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Inference of human migration to Yaponesia based on animal and plant genome sequence analyses.

Planned Research

Project AreaDeciphering Origin and Establishment of Japonesians mainly based on genome sequence data
Project/Area Number 18H05508
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionHokkaido University

Principal Investigator

鈴木 仁  北海道大学, 地球環境科学研究院, 名誉教授 (40179239)

Co-Investigator(Kenkyū-buntansha) 遠藤 俊徳  北海道大学, 情報科学研究院, 教授 (00323692)
坂井 寛章  国立研究開発法人農業・食品産業技術総合研究機構, 高度分析研究センター, ユニット長 (20455322)
増田 隆一  北海道大学, 理学研究院, 教授 (80192748)
伊藤 剛  国立研究開発法人農業・食品産業技術総合研究機構, 高度解析センター, チーム長 (80356469)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥98,280,000 (Direct Cost: ¥75,600,000、Indirect Cost: ¥22,680,000)
Fiscal Year 2022: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2021: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2018: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywordsヤポネシア / ゲノム / 先史時代 / 動植物 / 系統地理学 / ハツカネズミ / ヒョウタン / イネ / ヒグマ / ヒト随伴動植物 / オーストロネシア語族 / ヒト随伴動物 / 第四紀環境変動 / 縄文時代・弥生時代 / 全ゲノム解析 / 縄文・弥生時代 / 第四紀後期環境変動 / マウス / ヒト随伴野生生物
Outline of Annual Research Achievements

本年度は以下の6つの研究を遂行した。研究1:野生ハツカネズミ98個体の全核ゲノムデータを活用し、毛色関連遺伝子Asip (180 kb)およびMc1r (250 kb)に対する系譜学的解析を行った。先史時代、適応的な毛色変異が新規に移入した地域においてそれぞれ定着したことが示された。研究2: マダガスカルのハツカネズミ集団の全核ゲノム解析はアジア南部に展開する亜種M. m. castaneusの寄与、さらには先史時代の航海術を有したオーストロネシア語を繰る農耕民の関与を示唆した。研究3:クマネズミのmtDNA遺伝子変異の解析は、約5千年前に海洋域を含んだ南中国と東南アジアで急激な多様化が生じたことを示唆した。研究4:核ゲノムSNPを用いた集団解析および、15の代表的な栽培化遺伝子の系統解析から、ヤポネシアの栽培イネの集団構造を明らかにした。古い品種であると示唆された古代米(赤米)1系統のゲノム構成は、古いジャポニカ型アリルおよびインディカ由来のアリルからなることが明らかとなった。また、葉緑体ゲノムを用いた解析から、日本のジャポニカ品種は2500年前以降に有効集団サイズの増大が始まったことが示唆された。研究5:岡山県南方(済生会)および滋賀県粟津湖底の遺跡由来のヒョウタン標本(弥生時代中期頃)に関し、在来種を加えて核ゲノムのSNP解析に基づき、日本列島へのヒョウタンの移入経緯を推察した。研究6:解析した北海道のヒグマの全ゲノム情報と既報の海外ヒグマの全ゲノム情報を比較解析することにより,北海道ヒグマでは遺伝的多様性は低いが絶滅が危惧されているヨーロッパの個体群よりは多様性が高いこと、北米やヨーロッパのヒグマ集団とは明瞭に異なること、最終間氷期以前より大陸集団と異なる集団動態を経験していること、北海道ヒグマのミトコンドリアDNAの3系統集団間で交流があることが明らかとなった。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

鈴木はハツカネズミ98匹の全ゲノムデータを活用し、毛色変異に関わる地理的変異の創出に関わる初期農耕民の空間的動態と新規環境への適応に関する論文発表を行った。博物館剥製試料を用いた遺伝子解析によりネパール産ハツカネズミの遺伝的特性に関する論文発表を行った。時間依存性を示すmtDNAの進化速度の動態把握は集団の時空間動態の把握に必須である。24のmtDNA一斉放散クラスターに着目し、非同義置換の派生と除去に関する時空間動態を明らかにした論文を発表した。東南アジアの大陸部および島嶼部における初期農耕に関わる農耕民のオーストロネシア語を語る人々の関与をマダガスカルから琉球列島に及んでいることをハツカネズミおよびクマネズミの核ゲノムおよmtDNAの解析から明らかにし、その一部については論文発表を行った。また一般向け雑誌ビオストーリーにおいて「人とともに分布を拡大する”ネズミ”」という特集においてハツカネズミとクマネズミの琉球列島を含むアジア東南域の島嶼部における拡散に先史時代の海洋農耕民の関与があることを報告した。遠藤はヤポネシア周辺地域へのヒョウタンの伝播を解明するため、国内外のヒョウタン標本の解析を進めてきた。また、60標本の全ゲノムデータの解読と、古代ヒョウタンのゲノム解読を進めてきた。これらの結果について論文を執筆中である。増田は北海道産ヒグマを対象として全ゲノム解析を進め、海外のヒグマと比較した成果を論文発表した。また、バルカン半島に特異的な家畜である東バルカンブタの遺伝情報によりアジアとヨーロッパの文化交流が示唆されたデータを投稿発表した。坂井、熊谷は農研機構コアコレクションおよびイネ3000ゲノムプロジェクトのデータを用いて、集団遺伝学解析、葉緑体ゲノム多型DBの拡充を進め、これら結果の論文原稿を作製している。またイネ参照ゲノムIRGSP2.0の構築を進めている。

Strategy for Future Research Activity

次年度は以下の7つの研究を集中的に行い完結するとともに、最終年度であり、論文発表に向けて注力する。1)ジャコウネズミの拡散に関するゲノム学的解析を行い、特に琉球列島と大陸部の先史時代の集団動態を解明する。同時にハツカネズミおよびクマネズミの動態との比較を行い、5000年前頃のオーストロネシア語話者の関与を考察する。2)日本列島産ドブネズミの集団動態に関してゲノム学的解析を行う。すでに開示されている中国産ドブネズミ集団のゲノム情報を活用する。3)精密な分岐年代の推定を行うために、全ミトコンドリアゲノム配列を解析し、時間依存性進化速度の要因を解明し、標準的進化速度の提案を行う。特にアミノ酸コード領域における弱有害な同義置換の動態に着目する。4)ヒトに帯同して先史時代に分布拡大を行ったネズミ類(ナンヨウネズミ、クマネズミ、ドブネズミ)の毛色変異に注目し、毛色関連遺伝子AsipおよびMc1rの責任変異を特定し、自然選択の影響を考察する。5)農研機構ジーンバンクに登録収蔵されている古代米サンプルのゲノム配列を用いた集団遺伝学的な解析を進め、その由来を探る。また 農研機構が公開した日本列島の在来品種コレクションのゲノム情報を用いて、日本列島内でのイネの集団史の推定を試みる。6)現代のヒョウタン、および古代ヒョウタン(滋賀県粟津湖底遺跡、岡山県南方遺跡、愛媛県新谷遺跡)のNGS解読データに基づき、系統関係を解明し、ヤポネシアへの移入経路と進化の推定を明らかにする。解析結果はデータベース化して公開する。7)北半球に広く分布するヒグマおよび日本特有の哺乳類のゲノム解析を引き続き行う。ヒグマについては、ゲノム情報に基づき、北海道内の三重構造の有無の検証を行う。海外の動物集団と比較分析することにより、渡来と移動の歴史を探り、これらの結果と古環境の変遷や狩猟圧との関連を引き続き探る。

Report

(4 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(84 results)

All 2022 2021 2020 2019 2018

All Journal Article (50 results) (of which Int'l Joint Research: 25 results,  Peer Reviewed: 42 results,  Open Access: 19 results) Presentation (30 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Book (4 results)

  • [Journal Article] Genetic Insights Into the introduction history of Black Rats Into the Eastern Indian ocean.2022

    • Author(s)
      Vicki A A Thomson, Andrew S Wiewel, Russell Palmer, Neil Hamilton, Dave Algar, Caitlyn Pink, Harriet Mills, Ken P Aplin, Geoffrey Clark, Atholl Anderson, Michael B Herrera, Steven Myers, Terry Bertozzi, Philip J Piper, Hitoshi Suzuki, Steve Donnellan
    • Journal Title

      Front. Ecol. Evol.

      Volume: -

    • DOI

      10.3389/fevo.2021.786510

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phylogeographic study using nuclear genome sequences of <i>Asip</i> to infer the origins of ventral fur color variation in the house mouse <i>Mus musculus</i>2022

    • Author(s)
      Takeishi, T., Fujiwara, K., Osada, N., Mita, A., Takada, T., Shiroishi, T., and Suzuki, H.
    • Journal Title

      Genes & Genetic Systems

      Volume: - Issue: 6 Pages: 1-14

    • DOI

      10.1266/ggs.21-00075

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 第四紀後期のユーラシアを舞台とする小型哺乳類の進化的動態と人類拡散との関わり2022

    • Author(s)
      鈴木仁
    • Journal Title

      旧石器研究

      Volume: 18

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal dynamics of mildly deleterious nonsynonymous substitutions in mitochondrial gene sequences in rodents and moles.2022

    • Author(s)
      Inoue Y. and Suzuki H.
    • Journal Title

      Genes & Genet Systems

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic diversity and phylogeography of urban hedgehogs (Erinaceus europaeus) around Helsinki, Finland, revealed by mitochondrial DNA and microsatellite analyses.2022

    • Author(s)
      Osaka, M., Pynnonen-Oudman, K., Lavikainen, A., Amaike, Y., Nishita, Y., and Masuda, R.
    • Journal Title

      Mammal Research

      Volume: 67 Pages: 99-107

    • DOI

      10.1007/s13364-021-00603-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Population genetic structure and diversity of the East Balkan Swine (Sus scrofa) in Bulgaria, revealed by mitochondrial DNA and microsatellite analyses.2022

    • Author(s)
      Ishikawa, K., Doneva, R., Raichev, E.G., Peeva, S., Doichev, V.D., Amaike, Y., Nishita, Y., Kaneko, Y., and Masuda, R.
    • Journal Title

      Animal Science Journal

      Volume: 92

    • DOI

      10.1111/asj.13630

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 石狩低地帯と北海道の動物地理的特徴2022

    • Author(s)
      増田隆一
    • Journal Title

      北海道の自然

      Volume: 60 Pages: 11-18

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and molecular recharacterization of the rodent genus Mus from Nepal based on museum specimens.2021

    • Author(s)
      Kishimoto, M., Kato, M., Suzuki, H.
    • Journal Title

      Mammal Study

      Volume: 46 Issue: 4 Pages: 1-12

    • DOI

      10.3106/ms2020-0065

    • NAID

      40022723834

    • ISSN
      1343-4152
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 1-bp deletion in <i>Mc1r</i> in a Norway rat (<i>Rattus norvegicus</i>) from Sado Island, Japan gives rise to a yellowish color variant: an insight into mammalian <i>MC1R</i> variants2021

    • Author(s)
      Tsunoi, T., Noju, K., Eto, T., Suzuki, H.
    • Journal Title

      Genes & Genetic Systems

      Volume: 96 Issue: 2 Pages: 89-97

    • DOI

      10.1266/ggs.20-00049

    • NAID

      130008064672

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification, genetic variation, and structural analysis of 18S rRNA of Theileria orientalis and Theileria velifera-like isolates from Myanmar.2021

    • Author(s)
      Bawm S, Sagara R, Kakisaka K, Thu MJ, Hmoon MM, Htun LL, Mar Mar Win, Nonaka N, Makao R, Suzuki H, Katakura, K.
    • Journal Title

      Parasitology International

      Volume: 82 Pages: 102299-102299

    • DOI

      10.1016/j.parint.2021.102299

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan.2021

    • Author(s)
      Kikuchi F, Senoo K, Arai S, Tsuchiya K Son NT, Motokawa M, Ranorosoa MC, Bawm S, Lin KS, Suzuki H, Unno A, Nakata K, Harada M, Tanaka-Taya K, Morikawa S, Suzuki M, Mizutani T, Yanagihara R.
    • Journal Title

      Viruses

      Volume: 13 Pages: 1343-1343

    • DOI

      10.3390/v13071343

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-genome sequencing analysis reveals the population history of Mus musculus in Madagascar.2021

    • Author(s)
      Fujiwara, K., Ranorosoa, M. C., Ohdachi, S. D., Arai, S., Sakuma, Y., Suzuki, H., Osada, N.
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.09.10.459745

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ハツカネズミに見るアジア先史農耕の陸海展開ルート2021

    • Author(s)
      鈴木仁
    • Journal Title

      ビオストーリー

      Volume: 36 Pages: 10-17

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 日本列島のクマネズミはどこからやってきたのか?2021

    • Author(s)
      甲斐一・鈴木仁
    • Journal Title

      ビオストーリー

      Volume: 36 Pages: 18-23

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Demographic history of the brown bear (Ursus artcos) on Hokkaido Island, Japan, based on whole-genomic sequence analysis. Genome Biology and Evolution2021

    • Author(s)
      Endo, Y., Osada, N., Mano, T., and Masuda, R.
    • Journal Title

      Genome Biology and Evolution

      Volume: -

    • DOI

      10.1093/gbe/evab195

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the Genetic Diversity of a Rice Core Collection of Japanese Landraces using Whole-Genome Sequencing2021

    • Author(s)
      Tanaka Nobuhiro、Shenton Matthew、Kawahara Yoshihiro、Kumagai Masahiko、Sakai Hiroaki、Kanamori Hiroyuki、Yonemaru Jun-ichi、Fukuoka Shinichi、Sugimoto Kazuhiko、Ishimoto Masao、Wu Jianzhong、Ebana Kaworu
    • Journal Title

      Plant & Cell Physiology

      Volume: 61 Pages: 2087-2096

    • DOI

      10.1093/pcp/pcaa125

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Population dynamics in the Japanese Archipelago since the Pleistocene revealed by the complete mitochondrial genome sequences.2021

    • Author(s)
      Mizuno, F., Gojobori, J., Kumagai, M., Baba, H., Taniguchi, Y., Kondo, O., Matsushita, M., Matsushita, T., Matsuda, F., Higasa, K., Hayashi, M., Wang, L., Kurosaki, K. and Ueda, S.
    • Journal Title

      Scientific reports

      Volume: 11 Pages: 1-11

    • DOI

      10.1038/s41598-021-91357-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an SSR marker-based genetic linkage map and identification of a QTL associated with flowering time in <i>Eustoma</i>2021

    • Author(s)
      Kawakatsu, K., Yagi, M., Harada, T., Yamaguchi, H., Itoh, T., Kumagai, M., Itoh, R., Numa, H., Katayose, Y., Kanamori, H., Kurita, K., Fukuta, N.
    • Journal Title

      Breed. Sci.

      Volume: 71 Issue: 3 Pages: 344-353

    • DOI

      10.1270/jsbbs.20100

    • NAID

      130008069056

    • ISSN
      1344-7610, 1347-3735
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The time-dependent evolutionary rate of mitochondrial DNA in small mammals inferred from biogeographic calibration points with reference to the late Quaternary environmental changes in the Japanese archipelago2021

    • Author(s)
      Hitoshi Suzuki
    • Journal Title

      AS

      Volume: - Issue: 1 Pages: 23-34

    • DOI

      10.1537/ase.201201

    • NAID

      130008030438

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Quaternary environmental changes on mole populations inferred from mitochondrial sequences and evolutionary rate estimation.2021

    • Author(s)
      2.Nakamoto A, Harada M, Mitsuhashi R, Tsuchiya K, Kryukov AP, Shinohara A, Suzuki H.
    • Journal Title

      Zoological Letters

      Volume: -

    • DOI

      10.1186/s40851-021-00169-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] House mouse Mus musculus dispersal in East Eurasia inferred from 98 newly determined complete mitochondrial genome sequences.2021

    • Author(s)
      Li Y, Fujiwara K, Osada N, Kawai Y, Takada T, Kryukov AP, Abe K, Yonekawa H, Shiroishi T, Moriwaki K, Saitou N, Suzuki H
    • Journal Title

      Heredity

      Volume: 126 Pages: 132-147

    • DOI

      10.1038/s41437-020-00364-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phylogenetic relationships of ancient brown bears (Ursus arctos) on Sakhalin Island, revealed by APLP and PCR-direct sequencing analyses of mitochondrial DNA.2021

    • Author(s)
      2.Mizumachi, K., Gorbunov, S.V., Vasilevski, A.A., Amano, T., Ono, H., Kosintsev, P.A., Hirata, D., Nishita, Y., and Masuda, R.
    • Journal Title

      Mammal Research

      Volume: 66 Pages: 95-102

    • DOI

      10.1007/s13364-020-00542-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mouse hair significantly lightened through replacement of the cysteine residue in the N-terminal doma in of Mclr using the CRISPR/Cas9 system2020

    • Author(s)
      Hitoshi Suzuki, Gohta Kinoshita, Takeru Tsunoi, Mitsuki Noju, Kimi Araki
    • Journal Title

      Journal of Heredity

      Volume: 111 Issue: 7 Pages: 640-645

    • DOI

      10.1093/jhered/esaa054

    • NAID

      120007160279

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary History of the Subgenus Mus in Eurasia with Special Emphasis on the House Mouse Mus musculus.2020

    • Author(s)
      Hitoshi Suzuki
    • Journal Title

      Records of the Australian Museum

      Volume: 72 Pages: 317-323

    • DOI

      10.3853/j.2201-4349.72.2020.1727

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial haplogrouping of the ancient brown bears (Ursus arctos) in Bulgaria, revealed by the APLP method.2020

    • Author(s)
      3.Mizumachi, K., Spassov, N., Kostov, D., Raichev, E.G., Peeva, S., Hirata, D., Nishita, Y., Kaneko, Y., and Masuda, R.
    • Journal Title

      Mammal Research

      Volume: 65 Pages: 413-421

    • DOI

      10.1007/s13364-020-00482-2

    • Related Report
      2020 Annual Research Report
  • [Journal Article] How can you be active in the front line of mammalogy?2020

    • Author(s)
      増田隆一
    • Journal Title

      Honyurui Kagaku (Mammalian Science)

      Volume: 60 Issue: 2 Pages: 377-384

    • DOI

      10.11238/mammalianscience.60.377

    • NAID

      130007884413

    • ISSN
      0385-437X, 1881-526X
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Molecular evolution of MHC class II DRB exon 2 in Japanese and Russian raccoon dogs, Nyctereutes procyonoides (Carnivora: Canidae).2020

    • Author(s)
      Bartocillo, A.M., Nishita, Y., Abramov, A.V. and Masuda, R.
    • Journal Title

      Biological Journal of the Linnean Society

      Volume: 129 Pages: 61-73

    • DOI

      10.1093/biolinnean/blz153

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phylogeography of the Siberian weasel (Mustela sibirica), based on a mitochondrial DNA analysis.2020

    • Author(s)
      Ishikawa, K., Abramov, A.V., Amaike, Y., Nishita, Y. and Masuda, R.
    • Journal Title

      Biological Journal of the Linnean Society

      Volume: 129 Pages: 587-593

    • DOI

      10.1093/biolinnean/blz202

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive genome-wide identification of angiosperm upstream ORFs with peptide sequences conserved in various taxonomic ranges using a novel pipeline, ESUCA.2020

    • Author(s)
      Hiro Takahashi, Noriya Hayashi, Yuta Hiragori, Shun Sasaki, Taichiro Motomura, Yui Yamashita, Satoshi Naito, Anna Takahashi, Kazuyuki Fuse, Kenji Satou, Toshinori Endo, Shoko Kojima, Hitoshi Onouchi
    • Journal Title

      BMC Genomics

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late Pleistocene climate change and population dynamics of Japanese Myodes voles inferred from mitochondrial cytochrome b sequences.2019

    • Author(s)
      Asuka Honda, Shota Murakami, Masashi Harada, Kimiyuki Tsuchiya, Gohta Kinoshita, Hitoshi Suzuki
    • Journal Title

      Journal of Mammalogy

      Volume: 100 Pages: 1156-1168

    • DOI

      10.1093/jmammal/gyz093

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contrasting phylogeographic histories between the continent and islands of East Asia: Massive mitochondrial introgression and long-term isolation of hares (Lagomorpha: Lepus)2019

    • Author(s)
      Gohta Kinoshita, Mitsuo Nunome, Alexey P Kryukov, Irina V. Kartavtseva, San-Hoon Han, Fumio Yamada, Hitoshi Suzuki
    • Journal Title

      Molecular Phylogenetics and Evolution

      Volume: 136 Pages: 65-75

    • DOI

      10.1016/j.ympev.2019.04.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multiple conserved elements structuring inverted repeats in the mammalian coat color-related gene Asip2019

    • Author(s)
      Sakuma Y., Matsunami M., Takada T., and Suzuki H.
    • Journal Title

      Zoological Science

      Volume: 36 Issue: 1 Pages: 23-23

    • DOI

      10.2108/zs180081

    • NAID

      40021802414

    • ISSN
      0289-0003
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ヤポネシアの哺乳類の系統学的特性2019

    • Author(s)
      鈴木仁
    • Journal Title

      ANIMATE

      Volume: 15 Pages: 10-17

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Achiasmy and sex chromosome evolution.2019

    • Author(s)
      Kazuhiro Satomura, Naoki Osada, and Toshinori Endo
    • Journal Title

      Ecological Genetics and Genomics

      Volume: 129 Pages: 100046-100046

    • DOI

      10.1016/j.egg.2019.100046

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late Pleistocene climate change and population dynamics of Japanese Myodes voles inferred from mitochondrial cytochrome b sequences.2019

    • Author(s)
      Asuka Honda, Shota Murakami, Masashi Harada, Kimiyuki Tsuchiya, Gohta Kinoshita, and Hitoshi Suzuki.
    • Journal Title

      Journal of Mammalogy

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ESUCA: a pipeline for genome-wide identification of upstream open reading frames with evolutionarily conserved sequences and determination of the taxonomic range of their conservation2019

    • Author(s)
      Takahashi Hiro、Hayashi Noriya、Yamashita Yui、Naito Satoshi、Takahashi Anna、Fuse Kazuyuki、Endo Toshinori、Kojima Shoko、Onouchi Hitoshi
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/524090

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Variation in pancreatic amylase gene copy number among Eurasian badgers (Carnivora, Mustelidae, Meles) and its relationship to diet2019

    • Author(s)
      Abduriyim S.、Nishita Y.、Abramov A. V.、Solovyev V. A.、Saveljev A. P.、Kosintsev P. A.、Kryukov A. P.、Raichev E.、Vainola R.、Kaneko Y.、Masuda R.
    • Journal Title

      Journal of Zoology

      Volume: 印刷中

    • DOI

      10.1111/jzo.12649

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic diversity of MHC class II DRB alleles in the marbled polecat, Vormela peregusna, in Bulgaria.2019

    • Author(s)
      Nishita, Y., Spassov, N., Peeva, S., Raichev, E.G., Kaneko, Y., and Masuda, R
    • Journal Title

      Ethology, Ecology and Evolution

      Volume: 31 Pages: 59-72

    • DOI

      10.1080/03949370.2018.1486887

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hybridization between the European and Asian badgers (Meles, Carnivora) in the Volga-Kama region, revealed by analyses of maternally, paternally and biparentally inherited genes.2019

    • Author(s)
      Kinoshita, E., Abramov, A.V., Soloviev, V.A., Saveljev, A.P., Nishita, Y., Kaneko, Y., and Masuda, R.
    • Journal Title

      Mammalian Biology

      Volume: 94 Pages: 140-148

    • DOI

      10.1016/j.mambio.2018.05.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A perspective for resolving the systematics of Rattus, the vertebrates with the most influence on human welfare.2018

    • Author(s)
      Thomson, V., Wiewel, A., Chinen, A., Maryanto, I., Sinaga, M. H., How, R., Aplin, K., Suzuki, H.
    • Journal Title

      Zootaxa

      Volume: 4459 Pages: 431-452

    • DOI

      10.11646/zootaxa.4459.3.2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evolutionary Dynamics of Copy Number and Meiotic Recombination in Murine 5S rDNA: Possible Involvement of Natural Selection.2018

    • Author(s)
      Miyu Isobe, Mitsuo Nunome, Ken Katakura, Hitoshi Suzuki
    • Journal Title

      Journal of Molecular Evolution

      Volume: 86 Pages: 312-323

    • DOI

      10.1007/s00239-018-9848-6

    • NAID

      120006643587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quaternary-related genetic differentiation and parallel population dynamics of the Eurasian Jay (Garrulus glandarius) in the circum-Japan Sea region.2018

    • Author(s)
      Daisuke Aoki, Gohta Kinoshita, Alexey P. Kryukov, Isao Nishiumi, Sangim Lee, Hitoshi Suzuki
    • Journal Title

      Journal of Ornithology

      Volume: 159 Pages: 1087-1097

    • DOI

      10.1007/s10336-018-1573-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comprehensive phylogenomic analysis reveals a novel cluster of simian endogenous retroviral sequences in Colobinae monkeys2018

    • Author(s)
      Ikeda Masaki、Satomura Kazuhiro、Sekizuka Tsuyoshi、Hanada Kentaro、Endo Toshinori、Osada Naoki
    • Journal Title

      American Journal of Primatology

      Volume: 80

    • DOI

      10.1002/ajp.22882

    • NAID

      120006643589

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of MHC class I genes in Eurasian badgers, genus Meles (Carnivora, Mustelidae)2018

    • Author(s)
      Abduriyim Shamshidin、Nishita Yoshinori、Kosintsev Pavel A.、Raichev Evgeniy、Vainola Risto、Kryukov Alexey P.、Abramov Alexei V.、Kaneko Yayoi、Masuda Ryuichi
    • Journal Title

      Heredity

      Volume: 122 Pages: 205-218

    • DOI

      10.1038/s41437-018-0100-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic diversity of MHC class II DRB alleles in the continental and Japanese populations of the sable Martes zibellina (Mustelidae, Carnivola, Mammalia)2018

    • Author(s)
      Nishita, Y., Abramov, A.V., Murakami, T., and Masuda, R.
    • Journal Title

      Mammal Research

      Volume: 63 Pages: 369-378

    • DOI

      10.1007/s13364-018-0366-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low genetic diversity in an isolated red fox (Vulpes vulpes) population on Mt. Hakodate, Japan, revealed by microsatellite analyses of fecal samples.2018

    • Author(s)
      Amaike, Y., Murakami, T., and Masuda, R.
    • Journal Title

      Mammal Study

      Volume: 43 Issue: 3 Pages: 141-152

    • DOI

      10.3106/ms2017-0055

    • NAID

      120006716320

    • ISSN
      1343-4152, 1348-6160
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic Diversity of MHC Class II DRB1 Exon 2 in the Red Fox (Vulpes vulpes) on Hokkaido, Japan2018

    • Author(s)
      Amaike Yosuke、Nishita Yoshinori、Uraguchi Kohji、Masuda Ryuichi
    • Journal Title

      Zoological Science

      Volume: 35 Issue: 5 Pages: 402-402

    • DOI

      10.2108/zs170211

    • NAID

      210000179520

    • ISSN
      0289-0003
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low genetic variation in the MHC class II DRB gene and MHC-linked microsatellites in endangered island populations of the leopard cat (Prionailurus bengalensis) in Japan.2018

    • Author(s)
      Saka, T., Nishita, Y., and Masuda, R.
    • Journal Title

      mmunogenetics

      Volume: 70 Pages: 115-124

    • DOI

      10.1007/s00251-017-1020-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 乳類の系統地理を探る~ヒグマの移動史2018

    • Author(s)
      増田隆一
    • Journal Title

      生物科学

      Volume: 70 Pages: 25-30

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 遺伝子が解き明かす北海道の生物地理2018

    • Author(s)
      増田隆一
    • Journal Title

      ビオヒストリー

      Volume: 30 Pages: 12-15

    • Related Report
      2018 Annual Research Report
  • [Presentation] Genomics studies on Oryza species2022

    • Author(s)
      Masahiko KUMAGAI
    • Organizer
      共同利用・共同研究課題「アジア・アフリカ地理言語学研究」2021年度第2回研究会 公開 (オンライン)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 氷期最盛期の日本産小型哺乳類の集団動態を考える2021

    • Author(s)
      鈴木仁
    • Organizer
      旧石器学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 野ネズミと家ネズミに学んだ遺伝学2021

    • Author(s)
      鈴木仁
    • Organizer
      日本哺乳類学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 哺乳類の生物地理学研究から学んできたこと2021

    • Author(s)
      増田隆一
    • Organizer
      日本哺乳類学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 日本のネコ研究最前線2021

    • Author(s)
      増田隆一
    • Organizer
      日本哺乳類学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 国立沖縄自然史博物館の設立は万人のため2021

    • Author(s)
      増田隆一
    • Organizer
      日本動物学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 北海道のキツネ2021

    • Author(s)
      増田隆一
    • Organizer
      日本寄生虫学会・日本衛生動物学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ゲノムシーケンシングデータを処理する2021

    • Author(s)
      坂井寛章
    • Organizer
      第227回農林交流センターワークショップ (オンライン)
    • Related Report
      2021 Annual Research Report
  • [Presentation] NGSデータ解析のGalaxyによる実現(1)~初心者でもGalaxyでカンタン解析~2021

    • Author(s)
      熊谷真彦
    • Organizer
      第227回農林交流センターワークショップ「次世代シーケンサーのデータ解析技術」(オンライン)
    • Related Report
      2021 Annual Research Report
  • [Presentation] NGSデータ解析のGalaxyによる実現(2)~ワークフローを利用した解析~2021

    • Author(s)
      熊谷真彦
    • Organizer
      第227回農林交流センターワークショップ「次世代シーケンサーのデータ解析技術」(オンライン)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Geographic shift of the house mouse Mus musculus following humans during the past 15,000 years.2021

    • Author(s)
      Hitoshi Suzuki
    • Organizer
      Genome Concept Centennial Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 雌雄の移動能力差によるヒグマの集団形成史2021

    • Author(s)
      遠藤優,長田直樹,間野勉,増田隆一
    • Organizer
      日本動物学会北海道支部第65回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 簡便に使用できるミトコンドリアDNAの時間依存性進化速度の提案2020

    • Author(s)
      鈴木仁
    • Organizer
      日本動物学会第91回
    • Related Report
      2020 Annual Research Report
  • [Presentation] mtDNAゲノム配列に基づく野生ハツカネズミの東方移動とAsip遺伝子解析にもとづく毛色の多様化2020

    • Author(s)
      鈴木仁、藤原一道、河合洋介、高田豊行、城石俊彦、斎藤成也、長田直樹
    • Organizer
      2020年日本進化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ひぐま学への招待2020

    • Author(s)
      増田隆一
    • Organizer
      第29回先端科学移動大学2020(道民カレッジ連携講座)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 北日本産ヒメフナムシ類のミトコンドリア DNAの進化速度の検討2019

    • Author(s)
      張替若菜、齊藤彩,山本正伸,鈴木仁
    • Organizer
      日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲノム情報に基づくヒトに帯同した野生動植物の自然史研究2019

    • Author(s)
      鈴木仁
    • Organizer
      日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全ゲノム解析によるハツカネズミ(Mus musculus)の移住拡散様式の解明2019

    • Author(s)
      藤原一道,河合洋介,斎藤成也,長田直樹,鈴木仁
    • Organizer
      日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Two waves of mouse migrations to Yaponesia based on 100 mice genomes2019

    • Author(s)
      鈴木仁
    • Organizer
      日本遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハツカネズミ(Mus musculus)亜種を用いた全ゲノム集団解析による生態的種分化の解明2019

    • Author(s)
      藤原一道,河合洋介,斎藤成也,長田直樹,鈴木仁
    • Organizer
      日本遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ミトゲノム解析に基づくユーラシア産ハツカネズミの系統地理学分析:移動ルートと移動時期の解明2019

    • Author(s)
      Yue Li,鈴木仁,藤原一道,長田直樹,河合洋介,城石俊彦,高田豊行,斎藤成也
    • Organizer
      日本哺乳類学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 佐渡島産哺乳類の集団形成における氷期-間氷期サイクルによる影響2019

    • Author(s)
      柳瀬 拓郎, 鈴木 仁, 江藤 毅
    • Organizer
      日本哺乳類学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 日本在来モグラ類とダンゴムシ類の遺伝的構造における第四紀の環境変動による影響の比較2019

    • Author(s)
      吉川愛莉, 鈴木仁
    • Organizer
      日本哺乳類学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地下棲哺乳類モグラ類における毛色変異の進化的動態の把握2019

    • Author(s)
      角井建, 能重光希, 江藤 毅, 木下 豪太, 原田 正史, 鈴木 仁
    • Organizer
      日本哺乳類学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Compensatory back mutation in mammalian genome.2019

    • Author(s)
      里村和浩,長田直樹,遠藤俊徳
    • Organizer
      Society of Molecular Biology and Evolution
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネズミの進化と分化について2018

    • Author(s)
      鈴木仁
    • Organizer
      第 64 回日本寄生虫学会・日本衛生動物学会 北日本支部合同大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Phylogeography of the Siberian weasel (Mustela sibirica), based on mitochondrial DNA analysis(ミトコンドリアDNA解析によるシベリアイタチ(Mustela sibirica)の系統地理について)2018

    • Author(s)
      石川恵太,Alexei V. Abramov,西田義憲,増田隆一
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Y染色体上のマイクロサテライトの多様性からみたアカギツネ (Vulpes vulpes) の系統地理.2018

    • Author(s)
      織田 未希, Alexei V. Abramov, Evgeniy Raichev, Pavel A. Kosintsev, Alexey P. Kryukov, 浦口 宏二, 西田 義憲, 増田 隆一
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 古代ヒョウタンの軌跡を辿る2018

    • Author(s)
      遠藤俊徳
    • Organizer
      第72回日本人類学会大会公開シンポジウム2 DNAからみたヒトの進化
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Hybrid type of nuclear and plastid DNAs suggests the hypothesis for ancient propagation of American bottle gourd (Lagenaria siceraria)2018

    • Author(s)
      Dai Watabe, Hiroshi Yuasa, Naoki Osada, Kazuhiro Satomura, and Toshinori Endo
    • Organizer
      Society of Molecular Biology and Evolution
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] うんち学入門 ― 生き物にとって「排泄物」とは何か.2021

    • Author(s)
      増田隆一
    • Total Pages
      238
    • Publisher
      講談社
    • ISBN
      9784065170144
    • Related Report
      2021 Annual Research Report
  • [Book] ヒグマ学への招待~自然と文化で考える2020

    • Author(s)
      増田隆一
    • Total Pages
      368
    • Publisher
      北海道大学出版会
    • ISBN
      9784832974159
    • Related Report
      2019 Annual Research Report
  • [Book] ユーラシア動物紀行2019

    • Author(s)
      増田 隆一
    • Total Pages
      224
    • Publisher
      岩波書店
    • ISBN
      9784004317579
    • Related Report
      2018 Annual Research Report
  • [Book] 日本の食肉類2018

    • Author(s)
      増田 隆一
    • Total Pages
      320
    • Publisher
      東京大学出版会
    • ISBN
      9784130602372
    • Related Report
      2018 Annual Research Report

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Published: 2018-07-20   Modified: 2022-12-28  

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