Dynamic Multi-photon Spectroscopic Imaging of Intracellular Biomolecules Using a White-light Laser Source
| Project Area | Molecular Science for Supra Functional Systems ? Development of Advanced Methods for Exploring Elementary Process |
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| Project/Area Number |
19056010
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | University of Tsukuba (2011)
The University of Tokyo (2007-2010) |
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Principal Investigator |
KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥31,800,000 (Direct Cost: ¥31,800,000)
Fiscal Year 2011: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2010: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 2007: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | 分子分光学 / 分光イメージング / 生細胞 / コヒーレント・アンチストークス・ラマン散乱 / CARS / フォトニック結晶ファイバー / 白色レーザー / 顕微分光 / 多光子過程 / 分子分光 / イメージング |
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| Research Abstract |
In the present project, we extended our CARS work further to obtain CARS and other multi-photon processes simultaneously. Owing to the ultrabroadband spectral profile of the white-light laser source, we developed label-free tetra-modal molecular imaging system for the SH (second harmonics), TH (third harmonics), multiplex TSF and multiplex CARS processes, and applied this technique to a living cell.
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Report
(7 results)
Research Products
(95 results)
