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Dynamics of autophagy and its physiological roles

Planned Research

Project AreaProteolysis in the Regulation of Biological Processes
Project/Area Number 18076005
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MIZUSHIMA Noboru  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10353434)

Co-Investigator(Kenkyū-buntansha) TANIDA Isei  国立感染症研究所, 細胞化学部, 室長 (30296868)
KOMATSU Masaaki  順天堂大学, 医学部, 准教授 (90356254)
UENO Takashi  順天堂大学, 医学部, 准教授 (10053373)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥216,900,000 (Direct Cost: ¥216,900,000)
Fiscal Year 2010: ¥47,900,000 (Direct Cost: ¥47,900,000)
Fiscal Year 2009: ¥53,500,000 (Direct Cost: ¥53,500,000)
Fiscal Year 2008: ¥50,700,000 (Direct Cost: ¥50,700,000)
Fiscal Year 2007: ¥36,600,000 (Direct Cost: ¥36,600,000)
Fiscal Year 2006: ¥28,200,000 (Direct Cost: ¥28,200,000)
Keywordsオートファジー / ユビキチン / タンパク質分解 / タンパク質品質管理 / タンパク質凝集 / 発生 / mTOR / Tti1 / パーキン / ミトコンドリア / 腫瘍 / 糖新生 / プロテアソーム / ULK1 / PI3キナーゼ / 小胞体 / p62 / HCV / 細胞内情報伝達 / 初期胚発生 / 受精 / タンパク質凝集体 / 封入体 / ULKI / プリオン / インスリン / 飢餓 / GCN2
Research Abstract

Our mouse genetic studies revealed that autophagy is required for early embryogenesis and suppression of spontaneous tumorigenesis in the liver. We also proposed a mechanism of autophagy induction, based on our analyses on the relationship between autophagy factors and mTOR. Finally, we showed that selective degradation of p62 is important for protection of liver damage caused by an aberrant transcriptional regulation. These findings provided new insights into the physiological roles and regulation mechanism of autophagy.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (237 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (135 results) (of which Peer Reviewed: 78 results) Presentation (78 results) Book (2 results) Remarks (16 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Autophagy-deficient mice develop multiple liver tumors.2011

    • Author(s)
      Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., Mizushima, N.
    • Journal Title

      Genes Dev. 25

      Pages: 795-800

    • Related Report
      2010 Final Research Report
  • [Journal Article] p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.2011

    • Author(s)
      Itakura, E., Mizushima, N.
    • Journal Title

      J.Cell Biol. 192

      Pages: 17-27

    • Related Report
      2010 Final Research Report
  • [Journal Article] Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.2011

    • Author(s)
      Yoshii, S.R.
    • Journal Title

      J.Biol.Chem.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct mechanisms of ferritin delivery to lysosomes in iron depleted and iron-replete cells.2011

    • Author(s)
      Asano, T.
    • Journal Title

      Mol.Cell.Biol.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy-deficient mice develop multiple liver tumors.2011

    • Author(s)
      Takamura, A.
    • Journal Title

      Genes Dev.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crohn disease : A current perspective on genetics, autophagy and immunity.2011

    • Author(s)
      Stappenbeck, T.S
    • Journal Title

      Autophagy

      Volume: 7 Pages: 1-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy in immunity and inflammation.2011

    • Author(s)
      Levine, B.
    • Journal Title

      Nature

      Volume: 469 Pages: 323-335

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 飢餓におけるmTORの役割:オートファジー誘導とリソソーム生合成2011

    • Author(s)
      久万亜紀子
    • Journal Title

      実験医学

      Volume: 29 Pages: 877-882

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 飢餓における細胞応答:オートファジー2011

    • Author(s)
      久万亜紀子
    • Journal Title

      アディポサイエンス

      Volume: 7(3) Pages: 199-205

    • Related Report
      2010 Annual Research Report
  • [Journal Article] オートファジーの受精卵発生における役割2011

    • Author(s)
      塚本智史
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 18 Pages: 53-58

    • Related Report
      2010 Annual Research Report
  • [Journal Article] オートファジーと癌抑制2011

    • Author(s)
      西村多喜
    • Journal Title

      実験医学

      Volume: 29 Pages: 236-241

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.2011

    • Author(s)
      Saiki, S
    • Journal Title

      Autophagy

      Volume: 7 Pages: 176-187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy basics2011

    • Author(s)
      Tanida、I
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 1-11

    • NAID

      10031121434

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.2011

    • Author(s)
      Ezaki J.
    • Journal Title

      Autophagy

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.2010

    • Author(s)
      Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S., Natsume, T., Mizushima, N.
    • Journal Title

      J.Biol.Chem. 285

      Pages: 20109-20116

    • Related Report
      2010 Final Research Report
  • [Journal Article] Methods in mammalian autophagy research.2010

    • Author(s)
      Mizushima, N., Yoshimori, T., Levine, B.
    • Journal Title

      Cell 140

      Pages: 313-326

    • Related Report
      2010 Final Research Report
  • [Journal Article] Autophagy in mammalian development and differentiation.2010

    • Author(s)
      Mizushima, N., Levine, B.
    • Journal Title

      Nat.Cell Biol. 12

      Pages: 823-830

    • Related Report
      2010 Final Research Report
  • [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010

    • Author(s)
      Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.S., Ueno, I., Sakamoto, A., Tong, K.I., Kim, M., Nishito, Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M.
    • Journal Title

      Nat Cell Biol. 12

      Pages: 213-223

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway : a potential role for protein aggregation in autophagic substrate selection.2010

    • Author(s)
      Riley, B.E.
    • Journal Title

      J.Cell Biol.

      Volume: 191 Pages: 537-552

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010

    • Author(s)
      Taneike, M.
    • Journal Title

      Autophagy

      Volume: 6 Pages: 600-606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy influences glomerular disease susceptibility, and maintains podocyte homeostasis in aging mice.2010

    • Author(s)
      Hartleben, B.
    • Journal Title

      J.Clin.Invest.

      Volume: 120 Pages: 1084-1096

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo.2010

    • Author(s)
      Inoue, K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 14 Pages: 112-122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noboru Mizushima : All about autophagy. Interview by Caitlin Sedwick.2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      J.Cell Biol.

      Volume: 190 Pages: 946-947

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy in mammalian development and differentiation.2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      Nat.Cell Biol.

      Volume: 12 Pages: 823-830

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive glossary of autophagy-related molecules and processes.2010

    • Author(s)
      Klionsky, D.J.
    • Journal Title

      Autophagy

      Volume: 6 Pages: 438-448

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological role of autophagy as an intracellular recycling system : With an emphasis on nutrient metabolism.2010

    • Author(s)
      Kuma, A.
    • Journal Title

      Semin.Cell Dev.Biol.

      Volume: 21 Pages: 683-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 1279-1279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methods in mammalian autophagy research.2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      Cell

      Volume: 140 Pages: 313-326

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 初期胚発生におけるオートファジーの新しい役割2010

    • Author(s)
      塚本智史
    • Journal Title

      顕微鏡

      Volume: 45 Pages: 91-93

    • Related Report
      2010 Annual Research Report
  • [Journal Article] オートファジーの制御機構と代謝生理学的役割2010

    • Author(s)
      渡邉(浅野)貴子
    • Journal Title

      日本臨床

      Volume: 69 Pages: 211-221

    • Related Report
      2010 Annual Research Report
  • [Journal Article] がんとオートファジー2010

    • Author(s)
      高村聡人
    • Journal Title

      BIO Clinica

      Volume: 25 Pages: 227-232

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Autophagyの分子機構とその生物学的意義2010

    • Author(s)
      渡邉(浅野)貴子
    • Journal Title

      Diabetes Frontier

      Volume: 21 Pages: 36-40

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Measurement of autophagy in cells and tissues.2010

    • Author(s)
      Tanida、I
    • Journal Title

      Methods Mol Biol.

      Volume: 648 Pages: 193-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagosome Formation and Molecular Mechanism of Autophagy.2010

    • Author(s)
      Tanida、I
    • Journal Title

      Antioxid Redox Signal.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free fatty acids stimulate autophagy in pancreatic ss-cells via JNK pathway.2010

    • Author(s)
      Komiya K
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 401 Pages: 561-567

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation.2010

    • Author(s)
      Shibata M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393 Pages: 274-279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of pancreatic ss-cell autophagy in health and diabetes.2010

    • Author(s)
      Fujitani, Y.
    • Journal Title

      Am J Pyhsiol Cell Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010

    • Author(s)
      Komatsu M
    • Journal Title

      Nat.Cell Biol.

      Volume: 12 Pages: 213-223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo requirement for Atg5 in antigen presentation by dendritic cells2010

    • Author(s)
      Lee, H.K.
    • Journal Title

      Immunity 32

      Pages: 227-239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy controls glomerular disease susceptibility, and maintains podocyte homeostasis in aging mice2010

    • Author(s)
      Hartleben, B.
    • Journal Title

      J.Clin.Invest. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of neurodegeneration in lurcher mice : Constitutive ion fluxes cause cell death with, not by, autophagy2010

    • Author(s)
      Nishiyama, J.
    • Journal Title

      J.Neurosci. 30

      Pages: 2177-2187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methods in mammalian autophagy research2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      Cell 140

      Pages: 313-326

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the Atg1/ULK1 complex in autophagy regulation2010

    • Author(s)
      Mizushima, N.
    • Journal Title

      Curr Opin Cell Biol.

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がんとオートファジー2010

    • Author(s)
      高村聡人
    • Journal Title

      BIO Clinica 25

      Pages: 227-232

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.2009

    • Author(s)
      Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J.L., Oshiro, N., Mizushima, N.
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 1981-1991

    • Related Report
      2010 Final Research Report
  • [Journal Article] Atg101, a novel mammalian autophagy protein interacting with Atg132009

    • Author(s)
      Hosokawa, N.
    • Journal Title

      Autophagy 5

      Pages: 973-979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy2009

    • Author(s)
      Satoo, K.
    • Journal Title

      EMBO J. 28

      Pages: 1341-1350

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes2009

    • Author(s)
      Stephenson, L.M.
    • Journal Title

      Autophagy 5

      Pages: 625-635

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy2009

    • Author(s)
      Hosokawa, N.
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 1981-1991

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macroautophagy, endogenous MHC II loading and T cell selection : the benefits of breaking the rules2009

    • Author(s)
      Nedjic, J.
    • Journal Title

      Curr Opin Immunol. 21

      Pages: 92-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 哺乳類オートファジーの制御と生理機能2009

    • Author(s)
      板倉英祐
    • Journal Title

      実験医学 27

      Pages: 2937-2942

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 栄養飢餓とオートファジー2009

    • Author(s)
      原太一
    • Journal Title

      細胞工学 28

      Pages: 784-788

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.2009

    • Author(s)
      Hosokawa, N.
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 1981-1991

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macroautophagy, endogenous MHC II loading and T cell selection : the benefits of breaking the rules.2009

    • Author(s)
      Nedjic, J.
    • Journal Title

      Curr Opin Immunol. 21

      Pages: 92-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atg14 and UVRAG : Mutually exclusive subunits of mammalian Beclin1-PI3K complexes.2009

    • Author(s)
      Itakura, E.
    • Journal Title

      Autophagy 5(in press)

      Pages: 534-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] When more is less : Excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. 5 : (2009)2009

    • Author(s)
      Raben, N.
    • Journal Title

      Autophagy 5

      Pages: 111-113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of ULK-FIP200 complex in mammalian autophagy : FIP200, a counterpart of yeast Atg17?2009

    • Author(s)
      Hara, T.
    • Journal Title

      Autophagy 5

      Pages: 85-87

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG.2008

    • Author(s)
      Itakura, E., Kishi, C., Inoue, K., Mizushima, N.
    • Journal Title

      Mol.Biol.Cell 19

      Pages: 5360-5372

    • Related Report
      2010 Final Research Report
  • [Journal Article] Autophagy is essential for preimplantation development of mouse embryos.2008

    • Author(s)
      Tsukamoto, S., Kuma, A., Murakami, M., Kishi, C., Yamamoto, A., Mizushima, N.
    • Journal Title

      Science 321

      Pages: 117-120

    • Related Report
      2010 Final Research Report
  • [Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.2008

    • Author(s)
      Hara, T., Takamura, A., Kishi, C., Iemura, S., Natsume, T., Guan, J.L., Mizushima, N.
    • Journal Title

      J.Cell Biol. 181

      Pages: 497-510

    • Related Report
      2010 Final Research Report
  • [Journal Article] Autophagy fights disease through cellular self-digestion2008

    • Author(s)
      Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J.
    • Journal Title

      Nature 451

      Pages: 1069-1075

    • Related Report
      2010 Final Research Report
  • [Journal Article] Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG2008

    • Author(s)
      Itakura, E., Kishi, C., Inoue, K., Mizushima, N
    • Journal Title

      Mol. Biol. Cell 19

      Pages: 5360-5372

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Autophagy is essential for preimplantation development of mouse embryos2008

    • Author(s)
      Tsukamoto, S., Kuma, A., Murakami, M., Kishi, C., Yamamoto, A., Mizushima, N
    • Journal Title

      Science 321

      Pages: 117-120

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells2008

    • Author(s)
      Hara, T., Takamura, A., Kishi, C., Iemura, S., Natsume, T., Guan, J.L., Mizushima, N
    • Journal Title

      J. Cell Biol 181

      Pages: 497-510

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.2008

    • Author(s)
      Zhao, Z.
    • Journal Title

      Cell Host Microbe. 4

      Pages: 458-469

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A key role for autophagy and the autophagy gene Atg1611 in mouse bind human intastinal Paneth cells.2008

    • Author(s)
      Cadwell, K.
    • Journal Title

      Nature 456

      Pages: 259-263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG.2008

    • Author(s)
      Itakura, E.
    • Journal Title

      Mol.Biol.Cell 19

      Pages: 5360-5372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.2008

    • Author(s)
      Gozuacik, D.
    • Journal Title

      Cell Death Differ. 15

      Pages: 1875-1886

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.2008

    • Author(s)
      Raben, N.
    • Journal Title

      Hum Mol Genet. 17

      Pages: 3897-3908

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice.2008

    • Author(s)
      Sou, Y.S.
    • Journal Title

      Mol Biol Cell. 19

      Pages: 4762-4775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macroautophagy in thymic epithelial cells shapes the T cell repertoire and is essential for self-tolerance.2008

    • Author(s)
      Nedjic, J.
    • Journal Title

      Nature 455

      Pages: 396-400

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells.2008

    • Author(s)
      Hashimoto, D.
    • Journal Title

      J.Cell Biol. 181

      Pages: 1065-1072

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy is essential for preimplantation development of mouse embryos.2008

    • Author(s)
      Tsukamoto, S.
    • Journal Title

      Science 321

      Pages: 117-120

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.2008

    • Author(s)
      Hara, T.
    • Journal Title

      J.Cell Biol. 181

      Pages: 497-510

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジーを介した新しい抗原提示経路2008

    • Author(s)
      水島昇
    • Journal Title

      生体の科学 59

      Pages: 454-455

    • Related Report
      2008 Annual Research Report
  • [Journal Article] オートファジーと疾患2008

    • Author(s)
      高村聡人
    • Journal Title

      細胞 40

      Pages: 29-31

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes.2008

    • Author(s)
      Haruna, K.
    • Journal Title

      Journal of Dermatological Science 52

      Pages: 213-215

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC3 and Autophagy.2008

    • Author(s)
      Tanida, I.
    • Journal Title

      Methods in Molecular Biology 445

      Pages: 77-88

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for sorting mechanism of p62 in selective autophagy.2008

    • Author(s)
      Ichimura, Y.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 22847-22857

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.2008

    • Author(s)
      Ebato, C
    • Journal Title

      Cell Metabolism 8

      Pages: 325-332

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.2008

    • Author(s)
      Hara, T
    • Journal Title

      J. Cell Biol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.2008

    • Author(s)
      Kaushik, S
    • Journal Title

      Mol. Biol. Cell (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The autophagy gene ATG5 plays an essential role in B lymphocyte development.2008

    • Author(s)
      Miller, B.C.
    • Journal Title

      Autophagy 4

      Pages: 309-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice.2008

    • Author(s)
      Kuma, A.
    • Journal Title

      Autophagy 4

      Pages: 61-62

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy fights disease through cellular self-digestion.2008

    • Author(s)
      Mizushima, N.
    • Journal Title

      Nature 451

      Pages: 1069-1075

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジー概論2008

    • Author(s)
      水島昇
    • Journal Title

      実験医学 26

      Pages: 255-260

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A Synthetic Fibril Peptide Promotes Clearance of Scrapie Prion Protein by Lysosomal Degradation2008

    • Author(s)
      Nakamura
    • Journal Title

      Microbiology and Immunology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controlS.2008

    • Author(s)
      Tanida, I.
    • Journal Title

      Autophagy 4

      Pages: 131-134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.2008

    • Author(s)
      Oppenheim, R. W.
    • Journal Title

      J Neurosci. 28

      Pages: 1490-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive proteomics analysis of autophagy-deficient mouse liver.2008

    • Author(s)
      Matsumoto, N.
    • Journal Title

      Biochem Biophys Res Commun. 368

      Pages: 643-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.2008

    • Author(s)
      Koike, M.
    • Journal Title

      Am J Pathol. 172

      Pages: 454-69

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal autophagy: going the distance to the axon.2008

    • Author(s)
      Yue, Z.
    • Journal Title

      Autophagy 4

      Pages: 94-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 凝集体形成とオートファジー2008

    • Author(s)
      小松雅明
    • Journal Title

      実験医学 増刊 26

      Pages: 157-63

    • Related Report
      2007 Annual Research Report
  • [Journal Article] オートファジーによるユビキチン結合タンパク質p62の代謝と封入体形成2008

    • Author(s)
      小松雅明
    • Journal Title

      細胞工学 HOTPRESS 22

      Pages: 168-9

    • Related Report
      2007 Annual Research Report
  • [Journal Article] オートファジーと神経変性2008

    • Author(s)
      小松雅明
    • Journal Title

      難病と在宅ケア 13

      Pages: 48-50

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice.2007

    • Author(s)
      Komatsu, M., Waguri, S., Koike, M., Sou, Y.S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.I., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S.I., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Related Report
      2010 Final Research Report
  • [Journal Article] Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice2007

    • Author(s)
      Komatsu, M., Waguri, S., Koike, M., Sou, Y.S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.I., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S.I., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice.2007

    • Author(s)
      Komatsu, M.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An analysis of the role of autophagy in replication of herpes simplexvirus in cell culture.2007

    • Author(s)
      Alexander, D.E.
    • Journal Title

      J. Virol. 81

      Pages: 12128-12134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronavirus Replication Does Not Require the Autophagy Gene ATG5.2007

    • Author(s)
      Zhao, Z.
    • Journal Title

      Autophagy 3

      Pages: 581-585

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of autophagy in cardiomyocytes in the basal state and inresponse to hemodynamic stress.2007

    • Author(s)
      Nakai, A.
    • Journal Title

      Nat. Med. 13

      Pages: 619-24

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in ATG4C/autophagin-3.2007

    • Author(s)
      Marino, G.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 18573-18583

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization.2007

    • Author(s)
      Kuma, A.
    • Journal Title

      Autophagy 3

      Pages: 323-328

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy: process and function2007

    • Author(s)
      Mizushima, N.
    • Journal Title

      Genes Dev. 21

      Pages: 2861-2873

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How to interpret LC3 immunoblotting2007

    • Author(s)
      Mizushima, N.
    • Journal Title

      Autophagy 3

      Pages: 542-545

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein turnover via autophagy: Implications for metabolism.2007

    • Author(s)
      Mizushima, N.
    • Journal Title

      Annu. Rev. Nutr. 27

      Pages: 19-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress caused by aggregate-prone proteins containing homopolymeric amino acids.2007

    • Author(s)
      Uchio, N.
    • Journal Title

      FEBS J. 274

      Pages: 5619-5627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.2007

    • Author(s)
      Sanjuan, M. A.
    • Journal Title

      Nature 450

      Pages: 1253-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of Ufc1, the Ufm1-conjugating enzyme.2007

    • Author(s)
      Mizushima, T.
    • Journal Title

      Biochem Biophys Res Commun. 362

      Pages: 1079-84

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role for autophagy protein Atg7 in the maintenance of axonalhomeostasis and the prevention of axonal degeneration.2007

    • Author(s)
      Komatsu, M.
    • Journal Title

      Proc Natl Acad Sci U S A. 104

      Pages: 14489-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オートファジーの病態生理学的研究2007

    • Author(s)
      小松雅明
    • Journal Title

      生化学 79

      Pages: 749-60

    • NAID

      10019550459

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Autophagy-dependent viral recognition by plasmacytoid dendritic cell.2007

    • Author(s)
      Lee, H.K.et al.
    • Journal Title

      Science 315

      Pages: 1398-1401

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A critical role for the autophagy gene Atg5 in I cell survival and proliferation2007

    • Author(s)
      Pua, H.H.et al.
    • Journal Title

      J. Exp. Med. 204

      Pages: 25-31

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.2007

    • Author(s)
      Mizokami et al.
    • Journal Title

      Journal of Neuroscience 27・7

      Pages: 1692-1701

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Protein turnover via autophagy : Implications for metabolism.2007

    • Author(s)
      Mizushima, N. et al.
    • Journal Title

      Annu. Rev. Nutr. 27

      Pages: 19-39

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The role of mammalian autophagy in protein metabolism2007

    • Author(s)
      Mizushima, N.
    • Journal Title

      P. JPN Acad. B-Phys 82

      Pages: 39-46

    • NAID

      130000093911

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice2006

    • Author(s)
      Hara, I. et al.
    • Journal Title

      Nature 441

      Pages: 885-889

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration.2006

    • Author(s)
      Komatsu M, et al.
    • Journal Title

      Nature 441

      Pages: 880-884

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Excess peroxisomes are degraded by autophagic machinery in mammals2006

    • Author(s)
      Iwata JI et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 4035-4041

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of intracellular accumulation of mutant Huntingtin by Beclin 12006

    • Author(s)
      Shibata.M.et al.
    • Journal Title

      J Biol Chem 281

      Pages: 14474-14485

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intracellular inclusions containing mutant alpha 1-antitrypsin Z are propagated in the absence of autophagic activity.2006

    • Author(s)
      Kamimoto, I. et al.
    • Journal Title

      J. Biol. Chem 281

      Pages: 4467-4476

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Calpain is required for macroautophagy in mammalian cells.2006

    • Author(s)
      Demarchi et al.
    • Journal Title

      Journal of Cell Biology 175・4

      Pages: 595-605

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Atg8L/Apg8L is the fourth mammalian moditier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.2006

    • Author(s)
      Tanida et al.
    • Journal Title

      FEBS Journal 273・11

      Pages: 2553-2562

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.2006

    • Author(s)
      Sou et al.
    • Journal Title

      Journal of Biological Chemistry 281・6

      Pages: 3017-3024

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intracellular quality control by autophagy : How does autophagy prevent neurodegeneration?2006

    • Author(s)
      Mizushima, N. et al.
    • Journal Title

      Autophagy 2

      Pages: 302-304

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 神経細胞内浄化機構としてのオートファジー2006

    • Author(s)
      原太一 他
    • Journal Title

      細胞工学 25

      Pages: 644-645

    • Related Report
      2006 Annual Research Report
  • [Journal Article] オートファジー2006

    • Author(s)
      水島昇
    • Journal Title

      炎症と免疫 121

      Pages: 569-571

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 哺乳動物におけるオートファジーの可視化2006

    • Author(s)
      久万亜紀子, 水島昇
    • Journal Title

      顕微鏡 51

      Pages: 1503-1506

    • NAID

      10018183097

    • Related Report
      2006 Annual Research Report
  • [Journal Article] オートファジーによる細胞内品質管理2006

    • Author(s)
      小松雅明, 千葉智樹, 水島昇
    • Journal Title

      蛋白質核酸酵素 51

      Pages: 1515-1518

    • Related Report
      2006 Annual Research Report
  • [Journal Article] オートファジーのモニター方法 : 現状と課題2006

    • Author(s)
      水島昇
    • Journal Title

      蛋白質核酸酵素 51

      Pages: 1542-1548

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 発生・分化におけるオートファジーの役割2006

    • Author(s)
      久万亜紀子, 水島昇
    • Journal Title

      蛋白質核酸酵素 51

      Pages: 1503-1506

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 哺乳類オートファジーの制御因子2006

    • Author(s)
      原 太一, 水島昇
    • Journal Title

      蛋白質核酸酵素 51

      Pages: 1484-1489

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.

    • Author(s)
      Yoshii, S.R., Kishi, C., Ishihara, N., Mizushima, N.
    • Journal Title

      J.Biol.Chem. in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

    • Author(s)
      Inoue, K.
    • Journal Title

      Clin Exp Nephrol.

      Pages: 2009-2009

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

    • Author(s)
      Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J.L., Oshiro, N., Mizushima, N.
    • Journal Title

      Mol. Biol. Cell (in press)

    • Related Report
      2008 Self-evaluation Report
  • [Presentation] オートファジーによる細胞内分解の生理的役割と分子機構2011

    • Author(s)
      水島昇
    • Organizer
      第2回Cell Metabolism & Communication Conference
    • Place of Presentation
      東京
    • Year and Date
      2011-01-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of autophagy in tumorigenesis2011

    • Author(s)
      Noboru Mizushima
    • Organizer
      第6回オートファジー研究会
    • Place of Presentation
      掛川
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hierarchical Relationships among Mammalian Atg Proteins2011

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone symposium on Autophagy
    • Place of Presentation
      Whistler, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stability of luciferase activity during autophagy2010

    • Author(s)
      Isei Tanida
    • Organizer
      50th Annual Meeting of American Society of Cell Biology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] どんどん入れ替わっている私達の体~新鮮さを保つ秘密~2010

    • Author(s)
      水島昇
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)・市民公開講座「広がる生命科学の世界-体作りから病気の克服まで-」
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Liver autophagy is essential for the maintenance of blood glucose and plasma amino acids.2010

    • Author(s)
      江崎淳二
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of Autophagy in Pten-deficient Mouse Liver.2010

    • Author(s)
      Takashi Ueno.
    • Organizer
      The 9th JSH Single Topic Conference "NASH 2010"
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類オートファジーの生理的意義と分子機構2010

    • Author(s)
      水島昇
    • Organizer
      グローバルCOEシンポジウム「神経疾患とがんの共通機能分子をめぐって」
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] オートファジー研究の最前線:胚発生、神経変性、がんとの関連2010

    • Author(s)
      水島昇
    • Organizer
      第4回清水医師会学術講演会
    • Place of Presentation
      清水
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] オートファジーによる細胞内リサイクル2010

    • Author(s)
      水島昇
    • Organizer
      第11回抗加齢歯科医学研究会主催講習会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス初期胚発生および精子形成におけるオートファジーの役割2010

    • Author(s)
      水島昇
    • Organizer
      第51回日本組織細胞化学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autophagy and mTor-signaling in production of infectious HCV-particles2010

    • Author(s)
      Isei Tanida
    • Organizer
      World Congress of Virus and Infection-2010
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] オートファジーによる細胞内分解の生理的役割2010

    • Author(s)
      水島昇
    • Organizer
      第14回日本適応医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] オートファジーによる細胞内分解の役割と制御機構2010

    • Author(s)
      水島昇
    • Organizer
      第11回京都糖尿病・動脈硬化研究会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autophagy2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      The 8th Internal Conference on Hyaluronan
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autophagy and mTor-signaling in production of infectious HCV-particles2010

    • Author(s)
      Isei Tanida
    • Organizer
      Gordon Research Conferences "Autophay in Stress, Development and Disease"
    • Place of Presentation
      Barga, Italy
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lessons from Autophagy Deficient Mouse Models.2010

    • Author(s)
      Noboru Mizushima.
    • Organizer
      Keystone symposium "Autophagy".
    • Place of Presentation
      Whistler, Canada.
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological roles of autophagy: Hierarchical Relationships among Mammalian Atg Proteins.2010

    • Author(s)
      Noboru Mizushima.
    • Organizer
      The American Society of Cell Biology 50th Annual Meeting.
    • Place of Presentation
      Philadelphia, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological role of autophagy and its regulation mechanism.2010

    • Author(s)
      Noboru Mizushima.
    • Organizer
      OzBio2010/12th IUBMB2010.
    • Place of Presentation
      Melbourne, Australia.
    • Related Report
      2010 Final Research Report
  • [Presentation] Lessons from Autophagy Deficient Mouse Models.2010

    • Author(s)
      Noboru Mizushima.
    • Organizer
      Keystone symposium "Cell Death Pathways/Metabolism and Cancer Progression".
    • Place of Presentation
      Vancouver, Canada.
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological roles of autophagy in mammals.2010

    • Author(s)
      Noboru Mizushima.
    • Organizer
      EMBO Worshop Proteolysis and Neurodegeneration/5th INPROTEOLYS meeting.
    • Place of Presentation
      Madrid.
    • Related Report
      2010 Final Research Report
  • [Presentation] Autophagosome formation and early Atg proteins2010

    • Author(s)
      Eisuke Itakura
    • Organizer
      Gordon Research Conference "Autophagy in stress, development and disease"
    • Place of Presentation
      Barga, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological roles of autophagy in mammals2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      EMBO Worshop Proteolysis and Neurodegeneration/5th INPROTEOLYS meeting
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role of autophagy during embryogenesis and spermatogenesis in mice2010

    • Author(s)
      Satoshi Tsukamoto
    • Organizer
      43rd Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological role of autophagy and its regulation mechanism2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      New Horizons for Modern Science : Biology and Medicine at the Crossroads
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological roles of autophagy in mammals2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological role of autophagy and its regulation mechanism2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      OzBio2010/12th IUBMB2010
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of autophagy in tumorigenesis2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      1st Sino-Japan Autophagy Symposium
    • Place of Presentation
      Xi'an, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological role of autophagy : Lessons from autophagy deficient mouse models2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類におけるオートファジーの制御機構と生理的意義の研究2010

    • Author(s)
      水島昇
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ultrastructural analysis of Parkin-dependent mitochondrial degradation2010

    • Author(s)
      Chieko Kishi
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精子完成過程におけるオートファジーの生理機能の解析2010

    • Author(s)
      塚本智史
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of lysosome in organelle degradation during lens differentiation2010

    • Author(s)
      Hideaki Morishita
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Parkin-dependent degradation of depolarized mitochondria involves both autophagy and proteasome2010

    • Author(s)
      Saori Yoshii
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of Atg5-deficient mice rescued with Atg5 Expression in the brain2010

    • Author(s)
      Akiko Kuma
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological roles of autophagy : Lessons from autophagy deficient mouse models2010

    • Author(s)
      Noboru Mizushima
    • Organizer
      The American Society of Cell Biology 50th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] オートファジー条件におけるプロテアソームの活性化2010

    • Author(s)
      谷田以誠
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanism of autophagy induction and autophagosome formation in mammalian cells.2009

    • Author(s)
      Noboru Mizushima.
    • Organizer
      The EMBO Conference on Autophagy: Cell Biology, Physiology and Pathology.
    • Place of Presentation
      Monte Verita, Switzerland.
    • Year and Date
      2009-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of autophagy in tumor suppression2009

    • Author(s)
      水島昇
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of autophagy in protein metabolism : starvation adaptation, egg-to-embryo transition and intracellular clearance2009

    • Author(s)
      水島昇
    • Organizer
      The 9th World congress on Inflammation
    • Place of Presentation
      東京
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] オートファジーの生理的役割と制御シグナル2009

    • Author(s)
      水島昇
    • Organizer
      日本生化学会関東支部例会
    • Place of Presentation
      つくば
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] オートファジーの役割と制御機構2009

    • Author(s)
      水島昇
    • Organizer
      第73回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism of autophagy regulation in mammalian cells.2009

    • Author(s)
      Noboru Mizushima.
    • Organizer
      Gordon conference "Stress Proteins In Growth, Development & Disease".
    • Place of Presentation
      Andover, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] 老化に伴う卵子の品質管理とオートファジーの新たな生理機能2009

    • Author(s)
      塚本智史
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism of autophagy regulation in mammalian cells2009

    • Author(s)
      水島昇
    • Organizer
      Gordon conference "Stress Proteins In Growth, Development & Disease"
    • Place of Presentation
      Andover, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism of autophagosome formation in mammalian cells2009

    • Author(s)
      水島昇
    • Organizer
      The 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Shanghai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of autophagosome formation in mammalian cells2009

    • Author(s)
      水島昇
    • Organizer
      The 5th International Symposium of Autophagy
    • Place of Presentation
      Otsu
    • Related Report
      2009 Annual Research Report
  • [Presentation] オートファジー:細胞内リサイクルの生物学2009

    • Author(s)
      水島昇
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 全身性Atg5モザイク欠損マウスは多発性肝腫瘍を形成する2009

    • Author(s)
      高村聡人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism of autophagy regulation2009

    • Author(s)
      水島昇
    • Organizer
      The 4th Internatinoal Workshop on Cell Regulations in Division and Arrest Under Stress
    • Place of Presentation
      Okinawa
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nutrient-dependent regulation of autophagy in mammals2009

    • Author(s)
      水島昇
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      Yokohama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mammalian Tti1 and Tel2 are important for mTOR complex formation2009

    • Author(s)
      Takeshi Kaizuka
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      Yokohama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structural basis for sorting mechanism of p62 in selective autophagy2008

    • Author(s)
      Yoshinobu Ichimura
    • Organizer
      48th ASCB Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] New functional domain in an autophagy-related E1-like enzyme, Atg7.2008

    • Author(s)
      Isei Tanida
    • Organizer
      48th ASCB Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジーに必須のE1様酵素、Atg7、の新規機能領域2008

    • Author(s)
      谷田以誠
    • Organizer
      BMB2008(第31回日本分子生物学会年会.第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 選択的オートファジーにおけるp62選別機構の構造的基盤2008

    • Author(s)
      一村義信
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジー:新しい生命現象とその検出方法2008

    • Author(s)
      水島昇
    • Organizer
      第54回日本病理学会
    • Place of Presentation
      松山
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Physiological role of autophagy in mammals2008

    • Author(s)
      Noboru Mizushima
    • Organizer
      7th Surugadai International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Role of Autophagy in Protein Turnover in Mice2008

    • Author(s)
      Noboru Mizushima
    • Organizer
      18th Annual Symposium, Center for the Study of Inflammatory Bowel Disease Massachusetts General Hospital
    • Place of Presentation
      Boston
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジーによるタンパク質代謝の生理的役割2008

    • Author(s)
      水島昇
    • Organizer
      第24回Wakoワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Atg8 conjugation system is indispensable for proper elongation but not for generation of isolation membranes in mice.2008

    • Author(s)
      曽友深
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Role of Autophagy in Early Embryogenesis.2008

    • Author(s)
      Noboru Mizushima.
    • Organizer
      18th Annual Workshop, Center for the Study of Inflammatory Bowel Disease "Autophagy in Immunity".
    • Place of Presentation
      Boston.
    • Related Report
      2010 Final Research Report
  • [Presentation] オートファジーによるタンパク質代謝の多彩な役割2008

    • Author(s)
      水島昇
    • Organizer
      日本分子生物学会第8回春季シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジーによる細胞内分解の役割2008

    • Author(s)
      水島昇
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] オートファジーによるタンパク質分解の生理的役割2008

    • Author(s)
      水島昇
    • Organizer
      第36回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Role of Autophagy in Early Embryogenesis2008

    • Author(s)
      Noboru Mizushima
    • Organizer
      18th Annual Workshop, Center for the Study of Inflammatory Bowel Disease "Autophagy in Immunity"
    • Place of Presentation
      Boston
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳動物オートファジーの制御機構2008

    • Author(s)
      原太一
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類Atg13はULK1、FIP200とともに3MDaの複合体を形成する2008

    • Author(s)
      細川奈生
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Atg5キメラ欠損マウスにおける多発性腫瘤の解析2008

    • Author(s)
      高村聡人
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類Atg14依存的なクラスIIIPI3K複合体のリクルートがオートファゴソーム形成に必須である2008

    • Author(s)
      板倉英祐
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳生物Atg2ホモログのオートファジーにおける機能とその分構造の解析2008

    • Author(s)
      尾板英子
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of autophagy in protein metabolism and generation of an autophagy-regulatable cell line.2007

    • Author(s)
      Noboru Mizushima.
    • Organizer
      32nd FEBS Congress, Molecular Machines.
    • Place of Presentation
      Vienna.
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological Role of Autophagy in Protein Turnover.2007

    • Author(s)
      Noboru Mizushima.
    • Organizer
      Keystone symposium "Autophagy in Health and Disease".
    • Place of Presentation
      Monterey.
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological Role of Autophagy in Protein Turnover2007

    • Author(s)
      Noboru Mizushima
    • Organizer
      Keystone symposium"Autophagy in Health and Disease"
    • Place of Presentation
      Monterey
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of autophagy in protein metabolism and generation of an autophagy-regulatable cell Line2007

    • Author(s)
      Noboru Mizushima
    • Organizer
      32nd FEBS Congress, Molecular Machines
    • Place of Presentation
      Vienna
    • Related Report
      2007 Annual Research Report
  • [Presentation] FIP200 is required for autophagosome formation and proper function of ULK2007

    • Author(s)
      Taichi Hara
    • Organizer
      The American Society of Cell Biology 47th Annual Meeting
    • Place of Presentation
      Washington
    • Related Report
      2007 Annual Research Report
  • [Presentation] オートファジー関連因子FIP200の解析2007

    • Author(s)
      高村 聡人
    • Organizer
      BMB2007 (第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 哺乳類Atg13ホモログの同定と解析2007

    • Author(s)
      細川 奈生
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Book] オートファジーを介した抗原提示と免疫制御「Annual Review免疫2008」奥村康ら編2008

    • Author(s)
      水島昇
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report
  • [Book] Transgenic models of autophagy2006

    • Author(s)
      Mizushima N
    • Publisher
      Wiley-VCH
    • Related Report
      2006 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 領域HP

    • URL

      http://proteolysis.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究代表者HP

    • URL

      http://www.tmd.ac.jp/med/phy2/phy2-J.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://proteolysis.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2009 Annual Research Report
  • [Remarks] 毎日新聞(2008年7月4日)「受精卵、自分を栄養に」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 読売新聞(2008年7月4日)「受精卵 栄養を自給自足」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日本経済新聞(2008年7月4日)「受精卵の着床 必要条件確認」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 朝日新聞(2008年7月5日)「受精卵、自ら栄養作り着床」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日経産業新聞(2008年7月4日)「受精卵着床 たんぱく質分解し利用」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 科学新聞(2008年7月18日)「哺乳類の胚発生時 オートファジーの役割」(水島)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日刊工業新聞(2007年12月14日)「封入体形成を解明」(小松)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日経産業新聞(2007年12月14日)「神経疾患起こすたんぱく質特定」(小松)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 化学工業新聞(2007年12月14日)「神経変性疾患主因の細胞内異常構造体形成機構を解明」(小松)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/phy2/J.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/phy2/phy2-J.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2007

    • Inventor(s)
      谷田以誠、多田昇弘、木南英紀
    • Industrial Property Rights Holder
      学校法人順天堂
    • Filing Date
      2007-10-19
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2007

    • Inventor(s)
      谷田以誠、多田昇弘、木南英紀
    • Industrial Property Rights Holder
      学校法人順天堂
    • Filing Date
      2007-10-19
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2006

    • Inventor(s)
      谷田 以誠、多田 昇弘、木南 英紀
    • Industrial Property Rights Holder
      学校法人順天堂
    • Filing Date
      2006-10-19
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2006

    • Inventor(s)
      谷田 以誠、多田 昇弘、木南 英紀
    • Industrial Property Rights Holder
      学校法人順天堂
    • Filing Date
      2006-10-19
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2006

    • Inventor(s)
      谷田ら
    • Industrial Property Rights Holder
      順天堂大学
    • Filing Date
      2006-10-25
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] トランスジェニック非ヒト動物2006

    • Inventor(s)
      谷田ら
    • Industrial Property Rights Holder
      順天堂大学
    • Filing Date
      2006-10-25
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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