| Budget Amount *help |
¥95,000,000 (Direct Cost: ¥95,000,000)
Fiscal Year 2010: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2009: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2008: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2007: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2006: ¥19,000,000 (Direct Cost: ¥19,000,000)
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| Research Abstract |
This study was carried out to reveal how the virulence factors of Listeria and acid-fast bacteria, two representative intracellular parasitic bacteria, contribute to the host cytokine response. It was clearly shown that the activation of both calpain and caspase-1 in host macrophages is highly dependent on the major virulence factor, cytolysin and RD1 locus product of Listeria and Mycobacteria, respectively, resulting in the processing and secretion of IL-1α, IL-1β, and IL-18. The findings obtained in this study established the pivotal role of bacterial virulence factors for the induction of host cytokine response.
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