Pages: 1-28

    • DOI

      10.1371/journal.pgen.1008826

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactone-Driven Ester-to-Amide Derivatization for Sialic Acid Linkage-Specific Alkylamidation2020

    • Author(s)
      Jun-Ichi Furukawa 1, Hisatoshi Hanamatsu 2, Takashi Nishikaze 3, Hiroshi Manya 4, Nobuaki Miura 5, Hirokazu Yagi 6, Ikuko Yokota 1, Keiko Akasaka-Manya 4, Tamao Endo 4, Motoi Kanagawa 7 8, Norimasa Iwasaki 1, Koichi Tanaka 3
    • Journal Title

      Anal Chem .

      Volume: 3 Issue: 21 Pages: 14383-14392

    • DOI

      10.1021/acs.analchem.0c02209

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila2020

    • Author(s)
      Yamamoto-Hino Miki、Kawaguchi Kohei、Ono Masaya、Furukawa Kazuhiro、Goto Satoshi
    • Journal Title

      Journal of Cell Science

      Volume: 133 Pages: 238527-238527

    • DOI

      10.1242/jcs.238527

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.2020

    • Author(s)
      Kuwabara N, Imae R, Manya H, Tanaka T, Mizuno M, Tsumoto H, Kanagawa M, Kobayashi K, Toda T, Senda T, Endo T, Kato R.
    • Journal Title

      Nat Commun.

      Volume: 11 Issue: 1 Pages: 303-303

    • DOI

      10.1038/s41467-019-14220-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Galectin 3?binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein2020

    • Author(s)
      Seki Tsuneyoshi、Kanagawa Motoi、Kobayashi Kazuhiro、Kowa Hisatomo、Yahata Naoki、Maruyama Kei、Iwata Nobuhisa、Inoue Haruhisa、Toda Tatsushi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 11 Pages: 3678-3691

    • DOI

      10.1074/jbc.ra119.008703

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure2019

    • Author(s)
      Ujihara Yoshihiro、Kanagawa Motoi、Mohri Satoshi、Takatsu Satomi、Kobayashi Kazuhiro、Toda Tatsushi、Naruse Keiji、Katanosaka Yuki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5754-5754

    • DOI

      10.1038/s41467-019-13623-2

    • NAID

      120006777089

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment2019

    • Author(s)
      Sugawara Yumika、Hamada Keisuke、Yamada Yuji、Kumai Jun、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi、Negishi Yoichi、Katagiri Fumihiko、Hozumi Kentaro、Nomizu Motoyoshi、Kikkawa Yamato
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-49669-x

    • NAID

      120006728095

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stability of the transamidase complex catalyzing GPI anchoring of proteins2019

    • Author(s)
      Kawaguchi Kohei、Sato Tatsuro、Kondo Shu、Yamamoto-Hino Miki、Goto Satoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 3 Pages: 584-590

    • DOI

      10.1016/j.bbrc.2019.03.103

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myo-Glyco disease Biology: Genetic Myopathies Caused by Abnormal Glycan Synthesis and Degradation2019

    • Author(s)
      Kanagawa Motoi
    • Journal Title

      Journal of Neuromuscular Diseases

      Volume: - Issue: 2 Pages: 1-13

    • DOI

      10.3233/jnd-180369

    • NAID

      120006888540

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation2019

    • Author(s)
      Sekiya Hiroaki、Kowa Hisatomo、Koga Hinako、Takata Mariko、Satake Wataru、Futamura Naonobu、Funakawa Itaru、Jinnai Kenji、Takahashi Motonori、Kondo Takeshi、Ueno Yasuhiro、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi
    • Journal Title

      Acta Neuropathologica

      Volume: 137 Issue: 3 Pages: 455-466

    • DOI

      10.1007/s00401-019-01961-w

    • NAID

      120006599160

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila2018

    • Author(s)
      Yamamoto-Hino Miki、Katsumata Eri、Suzuki Emiko、Maeda Yusuke、Kinoshita Taroh、Goto Satoshi
    • Journal Title

      Journal of Cell Science

      Volume: 131 Pages: 1-12

    • DOI

      10.1242/jcs.218024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes2018

    • Author(s)
      Hirai Kazuyuki、Wang Zhuo、Miura Kohei、Hayashi Takaaki、Awasaki Takeshi、Wada Moe、Keira Yoko、Ishikawa Hiroyuki O.、Sawamura Kyoichi
    • Journal Title

      G3: Genes|Genomes|Genetics

      Volume: 8 Issue: 7 Pages: 2421-2431

    • DOI

      10.1534/g3.118.200361

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors2018

    • Author(s)
      Orlandi Cesare、Omori Yoshihiro、Wang Yuchen、Cao Yan、Ueno Akiko、Roux Michel J.、Condomitti Giuseppe、de Wit Joris、Kanagawa Motoi、Furukawa Takahisa、Martemyanov Kirill A.
    • Journal Title

      Cell Reports

      Volume: 25 Issue: 1 Pages: 130-145

    • DOI

      10.1016/j.celrep.2018.08.068

    • NAID

      120006531168

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease2018

    • Author(s)
      Uenaka Takeshi、Satake Wataru、Cha Pei-Chieng、Hayakawa Hideki、Baba Kousuke、Jiang Shiying、Kobayashi Kazuhiro、Kanagawa Motoi、Okada Yukinori、Mochizuki Hideki、Toda Tatsushi
    • Journal Title

      Human Molecular Genetics

      Volume: 27 Pages: 3974-3985

    • DOI

      10.1093/hmg/ddy279

    • NAID

      120006549191

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CDP-glycerol inhibits the synthesis of the functionalO-mannosyl glycan of α-dystroglycan2018

    • Author(s)
      Imae Rieko、Manya Hiroshi、Tsumoto Hiroki、Osumi Kenji、Tanaka Tomohiro、Mizuno Mamoru、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi、Endo Tamao
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 31 Pages: 12186-12198

    • DOI

      10.1074/jbc.ra118.003197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation2018

    • Author(s)
      Tsuchiya Masaki、Hara Yuji、Okuda Masaki、Itoh Karin、Nishioka Ryotaro、Shiomi Akifumi、Nagao Kohjiro、Mori Masayuki、Mori Yasuo、Ikenouchi Junichi、Suzuki Ryo、Tanaka Motomu、Ohwada Tomohiko、Aoki Junken、Kanagawa Motoi、Toda Tatsushi、Nagata Yosuke、Matsuda Ryoichi、Takayama Yasunori、Tominaga Makoto、Umeda Masato
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2049-2049

    • DOI

      10.1038/s41467-018-04436-w

    • NAID

      120006471161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.2018

    • Author(s)
      Nishihara, R., Kobayashi, K., Imae, R., Tsumoto, H., Manya, H., Mizuno, M., Kanagawa, M., Endo, T., and Toda, T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 497 Issue: 4 Pages: 1025-1030

    • DOI

      10.1016/j.bbrc.2018.02.162

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ribitol-phosphate-a newly identified posttranslational glycosylation unit in mammals: structure, modification enzymes and relationship to human diseases2018

    • Author(s)
      Kanagawa Motoi、Toda Tatsushi
    • Journal Title

      The Journal of Biochemistry

      Volume: 163 Issue: 5 Pages: 359-369

    • DOI

      10.1093/jb/mvy020

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage2018

    • Author(s)
      Sudo Atsushi、Kanagawa Motoi、Kondo Mai、Ito Chiyomi、Kobayashi Kazuhiro、Endo Mitsuharu、Minami Yasuhiro、Aiba Atsu、Toda Tatsushi
    • Journal Title

      Human molecular genetics

      Volume: 27 Issue: 7 Pages: 1174-1185

    • DOI

      10.1093/hmg/ddy032

    • NAID

      120006459805

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscular Dystrophy with Ribitol-Phosphate Deficiency: A Novel Post-Translational Mechanism in Dystroglycanopathy2017

    • Author(s)
      Kanagawa Motoi、Toda Tatsushi
    • Journal Title

      Journal of Neuromuscular Diseases

      Volume: 4 Issue: 4 Pages: 259-267

    • DOI

      10.3233/jnd-170255

    • NAID

      120006811130

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle2017

    • Author(s)
      Kamizaki Koki、Doi Ryosuke、Hayashi Makoto、Saji Takeshi、Kanagawa Motoi、Toda Tatsushi、Fukada So-ichiro、Ho Hsin-Yi Henry、Greenberg Michael Eldon、Endo Mitsuharu、Minami Yasuhiro
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 38 Pages: 15939-15951

    • DOI

      10.1074/jbc.m117.785709

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] An in vivo RNAi screen to identify genes involved in subcellar localization of the Golgi kinase Four-jointed2021

    • Author(s)
      Yusuke Kurihara, Koya Tamura, Kota Funakubo, Yuka Doi, Tomoko Nakamura, Yoko Keira, Hiroyuki O. Ishikawa
    • Organizer
      62nd Annual Drosophila Research Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] in vivo RNAiスクリーンによるゴルジ体キナーゼFour-jointedの局在化因子の同定と機能解析2020

    • Author(s)
      栗原優介、田村洸也、舟久保洸太、土井由香、中村知子、計良陽子、石川裕之
    • Organizer
      第43回 日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 福山型筋ジストロフィーのモデルマウスを用いた病態解明と治療戦略の開発2020

    • Author(s)
      金川基,戸田達史
    • Organizer
      第38回日本神経治療学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ジストログリカンが担う基底膜―細胞膜連携の破綻と筋ジストロフィー2020

    • Author(s)
      金川基
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] An organelle zone executing a posttranslational modification of proteins2019

    • Author(s)
      Satoshi Goto, Miki Yamamoto-Hino, Kohei Kawaguchi, Masaya Ono
    • Organizer
      Joint Annual Meeting of the 71th JSCB and 19th PSSJ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 複合糖質の合成・輸送・分解を担うオルガネラゾーン2019

    • Author(s)
      後藤聡
    • Organizer
      第38回 日本糖質学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] GPI修飾を司る翻訳後修飾ゾーン2019

    • Author(s)
      後藤聡、山本(日野)美紀、川口紘平、尾野雅哉、木下タロウ、古川和弘
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Coupling of translation and GPI modification2019

    • Author(s)
      Kohei Kawaguchi, Miki Yamamoto-Hino, Masaya Ono, Yoshiko Murakami, Taroh Kinoshita, Satoshi Goto
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Organelle zones executing GPI modification in the nuclear envelope and the perinuclear ER2018

    • Author(s)
      Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taroh Kinoshita, Satoshi Goto
    • Organizer
      ASCB/EMBO 2018 meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nuclear envelope localization of PIG-B is essential for glycosylphosphatidylinositol synthesis in Drosophila2018

    • Author(s)
      Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taroh Kinoshita, Satoshi Goto
    • Organizer
      FEBS advanced course, The 2018 Golgi meeting: Membrane trafficking in cell organization and homeostasis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nuclear envelope localization of PIG-B is essential for glycosylphosphatidylinositol synthesis in Drosophila2018

    • Author(s)
      Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taroh Kinoshita, Satoshi Goto
    • Organizer
      Gordon Research Conference, Glycolipid and Sphingolipid Biology
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Posttranslational zones in the ER and Golgi apparatus2017

    • Author(s)
      Satoshi Goto, Miki Yamamoto-Hino
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Nuclear envelope localization of PIG-B is essential for GPI anchor synthesis in Drosophila2017

    • Author(s)
      Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taro Kinoshita, Satoshi Goto
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GPI合成酵素PIG-Bの細胞内局在に関する解析2017

    • Author(s)
      山本(日野)美紀、前田祐輔、木下タロウ、後藤聡
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Localization of PIG-B involved in GPI anchr synthesis in Drosophila2017

    • Author(s)
      Miki Yamamoto-Hino, Satoshi Goto
    • Organizer
      The 4th Asia-Pacific Drosophila Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ細胞のゴルジ体におけるリン酸化ゾーン2017

    • Author(s)
      石川裕之
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification of the Drosophila ecto-phosphatase Nekomata2017

    • Author(s)
      Yoko Kubo, Yuka Doi, Hiroyuki O. Ishikawa
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエ組織形成におけるゴルジ体キナーゼFour-jointedの細胞内局在のダイナミクス2017

    • Author(s)
      石川裕之、明石孝平、計良陽子
    • Organizer
      第88回日本動物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 核膜孔複合体タンパク質ELYSの変異によるショウジョウバエの発生異常2017

    • Author(s)
      澤村京一、平井和之、Wang Zhuo、粟崎健、和田萌、計良陽子、石川 裕之
    • Organizer
      日本遺伝学会第89回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Involvement of the ecto-phosphatase Nekomata in planar cell polarity2017

    • Author(s)
      Yoko Kubo, Yuka Doi, Hiroyuki O. Ishikawa
    • Organizer
      The 4th Asia Pacific Drosophila Research Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] An overexpression screen identifies genes that regulate intercellular signaling2017

    • Author(s)
      Moe Wada, Tomoko Tanaka, Yuka Doi, Hiroyuki O. Ishikawa
    • Organizer
      58th Annual Drosophila Research Conference
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Mechanobiology of muscle and sugar chain2017

    • Author(s)
      Motoi Kanagawa,
    • Organizer
      The 3rd International Symposium on Mechanobiology
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋ジストロフィー発症に関わる糖鎖構造の解明と修飾酵素の同定2017

    • Author(s)
      金川 基
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 立教大学理学部後藤研究室

    • URL

      http://goto-lab.net/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 千葉大学 大学院理学研究院 生物学教室 発生遺伝学研究室

    • URL

      http://life.s.chiba-u.jp/ishikawa/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 神戸大学医学研究科分子脳科学

    • URL

      http://www.med.kobe-u.ac.jp/clgene/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規CDP-リビトール誘導体2020

    • Inventor(s)
      金川基
    • Industrial Property Rights Holder
      金川基
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi