| Budget Amount *help |
¥129,350,000 (Direct Cost: ¥99,500,000、Indirect Cost: ¥29,850,000)
Fiscal Year 2022: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2021: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2020: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2019: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2018: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
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| Outline of Final Research Achievements |
In the cell nucleus, many RNA bodies are formed based on non-coding RNAs that are act as "seeds." This study revealed the molecular mechanisms of the ELEANOR RNA cloud formed in the nucleus of hormone-dependent breast cancer cells. It also focused on the nucleolus which is the largest nuclear RNA body. Specifically, we have elucidated that, in breast cancer, the ELEANOR non-coding RNAs regulate transcription of multiple genes within the ELEANOR-TAD (topologically associated domains) that is a mega base-scale chromatin domain. ELEANOR also mediates long-range chromatin interactions to equilibrate between cancer cell proliferation and apoptosis.
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