Function of cytoplasmic double-stranded RNA sensor in viral infection

• Project Area: Matrix of Infection Phenomena
• Project/Area Number: 18073010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University (2008-2010); Osaka University (2006-2007)
• Principal Investigator: FUJITA Takashi (2008-2010) Kyoto University, ウイルス研究所, 教授 (10156870); 審良 静男 (2006-2007) Osaka University, 微生物病研究所, 教授 (50192919)
• Co-Investigator(Kenkyū-buntansha): 藤田 尚志 京都大学, ウイルス研究所, 教授 (10156870)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥112,200,000 (Direct Cost: ¥112,200,000); Fiscal Year 2010: ¥18,700,000 (Direct Cost: ¥18,700,000); Fiscal Year 2009: ¥18,700,000 (Direct Cost: ¥18,700,000); Fiscal Year 2008: ¥34,000,000 (Direct Cost: ¥34,000,000); Fiscal Year 2007: ¥20,400,000 (Direct Cost: ¥20,400,000); Fiscal Year 2006: ¥20,400,000 (Direct Cost: ¥20,400,000)
• Keywords: ウイルス / 自然免疫 / インターフェロン / 遺伝子改変マウス / ヘリカーゼ / 抗ウイルス自然免疫 / RIG-1 / 二重鎖RNA / 免疫学 / サイトカイン / 炎症 / RIG-I / RNA / RNA ウイルス / Toll - like receptor / シグナル伝達 / 核酸 / 遺伝子発現

Research Abstract

We analyzed the function of RIG-I-Like receptor (collectively termed as RLR). RLR functions as cytoplasmic receptors for RNA derived from viral replication. Our results elucidate virus specificity of each RLR, the RNA structures recognized by RLR and molecular mechanism of viral RNA recognition. These result will be critical bases for developing diagnosis and treatment of viral infections.

Research Products

• [Journal Article] Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. (2010)
  • Author(s): Slater L, Bartlett NW, Haas JJ, Zhu J, Message SD, Walton RP, Sykes A, Dahdaleh S, Clarke DL, Belvisi MG, Kon OM, Fujita T, Jeffery PK, Johnston SL, Edwards MR.
  • Journal Title: PLoS Pathog. 6(11)
• [Journal Article] Virus-Infection or 5'ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1. (2010)
  • Author(s): Onoguchi K, Onomoto K, Takamatsu S, Jogi M, Takemura A, Morimoto S, Julkunen I, Namiki H, Yoneyama M, Fujita T.
  • Journal Title: PLoS Pathog. 6(7)
  • NAID: 120002647328
• [Journal Article] 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication (2010)
  • Author(s): Ranjan P, Jayashankar L, Deyde V, Zeng H, Davis WG, Pearce MB, Bowzard JB, Hoelscher MA, Jeisy-Scott V, Wiens ME, Gangappa S, Gubareva L, Garcia-Sastre A, Katz JM, Tumpey TM, Fujita T, Sambhara S.
  • Journal Title: Virology Journal. 7 Pages: 102-102
• [Journal Article] LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. (2010)
  • Author(s): Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O.
  • Journal Title: Proc Natl Acad Sci USA. 107 Pages: 1512-1517
• [Journal Article] Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. (2010)
  • Author(s): Slater, L., et al.
  • Journal Title: PLoS Pathogens Volume: 6
  • Peer Reviewed
• [Journal Article] Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. (2010)
  • Author(s): Onoguchi, K., et al
  • Journal Title: PLoS Pathogens Volume: 6
  • Peer Reviewed
• [Journal Article] LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. (2010)
  • Author(s): Satoh, T., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 107 Pages: 1261-2
  • Peer Reviewed
• [Journal Article] RIG-I activation inhibits ebolavirus replication. (2009)
  • Author(s): Spiropoulou CF, Ranjan P, Pearce MB, Sealy TK, AlbarinoCG, Gangappa S, Fujita T, Rollin PE, Nichol ST, Ksiazek TG, Sambhara S.
  • Journal Title: Virology. 392 Pages: 11-15
• [Journal Article] RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive interstitial lung disease. (2009)
  • Author(s): Sato S., Hoshino K., Satoh T., Fujita T., Kawakami Y., Fujita T., Kuwana M.
  • Journal Title: Arthritis & Rheumatism. 60 Pages: 2193-2200
• [Journal Article] Solution Structures of MDA5 and LGP2 C-terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors. (2009)
  • Author(s): Takahasi K., Kumeta H., Tsuduki N., Narita R., Shigemoto T., Hirai R., Yoneyama M., Horiuchi M., Ogura K., Fujita T., Inagaki F.
  • Journal Title: J.Biol.Chem 284 Pages: 17465-17474
• [Journal Article] Identification of loss of function mutations in human genes encoding RIG-I and mda5:Implications for resistance to type I diabetes. (2009)
  • Author(s): Shigemoto T., Kageyama M., Hirai R., Zheng J-P., Yoneyama M., Fujita T.
  • Journal Title: J.Biol.Chem[Epub ahead of print]
• [Journal Article] Identification of loss of function mutations in human genes encoding RIG-I and mda5 : Implications for resistance to type I diabetes. (2009)
  • Author(s): Shigemoto, T.
  • Journal Title: J.Biol.Chem. 284 Pages: 13348-13354
  • Peer Reviewed
• [Journal Article] Solution Structures of MDA5 and LGP2 C-terminal Domains : Identification of the RNA Recognition Loop in RIG-I Like Receptors. (2009)
  • Author(s): Takahasi, K.
  • Journal Title: J.Biol.Chem. 284 Pages: 17465-17474
  • Peer Reviewed
• [Journal Article] RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopath is dermatomyositis : association with rapidly progressive interstitial lung disease. (2009)
  • Author(s): Sato, S.
  • Journal Title: Arthritis & Rheumatism 60 Pages: 2193-2200
  • Peer Reviewed
• [Journal Article] RIG-I activation inhibits ebolavirus replication (2009)
  • Author(s): Spiropoulou CF.
  • Journal Title: Virology 329 Pages: 11-15
  • Peer Reviewed
• [Journal Article] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. (2008)
  • Author(s): Kato H., Takeuchi O., Mikamo-Satoh E., Hirai R., Kawai T,.Matsushita K., Hiiragi A., Dermody TS., Fujita T., Akira S.
  • Journal Title: J Exp Med. 7 Pages: 1523-1527
• [Journal Article] Non-self RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2008)
  • Author(s): Takahasi K, Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita, R., Gale Jr.M., Inagaki F., Fujita T.
  • Journal Title: Molecular Cell. 29 Pages: 428-440
• [Journal Article] The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. (2008)
  • Author(s): Cui S., Eisenacher K., Kirchhofer A., Brzozka K., Lammens A., Lammens K., Fujita T., Conzelmann K-K., Krug A., Hopfner K-P.
  • Journal Title: Molecular Cell. 29 Pages: 169-179
• [Journal Article] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. (2008)
  • Author(s): Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T,. Matsushita, K., Hiiragi, A., Dermody, TS., Fujita, T., Akira, S.
  • Journal Title: J Exp Med. 7 Pages: 1523-1527
  • Peer Reviewed
• [Journal Article] Non-self RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2008)
  • Author(s): Takahasi K, Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita, R., Gale Jr. M., Inagaki F. and Fujita T.
  • Journal Title: Molecular Cell. 29 Pages: 428-440
  • Peer Reviewed
• [Journal Article] The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. (2008)
  • Author(s): Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K-K., Krug, A. and Hopfner, K-P.
  • Journal Title: Molecular Cell. 29 Pages: 169-179
  • Peer Reviewed
• [Journal Article] Non-self RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral, Immune Responses (2008)
  • Author(s): Takahasi K, Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita, R., Gale Jr. M., Inagaki F. and Fujita T.
  • Journal Title: Molecular Cell 29 Pages: 428-440
  • Peer Reviewed
• [Journal Article] The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I (2008)
  • Author(s): Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K-K., Krug. A. and Hopfner, K-P.
  • Journal Title: Molecular Cell 29 Pages: 169-179
  • Peer Reviewed
• [Journal Article] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid?inducible gene-I and melanoma differentiation-associated gene 5 (2008)
  • Author(s): Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T,. Matsushita, K., Hiiragi, A., Dermody, TS., Fuiita, T., Akira. S.
  • Journal Title: J Exp Med 7 Pages: 1523-1527
  • Peer Reviewed
• [Journal Article] Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. (2008)
  • Author(s): Ishii, K. J.・Kawagoe, T.・Koyama, S.・Matsui, K.・Kumar, H.・Kawai, T.・Uematsu, S.・Takeuchi, O.・Takeshita, F.・Coban, C.・Akira, S.
  • Journal Title: Nature 451 Pages: 725-729
  • Peer Reviewed
• [Journal Article] Lymphocytoid chorimeningitis virus activates plasmacytoid dendritic cells and induces ctotoxic T cell response via MyD88. (2008)
  • Author(s): Jung, A・Kato, H・Kumagai, Y・Kumar, H・Kawai, T・Takeuchi, O・Akira, S.
  • Journal Title: J Virol. 82 Pages: 196-206
  • Peer Reviewed
• [Journal Article] Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Eptihelial Cells. (2008)
  • Author(s): Le Goffic, R・Pothlichet, J・Vitour, D・Fujita, T・Meurs, E・Chignard, M・Si-Tahar, M.
  • Journal Title: J Immunol 178 Pages: 3368-3372
  • Peer Reviewed
• [Journal Article] The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. (2008)
  • Author(s): Cui, S.・Eisenacher, K.・Kirchofer, A.・Brzozka, K.・Lammens, A.・Lammens, K.・Fujita, T.・Conzelmann, K-K.・Krug, A.・Hopfner, K-P.
  • Journal Title: Molecular Cell 29 Pages: 169-179
  • Peer Reviewed
• [Journal Article] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. (2007)
  • Author(s): Arimoto K., Takahashi H., Hishiki T., Konishi H., Fujita T., Shimotohno K.
  • Journal Title: Proc Natl Acad Sci USA. 104 Pages: 7500-7505
• [Journal Article] Katn of Intracytoplasmic Pathogen Sensor, RIG-I. (2007)
  • Author(s): Guo Z., Chen L.M., Zeng H., Gomez J.A., Plowden J., Fujita T., Katz J.A., Plowden J., Fujita T.
  • Journal Title: Am J Respir Cell Mol Biol. 36 Pages: 263-269
• [Journal Article] Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism. (2007)
  • Author(s): Onoguchi K., Yoneyama M., Takemura A., Akira S., Taniguchi T., Namiki H., Fujita T.
  • Journal Title: J.Biol.Chem 282 Pages: 7576-7581
• [Journal Article] Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. (2007)
  • Author(s): Saito T., Hirai R., Loo Yueh-Ming., D Owen., C L.Johnson., S C.Shinha., Akira S., Fujita T., Gale Jr., M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 104 Pages: 582-587
• [Journal Article] Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 (2007)
  • Author(s): Saito, T., Hirai, R., Loo., Yueh-Ming., D, Owen., C, L. Johnson., S., C. Shinha., Akira, S., Fujita T. and Gale Jr., M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 582-587
  • Peer Reviewed
• [Journal Article] Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. (2007)
  • Author(s): Kumagai, Y・Takeuchi, O・Kato, H・Kumar, H・Matsui, K・Morii, E・Aozasa, K・Kawai, T・Akira, S.
  • Journal Title: Immunity 27 Pages: 240-252
  • Peer Reviewed
• [Journal Article] Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. (2007)
  • Author(s): Saito, T.・Hirai, R.・Loo., Yueh Ming・D., Owen・C.L., Johnson・S. C., Shinha・Akira, S.・Fujita, T.・Gale Jr., M.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 104 Pages: 582-587
  • Peer Reviewed
• [Journal Article] Viral Infections Activate Types I and III Interferon Genes through a Conmmon Mechanism. (2007)
  • Author(s): Onoguhci, K.・Yoneyama, M.・Takemura, A.・Akira, S.・Taniguchi, T.・Namiki, H.・Fujita, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 7576-7581
  • Peer Reviewed
• [Journal Article] NS1 Protein of Influenza A Virus Inhibits the Function of Intracytoplasmic Pathogen Sensor, RIG-I. (2007)
  • Author(s): Guo, Z.・Chen, L. M.・Zeng, H.・Gomez, J. A.・Plowden, J.・Fujita, T.・J. M.・Donis, R. O.・Sambhara, S.
  • Journal Title: Am J Respir Cell Mol Biol. 36 Pages: 263-269
  • Peer Reviewed
• [Journal Article] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 (2007)
  • Author(s): Arimoto, K.・Takahashi, H.・Hishiki, T.・Konishi, H.・Fujita, T.・Shimotohno, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 104 Pages: 7500-7505
  • Peer Reviewed
• [Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. (2007)
  • Author(s): Tasaka, M.・Sakamoto, N.・Itakura, Y.・Nakagawa, M.・Itsui, Y.・Sekine-Ossajima, Y.・Nishimura-Sakurai, Y.・Chen, C. H.・Yoneyama, M.・Fujita, T.・Wakita, T.・Maekawa, S.・Enomoto, N.・Watanabe, M.
  • Journal Title: J. Gen Virol. 88 Pages: 3323-3333
  • Peer Reviewed
• [Journal Article] Non-self RNA-Sensing Mechansism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2007)
  • Author(s): Takahasi, K・Yoneyama, M・Nishihori, T.・Hirai, R.・Kumeta, H.・Narita, R.・Gale, Jr. M, ・Inagaki, F・Fujita, T.
  • Journal Title: Molecular Cell 29 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Triggering antiviral response by RIG-I-related RNA helicases. (2007)
  • Author(s): Fujita, T.・Onoguchi, K.・Onomoto, K.・Hirai, R.・Yoneyama, M.
  • Journal Title: Biochimie 89 Pages: 754-760
  • Peer Reviewed
• [Journal Article] Function of RIG-I-Like receptors in antiviral innate immunity. (2007)
  • Author(s): Yoneyama, M.・Fujita, T.
  • Journal Title: J. Bilol. Chem. 282 Pages: 15315-15318
  • Peer Reviewed
• [Journal Article] RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity. (2007)
  • Author(s): Yoneyama, M.・Fujita, T.
  • Journal Title: Cytokine Growth Factor Rev. 18 Pages: 545-551
• [Journal Article] Gytoplasmic double-stranded DNA sensor. (2007)
  • Author(s): Yoneyama, M.・Fujita, T.
  • Journal Title: Nature Immunology 8 Pages: 907-908
• [Journal Article] Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases. (2007)
  • Author(s): Onomoto, K.・Yoneyama, M.・Fujita, T.
  • Journal Title: Current Topics in Microbiology and Immunology 316 Pages: 193-205
• [Journal Article] Viral infections activate types I and III interferon genes through a common mechanism (2007)
  • Author(s): Onoguchi, K., Fujita, T.et al.
  • Journal Title: J. Biol. Chem. 282 Pages: 7576-7581
• [Journal Article] Differential role of MDA5 and RIG-I in the recognition of RNA viruses. (2006)
  • Author(s): Kato H., Takeuchi O., Sato S., Yoneyama M., Yamamoto M., Matsui K., Uematsu S., Jung A., Kawai T., Ishii K.J., Yamaguchi O., Otsu K., Tsujimura T., Koh C-S., Reis e Sousa C., Matsuura Y., Fujita T., Akira S.
  • Journal Title: Nature 441 Pages: 101-105
• [Journal Article] Differential role of MDA5 and RIG-I in the recognition of RNA viruses. (2006)
  • Author(s): Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C-S., Reis e Sousa, C., Matsuura, Y., Fujita, T. and Akira, S.
  • Journal Title: Nature 441 Pages: 101-105
  • Peer Reviewed
• [Journal Article] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses (2006)
  • Author(s): Kato, H., Akira, S.et al.
  • Journal Title: Nature 441 Pages: 101-105
• [Journal Article] Essential role of IPS-I in innate immune responses against RNA viruses (2006)
  • Author(s): Kumar, H., Akira, S.et al.
  • Journal Title: J. Exp. Med. 203 Pages: 1792-1803
• [Journal Article] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA (2006)
  • Author(s): Takahashi, K, Akira, S. et al.
  • Journal Title: J. Immunol. 176 Pages: 4520-4524
• [Journal Article] Roles of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells (2006)
  • Author(s): Matsui, K., Akira, S.et al.
  • Journal Title: J. Immunol. 177 Pages: 5785-5789
• [Journal Article] 5'-Triphosphate RNA is the ligand for RIG-I (2006)
  • Author(s): Hornung, V., Akira, S.et al.
  • Journal Title: Science 314 Pages: 994-997
• [Presentation] Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. (2010)
  • Author(s): Fujita, T.
  • Organizer: Cytokine 2010
  • Place of Presentation: Chicago(招待講演)
  • Year and Date: 2010-10-05
• [Presentation] Virus-infection or 5´ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. (2010)
  • Author(s): Fujita T.
  • Organizer: Cytokines 2010:Cancer in Infectious Diseases, Autoimmune Disorders and Cancer.
  • Place of Presentation: Chicago, USA
• [Presentation] Regulation of the innate antiviral response by local condensation of IPS-1 mediated by mitochondrial dynamism. (2010)
  • Author(s): Fujita T.
  • Organizer: 50th ICAAC.
  • Place of Presentation: Boston, USA
• [Presentation] Regulation of the innate antiviral response by local condensation of IPS-1 mediated by mitochondrial dynamism. (2010)
  • Author(s): Fujita T.
  • Organizer: 14th International Congress of Immunology.
  • Place of Presentation: Kobe, Japan
• [Presentation] Recognition of viral nucleic acids by RLRs in antiviral innate immunity. (2010)
  • Author(s): Fujita T.
  • Organizer: 3rd International Workshop on Cell Communication in Health and Disease.
  • Place of Presentation: Vienna, Austria
• [Presentation] Mechanism of RNA recognition by the RIG-I-like receptors and activation of antiviral program: 2^nd International Centre for Genetic Engineering and Biotechnology Workshop on Human RNA viruses. (2010)
  • Author(s): Fujita T.
  • Place of Presentation: New Dehli, India
• [Presentation] Activation of an antiviral program through the cytoplasmic Recognition of non-self RNA patterns by RLR. (2009)
  • Author(s): Takashi Fujita
  • Place of Presentation: Tri-Society Annual Conference, Lisbon Portugal
  • Year and Date: 2009-10-19
• [Presentation] Activation of an antiviral program through the cytoplasmic Recognition of non-self RNA patterns by RLR (2009)
  • Author(s): Fujita, T.
  • Organizer: 2009 Tri-Society Annual Conference
  • Place of Presentation: Lisbon Portugal
  • Year and Date: 2009-10-19
• [Presentation] Sensing Viral Replication by RIG-I-Like Receptors and Antiviral Innate Immunity. (2009)
  • Author(s): Takashi Fujita
  • Organizer: 109^th General Meeting of American Society for Microbiology
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2009-05-19
• [Presentation] Sensing Viral Replication by RIG-I-Like Receptors and Antiviral Innate Immunity (2009)
  • Author(s): Fujita, T.
  • Organizer: 109^<th> General Meeting of American Society for Microbiology
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2009-05-01
• [Presentation] Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors. (2009)
  • Author(s): Fujita T.
  • Organizer: Keystone Symposia, Pattern Recognition Molecules and Immune Sensors of Pathogens.
  • Place of Presentation: Banff, Canada
  • Year and Date: 2009-04-01
• [Presentation] Solution Structures of MDA5 and LGP2 C-Terminal Domains : Identification of the RNA Recognition Loop in RIG-I Like Receptors (2009)
  • Author(s): Fujita, T.
  • Organizer: Keystone Symposia, Pattern Recognition Molecules and Immune Sensors of Pathogens
  • Place of Presentation: Banff, Canada
  • Year and Date: 2009-04-01
• [Presentation] Anti virus and anti cell growth responses induced by non-self RNA sensor, RIG-I RNA helicase (2008)
  • Author(s): Fujita, T.
  • Organizer: 67th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya
  • Year and Date: 2008-10-29
• [Presentation] Mechanism of Foreign RNA Recognition in the Cytoplasm. (2008)
  • Author(s): Fujita T.
  • Organizer: 7^th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research.
  • Place of Presentation: Montreal Quebec, Canada
• [Presentation] Non-self RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. (2008)
  • Author(s): Fujita T.
  • Organizer: 1^st International Centre for Genetic Engineering and Biotechnology Workshop on Human RNA viruses.
  • Place of Presentation: Trieste, Italy
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I-Like Helicase and Activation of Antiviral Immune Responses. (2008)
  • Author(s): Takahasi K, Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita, R., Gale Jr.M., Inagaki F.and Fujita T.
  • Organizer: XIV.International Congress of Virology
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I-Like Helicase and Activation of Antiviral Immune Responses. (2008)
  • Author(s): Fujita T.
  • Organizer: Keystone Symposia, Innate Immunity: Signaling Mechanisms.
  • Place of Presentation: Keystone, Colorado
• [Presentation] Regulation of interferon gene expression and virus infection of the liver. (2008)
  • Author(s): Fujita, T.
  • Organizer: Hepatic Inflammation and Immunity.
  • Place of Presentation: Moody Gardens Resort, Galveston, Texas
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I-Like Helicase and Activation of Antiviral Immune Responses. Keystone Symposia (2008)
  • Author(s): Fujita, T.
  • Organizer: Innate Immunity: Signaling Mechanisms
  • Place of Presentation: Keystone, Colorado
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I-Like Helicase and Activation of Antiviral Immune Responses (2008)
  • Author(s): Fujita, T.
  • Organizer: XIV. International Congress of Virology
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Non-self RNA-sensing mechanism of RIGL-I helicase and activation of antiviral immune responses (2008)
  • Author(s): Fujita, T.
  • Organizer: 1st International Centre for Genetic Engineering and Biotechnology Workshop on Human RNA viruses
  • Place of Presentation: Trieste. Italy
• [Presentation] Mechanism of Foreign-RNA Recognition in the Cytoplasm (2008)
  • Author(s): Fujita, T.
  • Organizer: 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research
  • Place of Presentation: Quebec, Canada
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2007)
  • Author(s): Fujita T.
  • Organizer: 3rd Annual Meeting of the Oligonucleotide Therapeutic Society
  • Place of Presentation: Langenbeck-Virchow Auditorium, Berlin, Germany
  • Year and Date: 2007-10-05
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2007)
  • Author(s): Fujita, T.
  • Organizer: 3rd Annual Meeting of the Oligonucleotide Thera peutic Society
  • Place of Presentation: Langenbeck-Virchow Auditorium, Berlin, Germany
  • Year and Date: 2007-10-05
• [Presentation] Toll-like receptors in Microbial and Viral Defense (2007)
  • Author(s): Shizuo, Akira
  • Organizer: Innate immunity and its interface with adaptive immunity
  • Place of Presentation: St.Odile, France
  • Year and Date: 2007-09-03
• [Presentation] 抗ウイルス生体防御のセンサー、RIG-I like receptors (2007)
  • Author(s): 藤由尚志
  • Organizer: 第31回阿蘇シンポジウム
  • Place of Presentation: 阿蘇
  • Year and Date: 2007-07-27
• [Presentation] RIG-I family helicases: Cytoplasmic sensor for non-self RNA.Viral Immunology Symposium (2007)
  • Author(s): Fujita T.
  • Organizer: Johns Hopkins Bloomberg School of Public Health, Baltimore
  • Place of Presentation: MD USA
  • Year and Date: 2007-07-23
• [Presentation] RIG-I family helicases: Cytoplasmi sensor for non-self RNA (2007)
  • Author(s): Fujita, T.
  • Organizer: Viral Immunology Symposium
  • Place of Presentation: 23 Johns Hopkins Bloom berg School of Public Health, Baltimore, MD USA
  • Year and Date: 2007-07-23
• [Presentation] Sensing viruses and antiviral response. (2007)
  • Author(s): Fujita T.
  • Organizer: Gordon Research Conferences: Viruses and Cells
  • Place of Presentation: Tilton School, Tilton NH USA
  • Year and Date: 2007-06-05
• [Presentation] Sensing viruses and antiviral response. (2007)
  • Author(s): Fujita, T.
  • Organizer: Gordon Research Conferences:Viruses and Cells
  • Place of Presentation: Tilton School, Tilton NHUSA
  • Year and Date: 2007-06-05
• [Presentation] ウイルスの複製を感知するCARDヘリカーゼ、RIG-Iファミリ- (2007)
  • Author(s): 藤田尚志
  • Organizer: 第3回神戸膠原病研究会
  • Place of Presentation: 神戸
  • Year and Date: 2007-05-25
• [Presentation] 抗ウイルス自然免疫機構制御するウイルスセンサー、RIG-I like receptor. (2007)
  • Author(s): 藤田尚志
  • Organizer: 第13回神広島肝臓研究会
  • Place of Presentation: 広島
  • Year and Date: 2007-05-17
• [Presentation] III型インターフェロンは1型インターフェロンと同じ転写制御を受ける (2007)
  • Author(s): 小野口和英、米山光俊、審良静男、谷口維紹、藤田尚志
  • Organizer: 第72回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-06
• [Presentation] 細胞内ウイルス感染センサーRIG-Iによる非自己RNA認識のメカニズム (2007)
  • Author(s): 米山光俊、平井玲子、成田亮、藤田尚志
  • Organizer: 第72回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-06
• [Presentation] RIG-I CARDのオリゴマー形成に夜シグナル伝達機構と生理的機能の解析 (2007)
  • Author(s): 尾野本浩司、米山光俊、大島宏之、藤田尚志
  • Organizer: 第72回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-06
• [Presentation] Triggering Antiviral responses and Cell Regulation by the Cytoplasmic RNA Helicase RIG-I. (2007)
  • Author(s): Fujita T.
  • Organizer: Keystone Symposia: Intracellular and Intercellular Signaling in Dendritic Cell Function
  • Place of Presentation: Keystone, CO USA
  • Year and Date: 2007-02-26
• [Presentation] Triggering Antiviral responses and Cell Regulation by the Cytoplasmic RNA Helicase RIG-I. (2007)
  • Author(s): Fujita, T.
  • Organizer: Keystone Symposia : Intracellular and Intercellular Signaling in Dendritic Cell Function
  • Place of Presentation: Keystone, CO USA
  • Year and Date: 2007-02-26
• [Presentation] Signal Transduction by Cytoplasmic Virus Receptors. (2007)
  • Author(s): Fujita T.
  • Organizer: Keystone Symposia: Jaks, Stats and Immunity
  • Place of Presentation: Steamboat Springs, CO USA
  • Year and Date: 2007-01-09
• [Presentation] Non-self RNA Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. (2007)
  • Author(s): Fujita T.
  • Organizer: ISICR 2007
  • Place of Presentation: Oxford, UK
• [Presentation] Pattern Ratternition by Innate Immunity (2007)
  • Author(s): Shizuo, Akira
  • Organizer: Dunham Lecture
  • Place of Presentation: Boston, USA
• [Presentation] Triggering Antiviral Responses and host regulation by the Cytoplasmic RNA Helicase RIG-I. (2006)
  • Author(s): Fujita T.
  • Organizer: Cytokines 2006
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-08-28
• [Book] Chapter 2 Type I interferon production by viruses, in Viruses and Interferon: Current Research, Ed. (2010)
  • Author(s): Kazuhide Onoguchi, Kiyohiro Takahasi, Mitsutoshi Yoneyama, Takashi Fujita
  • Publisher: Karen Mossman, Caister Academic Press
• [Book] Chapter 2 Type I interferon production by viruses,in Viruses and Interferon : Current Research, Ed.Karen Mossman (2010)
  • Author(s): Onoguchi, K., et al
  • Publisher: Caister Academic Press
• [Book] 免疫応答と免疫病態の総合的分子理解 : ウイルス感染における細胞内センシング機構 (2008)
  • Author(s): 尾野本浩司、米山光俊、藤田尚志
  • Publisher: 南山堂
• [Book] 炎症と免疫 (2007)
  • Author(s): 小野口和英、米山光俊、藤田尚志
  • Total Pages: 6
  • Publisher: 先端医学社
• [Book] 蛋白質 核酸 酵素 (2007)
  • Author(s): 成田亮、米山光俊、藤田尚志
  • Total Pages: 7
  • Publisher: 共立出版
• [Book] 免疫応答と免疫病態の統合的分子理解 (2007)
  • Author(s): 尾野本浩司、米山光俊、藤田尚志
  • Total Pages: 10
  • Publisher: 南山堂
• [Remarks] ホームページ等
  • URL: http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden/index.html