| Budget Amount *help |
¥119,860,000 (Direct Cost: ¥92,200,000、Indirect Cost: ¥27,660,000)
Fiscal Year 2021: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2020: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2019: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2018: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2017: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
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| Outline of Final Research Achievements |
In this research, we aimed to develop a two-component hybrid catalyst system that combines "selective molecular transformation using organocatalysts, especially chiral Bronsted acids", that the applicant has been involved in so far, with "a specific molecular transformation using a metal complex catalyst". In order to develop an efficient and selective method for the preparation of enantioenriched compounds that surpass conventional catalytic systems, we connected these catalytic systems in a relay manner in one-pot during the course of the substance conversion. We have successfully established several hybrid catalytic systems using chiral Bronsted acids combined not only with metal complexes but also with photoactivation system. In addition, we also achieved the development of a chiral Bronsted acid catalyst having a higher acidity than that of conventional chiral acids, which is the key to achieving a hybrid catalytic system.
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