| Project Area | Matrix of Infection Phenomena |
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| Project/Area Number |
18073016
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
NAKANISHI Kenji Hyogo College of Medicine, 医学部, 教授 (60172350)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥91,000,000 (Direct Cost: ¥91,000,000)
Fiscal Year 2010: ¥18,200,000 (Direct Cost: ¥18,200,000)
Fiscal Year 2009: ¥18,200,000 (Direct Cost: ¥18,200,000)
Fiscal Year 2008: ¥18,200,000 (Direct Cost: ¥18,200,000)
Fiscal Year 2007: ¥18,200,000 (Direct Cost: ¥18,200,000)
Fiscal Year 2006: ¥18,200,000 (Direct Cost: ¥18,200,000)
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| Keywords | Th2応答 / 好塩基球 / APC / 蠕虫感染 / アジュバント / キチン / IL-33 / Th2/IgE応答 / Th2アジュバント / IL-5/IL13 / 自然型2型ヘルパー細胞 / 抗原提示細胞 / IL-4 / アレルゲン / IgE複合体 / L.major / Th1 / 腸管寄生線虫 / IL-18 / ST2 / 杯細胞 / Nb / IL-13 / 排虫 / Leishmania major(L.major) / Th1宿主応答 / Th2宿主応答 / Strongyloides venezuelensis (Sv) / IL-27 / Strongyloides venezuelensis |
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| Research Abstract |
Although intestinal helinth is expelled mainly by the action of Th2 cells, the mechanism how helminth infection induces Th2/IgE response remains uncertain. To our surprise, basophils express MHC class II and CD80/86. They have the capacity to take-up and process protein antigen (Ag), particularly Ag-IgE complex, and to present peptide with MHC class II and produce IL-4. Thus, basophils are APC, which selectively induce Th2 cells. Furthermore Basophil-lacking mice showed diminished capacity to expel Strongyloides venezuelensis (Sv), although they developed Th2 response in response to infection with Sv. Since helminth infection induces Th2 response, we wished to determine the molecules responsible for inducing Th2 response. Here, we demonstrated that chtin is adjuvant. Furthermore, ip injection of chitin promptly induces IL-33, which in turn stimulates ST2-expressing innate type cells (e. g., natural helper cell) to produce IL-5 and IL-13.
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