• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Data-driven Mathematical Analysis for Single Cells and Singularity Cells

Planned Research

Project AreaSingularity biology
Project/Area Number 18H05413
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionHokkaido University

Principal Investigator

小松崎 民樹  北海道大学, 電子科学研究所, 教授 (30270549)

Co-Investigator(Kenkyū-buntansha) 中村 篤祥  北海道大学, 情報科学研究院, 教授 (50344487)
小野 峻佑  東京工業大学, 情報理工学院, 准教授 (60752269)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥98,280,000 (Direct Cost: ¥75,600,000、Indirect Cost: ¥22,680,000)
Fiscal Year 2022: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2021: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2020: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2019: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2018: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Keywords情報計測 / 因果推論 / バンディット手法 / 1細胞ラマン分光イメージング / スパース学習 / バンディットアルゴリズム / 1細胞ラマン分光 / 1細胞ラマン分光 / 異常検知
Outline of Annual Research Achievements

ある細胞と別の細胞の主従関係を推定する場合,それら2つの細胞の軌跡データなどを用いて評価されているが,2つの細胞の振る舞いを決める因子が,その2つの細胞以外にも,第3の細胞が介在する状況なども考えられる。主従関係や因果関係における“原因”と“結果”を解析するためには,単純な対の組み合わせで表現できない多体の相互作用から成り立っている。そのため,多体のあいだの因果関係を推定することは要素間の組み合わせの数が膨大になる。2対の軌跡データを変数とする移動エントロピーを細分化した新しい相乗情報量に着眼し,改良Vicsekモデルに基づいてこの問題を考察し、移動エントロピーに含まれる相乗情報量の振る舞いを解析することで,要素間の多体の相互作用が推定できることを見いだした(Sci Adv 2022)。
昨年度開発した、細胞毎の発火状態時系列からの伝搬時差推定をギャップを挿入する文字列のアライメントで行い伝搬グラフを構築する手法を発展させ、DTW(Dynamic Time Warping)ベースの実数値列アライメントを用いて伝搬グラフを構築する方法を開発した。位置情報を用いないで伝搬関係を推定できるため、細胞間の信号の伝搬のみでなく、株価の他の株価への影響の伝搬関係など曖昧な伝搬関係の抽出にも使えることを株価データを用いて確認した。
シンギュラリティ成分検出の前処理としてイメージングデータからノイズや外乱を取り除くための正則化手法について研究を進めた。具体的には、イメージングデータに内在するスパース性を引き出す変換を構成し、スパース性を評価するノルムと組み合わせて正則化関数を設計した。加えて、この正則化を含む最適化問題としてノイズ・外乱除去問題を定式化し、これを解くアルゴリズムを開発した。最後に、実際のハイパースペクトルイメージングデータを用いた大規模な比較実験によって有効性を実証した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

細胞状態を評価するうえでラマン画像のほか、細胞などの要素の軌跡データを用いて、細胞間の主従関係、細胞間の相互作用域を推定する手法を開発することに成功した(Phys Rev E 2020, J. Chem. Phys. 2021, BPPB 2021(招待))。また、Sci Adv 2022 (on line feature articleに選出)など成果が出ている。

Strategy for Future Research Activity

相互作用ポテンシャルの型(反発型ポテンシャル、モース型)が軌跡データから復元できるかを解析するとともに、相乗情報量を最大にする系の構成パラメータをベイズ最適化で算出し、移動エントロピーの成分である相乗情報量の物理的な解釈を与える。また、これまでに開発してきた手法群をAMATERASの画像データ解析に適用し、領域内の異分野融合をより加速する。
開発したDTWベースの実数値列アライメントを用いて伝搬グラフを構築する方法は、伝搬時差が変化する場合にも各時点での伝搬時差を推定することが可能である。しかし、どのくらい正確に推定できるかはわかっていないため、シミュレーションによりその有効性を確認し、有効な応用の範囲を明確化する。
今後は、2020年度に開発した正則化手法を始めとする様々な事前知識を取り入れることで、定常成分・シンギュラリティ成分・ノイズや外乱を同時に分離しながら推定する方
法論の構築を行う。また、実際のイメージングデータの異常検出における有効性(検出精度・ノイズ等への頑健性等)を実験的に検証する。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(93 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 7 results) Presentation (70 results) (of which Int'l Joint Research: 20 results,  Invited: 14 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] University of California, Davis(米国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Modes of information flow in collective cohesion2022

    • Author(s)
      Sulimon Sattari, Udoy S. Basak, Ryan G. James, Louis W. Perrin, James P. Crutchfield, Tamiki Komatsuzaki
    • Journal Title

      Science Advances

      Volume: 8 Issue: 6

    • DOI

      10.1126/sciadv.abj1720

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An information-theoretic approach to infer the underlying interaction domain among elements from finite length trajectories in a noisy environment2021

    • Author(s)
      Basak Udoy S.、Sattari Sulimon、Hossain Md. Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
    • Journal Title

      The Journal of Chemical Physics

      Volume: 154 Issue: 3 Pages: 034901-034901

    • DOI

      10.1063/5.0034467

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transfer entropy dependent on distance among agents in quantifying leader-follower relationships2021

    • Author(s)
      Basak Udoy S.、Sattari Sulimon、Hossain Motaleb、Horikawa Kazuki、Komatsuzaki Tamiki
    • Journal Title

      Biophysics and Physicobiology

      Volume: 18 Issue: 0 Pages: 131-144

    • DOI

      10.2142/biophysico.bppb-v18.015

    • NAID

      130008054076

    • ISSN
      2189-4779
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classification Bandits: Classification Using Expected Rewards as Imperfect Discriminators2021

    • Author(s)
      Tabata Koji、Nakumura Atsuyoshi、Komatsuzaki Tamiki
    • Journal Title

      Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD), Workshop on Machine Learning for MEasurement INformatics

      Volume: - Pages: 57-69

    • DOI

      10.1007/978-3-030-75015-2_6

    • ISBN
      9783030750145, 9783030750152
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of Propagation Graph by Pairwise Alignment of Time Series Data2020

    • Author(s)
      林 達也、中村 篤祥
    • Journal Title

      JSAI Technical Report, SIG-FPAI

      Volume: 114 Issue: 0 Pages: 01

    • DOI

      10.11517/jsaifpai.114.0_01

    • NAID

      130008061460

    • ISSN
      2436-4584
    • Year and Date
      2020-11-10
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Inferring domain of interactions among particles from ensemble of trajectories2020

    • Author(s)
      Basak Udoy S.、Sattari Sulimon、Horikawa Kazuki、Komatsuzaki Tamiki
    • Journal Title

      Physical Review E

      Volume: 102 Issue: 1

    • DOI

      10.1103/physreve.102.012404

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dependence of DNA length on binding affinity between TrpR and trpO of DNA2020

    • Author(s)
      Nobuo Shimamoto, Mikito Toda, Shigetoshi Nara, Tamiki Komatsuzaki, Kiyoto Kamagata, Takashi Kinebuchi, Jun-ichi Tomizawa
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 15624-15624

    • DOI

      10.1038/s41598-020-71598-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Data-Dependent Conversion to a Compact Integer-Weighted Representation of a Weighted Voting Classifier.2020

    • Author(s)
      Mitsuki Maekawa, Atsuyoshi Nakamura, Mineichi Kudo
    • Journal Title

      Proceedings of The 12th Asian Conference on Machine Learning (ACML 2020)

      Volume: - Pages: 241-256

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Constrained Convex Optimization Approach to Hyperspectral Image Restoration with Hybrid Spatio-Spectral Regularization2020

    • Author(s)
      Takeyama Saori、Ono Shunsuke、Kumazawa Itsuo
    • Journal Title

      Remote Sensing

      Volume: 12 Issue: 21 Pages: 3541-3541

    • DOI

      10.3390/rs12213541

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Joint Mixed-Noise Removal and Compressed Sensing Reconstruction of Hyperspectral Images via Convex Optimization2020

    • Author(s)
      Takeyama Saori、Ono Shunsuke
    • Journal Title

      IEEE International Geoscience and Remote Sensing Symposium (IGARSS)

      Volume: 1 Pages: 1492-1495

    • DOI

      10.1109/igarss39084.2020.9323489

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ハイパースペクトル画像復元のための低ランク正則化と空間-波長正則化の融合2020

    • Author(s)
      武山彩織, 小野峻佑
    • Journal Title

      第35回信号処理シンポジウム

      Volume: -

    • Related Report
      2020 Annual Research Report
  • [Journal Article] A bad arm existence checking problem: How to utilize asymmetric problem structure?2019

    • Author(s)
      Tabata Koji、Nakamura Atsuyoshi、Honda Junya、Komatsuzaki Tamiki
    • Journal Title

      Machine Learning

      Volume: 109 Issue: 2 Pages: 327-372

    • DOI

      10.1007/s10994-019-05854-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Raman spectroscopic histology using machine learning for nonalcoholic fatty liver disease2019

    • Author(s)
      Khalifa Mohammad Helal, James Nicholas Taylor, Harsono Cahyadi, Akira Okajima, Koji Tabata, Yoshito Itoh, Hideo Tanaka, Katsumasa Fujita, Yoshinori Harada, Tamiki Komatsuzaki
    • Journal Title

      FEBS Letters

      Volume: 593 Issue: 18 Pages: 2535-2544

    • DOI

      10.1002/1873-3468.13520

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High-Resolution Raman Microscopic Detection of Follicular Thyroid Cancer Cells with Unsupervised Machine Learning2019

    • Author(s)
      J. Nicholas Taylor, Kentaro Mochizuki, Kosuke Hashimoto, Yasuaki Kumamoto, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 123 Issue: 20 Pages: 4358-4372

    • DOI

      10.1021/acs.jpcb.9b01159

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feature selection as Monte-Carlo Search in Growing Single Rooted Directed Acyclic Graph by Best Leaf Identification2019

    • Author(s)
      Pelissier A, Nakamura A, Tabata K
    • Journal Title

      SIAM International Conference on Data Mining(SDM2019)

      Volume: - Pages: 450-458

    • DOI

      10.1137/1.9781611975673.51

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deciphering Molecular Complexity in Dynamics and Kinetics - From the Single Molecule to the Single Cell Level2019

    • Author(s)
      Komatsuzaki T, Press S, Senet P
    • Journal Title

      J. Phys. Chem. B

      Volume: 123 Issue: 30 Pages: 2535-2544

    • DOI

      10.1021/acs.jpcb.9b05382

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mixed Noise Removal for Hyperspectral Images Using Hybrid Spatio-Spectral Total Variation2019

    • Author(s)
      Takeyama Saori、Ono Shunsuke、Kumazawa Itsuo
    • Journal Title

      ICIP

      Volume: - Pages: 3128-3132

    • DOI

      10.1109/icip.2019.8803239

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Constrained Signal Reconstruction by Randomized Epigraphical Projection2019

    • Author(s)
      Ono Shunsuke
    • Journal Title

      ICASSP

      Volume: - Pages: 4993-4997

    • DOI

      10.1109/icassp.2019.8682191

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning2022

    • Author(s)
      Tamiki Komatsuzaki, Koji Tabata, Hiroyuki Kawagoe, James Nicholas Taylor, Kentaro Mochizuki, Toshiki Kubo, Jean-Emmanuel Clement, Yasuaki Kumamoto, Yoshinori Harada, Atsuyoshi Nakamura, Katsumasa Fujita
    • Organizer
      SPIE Photonics Europe 2022
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 情報理論による化学的空間不均一性に基づくラマン分光イメージングの解析2022

    • Author(s)
      近藤僚哉, TAYLOR J. Nicholas, CLEMENT Jean-Emmanuel, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
    • Organizer
      化学系学協会北海道支部2022年冬季研究発表会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 情報理論とラマン分光イメージングを用いた化学的不均一性の解析2022

    • Author(s)
      近藤僚哉, James N.Taylor, 水野雄太, Jean-Emmanuel Clement, 藤田克昌, 原田義規, 小松崎民樹
    • Organizer
      2021年度生物物理学会北海道支部-東北支部合同例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Detection of Cancer Stem Cells in Sarcoma Model Cells Using Morphological Features for Developing New Diagnostics Tools2021

    • Author(s)
      Zannatul Ferdous, Masumi Tsuda, Jean-Emmanuel Clement, Koji Tabata, Jian Ping Gong, Shinya Tanaka, Tamiki Komatsuzaki
    • Organizer
      ICReDD 3rd International Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Classification Bandits: Classification Using Expected Rewards as Imperfect Discriminators2021

    • Author(s)
      Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
    • Organizer
      PAKDD2021 Workshop on Machine Learning for MEasurement Informatics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning2021

    • Author(s)
      Tamiki Komatsuzaki , Koji Tabata, Hiroyuki Kawagoe, James Nicholas Taylor , Kentaro Mochizuki , Jean-Emmanuel Clement , Yasuaki Kumamoto , Atsuyoshi Nakamura , Yoshinori Harada , Katsumasa Fujita
    • Organizer
      FACSS SciX 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 強化学習を用いたラマン計測迅速化:On-the-fly Raman image microscopy2021

    • Author(s)
      小松崎民樹
    • Organizer
      (一社)大阪大学ナノ理工学人材育成産学コンソーシアム 令和2年度第3回ナノ理工学情報交流会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 機械学習を用いた化学的不均一性 の情報を含むラマン顕微鏡画像中のスペクトルの分類2021

    • Author(s)
      近藤僚哉, James N. Taylor, Jean-Emmanuel Clement, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
    • Organizer
      化学系学協会北海道支部2021年冬季研究発表会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 化学的不均一性も考慮したラマン顕微鏡画像解析2021

    • Author(s)
      近藤僚哉, James N.Taylor, Jean-Emmanuel Clement, 水野雄太, 藤田克昌, 原田義規, 小松崎民樹
    • Organizer
      生物物理学会学会 北海道支部-東北支部合同例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis Dictyostelium Discoideum cells motion response to a chemoattractant cyclic-AMP wave2021

    • Author(s)
      Md. Motaleb Hossain, Sulimon Sattari, Udoy S. Basak, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      生物物理学会学会 北海道支部-東北支部合同例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Study on Identification of Leader and Follower agents and its Interaction domain from Trajectories in a Collectively Moving Colony2021

    • Author(s)
      Udoy S. Basak, Sulimon Sattari, Md. Motaleb Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      生物物理学会学会 北海道支部-東北支部合同例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Modes of Information Flow in Collective Cohesion2021

    • Author(s)
      Sulimon Sattari, Udoy Basak, James P. Crutchfield, Tamiki Komatsuzaki
    • Organizer
      生物物理学会学会 北海道支部-東北支部合同例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ラマン分光イメージングにおける化学的空間不均一性の情報理論解析2021

    • Author(s)
      近藤 僚哉, James N. Taylor, Jean-Emmanuel Clement, 水野 雄太, 藤田 克昌, 原田 義規, 小松崎 民樹
    • Organizer
      第23回理論化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 計測介入型AIによる迅速ラマン計測2021

    • Author(s)
      小松崎 民樹
    • Organizer
      JST情報計測オンラインセミナーシリーズ
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 化学反応ネットワークにおける時間階層性(Timescale hierarchies in chemical reaction networks)2021

    • Author(s)
      小松崎 民樹
    • Organizer
      シンポジウム「化学反応経路探索のニューフロンティア2021」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ラマン分光イメージングにおける化学的空間不均一性 に基づいたファジークラスタリング手法の開発2021

    • Author(s)
      近藤 僚哉, James N.Taylor, Jean-Emmanuel Clement, 水野 雄太, 藤田 克昌, 原田 義規, 小松崎 民樹
    • Organizer
      第15回分子科学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一分子計測からたんぱく質のエネルギー地形の階層性を抽出する Capturing hierarchical features in protein energy landscape from single molecule time series2021

    • Author(s)
      小松崎 民樹
    • Organizer
      第59回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Classification of Spectra in Raman Microscopic Image by Chemical Heterogeneity2020

    • Author(s)
      Ryoya Kondo, James N Taylor, Jean-emmanuel Clement, Yuta Mizuno, Katsumasa Fujita, Yoshinori Harada, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] To classify Raman spectra using Deep Learning Approach2020

    • Author(s)
      Abdul Halim Bhuiyan, Jean-emmanuel Clement, Kentaro Mochizuki, James Nick Taylor, Koji Tabata, Yuta Mizuno, Atsuyoshi Nakamura, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Application of Linear Bandit in Drug Screening Example2020

    • Author(s)
      Md. Menhazul Abedin, Koji Tabata, Jean-Emmanuel Clement, Masumi Tsuda, Shinya Tanaka, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inferring domain of Interaction among Dictyostelium discoideum colony from the ensemble of Trajectories of cells2020

    • Author(s)
      Udoy S. Basak, Sulimon Sattari, Motaleb M. Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of Cancer Stem Cells in Sarcoma Model Cells by Deep Neural Network2020

    • Author(s)
      Zannatul Ferdous, Masumi Tsuda, Jean-Emmanuel Clement, Koji Tabata, Yusuke Ishida, Jun Suzuka, Jian Ping Gong, Shinya Tanaka, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Raman Imaging for Exploring Cancer Metabolism2020

    • Author(s)
      Jean-Emmanuel Clement, Mochizuki Kentaro, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Vector analysis of amoeba motion response to a cyclic-AMP wave2020

    • Author(s)
      Md. Motaleb Hossain, Sulimon Sattari, Udoy Sankar Basak, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Vector analysis of amoeba motion with respect to the propagation of chemoattractant cyclic-AMP2020

    • Author(s)
      Sulimon Sattari, Udoy Basak, Motaleb Md. Hossain, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      The 21st RIES-HOKUDAI International Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] シンギュラリティ生物学における情報×計測2020

    • Author(s)
      小松﨑 民樹
    • Organizer
      シンギュラリティ生物学×細胞ダイバース合同ワークショップ
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Quantifying the length- and time-scales of influence of cells in collective motion2020

    • Author(s)
      Sulimon Sattari, Basak Udoy, Motaleb Md. Hossain, 堀川 一樹, 小松崎 民樹
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inferring domain of Interactions among Dictyostelium discoideum colony from the Ensemble of Trajectories of cells2020

    • Author(s)
      Basak Udoy S, Sattari Sulimon, Hossain Md. Motaleb, Horikawa Kazuki, Komatsuzaki Tamiki
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Vector analysis of amoeba motion with respect to the propagation of chemoattractant cyclic-AMP2020

    • Author(s)
      Hossain Md. Motaleb, Sattari Sulimon, Basak Udoy S, Horikawa Kazuki, Komatsuzaki Tamiki
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Raman imaging for cancer diagnosis2020

    • Author(s)
      Jean-Emmanuel Clement, Kenntaro Mochizuki, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] シンギュラリティ生物学における情報計測2020

    • Author(s)
      小松﨑 民樹
    • Organizer
      シンギュラリティ生物学×細胞ダイバース合同ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] An Information-theoretic approach to identify the interaction radius of a group of collectively moving animals2019

    • Author(s)
      Udoy. S Basak, Sulimon Sattari, Tamiki Komatsuzaki
    • Organizer
      The 20th RIES-HOKUDAI International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A sandbox model system for analyzing leadership in collective motion2019

    • Author(s)
      Sulimon Sattari, Udoy Basak, Sky Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
    • Organizer
      The 20th RIES-HOKUDAI International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bad Arm Existence Checking Algorithm with Bandit Feeedback2019

    • Author(s)
      Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
    • Organizer
      The 20th RIES-HOKUDAI International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Raman Microscopic Histology using Ensemble Learning for Non-alcoholic Fatty Liver Disease2019

    • Author(s)
      Khalifa Mohammad Helal, Harsono Cahyadi, J. Nicholas Taylor, Akira Okajima, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Harada, Tamiki Komatsuzaki
    • Organizer
      The 20th RIES-HOKUDAI International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High Resolution Raman Microscopic Detection of Follicular Thyroid Cancer Cells with Unsupervised Machine Learning2019

    • Author(s)
      J. Nicholas Taylor, Kentaro Mochizuki, Kosuke Hashimoto, Yasuaki Kumamoto, Yoshinori Harada, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      The 20th RIES-HOKUDAI International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On-the-fly Raman image microscopy by reinforcement machine learning2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      Biomedical Raman Imaging 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Raman Hyperspectral Image Analysis Using Ensemble Learning for Non-alcoholic Fatty Liver Disease2019

    • Author(s)
      Khalifa Mohammad Helal, Harsono Cahyadi, J. Nicholas Taylor, Akira Okajima, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Harada, Tamiki Komatsuzaki
    • Organizer
      Biomedical Raman Imaging 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Causal inference in Leader-follower relationship2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      ICSB 2019: Singularity Biology: small elements change the function of the whole systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A leadership-based phase transition in a flocking model with activated and un-activated agents2019

    • Author(s)
      Sulimon Sattari, Tamiki Komatusaki, Mikito Toda, Sky Nicholson, Jason Green, Udoy Basak
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] An Information-theoretic approach toward identifying the leader(s) and aggregation place in Dictyostelium Discoideum colony2019

    • Author(s)
      Basak Udoy Sankar, Sattari Sulimon, Horikawa Kazuki, Komatsuzaki Tamiki
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Raman pathology and its phenotypic landscape for Non-alcoholic fatty liver diseases2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      The Complexity of Dynamics and Kinetics from Single Molecules to Cells
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アデニレートキナーゼの一分子観察データから再構成するエネルギー地形の階層性2019

    • Author(s)
      James Nicholas Taylor, Menahem Pirchi, Gilad Haran, 小松崎 民樹
    • Organizer
      第22回理論化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Deciphering hierarchical features in reaction network and energy landscape2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      Network analysis to elucidate natural system dynamics, diversity and performance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バンディット問題の方策を用いたモンテカルロ木探索による最適属性集合 探索2019

    • Author(s)
      中村篤祥, ペリシエ オレリアン, 田畑 公次, 小松崎 民樹
    • Organizer
      第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] モンテカルロ木特徴探索に基づく非線形グラフ分類回帰2019

    • Author(s)
      白川稜, 中村篤祥, 工藤峰一
    • Organizer
      第22回情報論的学習理論ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] Learning a Nonlinear Model of Subgraph Features Using Monte Carlo Tree Search2019

    • Author(s)
      Ryo Shirakawa, Atsuyoshi Nakamura, Mineichi Kudo
    • Organizer
      ACML 2019 Workshop on Statistics & Machine Learning Researchers in Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 空間-波長正則化を用いた圧縮pansharpening2019

    • Author(s)
      武山 彩織, 小野 峻佑
    • Organizer
      第34回信号処理シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of Leader(s) in a Dictyostelium Discoideum colony: An Information-theoretic Approach2019

    • Author(s)
      Udoy Sankar Basak, Sulimon Sattari, Sosuke Ito, Kazuki Horikawa, Tamiki Komatsuzaki
    • Organizer
      生物物理・回折構造生物学 合同研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A sandbox model system for understanding leadership in collective motion2019

    • Author(s)
      Sulimon Sattari, Udoy Basak, Schuyler Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
    • Organizer
      生物物理・回折構造生物学 合同研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ハイパースペクトルイメージングのための圧縮pansharpeningの検討2019

    • Author(s)
      Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
    • Organizer
      電子情報通信学会信号処理研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ブラックボックス関数の閾値以上の値の存在チェックのアルゴリズム2019

    • Author(s)
      Naoki Ito, Atsuyoshi Nakamura, Mineichi Kudo
    • Organizer
      第11回データ工学と情報マネジメントに関するフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] In combining single cell hyperspectral Raman images for the diagnosis of follicular thyroid carcinoma measured at different data2019

    • Author(s)
      Aurelien Pelissier
    • Organizer
      バイオ情報計測技術研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] High resolution Raman microscopic detection of follicular thyroid cancer cells with unsupervised machine learning2019

    • Author(s)
      Nicholas Taylor
    • Organizer
      バイオ情報計測技術研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mathematical information measurement science: acceleration of Raman spectroscopy by bridging information science2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      バイオ情報計測技術研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A bad arm existence checking problem: how to utilize asymmetric problem structure?2019

    • Author(s)
      Koji Tabata
    • Organizer
      バイオ情報計測技術研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nonsmooth Convex Optimization and Sparse Regularization in Signal and Information Processing2019

    • Author(s)
      Shunsuke Ono
    • Organizer
      ICMMA’18
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子時系列情報からどのように背後の反応ネットワークを抽出できるのか?2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      「生命動態の理解と制御のための基盤技術の創出」研究領域第7 回領域会議・第11 回数理デザイン道場
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] How can one bridge information science and measurement science to accelerate the measurements?2019

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      The 22nd SANKEN International Symposium The 17th SANKEN Nanotechnology International Symposium “Next Generation Science and Technology for Super Smart Society”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hyperspectral Pansharpening Using Noisy Panchromatic Image2018

    • Author(s)
      Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
    • Organizer
      Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非対称性を利用した悪腕存在チェックアルゴリズム2018

    • Author(s)
      Koji Tabata, Atsuyoshi Nakamura, Tamiki Komatsuzaki
    • Organizer
      第21回情報論的学習理論ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] ガウシアンノイズを考慮したハイパースペクトル画像とマルチスペクトル画像の合成法2018

    • Author(s)
      Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
    • Organizer
      第33回信号処理シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] A Randomized Epigraphical Projection Approach to Constrained Signal Reconstruction2018

    • Author(s)
      Shunsuke Ono
    • Organizer
      第33回信号処理シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] DOO アルゴリズムの悪腕存在チェック問題への応用2018

    • Author(s)
      Naoki Ito, Atsuyoshi Nakamura, Mineichi Kudo
    • Organizer
      情報処理北海道シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] A sandbox model system for studying leadership in collective motion2018

    • Author(s)
      Sulimon Sattari, Udoy Basak, Schuyler Nicholson, Jason Green, Mikito Toda, Tamiki Komatsuzaki
    • Organizer
      研究会「理論と実験」2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Classification of Raman Spectra of Healthy and Cancerous Human Follicular Thyroid Cells2018

    • Author(s)
      Nicholas Taylor, Kentaro Mochizuki, Katsumasa Fujita, Tamiki Komatsuzaki
    • Organizer
      研究会「理論と実験」2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラマン計測と情報科学:情報科学は計測を迅速化できるか2018

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      第1回計測インフォマティクス研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Information theoretic approach to reveal singularity in biology2018

    • Author(s)
      Tamiki Komatsuzaki
    • Organizer
      The 56th Annual Meeting of The Biophysical Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Machine Learning Approaches to Raman Micro-spectroscopic Images2018

    • Author(s)
      Helal Khalifa Mohammad, Cahyadi Harsono, Taylor J. Nicholas, Okajima Akira, Kumamoto Yasuaki, Tanaka Hideo, Harada Yoshinori, Komatsuzaki Tamiki
    • Organizer
      The 56th Annual Meeting of The Biophysical Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイパースペクトル画像の混合ノイズ除去におけるパラメータ設定に関する検討2018

    • Author(s)
      Saori Takeyama, Shunsuke Ono, Itsuo Kumazawa
    • Organizer
      2018年電子情報通信学会ソサイエティ大会
    • Related Report
      2018 Annual Research Report
  • [Book] The Personality of Small Numbers: Do Molecules Have Personality?2018

    • Author(s)
      Tamiki Komatsuzaki
    • Total Pages
      7
    • Publisher
      Springer
    • ISBN
      9789811320828
    • Related Report
      2018 Annual Research Report
  • [Book] Good arm identification via bandit feedback2018

    • Author(s)
      Hideaki Kano, Junya Honda, Kentaro Sakamaki, Kentaro Matsuura, Atsuyoshi Nakamura, Masashi Sugiyama
    • Total Pages
      25
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://mlns.es.hokudai.ac.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 細胞などの要素間相互作用の関係性をデータ駆動的に解明

    • URL

      https://www.es.hokudai.ac.jp/result/2022-02-10-mlns/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-07-20   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi