Development of Data-driven Mathematical Analysis for Single Cells and Singularity Cells

• Project Area: Singularity biology
• Project/Area Number: 18H05413
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Hokkaido University
• Principal Investigator: 小松崎 民樹 北海道大学, 電子科学研究所, 教授 (30270549)
• Co-Investigator(Kenkyū-buntansha): 中村 篤祥 北海道大学, 情報科学研究院, 教授 (50344487) ; 小野 峻佑 東京工業大学, 情報理工学院, 准教授 (60752269)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥98,280,000 (Direct Cost: ¥75,600,000、Indirect Cost: ¥22,680,000); Fiscal Year 2022: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2021: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2020: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2019: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2018: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
• Keywords: 情報計測 / 因果推論 / バンディット手法 / 1細胞ラマン分光イメージング / スパース学習 / バンディットアルゴリズム / 1細胞ラマン分光 / １細胞ラマン分光 / 異常検知

Outline of Annual Research Achievements

ある細胞と別の細胞の主従関係を推定する場合，それら2つの細胞の軌跡データなどを用いて評価されているが，2つの細胞の振る舞いを決める因子が，その2つの細胞以外にも，第3の細胞が介在する状況なども考えられる。主従関係や因果関係における“原因”と“結果”を解析するためには，単純な対の組み合わせで表現できない多体の相互作用から成り立っている。そのため，多体のあいだの因果関係を推定することは要素間の組み合わせの数が膨大になる。2対の軌跡データを変数とする移動エントロピーを細分化した新しい相乗情報量に着眼し，改良Vicsekモデルに基づいてこの問題を考察し、移動エントロピーに含まれる相乗情報量の振る舞いを解析することで，要素間の多体の相互作用が推定できることを見いだした（Sci Adv 2022）。
昨年度開発した、細胞毎の発火状態時系列からの伝搬時差推定をギャップを挿入する文字列のアライメントで行い伝搬グラフを構築する手法を発展させ、DTW(Dynamic Time　Warping)ベースの実数値列アライメントを用いて伝搬グラフを構築する方法を開発した。位置情報を用いないで伝搬関係を推定できるため、細胞間の信号の伝搬のみでなく、株価の他の株価への影響の伝搬関係など曖昧な伝搬関係の抽出にも使えることを株価データを用いて確認した。
シンギュラリティ成分検出の前処理としてイメージングデータからノイズや外乱を取り除くための正則化手法について研究を進めた。具体的には、イメージングデータに内在するスパース性を引き出す変換を構成し、スパース性を評価するノルムと組み合わせて正則化関数を設計した。加えて、この正則化を含む最適化問題としてノイズ・外乱除去問題を定式化し、これを解くアルゴリズムを開発した。最後に、実際のハイパースペクトルイメージングデータを用いた大規模な比較実験によって有効性を実証した。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

細胞状態を評価するうえでラマン画像のほか、細胞などの要素の軌跡データを用いて、細胞間の主従関係、細胞間の相互作用域を推定する手法を開発することに成功した（Phys Rev E 2020, J. Chem. Phys. 2021, BPPB 2021（招待））。また、Sci Adv 2022 (on line feature articleに選出)など成果が出ている。

Strategy for Future Research Activity

相互作用ポテンシャルの型（反発型ポテンシャル、モース型）が軌跡データから復元できるかを解析するとともに、相乗情報量を最大にする系の構成パラメータをベイズ最適化で算出し、移動エントロピーの成分である相乗情報量の物理的な解釈を与える。また、これまでに開発してきた手法群をAMATERASの画像データ解析に適用し、領域内の異分野融合をより加速する。
開発したDTWベースの実数値列アライメントを用いて伝搬グラフを構築する方法は、伝搬時差が変化する場合にも各時点での伝搬時差を推定することが可能である。しかし、どのくらい正確に推定できるかはわかっていないため、シミュレーションによりその有効性を確認し、有効な応用の範囲を明確化する。
今後は、2020年度に開発した正則化手法を始めとする様々な事前知識を取り入れることで、定常成分・シンギュラリティ成分・ノイズや外乱を同時に分離しながら推定する方
法論の構築を行う。また、実際のイメージングデータの異常検出における有効性（検出精度・ノイズ等への頑健性等）を実験的に検証する。

Research Products

• [Int'l Joint Research] University of California, Davis(米国)
• [Journal Article] Modes of information flow in collective cohesion (2022)
  • Author(s): Sulimon Sattari, Udoy S. Basak, Ryan G. James, Louis W. Perrin, James P. Crutchfield, Tamiki Komatsuzaki
  • Journal Title: Science Advances Volume: 8 Issue: 6
  • DOI: 10.1126/sciadv.abj1720
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An information-theoretic approach to infer the underlying interaction domain among elements from finite length trajectories in a noisy environment (2021)
  • Author(s): Basak Udoy S.、Sattari Sulimon、Hossain Md. Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
  • Journal Title: The Journal of Chemical Physics Volume: 154 Issue: 3 Pages: 034901-034901
  • DOI: 10.1063/5.0034467
  • Peer Reviewed
• [Journal Article] Transfer entropy dependent on distance among agents in quantifying leader-follower relationships (2021)
  • Author(s): Basak Udoy S.、Sattari Sulimon、Hossain Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
  • Journal Title: Biophysics and Physicobiology Volume: 18 Issue: 0 Pages: 131-144
  • DOI: 10.2142/biophysico.bppb-v18.015
  • NAID: 130008054076
  • ISSN: 2189-4779
  • Peer Reviewed / Open Access
• [Journal Article] Classification Bandits: Classification Using Expected Rewards as Imperfect Discriminators (2021)
  • Author(s): Tabata Koji、Nakumura Atsuyoshi、Komatsuzaki Tamiki
  • Journal Title: Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD), Workshop on Machine Learning for MEasurement INformatics Volume: - Pages: 57-69
  • DOI: 10.1007/978-3-030-75015-2_6
  • ISBN: 9783030750145, 9783030750152
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of Propagation Graph by Pairwise Alignment of Time Series Data (2020)
  • Author(s): 林 達也、中村 篤祥
  • Journal Title: JSAI Technical Report, SIG-FPAI Volume: 114 Issue: 0 Pages: 01
  • DOI: 10.11517/jsaifpai.114.0_01
  • NAID: 130008061460
  • ISSN: 2436-4584
  • Year and Date: 2020-11-10
• [Journal Article] Inferring domain of interactions among particles from ensemble of trajectories (2020)
  • Author(s): Basak Udoy S.、Sattari Sulimon、Horikawa Kazuki、Komatsuzaki Tamiki
  • Journal Title: Physical Review E Volume: 102 Issue: 1
  • DOI: 10.1103/physreve.102.012404
  • Peer Reviewed
• [Journal Article] Dependence of DNA length on binding affinity between TrpR and trpO of DNA (2020)
  • Author(s): Nobuo Shimamoto, Mikito Toda, Shigetoshi Nara, Tamiki Komatsuzaki, Kiyoto Kamagata, Takashi Kinebuchi, Jun-ichi Tomizawa
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 15624-15624
  • DOI: 10.1038/s41598-020-71598-3
  • Peer Reviewed / Open Access
• [Journal Article] Data-Dependent Conversion to a Compact Integer-Weighted Representation of a Weighted Voting Classifier. (2020)
  • Author(s): Mitsuki Maekawa, Atsuyoshi Nakamura, Mineichi Kudo
  • Journal Title: Proceedings of The 12th Asian Conference on Machine Learning (ACML 2020) Volume: - Pages: 241-256
  • Peer Reviewed
• [Journal Article] A Constrained Convex Optimization Approach to Hyperspectral Image Restoration with Hybrid Spatio-Spectral Regularization (2020)
  • Author(s): Takeyama Saori、Ono Shunsuke、Kumazawa Itsuo
  • Journal Title: Remote Sensing Volume: 12 Issue: 21 Pages: 3541-3541
  • DOI: 10.3390/rs12213541
  • Peer Reviewed / Open Access
• [Journal Article] Joint Mixed-Noise Removal and Compressed Sensing Reconstruction of Hyperspectral Images via Convex Optimization (2020)
  • Author(s): Takeyama Saori、Ono Shunsuke
  • Journal Title: IEEE International Geoscience and Remote Sensing Symposium (IGARSS) Volume: 1 Pages: 1492-1495
  • DOI: 10.1109/igarss39084.2020.9323489
• [Journal Article] ハイパースペクトル画像復元のための低ランク正則化と空間-波長正則化の融合 (2020)
  • Author(s): 武山彩織, 小野峻佑
  • Journal Title: 第35回信号処理シンポジウム Volume: -
• [Journal Article] A bad arm existence checking problem: How to utilize asymmetric problem structure? (2019)
  • Author(s): Tabata Koji、Nakamura Atsuyoshi、Honda Junya、Komatsuzaki Tamiki
  • Journal Title: Machine Learning Volume: 109 Issue: 2 Pages: 327-372
  • DOI: 10.1007/s10994-019-05854-7
  • Peer Reviewed / Open Access
• [Journal Article] Raman spectroscopic histology using machine learning for nonalcoholic fatty liver disease (2019)
  • Author(s): Khalifa Mohammad Helal, James Nicholas Taylor, Harsono Cahyadi, Akira Okajima, Koji Tabata, Yoshito Itoh, Hideo Tanaka, Katsumasa Fujita, Yoshinori Harada, Tamiki Komatsuzaki
  • Journal Title: FEBS Letters Volume: 593 Issue: 18 Pages: 2535-2544
  • DOI: 10.1002/1873-3468.13520
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High-Resolution Raman Microscopic Detection of Follicular Thyroid Cancer Cells with Unsupervised Machine Learning (2019)
  • Author(s): J. Nicholas Taylor, Kentaro Mochizuki, Kosuke Hashimoto, Yasuaki Kumamoto, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
  • Journal Title: The Journal of Physical Chemistry B Volume: 123 Issue: 20 Pages: 4358-4372
  • DOI: 10.1021/acs.jpcb.9b01159
  • Peer Reviewed
• [Journal Article] Feature selection as Monte-Carlo Search in Growing Single Rooted Directed Acyclic Graph by Best Leaf Identification (2019)
  • Author(s): Pelissier A, Nakamura A, Tabata K
  • Journal Title: SIAM International Conference on Data Mining(SDM2019) Volume: - Pages: 450-458
  • DOI: 10.1137/1.9781611975673.51
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deciphering Molecular Complexity in Dynamics and Kinetics - From the Single Molecule to the Single Cell Level (2019)
  • Author(s): Komatsuzaki T, Press S, Senet P
  • Journal Title: J. Phys. Chem. B Volume: 123 Issue: 30 Pages: 2535-2544
  • DOI: 10.1021/acs.jpcb.9b05382
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mixed Noise Removal for Hyperspectral Images Using Hybrid Spatio-Spectral Total Variation (2019)
  • Author(s): Takeyama Saori、Ono Shunsuke、Kumazawa Itsuo
  • Journal Title: ICIP Volume: - Pages: 3128-3132
  • DOI: 10.1109/icip.2019.8803239
  • Peer Reviewed
• [Journal Article] Efficient Constrained Signal Reconstruction by Randomized Epigraphical Projection (2019)
  • Author(s): Ono Shunsuke
  • Journal Title: ICASSP Volume: - Pages: 4993-4997
  • DOI: 10.1109/icassp.2019.8682191
  • Peer Reviewed
• [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning (2022)
  • Author(s): Tamiki Komatsuzaki, Koji Tabata, Hiroyuki Kawagoe, James Nicholas Taylor, Kentaro Mochizuki, Toshiki Kubo, Jean-Emmanuel Clement, Yasuaki Kumamoto, Yoshinori Harada, Atsuyoshi Nakamura, Katsumasa Fujita
  • Organizer: SPIE Photonics Europe 2022
  • Int'l Joint Research / Invited
• [Presentation] 情報理論による化学的空間不均一性に基づくラマン分光イメージングの解析 (2022)
  • Author(s): 近藤僚哉, TAYLOR J. Nicholas, CLEMENT Jean-Emmanuel, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
  • Organizer: 化学系学協会北海道支部2022年冬季研究発表会
• [Presentation] 情報理論とラマン分光イメージングを用いた化学的不均一性の解析 (2022)
  • Author(s): 近藤僚哉, James N.Taylor, 水野雄太, Jean-Emmanuel Clement, 藤田克昌, 原田義規, 小松崎民樹
  • Organizer: 2021年度生物物理学会北海道支部-東北支部合同例会
• [Presentation] Detection of Cancer Stem Cells in Sarcoma Model Cells Using Morphological Features for Developing New Diagnostics Tools (2021)
  • Author(s): Zannatul Ferdous, Masumi Tsuda, Jean-Emmanuel Clement, Koji Tabata, Jian Ping Gong, Shinya Tanaka, Tamiki Komatsuzaki
  • Organizer: ICReDD 3rd International Symposium
  • Int'l Joint Research
• [Presentation] Classification Bandits: Classification Using Expected Rewards as Imperfect Discriminators (2021)
  • Author(s): Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
  • Organizer: PAKDD2021 Workshop on Machine Learning for MEasurement Informatics
  • Int'l Joint Research
• [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning (2021)
  • Author(s): Tamiki Komatsuzaki , Koji Tabata, Hiroyuki Kawagoe, James Nicholas Taylor , Kentaro Mochizuki , Jean-Emmanuel Clement , Yasuaki Kumamoto , Atsuyoshi Nakamura , Yoshinori Harada , Katsumasa Fujita
  • Organizer: FACSS SciX 2021
  • Int'l Joint Research / Invited
• [Presentation] 強化学習を用いたラマン計測迅速化：On-the-fly Raman image microscopy (2021)
  • Author(s): 小松崎民樹
  • Organizer: (一社）大阪大学ナノ理工学人材育成産学コンソーシアム 令和２年度第３回ナノ理工学情報交流会
  • Invited
• [Presentation] 機械学習を用いた化学的不均一性 の情報を含むラマン顕微鏡画像中のスペクトルの分類 (2021)
  • Author(s): 近藤僚哉, James N. Taylor, Jean-Emmanuel Clement, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
  • Organizer: 化学系学協会北海道支部2021年冬季研究発表会
• [Presentation] 化学的不均一性も考慮したラマン顕微鏡画像解析 (2021)
  • Author(s): 近藤僚哉, James N.Taylor, Jean-Emmanuel Clement, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
  • Organizer: 生物物理学会学会 北海道支部－東北支部合同例会
• [Presentation] Analysis Dictyostelium Discoideum cells motion response to a chemoattractant cyclic-AMP wave (2021)
  • Author(s): Md. Motaleb Hossain, Sulimon Sattari, Udoy S. Basak, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: 生物物理学会学会 北海道支部－東北支部合同例会
• [Presentation] Study on Identification of Leader and Follower agents and its Interaction domain from Trajectories in a Collectively Moving Colony (2021)
  • Author(s): Udoy S. Basak, Sulimon Sattari, Md. Motaleb Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: 生物物理学会学会 北海道支部－東北支部合同例会
• [Presentation] Modes of Information Flow in Collective Cohesion (2021)
  • Author(s): Sulimon Sattari, Udoy Basak, James P. Crutchfield, Tamiki Komatsuzaki
  • Organizer: 生物物理学会学会 北海道支部－東北支部合同例会
• [Presentation] ラマン分光イメージングにおける化学的空間不均一性の情報理論解析 (2021)
  • Author(s): 近藤 僚哉, James N. Taylor, Jean-Emmanuel Clement, 水野 雄太, 藤田 克昌, 原田 義規, 小松崎 民樹
  • Organizer: 第23回理論化学討論会
• [Presentation] 計測介入型AIによる迅速ラマン計測 (2021)
  • Author(s): 小松崎 民樹
  • Organizer: JST情報計測オンラインセミナーシリーズ
  • Invited
• [Presentation] 化学反応ネットワークにおける時間階層性（Timescale hierarchies in chemical reaction networks） (2021)
  • Author(s): 小松崎 民樹
  • Organizer: シンポジウム「化学反応経路探索のニューフロンティア2021」
  • Invited
• [Presentation] ラマン分光イメージングにおける化学的空間不均一性 に基づいたファジークラスタリング手法の開発 (2021)
  • Author(s): 近藤 僚哉, James N.Taylor, Jean-Emmanuel Clement, 水野 雄太, 藤田 克昌, 原田 義規, 小松崎 民樹
  • Organizer: 第15回分子科学討論会
• [Presentation] 一分子計測からたんぱく質のエネルギー地形の階層性を抽出する Capturing hierarchical features in protein energy landscape from single molecule time series (2021)
  • Author(s): 小松崎 民樹
  • Organizer: 第59回日本生物物理学会年会
  • Invited
• [Presentation] Classification of Spectra in Raman Microscopic Image by Chemical Heterogeneity (2020)
  • Author(s): Ryoya Kondo, James N Taylor, Jean-emmanuel Clement, Yuta Mizuno, Katsumasa Fujita, Yoshinori Harada, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] To classify Raman spectra using Deep Learning Approach (2020)
  • Author(s): Abdul Halim Bhuiyan, Jean-emmanuel Clement, Kentaro Mochizuki, James Nick Taylor, Koji Tabata, Yuta Mizuno, Atsuyoshi Nakamura, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Application of Linear Bandit in Drug Screening Example (2020)
  • Author(s): Md. Menhazul Abedin, Koji Tabata, Jean-Emmanuel Clement, Masumi Tsuda, Shinya Tanaka, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Inferring domain of Interaction among Dictyostelium discoideum colony from the ensemble of Trajectories of cells (2020)
  • Author(s): Udoy S. Basak, Sulimon Sattari, Motaleb M. Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Analysis of Cancer Stem Cells in Sarcoma Model Cells by Deep Neural Network (2020)
  • Author(s): Zannatul Ferdous, Masumi Tsuda, Jean-Emmanuel Clement, Koji Tabata, Yusuke Ishida, Jun Suzuka, Jian Ping Gong, Shinya Tanaka, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Raman Imaging for Exploring Cancer Metabolism (2020)
  • Author(s): Jean-Emmanuel Clement, Mochizuki Kentaro, Katsumasa Fujita, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Vector analysis of amoeba motion response to a cyclic-AMP wave (2020)
  • Author(s): Md. Motaleb Hossain, Sulimon Sattari, Udoy Sankar Basak, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] Vector analysis of amoeba motion with respect to the propagation of chemoattractant cyclic-AMP (2020)
  • Author(s): Sulimon Sattari, Udoy Basak, Motaleb Md. Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: The 21st RIES-HOKUDAI International Symposium
• [Presentation] シンギュラリティ生物学における情報×計測 (2020)
  • Author(s): 小松﨑 民樹
  • Organizer: シンギュラリティ生物学×細胞ダイバース合同ワークショップ
  • Invited
• [Presentation] Quantifying the length- and time-scales of influence of cells in collective motion (2020)
  • Author(s): Sulimon Sattari, Basak Udoy, Motaleb Md. Hossain, 堀川 一樹, 小松崎 民樹
  • Organizer: 第58回日本生物物理学会年会
• [Presentation] Inferring domain of Interactions among Dictyostelium discoideum colony from the Ensemble of Trajectories of cells (2020)
  • Author(s): Basak Udoy S, Sattari Sulimon, Hossain Md. Motaleb, Horikawa Kazuki, Komatsuzaki Tamiki
  • Organizer: 第58回日本生物物理学会年会
• [Presentation] Vector analysis of amoeba motion with respect to the propagation of chemoattractant cyclic-AMP (2020)
  • Author(s): Hossain Md. Motaleb, Sattari Sulimon, Basak Udoy S, Horikawa Kazuki, Komatsuzaki Tamiki
  • Organizer: 第58回日本生物物理学会年会
• [Presentation] Raman imaging for cancer diagnosis (2020)
  • Author(s): Jean-Emmanuel Clement, Kenntaro Mochizuki, Katsumasa Fujita, Tamiki Komatsuzaki
  • Organizer: 第58回日本生物物理学会年会
• [Presentation] シンギュラリティ生物学における情報計測 (2020)
  • Author(s): 小松﨑 民樹
  • Organizer: シンギュラリティ生物学×細胞ダイバース合同ワークショップ
• [Presentation] An Information-theoretic approach to identify the interaction radius of a group of collectively moving animals (2019)
  • Author(s): Udoy. S Basak, Sulimon Sattari, Tamiki Komatsuzaki
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] A sandbox model system for analyzing leadership in collective motion (2019)
  • Author(s): Sulimon Sattari, Udoy Basak, Sky Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] Bad Arm Existence Checking Algorithm with Bandit Feeedback (2019)
  • Author(s): Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] Raman Microscopic Histology using Ensemble Learning for Non-alcoholic Fatty Liver Disease (2019)
  • Author(s): Khalifa Mohammad Helal, Harsono Cahyadi, J. Nicholas Taylor, Akira Okajima, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Harada, Tamiki Komatsuzaki
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] High Resolution Raman Microscopic Detection of Follicular Thyroid Cancer Cells with Unsupervised Machine Learning (2019)
  • Author(s): J. Nicholas Taylor, Kentaro Mochizuki, Kosuke Hashimoto, Yasuaki Kumamoto, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: Biomedical Raman Imaging 2019
  • Int'l Joint Research / Invited
• [Presentation] Raman Hyperspectral Image Analysis Using Ensemble Learning for Non-alcoholic Fatty Liver Disease (2019)
  • Author(s): Khalifa Mohammad Helal, Harsono Cahyadi, J. Nicholas Taylor, Akira Okajima, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Harada, Tamiki Komatsuzaki
  • Organizer: Biomedical Raman Imaging 2019
  • Int'l Joint Research
• [Presentation] Causal inference in Leader-follower relationship (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: ICSB 2019: Singularity Biology: small elements change the function of the whole systems
  • Int'l Joint Research
• [Presentation] A leadership-based phase transition in a flocking model with activated and un-activated agents (2019)
  • Author(s): Sulimon Sattari, Tamiki Komatusaki, Mikito Toda, Sky Nicholson, Jason Green, Udoy Basak
  • Organizer: 第57回日本生物物理学会年会
• [Presentation] An Information-theoretic approach toward identifying the leader(s) and aggregation place in Dictyostelium Discoideum colony (2019)
  • Author(s): Basak Udoy Sankar, Sattari Sulimon, Horikawa Kazuki, Komatsuzaki Tamiki
  • Organizer: 第57回日本生物物理学会年会
• [Presentation] Raman pathology and its phenotypic landscape for Non-alcoholic fatty liver diseases (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: The Complexity of Dynamics and Kinetics from Single Molecules to Cells
  • Int'l Joint Research / Invited
• [Presentation] アデニレートキナーゼの一分子観察データから再構成するエネルギー地形の階層性 (2019)
  • Author(s): James Nicholas Taylor, Menahem Pirchi, Gilad Haran, 小松崎 民樹
  • Organizer: 第22回理論化学討論会
• [Presentation] Deciphering hierarchical features in reaction network and energy landscape (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: Network analysis to elucidate natural system dynamics, diversity and performance
  • Int'l Joint Research / Invited
• [Presentation] バンディット問題の方策を用いたモンテカルロ木探索による最適属性集合 探索 (2019)
  • Author(s): 中村篤祥, ペリシエ オレリアン, 田畑 公次, 小松崎 民樹
  • Organizer: 第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
• [Presentation] モンテカルロ木特徴探索に基づく非線形グラフ分類回帰 (2019)
  • Author(s): 白川稜, 中村篤祥, 工藤峰一
  • Organizer: 第22回情報論的学習理論ワークショップ
• [Presentation] Learning a Nonlinear Model of Subgraph Features Using Monte Carlo Tree Search (2019)
  • Author(s): Ryo Shirakawa, Atsuyoshi Nakamura, Mineichi Kudo
  • Organizer: ACML 2019 Workshop on Statistics & Machine Learning Researchers in Japan
  • Int'l Joint Research
• [Presentation] 空間-波長正則化を用いた圧縮pansharpening (2019)
  • Author(s): 武山 彩織, 小野 峻佑
  • Organizer: 第34回信号処理シンポジウム
• [Presentation] Identification of Leader(s) in a Dictyostelium Discoideum colony: An Information-theoretic Approach (2019)
  • Author(s): Udoy Sankar Basak, Sulimon Sattari, Sosuke Ito, Kazuki Horikawa, Tamiki Komatsuzaki
  • Organizer: 生物物理・回折構造生物学 合同研究会
• [Presentation] A sandbox model system for understanding leadership in collective motion (2019)
  • Author(s): Sulimon Sattari, Udoy Basak, Schuyler Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
  • Organizer: 生物物理・回折構造生物学 合同研究会
• [Presentation] ハイパースペクトルイメージングのための圧縮pansharpeningの検討 (2019)
  • Author(s): Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
  • Organizer: 電子情報通信学会信号処理研究会
• [Presentation] ブラックボックス関数の閾値以上の値の存在チェックのアルゴリズム (2019)
  • Author(s): Naoki Ito, Atsuyoshi Nakamura, Mineichi Kudo
  • Organizer: 第11回データ工学と情報マネジメントに関するフォーラム
• [Presentation] In combining single cell hyperspectral Raman images for the diagnosis of follicular thyroid carcinoma measured at different data (2019)
  • Author(s): Aurelien Pelissier
  • Organizer: バイオ情報計測技術研究会
• [Presentation] High resolution Raman microscopic detection of follicular thyroid cancer cells with unsupervised machine learning (2019)
  • Author(s): Nicholas Taylor
  • Organizer: バイオ情報計測技術研究会
• [Presentation] Mathematical information measurement science: acceleration of Raman spectroscopy by bridging information science (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: バイオ情報計測技術研究会
• [Presentation] A bad arm existence checking problem: how to utilize asymmetric problem structure? (2019)
  • Author(s): Koji Tabata
  • Organizer: バイオ情報計測技術研究会
• [Presentation] Nonsmooth Convex Optimization and Sparse Regularization in Signal and Information Processing (2019)
  • Author(s): Shunsuke Ono
  • Organizer: ICMMA’18
  • Int'l Joint Research / Invited
• [Presentation] 1分子時系列情報からどのように背後の反応ネットワークを抽出できるのか？ (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: 「生命動態の理解と制御のための基盤技術の創出」研究領域第7 回領域会議・第11 回数理デザイン道場
  • Invited
• [Presentation] How can one bridge information science and measurement science to accelerate the measurements? (2019)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: The 22nd SANKEN International Symposium The 17th SANKEN Nanotechnology International Symposium “Next Generation Science and Technology for Super Smart Society”
  • Int'l Joint Research / Invited
• [Presentation] Hyperspectral Pansharpening Using Noisy Panchromatic Image (2018)
  • Author(s): Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
  • Organizer: Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC) 2018
  • Int'l Joint Research
• [Presentation] 非対称性を利用した悪腕存在チェックアルゴリズム (2018)
  • Author(s): Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
  • Organizer: 第21回情報論的学習理論ワークショップ
• [Presentation] ガウシアンノイズを考慮したハイパースペクトル画像とマルチスペクトル画像の合成法 (2018)
  • Author(s): Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
  • Organizer: 第33回信号処理シンポジウム
• [Presentation] A Randomized Epigraphical Projection Approach to Constrained Signal Reconstruction (2018)
  • Author(s): Shunsuke Ono
  • Organizer: 第33回信号処理シンポジウム
• [Presentation] DOO アルゴリズムの悪腕存在チェック問題への応用 (2018)
  • Author(s): Naoki Ito, Atsuyoshi Nakamura, Mineichi Kudo
  • Organizer: 情報処理北海道シンポジウム2018
• [Presentation] A sandbox model system for studying leadership in collective motion (2018)
  • Author(s): Sulimon Sattari, Udoy Basak, Schuyler Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
  • Organizer: 研究会「理論と実験」2018
• [Presentation] Classification of Raman Spectra of Healthy and Cancerous Human Follicular Thyroid Cells (2018)
  • Author(s): Nicholas Taylor, Kentaro Mochizuki, Katsumasa Fujita, Tamiki Komatsuzaki
  • Organizer: 研究会「理論と実験」2018
• [Presentation] ラマン計測と情報科学：情報科学は計測を迅速化できるか (2018)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: 第１回計測インフォマティクス研究会
• [Presentation] Information theoretic approach to reveal singularity in biology (2018)
  • Author(s): Tamiki Komatsuzaki
  • Organizer: The 56th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] Machine Learning Approaches to Raman Micro-spectroscopic Images (2018)
  • Author(s): Helal Khalifa Mohammad, Cahyadi Harsono, Taylor J. Nicholas, Okajima Akira, Kumamoto Yasuaki, Tanaka Hideo, Harada Yoshinori, Komatsuzaki Tamiki
  • Organizer: The 56th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] ハイパースペクトル画像の混合ノイズ除去におけるパラメータ設定に関する検討 (2018)
  • Author(s): Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
  • Organizer: 2018年電子情報通信学会ソサイエティ大会
• [Book] The Personality of Small Numbers: Do Molecules Have Personality? (2018)
  • Author(s): Tamiki Komatsuzaki
  • Total Pages: 7
  • Publisher: Springer
  • ISBN: 9789811320828
• [Book] Good arm identification via bandit feedback (2018)
  • Author(s): Hideaki Kano, Junya Honda, Kentaro Sakamaki, Kentaro Matsuura, Atsuyoshi Nakamura, Masashi Sugiyama
  • Total Pages: 25
  • Publisher: Springer
• [Remarks] 研究室HP
  • URL: https://mlns.es.hokudai.ac.jp/
• [Remarks] 細胞などの要素間相互作用の関係性をデータ駆動的に解明
  • URL: https://www.es.hokudai.ac.jp/result/2022-02-10-mlns/