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(Chemical biology for controlling ubiquitin function

Planned

Project AreaNew frontier for ubiquitin biology driven by chemo-technologies
Project/Area Number 18H05503
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

吉田 稔  国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617)

Co-Investigator(Kenkyū-buntansha) PRADIPTA AMBARA  東京工業大学, 物質理工学院, 助教 (90631648)
川谷 誠  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (50391925)
近藤 恭光  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (80333342)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥175,240,000 (Direct Cost: ¥134,800,000、Indirect Cost: ¥40,440,000)
Fiscal Year 2022: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2021: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2020: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2019: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2018: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywordsユビキチン化誘導キメラ分子 / ユビキチンリガーゼ / ユビキチンデコーダー / リガンド化合物 / 化合物アレイ / E3リガンド / UbTACs / ライブラリー合成 / クリック反応 / アジド / アルキン / ユビキチンデコーダ
Outline of Annual Research Achievements

本研究では、ケモテクノロジーを駆使して、ユビキチン修飾系を理解し、操作する新たな方法論を開拓しようとしている。その中心となる技術は、UbTACsと名付けた新たなユビキチン化誘導キメラ分子である。UbTACs創製を目的に様々なE3リガーゼの新規リガンドを探索するため、独自技術である化合物アレイを活用する。
2020年度は、膜タンパク質輸送を制御するユビキチンリガーゼであり、K63 鎖を特異的に形成する NEDD4 に結合するE3リガンドとして同定した1種の化合物がキメラ化合物への誘導化が可能な官能基を有することを明らかにし、モデル系のキメラ化合物として、Haloリガンドとのキメラ化合物を合成したが、ユビキチン化誘導活性は見られなかった。そこで、NEDD4全長タンパク質を用いて新たに化合物スクリーニングを実施し、5種のヒット化合物を得た。そのうちの1化合物において、NEDD4のユビキチン化活性を増強する活性を有することを見出した。また、CFTR関連E3リガーゼおよびプロテアソームサブユニットについても化合物アレイスクリーニングを実施し、ヒット化合物を得た。効率よくキメラ化する方法として、アジドとアルキンを用いたクリック法を利用し、ヒストン脱アセチル化酵素HDAC6阻害剤とのキメラ化合物を合成した。その結果、本化合物によって細胞内のHDAC6が効率よく分解されることを確認した。さらにがん細胞で蓄積する代謝物アクロレインと選択的に反応するアリルアジドを利用して、がん細胞内でカルベンを中間体として生成させ、がん細胞内のタンパク質と共有結合させることに成功した。また、数万化合物のライブラリーを用いてユビキチンに特異的に結合するデコーダー分子とユビキチンとの相互作用を阻害する化合物の探索を行い、Rpn10, Rpn13, HOIL-1Lのデコーダー阻害剤候補を同定した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究では、新規のE3リガンド及び標的タンパク質リガンドを探索し、それらを組織的にキメラ化してUbTACsを創製する計画であり、そのためにはクリック反応等を利用した効率的なキメラ化技術が必要となる。そこで、研究当初からそのための基盤を構築するため、E3であるセレブロンのリガンドとして知られているサリドマイドに各種長さのリンカーを介してアジド基を導入した方法を確立した。2020年度は、その有効性を検証するため、HDAC6の酵素阻害剤とキメラ化することにより、HDAC6を分解できる新規キメラ化合物の創製に成功したので、さらにHDAC6のユビキチン結合ドメインであるZnF-UBPを利用した新たなキメラ化合物の創製に着手した。また、新たなE3リガンドの探索に関しては、NEDD4リガンドの化合物アレイによる探索、結合親和性の解析、それらの構造類縁化合物を用いて構造活性相関研究を行い、キメラ化合物への誘導化が可能なリガンドを明らかにしたが、細胞内での効果が見られなかったことから、NEDD4全長タンパク質を用いて新たにリガンド探索を行い、in vitroでNEDD4のユビキチン化活性を増強する化合物を見出している。また、CFTR関連E3リガーゼおよびプロテアソームタンパク質についても、領域内の計画班員、公募班員と共同でスクリーニングを実施し、ヒット化合物を得ている。さらに特定のタンパク質を標的とするPROTACsの概念とは異なり、がん細胞内で強くユビキチン化を誘導する方法として代謝物アクロレインを標的としたキメラ化合物の合成にも成功した。2分子蛍光補完法を用いた評価系により、ユビキチンデコーダー阻害剤探索を開始し、3種類の系で候補化合物を同定した。このように、当初の計画通り、おおむね順調に進展している。

Strategy for Future Research Activity

NEDD4全長タンパク質を用いた化合物アレイスクリーニングから得られたNEDD4リガンド候補化合物の活性、特異性、有用性を検証し、有効性が確認されればキメラ化を実施する。NEDD4のユビキチン化活性を増強した化合物は、純品でなく、化学混合物であるため、活性本体の同定を試みる。さらに、CFTR関連E3リガーゼおよびプロテアソームタンパク質のリガンド候補については、タンパク質との結合活性や酵素活性への影響を評価し、リガンドの絞り込みを行なっていく。必要に応じて、新たなリガンド候補化合物の化合物アレイ法及び最新技術であるマイクロスケール熱泳動法による探索を実施する。さらに、領域内の共同研究を拡大し、新たなリガンド候補化合物の化合物アレイによる探索を実施する。得られた候補化合物については、結合解析、構造活性相関研究を行い、キメラ化するためのリガンド化合物の特定を行っていく。ユビキチン関連分子とデコーダーの結合を制御する新たな化合物の探索系として確立したGaussiaルシフェラーゼの2分子蛍光補完法を活用し、広範なスクリーニングを継続する。得られた候補化合物の容量依存性試験、特異性試験(カウンターアッセイ)を実施するとともに生理活性の検証を開始する。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(152 results)

All 2021 2020 2019 2018

All Journal Article (61 results) (of which Int'l Joint Research: 33 results,  Peer Reviewed: 59 results,  Open Access: 39 results) Presentation (91 results) (of which Int'l Joint Research: 26 results,  Invited: 12 results)

  • [Journal Article] Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation2021

    • Author(s)
      Yoshimoto Rei、Chhipi-Shrestha Jagat K.、Schneider-Poetsch Tilman、Furuno Masaaki、Burroughs A. Maxwell、Noma Shohei、Suzuki Harukazu、Hayashizaki Yoshihide、Mayeda Akila、Nakagawa Shinichi、Kaida Daisuke、Iwasaki Shintaro、Yoshida Minoru
    • Journal Title

      Cell Chem. Biol.

      Volume: -

    • DOI

      10.1016/j.chembiol.2021.03.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.2021

    • Author(s)
      Nielsen, A. L., Rajabi, N., Kudo, N., Lundo, K., Moreno-Yruela, C., Baek, M., Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M., Olsen, C. A.
    • Journal Title

      RSC Chem. Biol.

      Volume: 2(2) Pages: 612-626

    • DOI

      10.1039/d0cb00036a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.2021

    • Author(s)
      Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.
    • Journal Title

      Nature Chemical Biology

      Volume: 17 Pages: 335-343

    • DOI

      10.1038/s41589-020-00676-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能低下したミトコンドリアを活性化させる化合物の発見.2021

    • Author(s)
      小林大貴、吉田稔
    • Journal Title

      実験医学

      Volume: 39(6) Pages: 954-957

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation2021

    • Author(s)
      Pradipta, A. R., Ahmadi, P., Terashima, K., Muguruma, K., Fujii, M., Ichino, T., Maeda, S., Tanaka, K.
    • Journal Title

      Chemical Science

      Volume: -

    • DOI

      10.1039/d0sc06083f

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Application of acrolein imines to organic synthesis, biofunctional studies, and clinical practice2021

    • Author(s)
      Pradipta, A. R., Tanaka, K.
    • Journal Title

      The Chemical Record

      Volume: 21 Pages: 1-18

    • DOI

      10.1002/tcr.202000146

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns2020

    • Author(s)
      Shrestha Jagat Krishna Chhipi、Schneider-Poetsch Tilman、Suzuki Takehiro、Mito Mari、Khan Khalid、Dohmae Naoshi、Iwasaki Shintaro、Yoshida Minoru
    • Journal Title

      bioRxiv,

      Volume: NA

    • DOI

      10.1101/2020.11.23.393835

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide survey of ribosome collision2020

    • Author(s)
      Han P., Shichino Y., Schneider-Poetsch T., Mito M., Hashimoto S., Udagawa T., Kohno K., Yoshida M., Mishima Y., Inada T., and Iwasaki S.
    • Journal Title

      Cell Rep.

      Volume: 31(5) Issue: 5 Pages: 107610-107610

    • DOI

      10.1016/j.celrep.2020.107610

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis.2020

    • Author(s)
      Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J
    • Journal Title

      Aging (Albany NY)

      Volume: 12 Pages: 13991-14018

    • DOI

      10.18632/aging.103521

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.2020

    • Author(s)
      Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 84 Pages: 2113-2120

    • DOI

      10.1080/09168451.2020.1789445

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells2020

    • Author(s)
      Jo Tomoyasu、Nishikori Momoko、Kogure Yasunori、Arima Hiroshi、Sasaki Katsuhiro、Sasaki Yoshiteru、Nakagawa Tomoko、Iwai Fumie、Momose Shuji、Shiraishi Aki、Kiyonari Hiroshi、Kagaya Noritaka、Onuki Tetsuo、Shin-ya Kazuo、Yoshida Minoru、Kataoka Keisuke、Ogawa Seishi、Iwai Kazuhiro、Takaori-Kondo Akifumi
    • Journal Title

      Blood

      Volume: 136 Pages: 684-697

    • DOI

      10.1182/blood.2019002654

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索.2020

    • Author(s)
      住吉孝明、平中誠弥、出口芳春、伊藤昭博、吉田稔
    • Journal Title

      MEDCHEM NEWS

      Volume: 30(1) Pages: 43-46

    • NAID

      130008033678

    • Related Report
      2020 Annual Research Report
  • [Journal Article] A strategy for tumor targeting by higher-order glycan pattern recognition: Synthesis and in vitro and in vivo properties of glycoalbumins conjugated with four different N-glycan molecules2020

    • Author(s)
      Smirnov, I., Sibgatullina, R., Urano, S., Tahara, T., Ahmadi, P., Watanabe, Y., Pradipta, A. R., Kurbangalieva, A., Tanaka, K.
    • Journal Title

      Small

      Volume: 16 Pages: 2004831-2004831

    • DOI

      10.1002/smll.202004831

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry2020

    • Author(s)
      Muguruma, K., Pradipta, A. R., Ode, Y., Terashima, K., Michiba, H., Fujii, M., Tanaka, K.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Pages: 115831-115831

    • DOI

      10.1016/j.bmc.2020.115831

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Methods for acrolein detection: Recent advances and applications2020

    • Author(s)
      Pradipta, A. R., Tanaka, K.
    • Journal Title

      Journal of the Indonesian Chemical Society

      Volume: 3 Pages: 73-73

    • DOI

      10.34311/jics.2020.03.2.73

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions2020

    • Author(s)
      Chang Tsung‐Che、Pradipta Ambara R.、Tanaka Katsunori
    • Journal Title

      Chirality

      Volume: 32 Pages: 1160-1168

    • DOI

      10.1002/chir.23265

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics2020

    • Author(s)
      16)Kawamura, T., Futamura, Y., Shang, E., Muroi, M., Janning, P., Ueno, M., Wilke, J., Takeda, S., Kondoh, Y., Ziegler, S., Watanabe, N., Waldmann, H., Osada, H.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Pages: 2484-2490

    • DOI

      10.1080/09168451.2020.1812375

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.2020

    • Author(s)
      Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    • Journal Title

      Environmental Pollution

      Volume: 266 Pages: 115179-115179

    • DOI

      10.1016/j.envpol.2020.115179

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress2020

    • Author(s)
      Sophonnithiparasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R
    • Journal Title

      Heliyon

      Volume: 6

    • DOI

      10.1016/j.heliyon.2020.e05200

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.2020

    • Author(s)
      Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M
    • Journal Title

      ACS Chem. Biol

      Volume: 15 Pages: 2195-2204

    • DOI

      10.1021/acschembio.0c00381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana2020

    • Author(s)
      Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 8691-8691

    • DOI

      10.1038/s41598-020-65614-9

    • NAID

      120006876594

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry2020

    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Watanabe Nobumoto、Osada Hiroyuki
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3517

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of ATPase Activity of Valosin-containing Protein/p972020

    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Osada Hiroyuki、Watanabe Nobumoto
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3516

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emerging Technologies for Real‐Time Intraoperative Margin Assessment in Future Breast‐Conserving Surgery.2020

    • Author(s)
      Pradipta AR, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
    • Journal Title

      Adv. Sci.

      Volume: 10.1002 Pages: 1901519-1901519

    • DOI

      10.1002/advs.201901519

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms2020

    • Author(s)
      O. A. Lodochnikova, D. R. Chulakova, D. P. Gerasimova, I. A. Litvinov, A. R. Pradipta, K. Tanaka, A. R. Kurbangalieva
    • Journal Title

      J. Struct. Chem.

      Volume: 61

    • DOI

      10.26902/jsc_id49649

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.2020

    • Author(s)
      Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
    • Journal Title

      MEDCHEM NEWS

      Volume: 9(9) Pages: 43-46

    • DOI

      10.1021/acsmedchemlett.8b00099

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure2019

    • Author(s)
      Takase Shohei、Kurokawa Rumi、Kondoh Yasumitsu、Honda Kaori、Suzuki Takehiro、Kawahara Teppei、Ikeda Haruo、Dohmae Naoshi、Osada Hiroyuki、Shin-ya Kazuo、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1819-1828

    • DOI

      10.1021/acschembio.9b00410

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of ryuvidine as a KDM5A inhibitor.2019

    • Author(s)
      Mitsui, E., Yoshida, S., Shinoda, Y., Matsumori, Y., Tsujii, H., Tsuchida, M., Wada, S., Hasegawa, M., Ito, A., Mino, K., Onuki, T., Yoshida, M., Sasaki, R., Mizukami, T.
    • Journal Title

      Sci. Rep.

      Volume: 9(1) Pages: 9952-9952

    • DOI

      10.1038/s41598-019-46346-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr12019

    • Author(s)
      Feng Ling, Eliot Bradshaw, Minoru Yoshida
    • Journal Title

      Sci. Rep.

      Volume: 9 (1) Pages: 5433-5433

    • DOI

      10.1038/s41598-019-41699-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation‐Inhibitory Activity2019

    • Author(s)
      Nomura Yusaku、Thuaud Frederic、Sekine Daisuke、Ito Akihiro、Maeda Satoko、Koshino Hiroyuki、Hashizume Daisuke、Muranaka Atsuya、Cruchter Thomas、Uchiyama Masanobu、Ichikawa Satoshi、Matsuda Akira、Yoshida Minoru、Hirai Go、Sodeoka Mikiko
    • Journal Title

      Chemistry, A European Journal

      Volume: 25 Pages: 8387-8392

    • DOI

      10.1002/chem.201901093

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.2019

    • Author(s)
      Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
    • Journal Title

      J. Med. Chem.

      Volume: 62 Issue: 7 Pages: 3407-3427

    • DOI

      10.1021/acs.jmedchem.8b01888

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay2019

    • Author(s)
      Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
    • Journal Title

      J. Biochem.

      Volume: - Pages: 1-10

    • DOI

      10.1093/jb/mvz007

    • NAID

      40021952184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies2019

    • Author(s)
      Yoshida Kazuko、Kondoh Yasumitsu、Iwahashi Fukumatsu、Nakano Takeshi、Honda Kaori、Nagano Eiki、Osada Hiroyuki
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1964-1971

    • DOI

      10.1021/acschembio.9b00453

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors2019

    • Author(s)
      Shu Keitou、Iwamoto Naoya、Honda Kaori、Kondoh Yasumitsu、Hirano Hiroyuki、Osada Hiroyuki、Ohno Hiroaki、Fujii Nobutaka、Oishi Shinya
    • Journal Title

      Bioconjugate Chemistry

      Volume: 30 Pages: 1395-1404

    • DOI

      10.1021/acs.bioconjchem.9b00154

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile Access to Optically Active 2,6‐Dialkyl‐1,5‐Diazacyclooctanes2019

    • Author(s)
      Chulakova Dilyara R.、Pradipta Ambara R.、Lodochnikova Olga A.、Kuznetsov Danil R.、Bulygina Kseniya S.、Smirnov Ivan S.、Usachev Konstantin S.、Latypova Liliya Z.、Kurbangalieva Almira R.、Tanaka Katsunori
    • Journal Title

      Chem. Asian J.

      Volume: 14 Pages: 4048-4054

    • DOI

      10.1002/asia.201900938

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis.2019

    • Author(s)
      Shinohara, H., Yasue, N., Onuki, T., Yoshida, M. Matsubayashi, Y.
    • Journal Title

      Commun. Biol.

      Volume: 2 Pages: 61-61

    • DOI

      10.1038/s42003-019-0307-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments2019

    • Author(s)
      Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      Nat. Protoc.

      Volume: 14 Pages: 415-440

    • DOI

      10.1038/s41596-018-0099-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol2019

    • Author(s)
      Cornelio Kimberly、Espiritu Rafael Atillo、Hanashima Shinya、Todokoro Yasuto、Malabed Raymond、Kinoshita Masanao、Matsumori Nobuaki、Murata Michio、Nishimura Shinichi、Kakeya Hideaki、Yoshida Minoru、Matsunaga Shigeki
    • Journal Title

      Biochim. Biophys. Acta Biomembr.

      Volume: 1861 Pages: 228-235

    • DOI

      10.1016/j.bbamem.2018.07.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent advances in target identification of bioactive natural products.2019

    • Author(s)
      Yoshida M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 83(1) Pages: 1-9

    • DOI

      10.1080/09168451.2018.1533804

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology2019

    • Author(s)
      Tanei Tomonori、Pradipta Ambara R.、Morimoto Koji、Fujii Motoko、Arata Mayumi、Ito Akihiro、Yoshida Minoru、Saigitbatalova Elena、Kurbangalieva Almira、Ikeda Jun-ichiro、Morii Eiichi、Noguchi Shinzaburo、Tanaka Katsunori
    • Journal Title

      Adv. Sci (Weinh)

      Volume: 6 Pages: 1801479-1801479

    • DOI

      10.1002/advs.201801479

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tetramethylrhodamine is an essential scaffold of azide probe in detecting cellular acrolein2019

    • Author(s)
      Pradipta AR, Fujii M, Tanei T, Morimoto K, Shimazu K, Noguchi S, Tanaka K.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: - Pages: 2228-2234

    • DOI

      10.1016/j.bmc.2019.04.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.2019

    • Author(s)
      Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Pages: 2988-2996

    • DOI

      10.1074/jbc.ra118.004741

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opening the selectivity pocket in the human lysine deacetylase sirtuin2 - new opportunities, new questions.2018

    • Author(s)
      Robaa D, Monaldi D, W?ssner N, Kudo N, Rumpf T, Schiedel M, Yoshida M, Jung M.
    • Journal Title

      Chem. Rec.

      Volume: 18(12) Pages: 1701-1707

    • DOI

      10.1002/tcr.201800044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.2018

    • Author(s)
      Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 4003-4014

    • DOI

      10.1111/cas.13805

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions2018

    • Author(s)
      Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      PLoS Comput. Biol.

      Volume: 14

    • DOI

      10.1371/journal.pcbi.1006532

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.2018

    • Author(s)
      Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
    • Journal Title

      Oncotarget.

      Volume: 9(74) Pages: 33871-33883

    • DOI

      10.18632/oncotarget.26049

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses2018

    • Author(s)
      Yoshihiro Sohtome, Tadahiro Shimazu, Joaquin Barjau, Shinya Fujishiro, Mai Akakabe, Naoki Terayama, Kosuke Dodo, Akihiro Ito, Minoru Yoshida, Yoichi Shinkai, Mikiko Sodeoka
    • Journal Title

      Chem. Commun (Camb)

      Volume: 54 Pages: 9202-9205

    • DOI

      10.1039/c8cc03907k

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine2018

    • Author(s)
      Hirano Tomoya、Fujiwara Takashi、Niwa Hideaki、Hirano Michitake、Ohira Kasumi、Okazaki Yusuke、Sato Shin、Umehara Takashi、Maemoto Yuki、Ito Akihiro、Yoshida Minoru、Kagechika Hiroyuki
    • Journal Title

      ChemMedChem.

      Volume: 13 Pages: 1530-1540

    • DOI

      10.1002/cmdc.201800233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Along the Central Dogma Controlling Gene Expression with Small Molecules2018

    • Author(s)
      Schneider-Poetsch Tilman、Yoshida Minoru
    • Journal Title

      Annu. Rev. Biochem.

      Volume: 87 Pages: 1-30

    • DOI

      10.1146/annurev-biochem-060614-033923

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.2018

    • Author(s)
      Kudo N, Ito A, Arata M, Nakata A, Yoshida M.
    • Journal Title

      Philos. Trans. R Soc. Lond. B Biol. Sci.

      Volume: 373(1748)

    • DOI

      10.1098/rstb.2017.0070

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-12018

    • Author(s)
      Matsumoto Ken、Kose Shingo、Kuwahara Iku、Yoshimura Mami、Imamoto Naoko、Yoshida Minoru
    • Journal Title

      Sci. Rep.

      Volume: 8 Pages: 6198-6198

    • DOI

      10.1038/s41598-018-24401-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.2018

    • Author(s)
      Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, Seno H.
    • Journal Title

      JCI insight

      Volume: 3 Issue: 8 Pages: 1-15

    • DOI

      10.1172/jci.insight.91316

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preparation of Cell Lysates of Fission Yeast for Immunoprecipitation.2018

    • Author(s)
      Akihisa Matsuyama, Atsuko Shirai, Minoru Yoshida
    • Journal Title

      Methods Mol. Biol.

      Volume: 1721 Pages: 125-133

    • DOI

      10.1007/978-1-4939-7546-4_12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action2018

    • Author(s)
      Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
    • Journal Title

      Bioinformatics.

      Volume: 34 Pages: 1251-1252

    • DOI

      10.1093/bioinformatics/btx732

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptomic analysis of Arabidopsis thaliana plants treated with the Ky-9 and Ky-72 histone deacetylase inhibitors2018

    • Author(s)
      Nguyen HM, Sako K, Matsui A, Ueda M, Tanaka M, Ito A, Nishino N, Yoshida M, Seki M.
    • Journal Title

      Plant Signal Behav.

      Volume: 13

    • DOI

      10.1080/15592324.2018.1448333

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Halistanol sulfates I and J, new SIRT1?3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria2018

    • Author(s)
      Nakamura Fumiaki、Kudo Norio、Tomachi Yuki、Nakata Akiko、Takemoto Misao、Ito Akihiro、Tabei Hodaka、Arai Daisuke、de Voogd Nicole、Yoshida Minoru、Nakao Yoichi、Fusetani Nobuhiro
    • Journal Title

      J. Antibiot (Tokyo)

      Volume: 71 Pages: 273-278

    • DOI

      10.1038/ja.2017.145

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF62018

    • Author(s)
      Y. Qi, X. Zhao, J. Chen, A. R. Pradipta, J. Wei, H. Ruan, R. P. Hsung, K. Tanaka, L. Zhou
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: - Pages: 1-16

    • DOI

      10.1080/09168451.2018.1559030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expanding the applicability of metal-labeling of biomolecules by RIKEN click reaction: A case study with 68Ga-PET2018

    • Author(s)
      Y. Nakamoto, A. R. Pradipta, H. Mukai, M. Zouda, Y. Watanabe, A. Kurbangalieva, P. Ahmadi, Y. Manabe, K. Fukase, K. Tanaka
    • Journal Title

      ChemBioChem

      Volume: 19 Pages: 2055-2060

    • DOI

      10.1002/cbic.201800335

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cycloaddition reactions of N-alkyl-α,β-unsaturated imines: Facile preparation of azaheterocycles for synthesis and biological applications2018

    • Author(s)
      A. R. Pradipta, L. Latypova, D. Chulakova, I. Smirnov, A. Kurbangalieva, K. Tanaka
    • Journal Title

      HETEROCYCLES

      Volume: 97 Pages: 668-685

    • DOI

      10.3987/rev-18-sr(t)4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide2018

    • Author(s)
      Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 2769-2769

    • DOI

      10.1038/s41598-018-20987-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells2018

    • Author(s)
      Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.
    • Journal Title

      Cancer Medicine

      Volume: 7 Pages: 883-893

    • DOI

      10.1002/cam4.1339

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] HP1αクロモドメインを用いたFRET型蛍光プローブによる細胞分裂中のヒストン修飾動態の観察2021

    • Author(s)
      佐々木和樹、鈴木律裕、中尾 洋一、吉田 稔
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 天然物化学ゲノミクスによる真核生物セントラルドグマの制御機構解析2021

    • Author(s)
      吉田稔
    • Organizer
      第14回日本エピジェネティクス研究会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 細胞分裂過程におけるHP1αクロモドメインとヒストンH3の結合状態の経時観察2021

    • Author(s)
      佐々木和樹、鈴木律裕、中尾 洋一、吉田 稔
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 分裂酵母のオキシリピンを介した窒素代謝に関わる細胞間コミュニケーションの解明2021

    • Author(s)
      橋本莉央、八代田陽子、大澤晋、平井剛、森山裕充、吉田 稔
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] mTOR経路阻害でリー脳症モデルNdufs4 KOマウス寿命を延長する分子機構2021

    • Author(s)
      伊藤孝、小林大貴、吉田稔
    • Organizer
      J-mit 特別 オンラインシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見とその応用2021

    • Author(s)
      小林大貴、畠山英之、伊藤孝、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
    • Organizer
      J-mit 特別 オンラインシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reactivity of Acrolein Released from Cancer Cells: Application for Selective Cancer Therapy and Diagnosis2021

    • Author(s)
      Pradipta Ambara Rachmat, Ahmadi Peni, Tanaka Katsunori
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reactivity of Endogenous Acrolein: Application for Therapy and Diagnosis2021

    • Author(s)
      Pradipta Ambara Rachmat
    • Organizer
      新学術領域「ケモユビキチン 」第4回総括班会議
    • Related Report
      2020 Annual Research Report
  • [Presentation] 汚染物質輸送因子Major latex-like proteinの遺伝子発現と結合活性の制御によるウリ科作物汚染の低減化2021

    • Author(s)
      藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
    • Organizer
      日本農薬学会第46回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A new paradigm of eukaryotic mitochondrial genetic inheritance revealed from studies on yeast mitochondrial DNA replication2020

    • Author(s)
      Ling Feng, Yoshida Minoru
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns2020

    • Author(s)
      Chhipi Shrestha Jagat Krishna, Schneider-Poetsch Tilman, Suzuki Takehiro, Mito Mari, Khan Khalid, Dohmae Naoshi, Iwasaki Shintaro, Yoshida Minoru
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Discovery of a small molecule that rescues phenotypes of cells carrying disease- related mitochondrial DNA mutations by inducing metabolic redirection2020

    • Author(s)
      Minoru Yoshida
    • Organizer
      Target 2035 | a probe for every protein | Kick-off webinar series
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hippo経路におけるYAP-TEAD相互作用を標的とした阻害剤探索2020

    • Author(s)
      高瀬翔平、長田裕之、吉田稔、伊藤昭博、
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] エピジェネティクスリーダータンパク質GAS41の阻害剤探索2020

    • Author(s)
      高瀬翔平、高橋未帆、園田健、菊地正樹、近藤恭光、梅原崇史、長田裕之、吉田稔、伊藤昭博
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 化合物の標的分子同定のためのケミカルゲノミクス基盤の確立2020

    • Author(s)
      八代田陽子、Lien Pham、Sheena Li、Urvi Bhojoo、吉村麻美、木村寛美、河村優美、長田裕之、松本健、吉田稔、Jason Moffat、Charles Boone
    • Organizer
      新学術領域研究「化学コミュニケーションのフロンティア」第7回公開シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reactivity and Application of Acrolein Released from Cancer Cells2020

    • Author(s)
      Pradipta Ambara Rachmat
    • Organizer
      The 6th International Symposium on Applied Chemistry
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がんが風編的に過剰生産するアクロレイン代謝物:ヒト生組織でのカスケード反応による乳がん術中迅速診断の臨床成果2020

    • Author(s)
      Pradipta Ambara Rachmat, Tanei Tomonori, Morimoto Koji, Shimazu Kenzo, Noguchi Shinzaburo, Tanaka Katsunori
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Comprehensive detection of RNA targets that bind to chemical compounds using next-generation sequencing and data-driven method.2020

    • Author(s)
      Fujimoto Hayate, Kondoh Yasumitsu, Kawamura Tatsuro, Hase Sumitaka, Imoto Masaya, Osada Hiroyuki, Sakakibara Yasubumi
    • Organizer
      RNA 2020 Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイプシン化阻害剤GC7のミトコンドリアへの影響2020

    • Author(s)
      松本 健、黒川 留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌 楓、室井 誠、鈴木 健裕、堂前 直、伊藤 昭博、長田 裕之、吉田 稔
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] HP1αクロモドメインを用いた蛍光プローブによる細胞分裂中のクロマチン動態観察2020

    • Author(s)
      佐々木 和樹、鈴木 律裕、中尾 洋一、吉田 稔
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] TEAD-YAP相互作用を標的とした化合物の探索2020

    • Author(s)
      高瀬 翔平、林瀬 瑠奈、則次 恒太、市川 保恵、小川 健司、吉田 稔、伊藤 昭博
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 翻訳因子 eIF5Aによる酵母の代謝調節機能の研究2020

    • Author(s)
      高橋 匠、近藤 直子、白井 温子、ヒルバート マグパンタイ、松山 晃久、吉田 稔
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PAF複合体-SAGA複合体を介した窒素カタボライト抑制制御機構の解明2020

    • Author(s)
      大澤 晋、八代田 陽子、吉田 稔
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分裂酵母における栄養源感受性変異株の探索と解析2020

    • Author(s)
      三浦 俊一、八代田 陽子、西村 慎一、松山 晃久、吉田 稔
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分裂酵母の窒素シグナリング因子を介した細胞間コミュニケーションにおける受容機構の解明2020

    • Author(s)
      橋本 莉央、八代田 陽子、大澤 晋、平井 剛、森山 裕充、吉田 稔
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Autophagy deficiency boosts the production of kojic acid in the filamentous fungus Aspergillus oryzae2020

    • Author(s)
      Junlin CHEN, Minoru YOSHIDA, Manabu ARIOKA
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 統合表現型プロファイリングとケミカルプロテオミクスの手法による3量体Giタンパク質調節化合物の発見2020

    • Author(s)
      河村達郎、二村友史、Erchang Shang、室井誠、Petra Janning、上野雅佳、Julian Wilke、武田茂樹、近藤恭光、Slava Ziegler、渡辺信元、Herbert Waldmann、長田裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 天然物ケミカルバイオロジーによる新しい遺伝子発現制御機構の発見2020

    • Author(s)
      吉田 稔
    • Organizer
      日本農芸化学会四国支部第56回講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリア制御2020

    • Author(s)
      松本 健、黒川 留美、凌 楓、鈴木 健裕、堂前 直、吉田 稔
    • Organizer
      日本ポリアミン学会 第11回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Opening new avenues of chemical biology by bioactive natural products2020

    • Author(s)
      Minoru Yoshida
    • Organizer
      The 6th CSRS-ITbM Joint Workshop
    • Related Report
      2019 Annual Research Report
  • [Presentation] Acrolein Click Chemistry-Mediated Cancer Diagnosis2020

    • Author(s)
      Ambara Rachmat Pradipta
    • Organizer
      令和元年度基礎科学特別研究員成果発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactivity of Acrolein Released from Cancer Cells: Application for Selective Cancer Therapy2020

    • Author(s)
      Ambara Rachmat Pradipta, Peni Ahmadi, Motoko Fujii, Katsunori Tanaka
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酵母ケミカルゲノミクス法を用いた化合物の標的同定2019

    • Author(s)
      八代田陽子、吉村麻美、野口峻太朗、Sheena Li、木村寛美、河村優美、吉田稔、酒井隆一、Charles Boone
    • Organizer
      「化学コミュニケーションのフロンティア」第6回公開シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] A novel translational buffering system that links splicing and cancer2019

    • Author(s)
      Minoru Yoshida
    • Organizer
      第42回日本分子生物学会年会 Symposium on ” Crossroad of Chemical and RNA Biology”
    • Related Report
      2019 Annual Research Report
  • [Presentation] eIF5Aハイプシン化阻害剤GC7によるミトコンドリアタンパク質の減少2019

    • Author(s)
      松本 健、黒川 留美、Tariq Mohammad、Schneider-Poetsch Tilman、凌 楓、室井 誠、鈴木 健裕、堂前 直、伊藤 昭博、長田 裕之、吉田 稔
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンキラーゼ阻害剤の創薬研究(3):新規ジヒドロキナゾリノン誘導体の創出2019

    • Author(s)
      鷲塚 健一、白井 文幸 、八代田 陽子 、幸 瞳 、丹羽 英明 、佐藤 心 、安倍 昌子 、大貫 哲男 、眞﨑 唯 、平間 千津子 、深見 竹広 、本間 光貴 、梅原 崇史 、白水 美香子 、吉田 喜香 、水谷 アンナ 、村松 由紀子 、清宮 啓之 、吉田 稔 、小山 裕雄
    • Organizer
      第37回メディシナルケミストリーシンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンキラーゼ阻害剤の創薬研究(2):経口投与で抗腫瘍効果を示すスピロインドリノン誘導体RK582 の創製2019

    • Author(s)
      白井 文幸、水谷 アンナ 、八代田 陽子 、津村 武史 、狩野 ゆうこ 、近田 翼 、村松 由紀子 、幸 瞳 、丹羽 英明 、佐藤 心 、鷲塚 健一 、甲田 泰子 、眞﨑 唯 、張 明奎 、永森 晶子 、奥江 雅之 、渡邊 尚志 、北村 弘一 、設楽 永紀 、本間 光貴 、梅原 崇史 、白水 美香子 、深見 竹広 、清宮 啓之 、吉田 稔 、小山 裕雄
    • Organizer
      第37回メディシナルケミストリーシンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンキラーゼ阻害剤の創薬研究(1):細胞増殖阻害活性改善を指向した誘導体合成2019

    • Author(s)
      甲田 泰子、白井 文幸 、水谷 アンナ 、八代田 陽子 、津村 武史 、狩野 ゆうこ 、近田 翼 、村松 由紀子 、幸 瞳 、丹羽 英明 、佐藤 心 、吉田 喜香 、眞﨑 唯 、鷲塚 健一 、奥江 雅之 、渡邊 尚志 、北村 弘一 、設楽 永紀 、本間 光貴 、梅原 崇史 、白水 美香子 、深見 竹広 、清宮 啓之 、吉田 稔 、小山 裕雄
    • Organizer
      第37回メディシナルケミストリーシンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 内因性脂質代謝物N-アシルドーパミンによるHIF-1α 活性化機構2019

    • Author(s)
      石倉菜摘、前本佑樹、青木元秀、橘高敦史、上杉志成、吉田稔、伊藤昭博
    • Organizer
      第24回化学生物学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Opening new drug discovery frontiers through natural products chemical genetics2019

    • Author(s)
      Minoru Yoshida
    • Organizer
      8th annual conference of International Chemical Biology Society (ICBS-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target pathway identification of bioactive compounds by multifaceted approaches2019

    • Author(s)
      Ken Matsumoto, Shohei Takase, Rumi Kurokawa, Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of fluorescent probes for visualizing an interaction between intra-nucleosomal histone H3 K9 tri-methylation and HP1α chromodomain and live-cell imaging2019

    • Author(s)
      Kazuki Sasaki, Michihiro Suzuki, Akihiro Ito, Yoichi Nakao, Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical and genetic regulation of nitrogen catabolite repression by PAF complex in the fission yeast Schizosaccharomyces2019

    • Author(s)
      Shin Ohsawa, Yoko Yahiroda, Minoru Yohida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of NanoBiT-based 2- and 3-hybrid system in fission yeast2019

    • Author(s)
      Akihisa Matsuyama, Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of the mechanism of action of theonellamides, marine-derived antifungals, based on fission yeast ORFeome2019

    • Author(s)
      Shinichi Nishimura, Akifumi Suganaga, Akihisa Matsuyama, Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a novel compound that alters energy metabolism2019

    • Author(s)
      Hiroki Kobayashi, Hiroyuki Osada, Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanism of action of anticancer splicing modulators? Translational buffering linking splicing and cancer2019

    • Author(s)
      Minoru Yoshida
    • Organizer
      2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Translation factor eIF5A connects protein synthesis and energy metabolism2019

    • Author(s)
      Tilman Schneider-Poetsch, Jagat Shrestha, Shintaro Iwasaki, Minoru Yoshida
    • Organizer
      The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel compound that alters energy metabolism2019

    • Author(s)
      Hiroki Kobayashi, Hiroyuki Osada, Minoru Yoshida
    • Organizer
      The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ワールブルグ効果制御物質の発見2019

    • Author(s)
      小林大貴、長田 裕之、吉田 稔
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Translational buffering linking splicing and cancer2019

    • Author(s)
      Minoru Yoshida
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 7th Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Conversion of SIRT2 catalytic activity from deacetylase to defatty-acylase by fatty-acyl substrates2019

    • Author(s)
      Norio Kudo, Akihiro Ito, Mayumi Arata, Akiko Nakata, Seiji Matsuoka, Daria Monaldi, Manfred Jung, Minoru Yoshida
    • Organizer
      FASEB Conference on The Reversible Protein Acetylation in Health and Disease
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatty acyl metabolites as intrinsic inhibitors of SIRT2 deacetylase2019

    • Author(s)
      Minoru Yoshida
    • Organizer
      FASEB Conference on The Reversible Protein Acetylation in Health and Disease
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分裂酵母同士も「化合物」を使ってコミュニケーションする2019

    • Author(s)
      吉田 稔
    • Organizer
      微生物ウイーク2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] PAF complex regulates the cancelation of nitrogen catabolite repression2019

    • Author(s)
      Shin Ohsawa, Yoko Yashiroda, Minoru Yoshida
    • Organizer
      10th International Fission Yeast Meeting (Pombe meeting 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ウリ科作物の新規汚染低減化法の開発2019

    • Author(s)
      藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
    • Organizer
      神戸大学研究基盤センター若手フロンティア研究会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 汚染物質輸送因子の遺伝子発現と結合活性制御によるウリ科作物における作物汚染の低減化2019

    • Author(s)
      藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
    • Organizer
      第37回農薬環境科学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 受容体特異的な3′-alkyl ABAを用いたアブシジン酸受容体機能解析2019

    • Author(s)
      由田和津子、近藤恭光、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
    • Organizer
      植物化学調節学会第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reduction of pop contamination in Cucurbitaceae family focusing on the transporting factors for POPs by the treatment of pesticides2019

    • Author(s)
      Kentaro Fujita, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Hideyuki Inui
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants: DioXin 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and characterization of small-molecular compounds that inhibit salicylic acid-mediated signaling pathway in Arabidopsis2019

    • Author(s)
      Nobuaki Ishihama, Yoshiteru Noutoshi, Seung-won Choi, Ivana Saska, Shuta Asai, Kaori Takizawa, Yasumitsu Kondoh, Yuko Nomura, Hirofumi Nakagami, Hiroyuki Osada, Ken Shirasu
    • Organizer
      IS-MPMI XVIII Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective activation of abscisic acid receptors by 3’-alkyl ABAs2019

    • Author(s)
      Kazuko Yoshida, Yasumitsu Kondoh, Fukumatsu Iwahashi, Takeshi Nakano, Kaori Honda, Eiki Nagano, Hiroyuki Osada.
    • Organizer
      Chemical Probe Workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規UbTACsのためのリガンド化合物探索とキメラ化法開発2019

    • Author(s)
      Ambara Rachmat Pradipta
    • Organizer
      新学術領域「ケモユビキチン 」第3回総括班会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthetic Chemistry for Clinical Trials: Azide-Acrolein Click Reaction for Intraoperative Diagnosis of Breast Cancer Patients2019

    • Author(s)
      Ambara Rachmat Pradipta, Motoko Fujii, Katsunori Tanaka
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology the Seventh Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 実臨床合成化学:乳癌の術中断端迅速診断2019

    • Author(s)
      Ambara Rachmat Pradipta, Tomonori Tanei, Motoko Fujii, Koji Morimoto, Shinzaburo Noguchi, Katsunori Tanaka
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 実臨床合成化学:乳癌の術中断端迅速診断2019

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 受容体特異的な3’-alkyl ABAを用いたABA受容体機能解析 1.構造活性相関2019

    • Author(s)
      由田和津子、近藤恭光、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 受容体特異的な3’-alkyl ABAを用いたABA受容体機能解析 2.ドッキングシミュレーション2019

    • Author(s)
      近藤恭光、由田和津子、岩橋福松、中野雄司、本田香織、永野栄喜、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析2019

    • Author(s)
      河村 達郎、二村 友史、室井 誠、川谷 誠、SHANG Erchang、JANNING Petra、近藤 恭光、野川 俊彦、ZIEGLER Slava、渡辺 信元、WALDMANN Herbert、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] XIAP BIR3ドメインの化学合成と鏡像スクリーニングへの応用2019

    • Author(s)
      岩本 直也、周敬棠、本田香織、近藤恭光、長田裕之、井貫晋輔、大野浩章、藤井信孝、大石真也
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 汚染物質輸送因子の結合活性制御に着目したウリ科作物の汚染低減化2019

    • Author(s)
      藤田健太郎、近藤恭光、本田香織、羽賀雄紀、長田裕之、松村千里、乾秀之
    • Organizer
      日本農薬学会第44回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Target identification of a small-molecule that inhibits cancer cell-accelerated fibroblast migration2019

    • Author(s)
      Kruthi Suvarna, Kaori Honda, Makoto Muroi, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      The 5th CSRS-ITbM Joint Workshop
    • Related Report
      2018 Annual Research Report
  • [Presentation] エネルギー代謝のケミカルバイオロジー2018

    • Author(s)
      吉田 稔
    • Organizer
      産学協力研究委員会 第170委員会・第189委員会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 天然活性物質の作用機序研究から見えてきたもの2018

    • Author(s)
      吉田 稔
    • Organizer
      第5回生命科学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Power of chemical genetics to uncover eukaryotic gene expression and metabolism2018

    • Author(s)
      Minoru Yoshida
    • Organizer
      A3 Lecture(JSPS日中韓フォーサイト事業(A3事業))
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Acrolein Sensor for Rapid Intraoperative Diagnosis of Breast Cancer2018

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      The All-RIKEN Workshop 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment2018

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      GlycoTOKYO2018シンポジウム (東京糖鎖研究会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthetic Chemistry for Clinical Trials: Azide-Acrolein Click Reaction for Intraoperative Diagnosis of Breast Cancer Patients2018

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      The 14th International Kyoto Conference on New Aspects of Organic Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Organic Synthesis: Rapid Intraoperative Diagnosis of Breast Cancer2018

    • Author(s)
      Ambara Rachmat Pradipta, Motoko Fujii, Katsunori Tanaka
    • Organizer
      日本化学会新領域研究グループ「有機合成化学を起点とするものづくり戦略」最終研究成果発表シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment2018

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      ケミカルプローブ合同合宿セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 実臨床合成化学:乳癌の術中断端迅速診断2018

    • Author(s)
      Ambara Rachmat Pradipta, Tomonori Tanei, Motoko Fujii, Koji Morimoto, Shinzaburo Noguchi, Katsunori Tanaka
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Acrolein Click Chemistry-Mediated Cancer Imaging and Treatment2018

    • Author(s)
      Ambara Rachmat Pradipta, Katsunori Tanaka
    • Organizer
      The 54th International Conference on Medicinal Chemistry: Interfacing Chemical Biology and Drug Discovery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acrolein Click Chemistry-Mediated Oxidative Stress Imaging and Theranostics2018

    • Author(s)
      Ambara Rachmat Pradipta
    • Organizer
      日本化学会第98春季年会, Asian International Symposium (Medicinal Chemistry)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アクロレインのインビボクリック反応性に基づく生体内合成化学治療2018

    • Author(s)
      Ambara Rachmat Pradipta, Motoko Fujii, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Yasuyoshi. Watanabe, Katsunori Tanaka
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ケミカルバイオロジーからアプローチしたTAZの新しい制御機構の解析2018

    • Author(s)
      長島俊太、丸山順一、岩佐宏晃、有本-松崎京子、本田 香織、近藤恭光、長田裕之、名和眞希子、石上-湯浅磨里、影近弘之、中浜健一、仁科博史、畑裕
    • Organizer
      MBSJ日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A small-molecule ligand of VCP inhibits accelerated fibroblast migration by cancer cells2018

    • Author(s)
      Kruthi Suvarna, Kaori Honda, Makoto Muroi, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      MBSJ日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物成長促進化合物PPGによる植物カルス形成制御機構の解明2018

    • Author(s)
      前川琴美、田中翔太、竹野駿、山上あゆみ、筧 雄介、嶋田幸久、近藤恭光、堂前 直、嶋田勢津子、松井 南、久城哲夫、長田裕之、浅見忠男、篠崎一雄、中野雄司
    • Organizer
      第53回植物化学調節学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物免疫阻害剤を用いた植物免疫応答制御因子の探索2018

    • Author(s)
      石濱伸明, 能年義輝, 崔 勝媛, Ivana Saska, 浅井秀太, 瀧澤 香, 野村有子, 中神弘史, 近藤恭光, 長田裕之, 白須 賢
    • Organizer
      平成30年度日本植物病理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Reduction of crop contamination resulting from hydrophobic contaminants by the treatment of pesticides targeting to its transport factors2018

    • Author(s)
      Fujita K, Sakai A, Kondoh Y, Honda K, Osada H, Inui H
    • Organizer
      38th International Symposium on Halogenated Persistent Organic Pollutants & 10th International PCB Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] JBIR-140 の細胞増殖抑制機構の解析2018

    • Author(s)
      松本 健、高瀬翔平、近藤恭光、鈴木健裕、堂前直、新家一男、長田裕之、久城哲夫、吉田稔
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高脂溶性汚染物質によって引き起こされる作物汚染の化合物輸送因子を標的とした農薬による低減化2018

    • Author(s)
      藤田健太郎、酒井葵衣、近藤恭光、本田香織、長田裕之、乾秀之
    • Organizer
      日本農薬学会第43回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規インスリン分泌促進化合物の分子機構の解明2018

    • Author(s)
      松永 耕一、牛込剛史、近藤恭光、本田香織、長田裕之、泉 哲郎
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report

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Published: 2018-07-20   Modified: 2022-07-01  

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