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Conversion of touch sensation to pain by the modal shift of sensor function

Planned Research

Project AreaMolecular interaction and modal shift of cellular sensors
Project/Area Number 18077002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANABE Tsutomu  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (70183069)

Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥62,900,000 (Direct Cost: ¥62,900,000)
Fiscal Year 2010: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2009: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2008: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2007: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2006: ¥11,100,000 (Direct Cost: ¥11,100,000)
Keywords分子センサー / 触覚 / 神経因性疼痛 / アロディニア / 痛覚過敏 / 細胞感覚 / 分子センター
Research Abstract

We searched for the molecules which induce conversion of touch sensation to pain by the modal shift of their sensor functions. We identified μ-opioid, peripheral-type benzodiazepine receptor, and casein kinase 1ε as effectors which are functionally located downstream of N-type calcium channel activation. We also clarified how the modal shift of these molecules affect the excitability of neurons and their intracellular calcium transient [Ca^<2+>]i , and how the inhibitor of each molecule affects the observed changes caused by the modal shift of these molecules.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (61 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (16 results) Remarks (6 results) Patent(Industrial Property Rights) (21 results) (of which Overseas: 10 results)

  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.2009

    • Author(s)
      Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S., Tanabe, T.
    • Journal Title

      J.Pharmacol.Sci. 110

      Pages: 55-63

    • NAID

      10025736602

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficit of heat shock transcription factor 1-heat shock 70kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6.2009

    • Author(s)
      Li, L., Saegusa, H., Tanabe, T.
    • Journal Title

      Genes to Cells 14

      Pages: 1253-1269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1 epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain.2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S., Tanabe, T.
    • Journal Title

      Molecular Pain 5

      Pages: 74-74

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice2009

    • Author(s)
      Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S., Tanabe, T.
    • Journal Title

      J Pharmacol.Sci. 110

      Pages: 55-63

    • NAID

      10025736602

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficit of heat shock transcription factor 1-heat shock 70kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 62009

    • Author(s)
      Li, L., Saegusa, H., Tanabe, T.
    • Journal Title

      Genes to Cells 14

      Pages: 1253-1269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1 epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S., Tanabe, T.
    • Journal Title

      Molecular Pain 5

      Pages: 74-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells.2007

    • Author(s)
      Saegusa, H., Wakamori, M., Matsuda, Y., Wang, J., Mori, Y., Zong, S., Tanabe, T.
    • Journal Title

      Molec.Cell.Neurosci. 34

      Pages: 261-270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells2007

    • Author(s)
      Saegusa, H., Wakamori, M., Matsuda, Y., Wang, J., Mori, Y., Zong, S. and Tanabe, T
    • Journal Title

      Mol. Cell. Neurosci 34

      Pages: 261-270

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Properties of human Ca_v2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells2007

    • Author(s)
      Saegusa, H., Wakamori, M., Matsuda, Y., Wang, J., Mori, Y., Zong, S. and Tanabe, T.
    • Journal Title

      Mol. Cell. Neurosci 34

      Pages: 261-270

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 創薬ターゲットとしての電位依存性Ca^<2+>チャネル2007

    • Author(s)
      田邊 勉
    • Journal Title

      医学のあゆみ 233

      Pages: 474-478

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Properties of human Ca_v2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells.2007

    • Author(s)
      Saegusa, H.
    • Journal Title

      Mol. Cell. Neurosci. 34

      Pages: 261-270

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Progesterone receptor antagonist is effective for relieving neuropathic pain.2006

    • Author(s)
      Kondo, D., Yabe, R., Kurihara, T., Saegusa, H., Zong, S., Tanabe, T.
    • Journal Title

      Eur.J.Pharm. 541

      Pages: 44-48

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered cerebellar function in mice lacking Cav2.3 Ca^<2+> channel.2006

    • Author(s)
      Osanai, M.., Saegusa, H., Kazuno, A., Nagayama, S., Hu, Q., Zong, S., Murakoshi, T., Tanabe, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 344

      Pages: 920-925

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progesterone receptor antagonist is effective for relieving neuropathic pain2006

    • Author(s)
      Kondo, D., Yabe, R., Kurihara, T., Saegusa, H., Zong, S. and Tanabe, T
    • Journal Title

      Eur. J. Pharm 541

      Pages: 44-48

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Altered cerebellar function in mice lacking Ca_v2.3 Ca^<2+> channel.2006

    • Author(s)
      Osanai, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 344

      Pages: 920-925

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Progesterone receptor antagonist is effective for relieving neuropathic pain.2006

    • Author(s)
      Kondo, D.
    • Journal Title

      Eur. J. Pharm. 541

      Pages: 44-48

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Caチャネルと痛み伝達2006

    • Author(s)
      田邊 勉
    • Journal Title

      日薬理誌 127

      Pages: 156-160

    • NAID

      10019251744

    • Related Report
      2006 Annual Research Report
  • [Journal Article] カルシウムチャネル2006

    • Author(s)
      田邊 勉
    • Journal Title

      Clinical Neuroscience 24

      Pages: 730-731

    • Related Report
      2006 Annual Research Report
  • [Presentation] Activation of casein kinase 1δ/ε in dorsal root ganglia and spinal cord contributes to behavioral hypersensitivity induced by peripheral inflammation in mice2011

    • Author(s)
      Kurihara, T., Sakurai, E., Asada T., Miyata, A., Tanabe, T.
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord contributes to neuropathic pain induced by spinal nerve ligation in mice2011

    • Author(s)
      Sakurai, E., Kurihara, T., Miyata, A., Tanabe, T.
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Upregulation of casein kinase 1 epsilon after spinal nerve injury contributes to neuropathic pain2010

    • Author(s)
      Tsutomu Tanabe, Eri Sakurai, Takashi Kurihara, Kasumi Kouchi, Hironao Saegusa, Shuqin Zong
    • Organizer
      The Third International Congress on Neuropathic Pain Athens
    • Place of Presentation
      Greece
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibitors of casein kinase 1 epsilon are effective in blocking pain in neuropathic mice without showing any appreciable side effect in normal mice2010

    • Author(s)
      Tsutomu Tanabe, Eri Sakurai, Takashi Kurihara, Kasumi Kouchi, Hironao Saegusa, Shuqin Zong
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Upregulation of casein kinase 1 epsilon after spinal nerve injury contributes to neuropathic pain2010

    • Author(s)
      Tanabe, T., Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S.
    • Organizer
      The Third International Congress on Neuropathic Pain
    • Place of Presentation
      Athens, Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Searching for downstream molecules of N-type voltage-dependent calcium channels (Cav2.2) contributing to the neuropathic pain2010

    • Author(s)
      Tanabe, T., Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S.
    • Organizer
      16th World Congress of Basic and Clinical Pharmacology
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2010 Annual Research Report
  • [Presentation] Specific blockade of synaptic transmission and behavioral pain responses by casein kinase 1 epsilon inhibitors in neuropathic mice2010

    • Author(s)
      Tanabe, T., Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S.
    • Organizer
      The 50th Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Heat shock 70kDa protein 1A in a cellular model of spinocerebellar ataxia type 62009

    • Author(s)
      T.Tanabe, L.Li, H.Saegusa
    • Organizer
      The 49th Annual Meeting of the Americal Society for Cell Biology
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of the molecules determining cell death vulnerability in a cellular model of spinocerebellar ataxia type 62009

    • Author(s)
      T.Tanabe, L.Li, H.Saegusa
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enhanced stress-induced cell death in HEK293 cells expressing carboxyl-terminal portion of human Cav2.1 with a spinocerebellar ataxia type 6 mutation2009

    • Author(s)
      T. Tanabe, L. Li, and H. Saegusa
    • Organizer
      Keystone Symposia : Neurodegenerative Diseases : New Molecular Mechanisms
    • Place of Presentation
      Keystone CO, USA
    • Year and Date
      2009-02-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Co-administration of ATP attenuates peripheral type benzodiazepine receptor antagonist-induced antinociception of neuropathic pain2008

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa and S. Zong
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain through the activation of microglia2008

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa and S. Zong
    • Organizer
      The 3rd Asian Pain symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Co-administration of ATP attenuates peripheral type benzodiazepine receptor antagonist-induced antinociception of neuropathic pain.2008

    • Author(s)
      T.Tanabe, D.Kondo, R.Yabe, I.Takasaki, T.Kurihara, H.Saegusa, S.Zong
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain2007

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa and S. Zong
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego CA, USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain.2007

    • Author(s)
      T.Tanabe, D.Kondo, R.Yabe, I.Takasaki, T.Kurihara, H.Saegusa, S.Zong
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego CA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of steroid hormone receptors in the maintenance of neuropathic pain.2006

    • Author(s)
      T.Tanabe ; D.Kondo, I.Takasaki, R.Yabe, T.Kurihara, H.Saegusa, S.Zong
    • Organizer
      The 35rd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] Therapeutic agent for neuropathic pain2010

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2010-12-14
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2010

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2010-09-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2009

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2009-12-25
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2009

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2009

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2009-08-21
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2008-12-05
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2008-11-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Acquisition Date
      2008-11-21
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      科学技術振興機構・東京医科歯科大学
    • Acquisition Date
      2008-11-28
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      科学技術振興機構・東京医科歯科大
    • Acquisition Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      科学技術振興機構・東京医科歯科大
    • Acquisition Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経因性疼痛治療剤2008

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      科学技術振興機構・東京医科歯科大
    • Acquisition Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] THERAPEUTIC AGENT FOR NEUROGENIC PAIN2007

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2007-01-15
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] THERAPEUTIC AGENT FOR NEUROPATHIC PAIN2007

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2007-01-15
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Therapeutic agent for neuropathic pain2007

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      科学技術振興機構・東京医科歯科大学
    • Filing Date
      2007-01-15
    • Related Report
      2008 Self-evaluation Report
    • Overseas
  • [Patent(Industrial Property Rights)] THERAPEUTIC AGENT FOR NEUROGENIC PAIN2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-09-26
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] THERAPEUTIC AGENT FOR NEUROPATHIC PAIN2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-08-30
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] THERAPEUTIC AGENT FOR NEUROGENIC PAIN2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-06-08
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] AGENT FOR TREATING NEUROPATHIC PAIN2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-04-26
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] PSYCHOGENIC PAIN THERAPEUTIC AGENT2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-02-10
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] REMEDY FOR NEUROGENIC PAIN2006

    • Inventor(s)
      田邊勉
    • Industrial Property Rights Holder
      東京医科歯科大学・JST
    • Filing Date
      2006-02-10
    • Related Report
      2010 Final Research Report
    • Overseas

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Published: 2006-04-01   Modified: 2018-03-28  

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