| Budget Amount *help |
¥128,960,000 (Direct Cost: ¥99,200,000、Indirect Cost: ¥29,760,000)
Fiscal Year 2022: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2021: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2020: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2019: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Outline of Final Research Achievements |
Developmental pattern formation is an excellent model of singularity phenomena. By using a newly developed transscale scope, we investigated the onset dynamics of collective signaling in the population of chemotacting cells at 1-cell resolution. A large-scale 1-cell tracking revealed that the cell population is highly heterogeneous in their signal-relaying ability where a small number of cells, called leaders and followers, functioned as a signal initiator and amplifier, respectively. Our mathematical simulation incorporating experimentally observed features demonstrated that such cellular heterogeneity is the key determinant to developing the spiral-shaped signaling pattern, whose initiation mechanisms have remained long elusive. Associated development of new technologies, such as a semi-automated detection of signaling cells and optical highlighters for leaders and followers, would benefit the analysis of other models for singularity phenomena in physiological and pathological cases.
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