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Spectroscopic study of non-destructive ionization process for mass spectrometry

Planned Research

Project AreaMolecular Science for Supra Functional Systems ? Development of Advanced Methods for Exploring Elementary Process
Project/Area Number 19056008
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Metropolitan University

Principal Investigator

FUJINO Tatsuya  首都大学東京, 理工学研究科, 准教授 (20360638)

Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥33,300,000 (Direct Cost: ¥33,300,000)
Fiscal Year 2011: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2010: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2009: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2008: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2007: ¥13,400,000 (Direct Cost: ¥13,400,000)
Keywords質量分析法 / MALDI法 / プロトン移動 / 時間分解分光 / 時間分解分光法 / イオン化
Research Abstract

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry allows us to know molecular weight of compounds. Although sample preparation and operation of instruments are quite easy compared with other soft ionization methods, there are several drawbacks at the same time. In the study, we investigated desorption and ionization mechanisms by spectroscopic methods, and we developed useful techniques to overcome such drawbacks in MALDI.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (26 results) (of which Peer Reviewed: 25 results) Presentation (15 results) Book (5 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Desorption Dynamics of Tetracene-Doped Anthracene Crystals Studied by Femtosecond Time-Resolved Mass Spectrometry2012

    • Author(s)
      Y. Minegishi, D. Morimoto, J. Matsumoto, H. Shiromaru, K. Hashimoto, *T. Fujino
    • Journal Title

      J. Phys. Chem.

      Volume: C 116 Pages: 3059-3064

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Desorption Dynamics of Tetracene Ion from Tetracene-doped Anthracene Crystals Studied by Femtosecond Time-Resolved Mass Spectrometry2012

    • Author(s)
      Yuuki Minegishi, Daisuke Morimoto, Jun Matsumoto, Haruo Shiromaru, Kenro Hashimoto, Tatsuya Fujino
    • Journal Title

      J.Phys.Chem.C

      Volume: 116 Issue: 4 Pages: 3059-3064

    • DOI

      10.1021/jp210884p

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometry of low-molecular-weight compounds with 2,4,6-trihydroxyacetophenone and 2,4-dihydroxyacetophenone in ・- cyclodex- trin2010

    • Author(s)
      T. Fujita, *T. Fujino, K. Hirabayashi, T. Korenaga
    • Journal Title

      Anal. Sci.

      Volume: 26 Pages: 743-748

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pronounced Selectivity in MALDI Mass Spectrometry with 2,4,6-Trihydroxyacetophenone on Zeolite Surface: Intensity Enhancement of Protonated Peptides and Suppression of Matrix-related Ions2010

    • Author(s)
      Y. Komori, H. Shima, *T. Fujino, J. N. Kondo, K. Hashimoto, T. Korenaga
    • Journal Title

      J. Phys. Chem.

      Volume: C 114 Pages: 1593-1600

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of polyyne molecules from Hexane irradiation by intense femtosecond laser pulses2010

    • Author(s)
      Y. Sato, T. Kodama, H. Shiromaru, J. H. Sanderson, T. Fujino, Y. Wada, T. Wakabayashi ,Y. Achiba
    • Journal Title

      Carbon

      Volume: 48 Pages: 1673-1676

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometry of low-molecular-weight compounds with 2,4,6-trihydroxyacetophenone and 2,4-dihydroxyacetophenone in β-cyclodextrin2010

    • Author(s)
      T.Fujita, T.Fujino, K.Hirabayashi, T.Korenaga
    • Journal Title

      Anal.Sci.

      Volume: 26 Pages: 743-748

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pronounced Selectivity in MALDI Mass Spectrometry with 2, 4, 6-Trihydroxyacetophenone on Zeolite Surface: Intensity Enhancement of Protonated Peptides and Suppression of Matrix-related Ions2010

    • Author(s)
      Y. Komori, H. Shima, *T. Fujino, J.N. Kondo, K. Hashimoto, T. Korenaga
    • Journal Title

      J. Phys. Chem. C 114

      Pages: 1593-1600

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Pronounced Selectivity in MALDI Mass Spectrometry with 2,4,6-Trihy droxyacetophenone on Zeolite Surface : Intensity Enhancement of Protonated Peptides and Suppression of Matrix-related Ions2010

    • Author(s)
      Y.Komori, H.Shima, ^*T.Fujino, J.N.Kondo, K.Hashimoto, T.Korenaga
    • Journal Title

      J.Phys.Chem.C 114

      Pages: 1593-1600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of polyyne molecules from Hexane irradiation by intense femtosecond laser pulses2010

    • Author(s)
      Y.Sato, T.Kodama, H.Shiromaru, J.H.Sanderson, T.Fujino, Y.Wada, T.Wakabayashi, Y.Achiba
    • Journal Title

      Carbon 48

      Pages: 1673-1676

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Picosecond Time-resolved Fluorescence Study of Poly Vinyl Methyl Ether Aqueous Solution2009

    • Author(s)
      T. Sakamaki, *T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
    • Journal Title

      Chem. Phys. Lett.

      Volume: 468 Pages: 171-175

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Picosecond Time-resolved Fluorescence Study of Poly Vinyl Methyl Ether Aqueous Solution2009

    • Author(s)
      T. Sakamaki, *T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
    • Journal Title

      Chem. Phys. Lett. 468

      Pages: 171-175

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Picosecond Time-resolved Fluorescence Study of Poly Vinyl Methyl Ether Aaueous Solution2009

    • Author(s)
      T. Sakamaki, T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
    • Journal Title

      Chem. Phys. Lett 468

      Pages: 171-175

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-cell Viscosity Measurement Using a Fluorescence Up-conversion Microscope2008

    • Author(s)
      *T. Fujino, K. Hirota, K. Ohta, T. Tahara
    • Journal Title

      Chem. Lett.

      Volume: 37 Pages: 1240-1241

    • NAID

      10024397974

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Diffusion and Mixing Process in Microchannels2008

    • Author(s)
      Y. Takabayashi, T. Fujino, T. Korenaga
    • Journal Title

      Anal. Sci.

      Volume: 24 Pages: 1481-1485

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MALDI Mass Spectrometry with Cyclodextrin-Supported Matrix2008

    • Author(s)
      S. Yamaguchi, T. Fujita, *T. Fujino, T. Korenaga
    • Journal Title

      Anal. Sci

      Volume: 24 Pages: 1497-1500

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solvation Structure of Polyacrylamide Fine Particle Surfaces Studied by Picosecond Time-resolved Fluorescence Spectroscopy2008

    • Author(s)
      T. Sakamaki, *T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
    • Journal Title

      Chem. Lett.

      Volume: 37 Pages: 980-981

    • NAID

      10024282611

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In-cell Viscosity Measurement Using a Fluorescence Up-conversion Microscope2008

    • Author(s)
      T. Fujino, K. Hirota, K. Ohta, T. Tahara
    • Journal Title

      Chem. Lett. 37

      Pages: 1240-1241

    • NAID

      10024397974

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] MALDI Mass Spectrometry with Cyclodextrin-Supported Matrix2008

    • Author(s)
      S. Yamaguchi, T. Fujita, *T. Fujino, T. Korenaga
    • Journal Title

      Anal. Sci 24

      Pages: 1497-1500

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] In cell viscosity measurement using a fluorescence up-conversion microscope2008

    • Author(s)
      T. Fujino, K. Hirota, K. Ohta, T. Tahara
    • Journal Title

      Chem. Lett 37

      Pages: 1240-1241

    • NAID

      10024397974

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of matrix-related ions using cyclodextrin in MALDI mass spectrometry2008

    • Author(s)
      S. Yamaguchi, T. Fujita, T. Fuiino, T. Korenaga
    • Journal Title

      Anal. Sci 24

      Pages: 1497-1500

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solvation structure of polyacrylamide fine particle surfaces studi by picosecond time-resolved fluorescence spectroscopy2008

    • Author(s)
      T. Sakamaki, T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
    • Journal Title

      Chem. Left 37

      Pages: 980-981

    • NAID

      10024282611

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of dispresion and mixing process in microfluidic system2008

    • Author(s)
      Y. Takabayashi, T. Fujino, T. Korenaga
    • Journal Title

      Anal. Sci 24

      Pages: 1481-4485

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Femtosecond/picosecond Time-resolved Fluorescence Study of Hydrophilic Polymer Fine Particles2007

    • Author(s)
      D. Nanjo, H. Hosio, *T. Fujino, T. Tahara, and T. Korenaga
    • Journal Title

      J. Phys. Chem.

      Volume: B, 111 Pages: 2759-2764

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Femtosecond/picosecond Time-resolved Fluorescence Study of Hydrophilic Polymer Fine Particles2007

    • Author(s)
      D. Nanjo, H. Hosio, *T. Fujino, T. Tahara, T. Korenaga
    • Journal Title

      J. Phys. Chem. B 111

      Pages: 2759-2764

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Excited-state Structure and Dynamics of 1,3,5-tris(phenylethynyl)benzene as Studied by Raman and Time-resolved Fluorescence Spectroscopy2007

    • Author(s)
      T.Nomoto, H.Hosoi, T.Fujino, T.Tahara, H.Hamaguchi
    • Journal Title

      J.Phys.Chem.A 111

      Pages: 2907-2912

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アゾベンゼンの超高速光異性化メカニズム2007

    • Author(s)
      藤野 童也、田原 太平
    • Journal Title

      高分子 56

      Pages: 488-492

    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Zeolite Matrix for Soft Ionization2011

    • Author(s)
      J. Suzuki, Y. Komori, T. Fujino, H. Shima, J.N. Kondo, K. Hashimoto, T. Korenaga
    • Organizer
      IUPAC International Congress on Analytical Science 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Spectroscopic Characterization of Hydrophilic Fine Particles2010

    • Author(s)
      T. Fujino
    • Organizer
      BIT’s 8th Annual Congress of International Drug Discovery Science and Technology
    • Place of Presentation
      Beijin, China
    • Year and Date
      2010-10-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Pronounced Selectivity in MALDI Mass Spectrometry with 2,4,6-trihydroxyacetophenone on zeolite surface2010

    • Author(s)
      T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
    • Organizer
      The 13th Asia Pacific Confederation of Chemical Engineering Congress
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] MALDI mass spectrometry using 2,4,6-trihydroxyacetophenone on zeolite surface enhancement of protonated species of matrix and analyte molecules2010

    • Author(s)
      T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
    • Organizer
      Molecular and Ionic Clusters Conference in 2010
    • Place of Presentation
      Tokamachi, Niigata
    • Related Report
      2011 Final Research Report
  • [Presentation] Pronounced Selectivity in MALDI Mass Spectrometry using 2,4,6-trihydroxy acetophenone on zeolite surface2010

    • Author(s)
      T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
    • Organizer
      XIII IUPAC Symposium on Photochemistry
    • Place of Presentation
      Ferrara, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Spectroscopic Study of non-destructive ionization process for mass spectrometry2009

    • Author(s)
      T. Fujino
    • Organizer
      International Symposium on “Molecular Science for Supra Functional System”
    • Place of Presentation
      O-okayama, Tokyo
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Spectroscopic Study of non-destructive ionization process for mass spectrometry2009

    • Author(s)
      T. Fujino
    • Organizer
      International Symposium on "Molecular Science for Supra Functional System"
    • Place of Presentation
      O-okayama, Tokyo
    • Year and Date
      2009-06-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Spectroscopic Study of non-destructive ionization process for mass spectrometry2009

    • Author(s)
      T.Fujino
    • Organizer
      International Symposium on "Molecular Science for Supra Functional System
    • Place of Presentation
      O-okayama, Tokyo
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 包接マトリクスを用いた脱塩化MALDI法の開発2008

    • Author(s)
      藤野竜也、山口惣大、伊永隆史
    • Organizer
      日本化学会第2回関東支部大会
    • Place of Presentation
      群馬大学
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] In-cell Viscosity Measurements by Femtosecond Fluorescence Up-conversion Microscopy2008

    • Author(s)
      T. Fujino, K. Hirota, K. Ohta, T. Tahara
    • Organizer
      Focus On Microscopy 2008
    • Place of Presentation
      Awaji Osaka, Japan
    • Year and Date
      2008-04-15
    • Related Report
      2011 Final Research Report 2009 Self-evaluation Report
  • [Presentation] In-cell Viscosity Measurements by Femtosecond Fluorescence Up-conversion Microscopy2008

    • Author(s)
      T. Fujino, K. Hirota, K. Ohta, T. Tahara
    • Organizer
      Focus On Microscopy 2008
    • Place of Presentation
      Awaji Osaka
    • Year and Date
      2008-04-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ultrafast Solvation Dynamics of Hydrophilic Polymer Fine Particles2007

    • Author(s)
      T. Fujino, H. Hosoi, D. Nanjo, T. Tahara, and T. Korenaga
    • Organizer
      XXIII International Conference on Photochemistry
    • Place of Presentation
      Koln, Germany
    • Year and Date
      2007-08-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultrafast Solvation Dynamics of Hydrophilic Polymer Fine Particles2007

    • Author(s)
      T. Fujino, H. Hosio, D. Nanjo, T. Tahara, T. Korenaga
    • Organizer
      XXIII International Conference on Photochemistry
    • Place of Presentation
      Koln Germany
    • Year and Date
      2007-08-02
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Ultrafast Solvation Dynamics of Hydrophilic Polymer Fine Particles2007

    • Author(s)
      F.Fujino, H.Hosio, D.Nanjo, T.Tahara, and T.Korenaga
    • Organizer
      XXIII International Conference on Photochemistry
    • Place of Presentation
      ドイツ ケルン
    • Year and Date
      2007-08-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pronounced Selectivity in MALDI Mass Spectrometry using 2,4,6-trihydroxy acetophenone on zeolite surface

    • Author(s)
      T.Fujino, Y.Komori, H.Shima, J.N.Kondo, K.Hashimoto, T.Korenaga
    • Organizer
      XIII IUPAC Symposium on Photochemistry
    • Place of Presentation
      Ferrara, Italy
    • Related Report
      2010 Annual Research Report
  • [Book] 生命科学のための分析化学2011

    • Author(s)
      伊永隆史, 藤野竜也, 他6名
    • Publisher
      化学同人
    • Related Report
      2011 Final Research Report
  • [Book] 生命科学のための分析化学2011

    • Author(s)
      伊永隆史、藤野竜也, 他6名
    • Publisher
      化学同人
    • Related Report
      2011 Annual Research Report
  • [Book] Ultrafast Fluorescence Microscope Chapter 3 (pp. 51-70) in “Biochemical applications of nonlinear optical spectroscopy” ed. Vladislav V. Yakovlev2009

    • Author(s)
      T. Fujino, T. Tahara
    • Publisher
      CRC Press
    • Related Report
      2011 Final Research Report
  • [Book] Ultrafast Fluorescence Microscope Chapter 32009

    • Author(s)
      T. Fujino, T. Tahara
    • Publisher
      CRC Press
    • Related Report
      2009 Self-evaluation Report
  • [Book] Ultrafast Fluorescence Microscope in "Biochemical applications of nonlinear optical spectroscopy"

    • Author(s)
      T.Fujino, T.Taliara
    • Publisher
      Taylor and Francis(in press)
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 包接マトリックスを用いたMALDI法2008

    • Inventor(s)
      藤野童也、山口惣大、伊永隆史
    • Industrial Property Rights Holder
      首都大学東京
    • Industrial Property Number
      2008-025881
    • Filing Date
      2008-02-06
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 包接マトリックスを用いたMALDI法

    • Inventor(s)
      藤野竜也, 山口惣大, 伊永隆史
    • Industrial Property Rights Holder
      公立大学法人首都大学東京
    • Patent Publication Number
      2009-186298
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 包接マトリックスを用いたmaldi法

    • Inventor(s)
      藤野竜也, 山口惣大, 伊永隆史
    • Industrial Property Rights Holder
      公立大学法人首都大学東京
    • Industrial Property Number
      2008-025881
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2018-03-28  

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