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Generation of Organometallics from Alkanes by Organoradical-Metal Complex Hybrid Catalysis

Planned Research

Project AreaHybrid Catalysis for Enabling Molecular Synthesis on Demand
Project/Area Number 17H06442
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

金井 求  東京大学, 大学院薬学系研究科(薬学部), 教授 (20243264)

Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥171,210,000 (Direct Cost: ¥131,700,000、Indirect Cost: ¥39,510,000)
Fiscal Year 2021: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2020: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2019: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2018: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2017: ¥65,000,000 (Direct Cost: ¥50,000,000、Indirect Cost: ¥15,000,000)
Keywordsハイブリッド触媒 / 分子合成オンデマンド / 触媒 / 有機合成化学 / 光触媒 / ラジカル触媒 / C-H活性化 / アリル化 / アルキル化 / ケイ素触媒 / ボリン酸触媒 / 結合弱化 / アルカン / ハイブリッド触媒系 / クロム錯体触媒 / 不斉触媒 / 不斉アリル化 / アルデヒド / 付加反応 / 触媒・化学プロセス / 有機金属 / 水素放出 / 合成化学 / 蛋白質
Outline of Annual Research Achievements

本研究の目的は、豊富な炭素資源であるアルカンを原料として、抗癌剤などの高付加価値な有機分子を実践的に合成できるハイブリッド触媒系の創製である。ハイブリッド触媒系によるアルカンの炭素-水素結合活性化を経る有機金属活性種の発生と分子合成オンデマンドへの展開を計画した。光触媒-ラジカル触媒ハイブリッドによるアルカンからの水素原子の引き抜きと、生じた炭素ラジカルの金属錯体触媒での捕捉により目的の変換を達成する。本研究では、強力な水素原子引き抜き能と迅速な炭素ラジカル捕捉能を兼ね備えたハイブリッド触媒系の創製により課題を克服する。アルカンから生成する有機金属活性種は、位置・立体化学制御をともなう選択的反応への適用が可能で、高付加価値な有機分子を合成するための有用な活性種である。
本年度は、アクリジニウム光触媒、チオリン酸イミドラジカル触媒、キラルクロム錯体触媒の三成分ハイブリッド触媒系を構築し、安定で豊富に存在する炭化水素アルケンを用いたアルデヒドの触媒的不斉アリル化反応を開発した。可視光照射により励起されたアクリジニウム光触媒がチオリン酸イミド触媒を一電子酸化し、有機ラジカル触媒を生成する。このラジカルが安定アルケンのアリル位C-H結合を引き抜き、アリルラジカルが生じる。これをキラルクロム錯体触媒が捕捉してアリルクロムが生じ、アルデヒドへの不斉付加反応が進行する。
また、アルケンをSchwartz試薬でヒドロジルコニウム化し、これに可視光を照射することでアルキルラジカルを生成、クロム錯体触媒がこのアルキルラジカルを捕捉してアルキルクロムを経由して進行する、アルデヒドのアルキル化反応を開発した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

本新学術領域研究での最終目標の一つとしていた反応を、最終年度1年前にほぼ達成できたため。

Strategy for Future Research Activity

より広く使ってもらえる反応とするために、アルケン側の当量を減らしても進行する条件へと進化させていく予定である。

Report

(4 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(77 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (24 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 24 results,  Open Access: 6 results) Presentation (40 results) (of which Int'l Joint Research: 11 results,  Invited: 23 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) Funded Workshop (3 results)

  • [Int'l Joint Research] 上海有機化学研究所(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 上海有機化学研究所(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マルセイユ大学(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] IMDEA nanoscience(スペイン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Catalytic Allylation of Aldehydes Using Unactivated Alkenes2020

    • Author(s)
      Tanabe Shun、Mitsunuma Harunobu、Kanai Motomu
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 28 Pages: 12374-12381

    • DOI

      10.1021/jacs.0c04735

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes2020

    • Author(s)
      Fuse Hiromu、Nakao Hiroyasu、Saga Yutaka、Fukatsu Arisa、Kondo Mio、Masaoka Shigeyuki、Mitsunuma Harunobu、Kanai Motomu
    • Journal Title

      Chemical Science

      Volume: 11 Issue: 44 Pages: 12206-12211

    • DOI

      10.1039/d0sc04114a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chromium-Catalyzed Linear-Selective Alkylation of Aldehydes with Alkenes2020

    • Author(s)
      Hirao Yuki、Katayama Yuri、Mitsunuma Harunobu、Kanai Motomu
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 21 Pages: 8584-8588

    • DOI

      10.1021/acs.orglett.0c03180

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic Acceptorless Dehydrogenation of Aliphatic Alcohols2020

    • Author(s)
      Hiromu Fuse, Harunobu Mitsunuma, Motomu Kanai
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 9 Pages: 4493-4499

    • DOI

      10.1021/jacs.0c00123

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C?H Alkylation of Alcohols2020

    • Author(s)
      Oisaki Kounosuke、Kanai Motomu、Sakai Kentaro
    • Journal Title

      Synthesis

      Volume: 52 Issue: 15 Pages: 2171-2189

    • DOI

      10.1055/s-0040-1707114

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydrogen Bond-Accelerated meta-Selective C-H Borylation of Aromatic Compounds and Expression of Functional Group and Substrate Specificities2019

    • Author(s)
      Lu, X.; Yoshigoe, Y.; Ida, H.; Nishi, M.; Kanai, M.; Kuninobu, Y.
    • Journal Title

      ACS Catal.

      Volume: 9 Issue: 3 Pages: 1705-1709

    • DOI

      10.1021/acscatal.8b05005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copper(I)-Catalyzed Stereodivergent Propargylation of N-Acetyl Mannosamine for Protecting Group Minimal Synthesis of C3-Substituted Sialic Acids2019

    • Author(s)
      Ishizawa Kouhei、Majima Sohei、Wei Xiao-Feng、Mitsunuma Harunobu、Shimizu Yohei、Kanai Motomu
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 84 Issue: 17 Pages: 10615-10628

    • DOI

      10.1021/acs.joc.9b00887

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amine-Tethered Phenylboronic Acid-Enabling Ring-Opening Strategy for Carbon Chain Elongation from Double Aldol Cyclic Hemiacetals2019

    • Author(s)
      Yamato Kanzaki, Yuki Hirao, Harunobu Mitsunuma, Motomu Kanai
    • Journal Title

      Org. Biomol. Chem.

      Volume: 17 Issue: 27 Pages: 6562-6565

    • DOI

      10.1039/c9ob01263j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Bond‐Weakening Spirosilane Catalyst for Photoredox α‐C-H Alkylation of Alcohols2019

    • Author(s)
      Sakai Kentaro、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 362 Issue: 2 Pages: 337-343

    • DOI

      10.1002/adsc.201901253

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catalytic asymmetric allylation of aldehydes with alkenes through allylic C(sp3)-H functionalization mediated by organophotoredox and chiral chromium hybrid catalysis2019

    • Author(s)
      Mitsunuma Harunobu、Tanabe Shun、Fuse Hiromu、Ohkubo Kei、Kanai Motomu
    • Journal Title

      Chemical Science

      Volume: 10 Issue: 12 Pages: 3459-3465

    • DOI

      10.1039/c8sc05677c

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palladium-Catalyzed C-H Heteroarylation of 2, 5-Disubstituted Imidazoles2019

    • Author(s)
      T Togo, Y Sohma, Y Kuninobu, M Kanai
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Pages: 196-198

    • NAID

      130007607157

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalytic Regio- and Enantioselective Proton Migration from Skipped Enynes to Allenes2019

    • Author(s)
      Wei Xiao-Feng、Wakaki Takayuki、Itoh Taisuke、Li Hong-Liang、Yoshimura Takayoshi、Miyazaki Aya、Oisaki Kounosuke、Hatanaka Miho、Shimizu Yohei、Kanai Motomu
    • Journal Title

      Chem

      Volume: 5 Issue: 3 Pages: 585-599

    • DOI

      10.1016/j.chempr.2018.11.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent and Functional-Group-Tolerant Synthesis of B-Organo BODIPYs2018

    • Author(s)
      Sawazaki Taka、Shimizu Yusuke、Oisaki Kounosuke、Sohma Youhei、Kanai Motomu
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 24 Pages: 7767-7770

    • DOI

      10.1021/acs.orglett.8b03138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxy Group Directed Catalytic Hydrosilylation of Amides2018

    • Author(s)
      Ni Jizhi、Oguro Tsubasa、Sawazaki Taka、Sohma Youhei、Kanai Motomu
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 23 Pages: 7371-7374

    • DOI

      10.1021/acs.orglett.8b03014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organophotoredox/Copper Hybrid Catalysis for Regioselective Allylic Aminodecarboxylation of β,γ-Unsaturated Carboxylic Acids2018

    • Author(s)
      Oisaki Kounosuke、Kanai Motomu、Manick Anne-Doriane、Tanaka Hirotaka
    • Journal Title

      Synthesis

      Volume: 50 Issue: 15 Pages: 2936-2947

    • DOI

      10.1055/s-0036-1591983

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copper(I)-Catalyzed Enantio- and Diastereodivergent Borylative Coupling of Styrenes and Imines2018

    • Author(s)
      Itoh Taisuke、Kanzaki Yamato、Shimizu Yohei、Kanai Motomu
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 27 Pages: 8265-8269

    • DOI

      10.1002/anie.201804117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C(sp3)-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis2018

    • Author(s)
      Wakaki Takayuki、Sakai Kentaro、Enomoto Takafumi、Kondo Mio、Masaoka Shigeyuki、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 32 Pages: 8051-8055

    • DOI

      10.1002/chem.201801746

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids2018

    • Author(s)
      Fujita Taiki、Yamamoto Tomohiro、Morita Yuya、Chen Hongyu、Shimizu Yohei、Kanai Motomu
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Issue: 18 Pages: 5899-5903

    • DOI

      10.1021/jacs.8b02783

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes2018

    • Author(s)
      Tanabe Kana、Liu Jiaan、Kato Daiki、Kurumizaka Hitoshi、Yamatsugu Kenzo、Kanai Motomu、Kawashima Shigehiro A.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2656-2656

    • DOI

      10.1038/s41598-018-21060-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide2018

    • Author(s)
      Ni Jizhi、Taniguchi Atsuhiko、Ozawa Shuta、Hori Yukiko、Kuninobu Yoichiro、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Sohma Youhei、Kanai Motomu
    • Journal Title

      Chem

      Volume: 4 Issue: 4 Pages: 807-820

    • DOI

      10.1016/j.chempr.2018.02.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C?H Bond Activation2018

    • Author(s)
      Wakaki Takayuki、Togo Takaya、Yoshidome Daisuke、Kuninobu Yoichiro、Kanai Motomu
    • Journal Title

      ACS Catal.

      Volume: 8 Issue: 4 Pages: 3123-3128

    • DOI

      10.1021/acscatal.8b00440

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Position-Selective C?H Perfluoroalkylation of Quinoline Derivatives2018

    • Author(s)
      Shirai Takahiro、Kanai Motomu、Kuninobu Yoichiro
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 6 Pages: 1593-1596

    • DOI

      10.1021/acs.orglett.8b00339

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boron-Catalyzed Carboxylic Acid-Selective Aldol Reaction with Trifluoromethyl Ketones2018

    • Author(s)
      Ishizawa Kouhei、Nagai Hideoki、Shimizu Yohei、Kanai Motomu
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 3 Pages: 231-234

    • DOI

      10.1248/cpb.c17-00545

    • NAID

      130006407099

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iridium/Bipyridine-Catalyzed ortho-Selective C?H Borylation of Phenol and Aniline Derivatives2017

    • Author(s)
      Li Hong-Liang、Kanai Motomu、Kuninobu Yoichiro
    • Journal Title

      Org. Lett.

      Volume: 19 Issue: 21 Pages: 5944-5947

    • DOI

      10.1021/acs.orglett.7b02936

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 光触媒を用いたN-ヘテロ芳香環のヒドロキシアルキル化2021

    • Author(s)
      中尾裕康
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] データ駆動型分子設計を利用したイリジウム/ホウ素ハイブリッド触媒系によるカルボン酸α位不斉アリル化反応の最適化2021

    • Author(s)
      陳虹宇
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 三成分ハイブリッド触媒系を用いたアリル位C(sp3)-H結合活性化によるアルデヒドの直接的アリル化反応の開発2021

    • Author(s)
      田辺駿
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホウ素・ケイ素二元素重奏的活性化による、カルボン酸選択的触媒的不斉アルドール反応の開発2021

    • Author(s)
      藤田大樹
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Chemo-, Diastereo-, and Enantioselective Catalytic aldol Reaction of Carboxylic Acids by Boron and Silicon Hybrid Activation2021

    • Author(s)
      Taiki Fujita
    • Organizer
      日本化学会 第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes2021

    • Author(s)
      Hiromu Fuse
    • Organizer
      日本化学会 第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] クロム触媒を用いたアルデヒドの直鎖選択的アルキル化2021

    • Author(s)
      平尾祐樹
    • Organizer
      日本化学会 第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 超高収率ヒストンアセチル化触媒システムの開発とアフリカツメガエル精子核クロマチンへの展開2021

    • Author(s)
      梶野英俊
    • Organizer
      日本化学会 第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Live-Cell Protein Lysine Acylation Using Boronate-Assisted Hydroxamic Acid Catalyst2021

    • Author(s)
      Adamson Christopher
    • Organizer
      日本化学会 第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外免疫療法に有用な対称シリコンフタロシアニンの開発2021

    • Author(s)
      高橋和希
    • Organizer
      日本薬学会 第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 個体におけるエピゲノム編集を指向した化学触媒システムの開発2021

    • Author(s)
      山梨祐輝
    • Organizer
      日本薬学会 第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 位置選択性を制御可能なヒストンアシル化触媒システム2021

    • Author(s)
      野崎多実子
    • Organizer
      日本薬学会 第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒストンアセチル化触媒システムによる合成的エピゲノム操作2021

    • Author(s)
      川島 茂裕
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 疾患原因アミロイドを光酸素化する人工触媒の創製2021

    • Author(s)
      相馬洋平
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病治療戦略を指向したαシヌクレインに対する光酸素化触媒2021

    • Author(s)
      岩井 篤志
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] トランスサイレチンアミロイドに対する光酸素化触媒の開発2021

    • Author(s)
      山根三奈
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] メチレンブルー誘導体を基盤とした新規Aβ光酸素化触媒の開発と機能評価2021

    • Author(s)
      大井 未来
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ハイブリッド触媒:複数の触媒が奏でる重奏曲2020

    • Author(s)
      金井 求
    • Organizer
      令和2年度 日本化学会関東支部 群馬地区 研究交流発表会(on line)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 三成分ハイブリッド触媒によるアルデヒドのアリル化反応2020

    • Author(s)
      金井 求
    • Organizer
      「ハイブリッド触媒」第 4 回公開シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] From Acceptorless Dehydrogenation to Asymmetric C-C Bond Formation Based on Hybrid Catalysis2019

    • Author(s)
      金井 求
    • Organizer
      The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis on Demand, The University of Tokyo
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Protecting Group-Minimal Asymmetric Catalysis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      The 6th Japan-UK Symposium on Asymmetric Catalysis, Kyushu University, Fukuoka, Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 保護基=必要悪に挑む触媒2018

    • Author(s)
      金井求
    • Organizer
      化学フェスタ 特別企画、船堀、東京
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Methodology Development toward Protecting Group-Minimal Synthesis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      元素有機化学国家重点実験室本年会, Nankai University, Tenjin, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Methodology Development toward Protecting Group-Minimal Synthesis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      Huazhong University of Science and Technology, Wuhan, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Methodology Development toward Protecting Group-Minimal Synthesis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      Wuhan University, Wuhan, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Methodology Development toward Protecting Group-Minimal Synthesis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      Central China Normal University, Wuhan, China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 保護基のいらない有機合成を目指した触媒研究2018

    • Author(s)
      金井求
    • Organizer
      有機金属部会平成30年度第2回(東京)例会、東京大学本郷キャンパス(浅野地区)武田先端知ビル
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Protecting Group-Minimized Asymmetric Catalysis2018

    • Author(s)
      Motomu Kanai
    • Organizer
      The 2nd Japanese-Spanish Symposium on Organic Synthesis, Kyoto University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 保護基使用の最少化を目指した触媒反応開発2018

    • Author(s)
      金井求
    • Organizer
      第194委員会「分子性触媒による高度分子変換技術」 設立総会、東京
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Synthetic chromatin acylation promoted by chemical catalyst systems2018

    • Author(s)
      金井求
    • Organizer
      理研H29年度 エピジェネティクスセミナーシリーズ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ハイブリッド触媒系構築のための新規な水素原子移動触媒2018

    • Author(s)
      金井 求
    • Organizer
      ハイブリッド触媒 第1回公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化学触媒による凝集アミロイドの無毒化・除去2018

    • Author(s)
      金井 求
    • Organizer
      第1回ライフサイエンスイノベーションセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cu(I)-Catalyzed Asymmetric Reactions2017

    • Author(s)
      Motomu Kanai
    • Organizer
      Chirality 2017 (ISCD-29)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体分子を標的とする触媒反応の開発と応用2017

    • Author(s)
      金井求
    • Organizer
      創薬セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Aerobic Oxygen-Driven Functionalization of Proteins2017

    • Author(s)
      Motomu Kanai
    • Organizer
      6th French-Japanese Symposium on Medicinal & Fine Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Aerobic Oxygen-Driven Functionalization of Proteins2017

    • Author(s)
      Motomu Kanai
    • Organizer
      1st International Symposium on Catalysis for Sustainable Chemical Synthesis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 一価銅触媒による求核種発生の概念と応用2017

    • Author(s)
      金井求
    • Organizer
      第1回日本プロセス化学会 東海地区フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] タンパク質を基質とする化学反応開発2017

    • Author(s)
      金井求
    • Organizer
      蛋白研セミナー、カルコゲン、ヘテロ元素を含む生体分子の化学、大阪大学蛋白質研究所
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A Method for Site-Selective Histone Lysine N-Acylation2017

    • Author(s)
      Motomu Kanai
    • Organizer
      the 2017 International Symposium on Bio-related Chemistry (ISBC2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ラジカル-金属錯体ハイブリッド触媒系によるアルカンからの有機金属活性種発生2017

    • Author(s)
      金井 求
    • Organizer
      新学術ハイブリッド触媒キックオフミーティング
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科 有機合成化学教室HP

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 分子合成オンデマンドを実現するハイブリッド触媒系の創製「ハイブリッド触媒」

    • URL

      http://hybridcatalysis.jp/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科 有機合成化学教室

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/index.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光を有する複合体2017

    • Inventor(s)
      國信 洋一郎、金井 求、山川 健司、王 子嘉、吉越 裕介
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-161912
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光を有する複合体2017

    • Inventor(s)
      國信 洋一郎、金井 求、山川 健司、王 子嘉、吉越 裕介
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-037356
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗体薬物複合体およびそれを含む医薬組成物2017

    • Inventor(s)
      金井求ら
    • Industrial Property Rights Holder
      東大TLO・カネカ
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-015404
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] From Acceptorless Dehydrogenation to Asymmetric C-C Bond Formation Based on Hybrid Catalysis2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] Lecture by Prof. Ojima at Stoney Brook Univ.2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] Lecture by Prof. Groger at Bielefeld Univ.2017

    • Related Report
      2017 Annual Research Report

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Published: 2017-07-04   Modified: 2021-12-27  

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