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The turning point from cell proliferation to cell differentiation

Planned Research

Project AreaCell Proliferation Control
Project/Area Number 19057001
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

NAKAYAMA Keiko  Tohoku University, 医学(系)研究科(研究院), 教授 (60294972)

Co-Investigator(Kenkyū-buntansha) 石田 典子  東北大学, 大学院・医学系研究科, 助教 (10361073)
舟山 亮  東北大学, 大学院・医学系研究科, 助教 (20452295)
中野 星児  東北大学, 大学院・医学系研究科, 助手 (00529448)
西田 有一郎  東北大学, 大学院・医学系研究科, 助教 (00551821)
山田 秀俊  東北大学, 大学院・医学系研究科, 助手 (70511955)
原 賢太郎  東北大学, 大学院・医学系研究科, COEフェロー (60400248)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥87,700,000 (Direct Cost: ¥87,700,000)
Fiscal Year 2011: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2010: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2009: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2008: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2007: ¥8,900,000 (Direct Cost: ¥8,900,000)
KeywordsGeminin / ノックアウトマウス / 細胞周期 / DNA複製 / ES細胞 / 細胞増殖 / 分化 / 転写制御 / 複製ライセンシング
Research Abstract

Gemininノックアウトマウス胚とコンディショナルノックアウトマウスを用いて、pre-RCによる細胞増殖制御とHoxタンパク質、Polycomb遺伝子群による分化制御との関係を明らかにすることを目標とした。
特に、今年度は造血幹細胞特異的Gemininノックアウトマウスの作製と解析を中心に研究を進めた。
Geminin欠失マウスの骨髄細胞中では長期造血系再構築能をもつ造血幹細胞(LT-HSC)の細胞数がコントロールに比較し約15%に減少しており、GemininはLT-HSCの維持に必要であることが示された。また、Geminin欠失マウスでは骨髄前駆細胞の分画である共通ミエロイド系前駆細胞(CMP)、巨核球・赤血球前駆細胞(MEP)がそれぞれ約50%、3%に減少し、CMP、MEP、顆粒球・マクロファージ前駆細胞(GMP)はいずれもコロニー形成能を消失していた。しかしながら、巨核球は約8倍に増加していた。成熟細胞では血小板が約8倍に増加し、赤血球が約半分に減少していた。このように、造血幹細胞でのGemininの欠失は巨核球・血小板系統への分化を強く誘導し、他の系統への分化を強く阻害した。
この表現型より、骨髄幹細胞は、これまで言われているような多段階を経て巨核球へ分化するのではなく、Gemininの発現量が適当に調節されることで、pre-RCによる細胞増殖制御と転写因子への効果によって、中間段階を経ずに骨髄幹細胞から直接巨核球へ分化することが可能であることを示唆している。

Report

(5 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (68 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (38 results) (of which Peer Reviewed: 37 results) Presentation (28 results) Remarks (2 results)

  • [Journal Article] Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.2011

    • Author(s)
      Matsumoto A, Tateishi Y, Onoyama I, Okita, Y, Nakayama K, Nakayama KI
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 749-755

    • NAID

      10029292153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport.2011

    • Author(s)
      Funaki T, Kon S, Ronn RE, Henmi Y, Watanabe T, Nakayama K, Tanabe K, Satake M
    • Journal Title

      Cell Struct Funct.

      Volume: 36 Pages: 83-95

    • NAID

      130004137566

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired ovarian development and reduced fertility in female mice deficient in Skp2.2011

    • Author(s)
      Fotovati A, Abu-Ali S, Nakayama K, Nakayama KI
    • Journal Title

      J Anat.

      Volume: (未定 印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.2011

    • Author(s)
      Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimmura M, Kitano H
    • Journal Title

      ORL J Otorhinolarygol Relat Spec

      Volume: 73 Pages: 17-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.2010

    • Author(s)
      Tsuchiya Y, Asano T, Nakayama K, Kato T Jr, Karin M, Kamata H
    • Journal Title

      Mol Cell.

      Volume: 39 Pages: 570-582

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.2010

    • Author(s)
      Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Dike Y, Nakayama K, Nakayama KI
    • Journal Title

      J Clin Invest.

      Volume: 121 Pages: 342-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts.2010

    • Author(s)
      Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K.
    • Journal Title

      Oncogene 29

      Pages: 1798-1798

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1(+/-) mice.2010

    • Author(s)
      Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L.
    • Journal Title

      Nat Genet 42

      Pages: 83-83

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice2010

    • Author(s)
      Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L
    • Journal Title

      Nat Genet 42

      Pages: 83-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.2009

    • Author(s)
      Susaki E, Nakayama K, Yamasaki L, Nakayama KI.
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 5192-5192

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] S-phase kinase-associated protein-2(Skp2)promotes vascular smooth muscle cell proliferation and neointima formation in vivo2009

    • Author(s)
      Wu YJ, Sala-Newby GB, Shu KT, Yeh HI, Nakayama KI, Nakayama K, Newby AC, Bond M
    • Journal Title

      J Vasc Surg. 50

      Pages: 1135-1142

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanoregulation of proliferation2009

    • Author(s)
      Jiang X, Austin PF, Niederhoff RA, Manson SR, Riehm JJ, Cook BL, Pengue G, Chitaley K, Nakayama K, Nakayama KI, Weintraub SJ
    • Journal Title

      Mol Cell Biol 18

      Pages: 5104-5114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration2009

    • Author(s)
      Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI
    • Journal Title

      Lab Invest 89

      Pages: 645-656

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C[delta]differentially regulates platelet functional responses2009

    • Author(s)
      Chari R, Getz T, Nagy B Jr, Bhavaraju K, Mao Y, Bynagari YS, Murugappan S, Nakayama K, Kunapuli SP
    • Journal Title

      Arterioscler Thromb Vase Biol. 29

      Pages: 699-705

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts2009

    • Author(s)
      Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K
    • Journal Title

      Oncogene 29

      Pages: 1798-1809

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model2009

    • Author(s)
      E. Susaki, et.al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 5192-5197

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.2008

    • Author(s)
      Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
    • Journal Title

      Genes Dev 22

      Pages: 986-986

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.2008

    • Author(s)
      Ishikawa Y, Onoyama I, Nakayama KI, Nakayama K.
    • Journal Title

      Oncogene 27

      Pages: 6164-6164

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Skp2 regulates the antiproliferative function of tht tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition2008

    • Author(s)
      M.S. Song, et.al.
    • Journal Title

      Oncogene 27

      Pages: 3176-3185

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating degradation of Clock Protein PER22008

    • Author(s)
      K. Ohsaki, et.al.
    • Journal Title

      J. Biochem 144

      Pages: 609-618

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors2008

    • Author(s)
      G.A. Miranda-Carboni, et.al.
    • Journal Title

      Genes Dev 22

      Pages: 3121-3134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw72008

    • Author(s)
      Y. Ishikawa, et.al.
    • Journal Title

      Oncogene 27

      Pages: 6164-6174

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the p27 E3 ligase SCF(Skp2) results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy2008

    • Author(s)
      Q. Chen, et.al.
    • Journal Title

      Blood 111

      Pages: 4690-4699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCF型ユビキチンリガーゼによる細胞周期制御と発癌2008

    • Author(s)
      中山敬一 and 中山啓子
    • Journal Title

      実験医学(増刊) 26

      Pages: 46-54

    • Related Report
      2007 Annual Research Report
  • [Journal Article] SCFbeta TRCP1 activates and ubiquitylates TAp63gamma2007

    • Author(s)
      J. R. Gallegos, et al
    • Journal Title

      J Biol Chem 283

      Pages: 66-75

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Skp2-mediated p27 degradation in growth and adaptive expanison of pancreatic beta cells.2007

    • Author(s)
      L. Zhong, et al
    • Journal Title

      J Clin Invest 117

      Pages: 2869-2876

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of p27 enhance lainate-induced seizure and hippocampal Degeneration2007

    • Author(s)
      C. Ueyama, et al.
    • Journal Title

      Neuroreport 18

      Pages: 1781-1785

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of Fbxm7 impairs cell-cycle exit during T : cell differentiation and results in lymphomatogenesis2007

    • Author(s)
      I. Onoyama, et al
    • Journal Title

      J Exp Med 204

      Pages: 2875-2888

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nPKC(varepsilon), a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells2007

    • Author(s)
      C. Ehre, et al
    • Journal Title

      Am J Physiol Cell Physiol 293

      Pages: 1445-1454

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival2007

    • Author(s)
      Z. Liu, et al
    • Journal Title

      J Neurochem 100

      Pages: 1278-1288

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative Feedback Loop in Bim-Caspase-3 Axis Regulating Apoptosis and Activity of Osteoclasts2007

    • Author(s)
      H. Wakeyama, et al
    • Journal Title

      J Bone Miner Res 22

      Pages: 1631-1639

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The F Box Protein S Phase Kinase-associated Protein 2 Regulates Adipose Mass and Adipocyte Number in Vivo,2007

    • Author(s)
      P. S. Cooke, et al
    • Journal Title

      Obesity (Silver Spring) 15

      Pages: 1400-1408

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition2007

    • Author(s)
      E. Susaki, et al
    • Journal Title

      Mol Cell Biol 27

      Pages: 4626-4640

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 controls adipocyte proliferation during the development ofobesity2007

    • Author(s)
      T. Sakai, et al
    • Journal Title

      J Biol Chem 282

      Pages: 2038-2046

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex2007

    • Author(s)
      Y. Itoh, et al
    • Journal Title

      J Biol Chem 282

      Pages: 390-396

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation2007

    • Author(s)
      X. Tu, et al
    • Journal Title

      Dev Cell 12

      Pages: 113-127

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asbestos9induced peribronchiolar cell proliferation and cytokine prodction are attenuated in lungs of protein kinase C-delta knockout mice2007

    • Author(s)
      A. Shukla, et al
    • Journal Title

      Am J Pathol 170

      Pages: 140-151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] renal damage in obstructive nephropathy is decreased in Skp2-deficient mice2007

    • Author(s)
      S. Suzuki, et al
    • Journal Title

      Am J Pathol 171

      Pages: 473-483

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ras-mediated regional silencing around Fas gene locus.2011

    • Author(s)
      Masaki Hosogane, Ryo Funayama, Yuichiro Nishida, Keiko Nakayama
    • Organizer
      東北大学グローバルCOE Network Medicine創生拠点 冬の合宿2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Geminin deletion in hematopoietic stem cells promotes differentiation of megakaryocytes and platelets.2011

    • Author(s)
      Seiji Nakano, Yousuke Sasaki, Hozumi Motohashi, Keiko Nakayama
    • Organizer
      東北大学グローバルCOE Network Medicine創生拠点 冬の合宿2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gemininは造血幹細胞の維持と巨核球の分化を制御する2010

    • Author(s)
      中野星児、佐々木陽丞、本橋ほづみ、中山啓子
    • Organizer
      第33回分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん遺伝子RASによる広範囲染色体領域の遺伝子サイレンシング機構の解析2010

    • Author(s)
      舟山亮、細金正樹、西田有一郎、中山啓子
    • Organizer
      第33回分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ras-mediated gene silencingによるFas遺伝子領域のエピジェネティック制御2010

    • Author(s)
      細金正樹、舟山亮、西田有一郎、中山啓子
    • Organizer
      第33回分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Geminin negatively regulates thrombopoiesis2010

    • Author(s)
      Keiko Nakayama
    • Organizer
      MEXT Priority Research Project "Cell Proliferation Control" International Symposium Cell Cycle and Cell Differentiation From A to Z
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん遺伝子Rasは複数の遺伝子を含む広範囲な染色体領域を抑制する2010

    • Author(s)
      細金正樹、舟山亮、中山啓子
    • Organizer
      日本分子生物学会第10回春季シンポジウム
    • Place of Presentation
      松島
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ras-mediated regional silencing around Fas gene locus2010

    • Author(s)
      Masaki Hosogane, Ryo Funayama, Jafar Sharif, Haruhiko Koseki, Keiko Nakayama
    • Organizer
      COLD SPRING HARBOR ASIA CONFERENCES, Epigenetics, Chromatin & Transcription
    • Place of Presentation
      蘇州、中国
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ku80のユビキチン化を介したDNA二重鎖切断修復制御2009

    • Author(s)
      石田典子, 家村俊一郎, 安井明, 夏目徹, 中山啓子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] T-cell differentiation and proliferation in Geminin gene-deleted mouse2009

    • Author(s)
      中野星児, 山田秀俊, 村井寛子, 佐竹正延, 中山啓子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ユビキチンリガーゼSCFFbxw 7はNotchタンパク質分解によりB細胞の分化を制御する2009

    • Author(s)
      青山慧, 石川善則, 小野山一郎, 中山敬一, 中山啓子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 核内IKKβを介したNF-kB活性化による細胞死充進2009

    • Author(s)
      土谷佳弘, 浅野知一郎, 中山啓子, 加藤友久, Michael Karin, 鎌田英明
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chromobox homologue 3 is a essential modulator of endodermal and mesodermal differentiation in F9 cells2009

    • Author(s)
      池田信人, 森川久未, 中野星児, 久留一郎, 白吉安昭
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differential tissue specificity of ubiquitin ligase SCFFbxw72009

    • Author(s)
      中山啓子
    • Organizer
      東北大学グローバルCOE Network Medicine 創生拠点国際シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Defect of T-cell differentiation and proliferation in Geminin genedeleted mouse2009

    • Author(s)
      中野星児
    • Organizer
      東北大学グローバルCOE Network Medicine 創生拠点国際シンボジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell cycle control during differentiation : regulation by two F-box protein, Fbw72009

    • Author(s)
      中山啓子
    • Organizer
      CSI Singapore, NUS-Tohoku University GCOE Joint Symposium
    • Place of Presentation
      シンガポール
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differential specificity of substrate accumulation in ubiquitin ligase SCFFBXW7 deficient cells2009

    • Author(s)
      中山啓子
    • Organizer
      nstitite of Molecular and Cell Biology(IMCB)Cell Cycle Regulation and Tumorigenesis Symposium
    • Place of Presentation
      シンガポール
    • Year and Date
      2009-09-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Geminin は mouse Embryonic Stem Cell におけるDNA複製と遺伝子発現を制御する2009

    • Author(s)
      山田秀俊
    • Organizer
      第6回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規RING-Fingerタンパク質はNAP1L1のユビキチン化を介して細胞増殖を抑制する2008

    • Author(s)
      石田典子, et.al.
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ノックインマウスを用いたp27とp57の機能的類似性と特異性の検討2008

    • Author(s)
      洲崎悦生, et.al.
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンリガーゼSCF^<Fbxw7>はBリンパ球の分化・生存の抑制因子である2008

    • Author(s)
      青山慧
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンリガーゼSCF^<Fbxw7>は表皮角化細胞において増殖と分化を抑制する2008

    • Author(s)
      石川善則, et.al.
    • Organizer
      第61回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gdx, an X-Linked Ubiquitin-Like Modifier, Is Conjugated to Cyclin F and Regulates Mitosis2008

    • Author(s)
      N. Ishida, et al
    • Organizer
      4th International Conference, Ubiquitin, Ubiquitin-Like Proteins, and Cancer
    • Place of Presentation
      Huston, TX, USA
    • Year and Date
      2008-02-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腎障害進行におけるSkp2発現亢進の解析 : Skp2KOマウスを用いた検討2007

    • Author(s)
      鈴木小由理, et al
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ユビキチン様修飾分子GdXによるcyclin Fと細胞周期M期の制御2007

    • Author(s)
      石田典子, et al
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチンリガーゼFbw7は表皮角化細胞において増殖と分化を制御する2007

    • Author(s)
      石川善則, et al
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fbxw7によるGO期維持機構とその破綻による発がん2007

    • Author(s)
      小野山一郎 et al
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gemininは着床前初期発生に必須である,第30回日本生物学会年会2007

    • Author(s)
      原賢太郎, et al
    • Organizer
      第30回日本物資生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2018-03-28  

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