Emergence of autonomous functions through hierarchical integration of molecular engines

• Project Area: Molecular Engine: Design of Autonomous Functions through Energy Conversion
• Project/Area Number: 18H05423
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Hokkaido University
• Principal Investigator: 角五 彰 北海道大学, 理学研究院, 准教授 (10374224)
• Co-Investigator(Kenkyū-buntansha): 景山 義之 北海道大学, 理学研究院, 助教 (90447326)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥154,830,000 (Direct Cost: ¥119,100,000、Indirect Cost: ¥35,730,000); Fiscal Year 2022: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000); Fiscal Year 2021: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000); Fiscal Year 2020: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000); Fiscal Year 2019: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000); Fiscal Year 2018: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
• Keywords: 生体発動分子 / 人工発動分子 / 集団運動 / 時空間制御 / アゾベンゼン / 自律機能

Outline of Annual Research Achievements

本研究では、１）二次元界面を足場とした生体発動分子の運動発現系の確立、２）生体発動分子の集団運動発現系の確立、３）生体発動分子による物質輸送システムを確立することで標的物質を集団で輸送し機能的な組織体へと組み上げる集積場を提供する。さらに得られた知見をもとに４）人工発動分子の集団化による自律運動を実現することを目的としている。本年度は、生体発動分子（微小管・キネシン）をガラスやソフトエラストマーなどの二次元基板表面上に固定化する技術、さらにATPをエネルギー源とした微小管の機械的な運動発現により得られた画像データーを解析することでロバストな運動の評価を行ってきた。新たに熱耐性キネシンの開発に向け理論予測と遺伝子工学を融合した熱安定化変異体のスクリーニング実験を開始させ、熱安定性が得られると予測される候補の絞り込みを済ませるとともに熱耐性キネシンの変異体の作製にも着手した。さらに特異的な相互作用を有する半人工分子機械（DNA）などと生体発動分子を複合化したハイブリッド型生体発動分子の設計指針を立て予備実験を開始させた。ハイブリッド化が生体発動分子の動力性能に大きな影響を与えないことも確認済みである。人工発動分子による自律運動系の構築の試みでは、化学基質の変換をエネルギー源とする物体輸送系を実現した。具体的には、人工発動分子を埋設した二次元液晶界面上を、シリカゲルマイクロ微粒子が、時速15マイクロメートル程度の極めてゆっくりとした速度で遊走した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

予定していた生体発動分子（微小管・キネシン）の運動評価、さらに熱耐性キネシンの開発に向け理論予測ならびに変異体の作製、ハイブリッド型生体発動分子の設計および動作確認、人工発動分子による物質輸送系の確立など、計画通りに研究が進展しているため。

Strategy for Future Research Activity

本研究では、１）二次元界面を足場とした生体発動分子の運動発現系の確立、２）生体発動分子の集団運動発現系の確立、３）生体発動分子による物質輸送システムを確立することで標的物質を集団で輸送し機能的な組織体へと組み上げる集積場を提供する。さらに得られた知見をもとに４）人工分子による自律集団運動を実現することを目的としている。本年度は、班内連携を継続して行いながらハイブリッド分子の創出、分子ダイナミクスのリアルタイムにイメージングを行うとともに、挙動の動力学的な解釈を行うことを目指す。具体的には、ＤＮＡの分子認識やリガンド・レセプターなどの特異的な相互作用を有する人工分子機械などと複合化することで発動分子の機能化を目指す。人工分子機械との複合化は、分担者との協同で実施し、人工分子機械による集団機能の変調を実現する。また班内連携を行いながら二次元界面上での生体発動分子のダイナミクスを蛍光顕微鏡や高速ＡＦＭなどの観察装置を用いリアルタイムにイメージングするともに、その挙動の動力学的な解釈を行う。人工発動分子の集団化によるエネルギー変換系の学理構築に向けた取り組みでは、実現した物体輸送システムの運動能力の向上を目的に、用いる液晶分子や発動分子を変えて実験調査する。微粒子の遊走において、定量的比較検討が可能な速度にまでシステムの改善が行われ次第、物体輸送を実現する自己組織化の仕組みを探る研究を開始する。

Research Products

• [Journal Article] Light-driven flipping of azobenzene assemblies sparse crystal structures and responsive behavior to polarized light (2020)
  • Author(s): Yoshiyuki Kageyama, Tomonori Ikegami, Shinnosuke Satonaga, Kazuma Obara, Hiroyasu Sato, Sadamu Takeda
  • Journal Title: Chemistry - A European Journal Volume: 26 Issue: 47 Pages: 10759-10768
  • DOI: 10.1002/chem.202000701
  • Peer Reviewed / Open Access
• [Journal Article] 光を浴びて舞い踊る結晶 (2019)
  • Author(s): 小原一馬・景山義之
  • Journal Title: CHEMISTRY & EDUCATION Volume: 67 Issue: 2 Pages: 74-75
  • DOI: 10.20665/kakyoshi.67.2_74
  • NAID: 130007793409
  • ISSN: 0386-2151, 2424-1830
  • Year and Date: 2019-02-20
  • Peer Reviewed / Open Access
• [Journal Article] Substrate selectivity and its mechanistic insight of the photo-responsive non-nucleoside triphosphate for myosin and kinesin (2019)
  • Author(s): Islam, Md. J., Matsuo, K., Menezes, H. M., Takahashi, M., Nakagawa, H., Kakugo, A., Sada, K., Tamaoki, N.
  • Journal Title: Organic & Biomolecular Chemistry Volume: 17 Issue: 1 Pages: 53-65
  • DOI: 10.1039/c8ob02714e
  • Peer Reviewed
• [Journal Article] Artificial Smooth Muscle Model Composed of Hierarchically Ordered Microtubule Asters Mediated by DNA Origami Nanostructures (2019)
  • Author(s): Matsuda Kento、Kabir Arif Md. Rashedul、Akamatsu Naohide、Saito Ai、Ishikawa Shumpei、Matsuyama Tsuyoshi、Ditzer Oliver、Islam Md. Sirajul、Ohya Yuichi、Sada Kazuki、Konagaya Akihiko、Kuzuya Akinori、Kakugo Akira
  • Journal Title: Nano Letters Volume: 19 Issue: 6 Pages: 3933-3938
  • DOI: 10.1021/acs.nanolett.9b01201
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide (2019)
  • Author(s): Hiroshi Inaba, Takahisa Yamamoto, Takashi Iwasaki, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
  • Journal Title: Chemical Communications Volume: 55 Issue: 62 Pages: 9072-9075
  • DOI: 10.1039/c9cc04345d
  • Peer Reviewed
• [Journal Article] Stabilization of microtubules by cevipabulin (2019)
  • Author(s): Syeda Rubaiya Nasrina Arif Md. Rashedul Kabir, Akihiko Konagaya, Tsukasa Ishihara,Kazuki Sada, Akira Kakugo
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 516 Issue: 3 Pages: 760-764
  • DOI: 10.1016/j.bbrc.2019.06.095
  • Peer Reviewed
• [Journal Article] Fluorescent Tau-derived Peptide for Monitoring Microtubules in Living Cells (2019)
  • Author(s): Hiroshi Inaba, Takahisa Yamamoto, Takashi Iwasaki, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
  • Journal Title: ACS Omega Volume: 4 Issue: 6 Pages: 11245-11250
  • DOI: 10.1021/acsomega.9b01089
  • Peer Reviewed / Open Access
• [Journal Article] Adaptation of Patterns of Motile Filaments under Dynamic Boundary Conditions (2019)
  • Author(s): Daisuke Inoue, Greg Gutmann, Takahiro Nitta, Arif Md. Rashedul Kabir, Akihiko Konagaya, Kiyotaka Tokuraku, Kazuki Sada, Henry Hess, Akira Kakugo
  • Journal Title: ACS Nano Volume: 13 Issue: 11 Pages: 12452-12460
  • DOI: 10.1021/acsnano.9b01450
  • NAID: 120006890339
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Light‐Powered Self‐Sustainable Macroscopic Motion for the Active Locomotion of Materials (2019)
  • Author(s): Yoshiyuki Kageyama
  • Journal Title: ChemPhotoChem Volume: 3 Issue: 6 Pages: 327-336
  • DOI: 10.1002/cptc.201900013
  • Peer Reviewed / Open Access
• [Journal Article] Fusion of inorganic nanosheets and microtubules for active anisotropic colloid driven by biochemical energy and entropic force (2018)
  • Author(s): R. Kato;A. Kakugo;K. Shikinaka;Y. Ohsedo;A. M. R. Kabir;N. Miyamoto
  • Journal Title: ACS Omega Volume: 3 Issue: 11 Pages: 14869-14874
  • DOI: 10.1021/acsomega.8b01050
  • Peer Reviewed / Open Access
• [Journal Article] Construction of artificial cilia from microtubules and kinesins through a with designed bottom-up approach (2018)
  • Author(s): Ren Sasaki, Arif Md. Rashedul Kabir, Daisuke Inoue, Shizuka Anan, Atsushi P. Kimura, Akihiko Konagaya, Kazuki Sada, *Akira Kakugo
  • Journal Title: Nanoscale Volume: 10 Issue: 14 Pages: 6323-6332
  • DOI: 10.1039/c7nr05099b
  • Peer Reviewed
• [Journal Article] Molecular Encapsulation Inside Microtubules Based on Tau-Derived Peptides (2018)
  • Author(s): Inaba Hiroshi、Yamamoto Takahisa、Kabir Arif Md. Rashedul、Kakugo Akira、Sada Kazuki、Matsuura Kazunori
  • Journal Title: Chemistry - A European Journal Volume: 24 Issue: 56 Pages: 14958-14967
  • DOI: 10.1002/chem.201802617
  • Peer Reviewed / Open Access
• [Journal Article] Control of swarming of molecular robots (2018)
  • Author(s): Keya Jakia Jannat、Kabir Arif Md. Rashedul、Inoue Daisuke、Sada Kazuki、Hess Henry、Kuzuya Akinori、Kakugo Akira
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-018-30187-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 群れのように振る舞う分子ロボットの開発 (2018)
  • Author(s): 葛谷明紀、ケア ジャキア ジャンナット、 角五彰
  • Journal Title: 化学 Volume: 73 Pages: 40-42
• [Journal Article] 群れを成して動くモノ (2018)
  • Author(s): 角五彰
  • Journal Title: 高分子 Volume: 67 Pages: 252-252
  • Peer Reviewed
• [Journal Article] スワーム型分子ロボット (2018)
  • Author(s): 角五彰
  • Journal Title: PEPTIDE NEWSLETTER JAPAN Volume: 108 Pages: 4-6
  • Peer Reviewed
• [Presentation] Self-propelled swimming of an organic crystal in water with flapping motion under continuous blue light irradiation (2020)
  • Author(s): Kazuma Obara, Yoshiyuki Kageyama, Sadamu Takeda
  • Organizer: The 20th RIES-HOKUDAI International Symposium 稀[ki]
  • Int'l Joint Research
• [Presentation] Dissipative Self-Organization for Making Molecular Machine to Work Autonomously (2020)
  • Author(s): Yoshiyuki Kageyama, Tomonori Ikegami, Kazuma Obara, Sadamu Takeda
  • Organizer: The 20th RIES-HOKUDAI International Symposium 稀[ki]
  • Int'l Joint Research
• [Presentation] Self-propelled swimming of an organic crystal in water with flapping motion under continuous blue-light irradiation (2020)
  • Author(s): Kazuma Obara, Yoshiyuki Kageyama, Sadamu Takeda
  • Organizer: Workshop on Physics of Soft, Active and Living Matter
  • Int'l Joint Research
• [Presentation] Self-repetitive strokes of azobenzene assemblies under steady light-irradiation and their anisotropic structures (2020)
  • Author(s): Yoshiyuki Kageyama, Tomonori Ikegami, Kazuma Obara, Shinnosuke Satonaga, Daisuke Yazaki, Sadamu Takeda
  • Organizer: The 1st International Symposium on Molecular Engine
  • Int'l Joint Research
• [Presentation] Self-propelled swimming of an organic crystal in water with flapping motion under continuous blue-light irradiation (2020)
  • Author(s): Kazuma Obara, Yoshiyuki kageyama, Sadamu Takeda
  • Organizer: The 1st International Symposium on Molecular Engine
  • Int'l Joint Research
• [Presentation] キラルアゾベンゼン誘導体を含む結晶の青色定常光照射下での振動運動 (2020)
  • Author(s): 里永慎之介・景山義之・武田定
  • Organizer: 化学系学協会北海道支部2020年冬季研究発表会
• [Presentation] 発動分子の動きの集団化による時空間周期構造の形成と分子性材料の自律機能 (2020)
  • Author(s): 景山義之
  • Organizer: 日本化学会第100春季年会（コラボ企画）
  • Invited
• [Presentation] 波打ち型の自励振動を示すアゾベンゼン誘導体結晶の運動と構造解析 (2020)
  • Author(s): 矢崎 大介・池上 智則・景山 義之・武田 定
  • Organizer: 日本化学会第100春季年会
• [Presentation] ヒレを振動させて水中を推進する薄膜微結晶の遊泳 (2020)
  • Author(s): 小原 一馬・景山 義之・武田 定
  • Organizer: 日本化学会第100春季年会
• [Presentation] 化学で創る分子モーターと実働のための自己組織化 (2019)
  • Author(s): 景山義之
  • Organizer: 第9回分子モーター研究会
  • Invited
• [Presentation] 生命システムを有機化学で模倣する：分子集合体の自己複製と自律運動 (2019)
  • Author(s): 景山義之
  • Organizer: 高分子研究会（鳥取）
  • Invited
• [Presentation] 生命の本質的特徴を化学で現してみる (2019)
  • Author(s): 景山義之
  • Organizer: 化学教育講演会
  • Invited
• [Presentation] 有機分子の自己組織化で実現する分子集合体の自律運動 (2019)
  • Author(s): 景山義之
  • Organizer: 景山義之博士講演会
  • Invited
• [Presentation] 光照射によってリンカー長が変わるラジカルプローブの開発 (2019)
  • Author(s): 李ギョレ・景山義之・武田定
  • Organizer: 日本化学会北海道支部夏季研究発表会2019
• [Presentation] ヒレ運動型結晶スイマーの鈍い遊泳のモデル化 (2019)
  • Author(s): 景山義之
  • Organizer: 札幌非線形現象研究会2019
• [Presentation] 動的核分極NMRを用いた脂質膜近傍の局所的な水和環境の解析 (2019)
  • Author(s): 李ギョレ・景山義之・武田定
  • Organizer: 第13回バイオ関連化学シンポジウム
• [Presentation] 両親媒性アゾベンゼン誘導体の集合体がみせる自己秩序型メカニカル運動 (2019)
  • Author(s): 景山義之・池上智則・小原一馬・里永慎之介・佐藤寛泰・武田 定
  • Organizer: 第68回高分子討論会
  • Invited
• [Presentation] 動的核分極NMRを用いたリン脂質表面の局所的水和環境解析のためのプローブ合成 (2019)
  • Author(s): 李ギョレ・景山義之・武田定
  • Organizer: 電子スピンサイエンス学会2019
• [Presentation] 光で駆動される自律運動性結晶の構造と偏光の効果 (2019)
  • Author(s): 景山義之・池上智則・佐藤寛泰・武田 定
  • Organizer: 第28回 有機結晶シンポジウム
• [Presentation] Trans on switched cargo transportation by molecular swarm robot (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Kentaro Kayano, Arif Md. Rashedul Kabir, Daisuke Inoue, Kazuki Sada, Hiroyuki Asanuma, Henry Hess, Akinori Kuzuya, Akira kakugo
  • Organizer: The10th Graduate School of Chemical Sciences and Engineering (CSE) and Ambitious Leaders’s Program (ALP) International Summer School
  • Int'l Joint Research
• [Presentation] Regulation of trans on switched cargo transportation by molecular swarm robot (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Kentaro Kayano, Arif Md. Rashedul Kabir, Daisuke Inoue, Kazuki Sada, Hiroyuki Asanuma, Henry Hess, Akinori Kuzuya, Akira Kakugo
  • Organizer: 2nd Asian-French Workshop on Polymer Science 2019 (CSE International Student Symposium 2019)
  • Int'l Joint Research
• [Presentation] Photo-regulated spatiotemporal cargo transportation by molecular swarm robot (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Hiroyuki Asanuma, Akinori Kuzuya, Akira Kakugo
  • Organizer: The 57th Annual meeting of the Biophysical Society of Japan (BSJ 2019)
• [Presentation] Spatiotemporal trans on switched cargo transportation by molecular swarm robot (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Hiroyuki Asanuma, Akinori Kuzuya, Akira Kakugo
  • Organizer: Okinawa Colloids 2019
  • Int'l Joint Research
• [Presentation] Spatiotemporal regulation of trans on switched molecular swarm robot (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Hiroyuki Asanuma, Akinori Kuzuya, Akira Kakugo
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] Molecular swarm robot- a highly efficient molecular cargo carrier system (2019)
  • Author(s): Mousumi Akter, Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Hiroyuki Asanuma, Akinori Kuzuya, Akira Kakugo
  • Organizer: Hokkaido University National Central University Joint Symposium on Materials Chemistry and Physics 2019
  • Int'l Joint Research
• [Presentation] Effect of Mechanical Deformation of Microtubule by External Stimuli on Microtubule-Dynein Interaction (2019)
  • Author(s): Syeda Rubaiya Nasrin, Arif Md. Rashedul Kabir, Kazuki Sada, Akira Kakugo
  • Organizer: 2nd Asian-French Workshop on Polymer Science 2019 (CSE International Student Symposium 2019)
  • Int'l Joint Research
• [Presentation] High-Resolution Observation of the Effect of Microtubule Bending on Single Kinesin Motility (2019)
  • Author(s): Syeda Rubaiya Nasrin, Christian Ganser, Seiji Nishikawa, Kazuki Sada, Takayuki Uchihashi, Henry Hess, Akira Kakugo
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] High-Resolution Observation of the Effect of Deformation Microtubule on Single Kinesin Motility (2019)
  • Author(s): Syeda Rubaiya Nasrin, Christian Ganser, Seiji Nishikawa, Kazuki Sada, Takayuki Uchihashi, Henry Hess, Akira Kakugo
  • Organizer: Hokkaido University-National Central University Joint Symposium on Materials Chemistry and Physics 2019
  • Int'l Joint Research
• [Presentation] Force Measurement of Microtubules in Swarming Using Electromagnetic Tweezers (2019)
  • Author(s): Mst. Rubaya Rashid, Mousumi Akter, Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Akira Kakugo
  • Organizer: 7th International Life Science Symposium for Young Scientist (ILSS).
  • Int'l Joint Research
• [Presentation] Regulation of the motility of a nano-biomolecular machine using trimethylamine-N-oxide (2019)
  • Author(s): Tasrina Munmun, Arif Md. Rashedul Kabir, Kazuki Sada and Akira Kakugo
  • Organizer: 7th International Life Science Symposium for Young Scientist (ILSS).
  • Int'l Joint Research
• [Presentation] Complete, rapid and reversible regulation of the motility of a nanobiomolecular machine using trimethylamine-N-oxide (2019)
  • Author(s): Tasrina Munmun, Arif Md. Rashedul Kabir, Kazuki Sada and Akira Kakugo
  • Organizer: 2nd ICReDD International Symposium
  • Int'l Joint Research
• [Presentation] A deep-sea osmolyte TMAO regulates the motility of a nano-biomolecular machine (2019)
  • Author(s): Tasrina Munmun, Arif Md. Rashedul Kabir, Kazuki Sada and Akira Kakugo
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] Repeated on/off switching of the motility of a nano-biomolecular machine using a deep-sea osmolyte trimethylamine-N-oxide (2019)
  • Author(s): Tasrina Munmun, Arif Md. Rashedul Kabir, Kazuki Sada and Akira Kakugo
  • Organizer: Hokkaido University-National Central University Joint Symposium on Materials Chemistry and Physics 2019
  • Int'l Joint Research
• [Presentation] キネシンおよびDNA-origamiを介した微小管ネットワークの収縮弛緩挙動の制御 (2019)
  • Author(s): 松田健人、アリフ コビル ムハンマド ラセドゥル、角五彰、葛谷明紀、佐田和己
  • Organizer: 第68回高分子討論会
• [Presentation] Control of volume change of microtubule network by using kinesin and DNA-origami (2019)
  • Author(s): Kento MATSUDA, Arif Md. Rashedul KABIR, Kazuki SADA, Akinori KUZUYA, Akira KAKUGO
  • Organizer: 2nd Glowing Polymer Symposium in KANTO
• [Presentation] キネシンおよびDNA-origamiを介した微小管ネットワークの収縮・弛緩挙動の制御 (2019)
  • Author(s): 松田健人、Arif Md. Rashedul Kabir、佐田和己、角五彰、葛谷明紀
  • Organizer: 2019年度北海道高分子若手研究会 34th Summer University in Hokkaido
• [Presentation] Autonomous information transfer by molecular swarm robots through DNA-based sequential signaling (2019)
  • Author(s): Jakia Jannat Keya, Arif Md. Rashedul Kabir, Kazuki Sada, Akinori Kuzuya, Akira Kakugo
  • Organizer: 68th Symposiym on Macromolecules
  • Invited
• [Presentation] Swarming of molecular robots under autonomous strand generator (2019)
  • Author(s): Jakia Jannat Keya, Sosei Ichiseki, Ibuki Kawamata, Arif Md. Rashedul Kabir, Shinichiro M. Nomura, Akira Kakugo
  • Organizer: The 20th RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] Computing swarming of molecular robots under autonomous strand generator (2019)
  • Author(s): Jakia Jannat Keya, Sosei Ichiseki, Ibuki Kawamata, Arif Md. Rashedul Kabir, Shinichiro M. Nomura, Akira Kakugo
  • Organizer: Hokkaido University-National Central University Joint Symposium on Materials Chemistry and Physics 2019
  • Int'l Joint Research
• [Presentation] Design of molecular swarm robots (2019)
  • Author(s): Akira Kakugo
  • Organizer: Energy Science and Engineering (ESE) seminar 2019
  • Int'l Joint Research / Invited
• [Presentation] Construction of molecular swarm robot (2019)
  • Author(s): Akira Kakugo
  • Organizer: 18th International Conference on Unconventional Computation and Natural Computation (UCNC2019)
  • Int'l Joint Research / Invited
• [Presentation] Construction of molecular swarm robot integrating biomolecular soft actuators and processors (2019)
  • Author(s): Akira Kakugo
  • Organizer: The 3rd International Symposium for Advanced Gel Materials & Soft Matters
  • Int'l Joint Research / Invited
• [Presentation] Molecular swarm robot driven by chemical energy (2019)
  • Author(s): Akira Kakugo
  • Organizer: International Conference on Manipulation Automation and Robotics at Small Scales (MARSS)
  • Int'l Joint Research / Invited
• [Presentation] Overcoming the challenges for designing swarm molecular robots (2019)
  • Author(s): Akira Kakugo
  • Organizer: CSJ, Okinawa Colloids 2019
  • Int'l Joint Research / Invited
• [Presentation] A swarm molecular robot fabricated from photo-sensor, DNA processor and biomolecular motor (2019)
  • Author(s): Akira Kakugo
  • Organizer: Japan-Israel Nano-Bio Interfaces Workshop
  • Int'l Joint Research / Invited
• [Presentation] Task execution by molecular robots through DNA based information transfer (2019)
  • Author(s): Akira Kakugo
  • Organizer: Research Seminar in Mathematics and Computer Science, Research Group in Mathematics and its Applications (RGMA)
  • Int'l Joint Research / Invited
• [Presentation] Task execution by molecular robots through DNA based information transfer (2019)
  • Author(s): Akira Kakugo
  • Organizer: Seminar on MOLECULAR ROBOTS AND ARTIFICIAL LIFE
  • Int'l Joint Research / Invited
• [Presentation] A swarm molecular robot constructed from photo-sensor, DNA processor and biomolecular motor (2019)
  • Author(s): Akira Kakugo
  • Organizer: The 2nd International Conference on Materials Research and Innovation (ICMARI)
  • Int'l Joint Research / Invited
• [Presentation] Light-driven limit-cycle self-oscillation and autonomous swimming of azobenzene-assembly under photostationary state (2019)
  • Author(s): Yoshiyuki Kageyama
  • Organizer: Active Matter Workshop 2019
  • Int'l Joint Research / Invited
• [Presentation] 生命システム模倣としての分子集合体の自触媒反応と自律運動 (2019)
  • Author(s): 景山義之
  • Organizer: CNRSセミナー・第一回NIMS発動分子科学セミナー
  • Invited
• [Presentation] Synthetic creation of nonlinear dynamics towards autonomous molecular-based materials (2019)
  • Author(s): Yoshiyuki Kageyama
  • Organizer: MANA Seminar 2019
  • Invited
• [Presentation] ミクロサイズの薄膜結晶の定常青色光照射で誘起される素早い振動運動による水中での遊泳運動 (2019)
  • Author(s): ○小原一馬・景山義之・武田定
  • Organizer: 第99日本化学会春季年会
• [Presentation] DNP-NMRを用いたソフトマター近傍の水のダイナミクス解析のための光開裂性ラジカルプローブの設計と合成 (2019)
  • Author(s): ○李ギョレ・景山義之・武田定
  • Organizer: 第99日本化学会春季年会
• [Presentation] 可視光照射下において巨視的振動をする両親媒性アゾベンゼン誘導体結晶の構造と運動の解析 (2019)
  • Author(s): ○里永慎之介・池上智則・佐藤寛泰・景山義之・武田定
  • Organizer: 第99日本化学会春季年会
• [Presentation] Continuous mechanical motion of layered self-assembly of azobenzene derivatives under photo stationary state (2019)
  • Author(s): Yoshiyuki Kageyama
  • Organizer: Asia International Conference (Photo-Chemistry)
  • Int'l Joint Research / Invited
• [Presentation] 発動分子素子の階層化による自己秩序機能の創出/Emergence of autonomous functions through hierarchical integration of molecular engines (2019)
  • Author(s): 角五彰
  • Organizer: 第99回日本化学会春季年会
  • Invited
• [Presentation] 青色光照射下で自律的に振動する薄膜微結晶の遊泳運動の解析 (2018)
  • Author(s): ○小原一馬・池上智則・景山義之・武田定
  • Organizer: 第19回細胞運動系交流セミナー
• [Presentation] Light-powered self-sustained mechanical motion of azobenzene crystal as the resultant of a couple of photoreaction and phase transition (2018)
  • Author(s): Yoshiyuki Kageyama
  • Organizer: 岡崎コンファレンス2018
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of radical probe with photolabile group for DNP-NMR analysis of dynamic water surrounding soft matter (2018)
  • Author(s): ○Gyeorye Lee・Yoshiyuki Kageyama・Sadamu Takeda
  • Organizer: 岡崎コンファレンス2018
  • Int'l Joint Research
• [Presentation] Swimming motion of thin crystal caused by caudal fin-like periodical flips under blue light irradiation (2018)
  • Author(s): ○Kazuma Obara・Tomonori Ikegami・Yoshiyuki Kageyama・Sadamu Takeda
  • Organizer: 岡崎コンファレンス2018
  • Int'l Joint Research
• [Presentation] 脂肪族カルボキシ基を有するアゾベンゼン誘導体の結晶の青色定常光照射下における巨視的振動の解析 (2018)
  • Author(s): ○里永慎之介・池上智則・佐藤寛泰・景山義之・武田定
  • Organizer: 分子科学討論会2018
• [Presentation] 自泳するアゾベンゼン含有ソフトマター (2018)
  • Author(s): ○景山義之・池上智則・小原一馬・里永慎之介・武田定
  • Organizer: 高分子科学討論会
  • Invited
• [Presentation] 機能的動的核偏極ＮＭＲ(fDNP-NMR)を志向したラジカルプローブの合成 (2018)
  • Author(s): 景山義之
  • Organizer: 2018 構造有機化学研究会・ミニシンポジウム
• [Presentation] 形態変化を続ける分子集合体の創出 (2018)
  • Author(s): 景山義之
  • Organizer: 日本化学会北海道支部室蘭地区講演会
  • Invited
• [Presentation] 自律遊走マイクロロボットを志向する光エネルギー駆動型の微結晶の魚に似た遊泳運動 (2018)
  • Author(s): ○小原一馬・池上智則・景山義之・武田定
  • Organizer: 第8回CSJ化学フェスタ2018
• [Presentation] DNP-NMRを用いた分子集合体近傍の水のダイナミクス解析のための光開裂性ラジカルプローブの設計と合成 (2018)
  • Author(s): ○李ギョレ・景山義之・武田定
  • Organizer: 第57回電子スピンサイエンス学会
• [Presentation] Self-sustained dynamics of molecular assembly towards construction of autonomous molecular systems (2018)
  • Author(s): Yoshiyuki Kageyama
  • Organizer: Hokkaido-Strasbourg Symposium Biotic and Abiotic Molecular Machines and Motors
  • Int'l Joint Research / Invited
• [Presentation] ATP fueled molecular swarm robots (2018)
  • Author(s): Akira Kakugo
  • Organizer: Hokkaido-Strasbourg Symposium Biotic and Abiotic Molecular Machines and Motors
  • Int'l Joint Research / Invited
• [Presentation] Molecular swarm robot driven by Biomolecular motors (2018)
  • Author(s): Akira Kakugo
  • Organizer: The 79th Okazaki Conference, Synthetic, Biological and Hybrid Molecular Engines
  • Int'l Joint Research / Invited
• [Book] 次世代のポリマー・高分子開発、新しい用途展開と将来展望 (2019)
  • Author(s): 栢野健太郎、角五彰
  • Total Pages: 11
  • Publisher: 技術情報協会
• [Funded Workshop] The 8th Conference on Exploring Next-Generation Materials Science and Nanoscience (8 th CENG-MSN) (2019)
• [Funded Workshop] Workshop on Soft and Nano Materials Orchestrated with Wisdom from Japan 2019 (2019)
• [Funded Workshop] Hokkaido-Strasbourg Symposium Biotic and Abiotic Molecular Machines and Motors (2018)