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Cell cycle regulation via ubiquitin system

Planned Research

Project AreaCell Proliferation Control
Project/Area Number 19057005
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KITAGAWA Masatoshi  浜松医科大学, 医学部, 教授 (50294971)

Co-Investigator(Kenkyū-buntansha) WATANABE Nobumoto  独立行政法人理化学研究所, 化合物バンク評価研究チーム, チームヘッド (90221689)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥83,000,000 (Direct Cost: ¥83,000,000)
Fiscal Year 2011: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2010: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2009: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2008: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
Keywordsユビキチン / リン酸化 / タンパク分解 / 細胞周期 / プロテアソーム / GATA / Fbw7 / リン酸 / 癌 / CDK / 癌抑制遺伝子 / 発現制御 / プロテオミクス
Research Abstract

In this research, we investigated regulation of both cell cycle regulators and differentiation factors via post-translational modification such as ubiquitylation and phospholylation to solve the molecular mechanisms of cell cycle and cell differentiation and thereby We aim at the contribution to the cause elucidation and cure for human disease development of symptoms. We achieved the following success in this research. (1)Phosphorylation-dependent degradation of c-Myb. (2) Inhibition of SCF-Fbw7 by adenovirus E1A protein. (3) Pirh2 as a novel E3 ligase for p27. (4) Involvement of Skp2/p27 axis in nephropathy (5) Regulation of Mig-6 by Chk1. (6)Regulation of Wee1 via CK2 and Plk (7) Identification of binding inhibitor of polobox domain to .-TrCP (8) JNK function in .-TrCP-mediated ubiquitylation of Cdc25B

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(164 results)

All 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article (104 results) (of which Peer Reviewed: 59 results) Presentation (48 results) Book (4 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] SCF β TrCP mediates stress-activated MAP kinase-induced Cdc25B degradation.2014

    • Author(s)
      Uchida, S, et al.
    • Journal Title

      J Cell Sci.

      Volume: 124 Pages: 2816-2825

    • DOI

      10.1242/jcs.083931

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ユビキチンシステムによる細胞周期制御と疾患 腎疾患におけるユビキチンシステムの機能2013

    • Author(s)
      北川雅敏
    • Journal Title

      実験医学増刊号

      Volume: 31 Pages: 33-38

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome2012

    • Author(s)
      Egawa, K., Kitagawa, K., Inoue K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M., Fukuda, A
    • Journal Title

      Sci Transl Med

      Volume: 4, 163ra157 Pages: 1-10

    • Related Report
      2011 Final Research Report
  • [Journal Article] Chk1 phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling2012

    • Author(s)
      Liu, N., Matsumoto M., Kitagawa K., Kotake Y., Suzuki S., Shirasawa S., Nakayama KI., Nakanishi M., Niida H., Kitagawa M
    • Journal Title

      EMBO J

      Volume: 31 Pages: 2365-2377

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long noncoding RNA involved in cancer development and cell fate determination2012

    • Author(s)
      Kitagawa, M., Kotake, Y. and Ohhata, T
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1616-1621

    • Related Report
      2011 Final Research Report
  • [Journal Article] The SCF ubiquitin ligases involved in hematopoietic linage2012

    • Author(s)
      Kitagawa, K. and Kitagawa, M
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1641-1648

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA replication licensing2012

    • Author(s)
      Niida, H. and Kitagawa, M
    • Journal Title

      Curr. Drug Target

      Volume: 13 Pages: 1588-1592

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy Curr2012

    • Author(s)
      Watanabe, N. and Osada H
    • Journal Title

      Drug Targets

      Volume: 13 Pages: 1654-1658

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The amelioration of renal damage in Skp2-deficient mice is canceled by p27^<Kip1> deficiency in Skp^<2-/>- p27^<-/-> mice2012

    • Author(s)
      Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., Kitagawa, K., Kotake, Y., Niida, H., Liu, N., Nakayama. K., Nakayama, K.I., Yamamoto, T. and Kitagawa, M
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e31249

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis2012

    • Author(s)
      Fukasawa, H., Fujigaki Y., Yamamato, T., Hishida, A. and Kitagawa, M
    • Journal Title

      Current Medicinal Chemistry (review article)

      Volume: 19 Pages: 893-900

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.2012

    • Author(s)
      Egawa, K., et al.
    • Journal Title

      Sci. Transl. Med.

      Volume: 4 Pages: 163ral57

    • DOI

      10.1126/scitranslmed.3004655

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the Skp2/p27 axis in the progression of chronic nephropathy.2012

    • Author(s)
      Suzuki, S., et al.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: (in press)

    • DOI

      10.1007/S00018-012-1232-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chkl phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling.2012

    • Author(s)
      Liu, N., et al.
    • Journal Title

      EMBO J.

      Volume: 31 Pages: 2365-2377

    • DOI

      10.1038/emboj.2012.88

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long noncoding RNA involved in cancer development and cell fate determination.2012

    • Author(s)
      Kitagawa, M., et al.
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1616-1621

    • DOI

      10.2174/138945012803530026

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The SCF ubiquitin ligases involved in hematopoietic linage.2012

    • Author(s)
      Kitagawa, K., Kitagawa, M.
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1641-1648

    • DOI

      10.2174/138945012803529974

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA replication licensing.2012

    • Author(s)
      Niida, H., Kitagawa, M.
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1588-1592

    • DOI

      10.2174/138945012803529965

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy2012

    • Author(s)
      Watanabe, N., Osada H
    • Journal Title

      Curr. Drug Targets

      Volume: 13 Pages: 1654-1658

    • DOI

      10.2174/138945012803530035

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The amelioration of renal damage in Skp2-deficient mice is canceled by p27 Kipl deficiency in Skp2^-/- p27^-/- mice.2012

    • Author(s)
      Suzuki, S., et al.
    • Journal Title

      PLoS ONE

      Volume: 13 Pages: e31249

    • DOI

      10.1371/journal.pone.0036249

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis.2012

    • Author(s)
      Fukasawa, H., et al.
    • Journal Title

      Current Medicinal Chemistry

      Volume: 19 Pages: 893-900

    • DOI

      10.2174/092986712799034941

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of Cks1 and Skp2 with TNFa/NFkB signaling in chronic progressive nephropathy2011

    • Author(s)
      Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., Kitagawa, K., Kotake, Y., Niida, H., Hishida, A., Yamamoto, T. and Kitagawa M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 1110-1120

    • Related Report
      2011 Final Research Report
  • [Journal Article] Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene2011

    • Author(s)
      Kotake, Y., Nakagawa, T., Kitagawa, K., Suzuki, S., Liu, N., Kitagawa, M. and Xiong, Y. (co-corresponding authors)
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1956-1962

    • Related Report
      2011 Final Research Report
  • [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonnji (Jarid2)-cyclin D1 pathway2011

    • Author(s)
      Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Kojima, M., Kubota, K., Noda, M., Ogawa S., Shirato, H., Sato M., Suzuki-Migishima, R., Hino, T., Kitagawa, M. and Takeuchi, T
    • Journal Title

      Development

      Volume: 138 Pages: 1771-1782

    • Related Report
      2011 Final Research Report
  • [Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification2011

    • Author(s)
      Futamura, Y. Kawatani, M., Kazami, S., Tanaka, K., Muroi, M., Shimizu, T., Tomita, K., Watanabe, N., Osada, H
    • Journal Title

      Chem Biol

      Volume: 19 Pages: 1620-1630

    • Related Report
      2011 Final Research Report
  • [Journal Article] Vipirinin, a coumarin-based HIV-1 VPR inhibitor, interacts with a hydrophobic region of VPR2011

    • Author(s)
      Ong, EB., Watanabe, N., Saito, A., Futamura, Y., Abd El Galil, K.H., Koito, A., Najimudin, N., Osada, H
    • Journal Title

      J Biol. Chem

      Volume: 286 Pages: 14049-14056

    • Related Report
      2011 Final Research Report
  • [Journal Article] SCFβTrCP mediates stress-activated MAP kinase-induced Cdc25B degradation2011

    • Author(s)
      Uchida, S., Watanabe, N., Kudo, Y., Yoshioka, K., Matsunaga, T., Ishizaka, Y., Nakagama, H., Poon, R.Y.C., and Yamashita, K
    • Journal Title

      J. Cell Sci

      Volume: 124 Pages: 2816-2825

    • Related Report
      2011 Final Research Report
  • [Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2011

    • Author(s)
      Futamura, Y., et al.
    • Journal Title

      Chem Biol.

      Volume: 19 Pages: 1620-1630

    • DOI

      10.1016/j.chembiol.2012.10.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of P15INK4B tumor suppressor gene.2011

    • Author(s)
      Kotake, Y., et al.
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1110-1120

    • DOI

      10.1038/onc.2010.568

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of Cksl and Skp2 with TNFcx/NFkB signaling in chronic progressive nephropathy.2011

    • Author(s)
      Suzuki, S., et al.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 1110-1120

    • DOI

      10.1111/j.1365-2443.2011.01553.x.

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonnii (Jarid2)-cyclin D1 pathway.2011

    • Author(s)
      Nakajima, K., et al.
    • Journal Title

      Development

      Volume: 138 Pages: 1771-1782

    • DOI

      10.1242/dev.059295

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR2011

    • Author(s)
      Ong E. B., et al.
    • Journal Title

      J Biol Chem.

      Volume: 286 Pages: 14049-14056

    • DOI

      10.1074/jbc.M110.185397

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 長鎖ncRNAによるクロマチン修飾因子のリクルートメント機構2011

    • Author(s)
      神武洋二郎、北川雅敏
    • Journal Title

      実験医学

      Volume: 29 Pages: 1716-1721

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 長鎖ノンコーディングRNAと細胞老化2011

    • Author(s)
      神武洋二郎、北川雅敏
    • Journal Title

      細胞工学

      Volume: 20 Pages: 729-733

    • Related Report
      2011 Annual Research Report
  • [Journal Article] VIPIRININ, a coumarin-based HIV-1 VPR inhibitor, interacts with a hydrophobic region of VPR2011

    • Author(s)
      Ong E.B., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GSK3 regulates the expression of human and mouse c-Myb via different mechanisms2010

    • Author(s)
      Kitagawa, K., Kotake, Y., Hiramatsu, Y., Liu, N., Suzuki, S., Nakamura, S., Kikuchi, A. and Kitagawa, M
    • Journal Title

      Cell Div

      Volume: 5 Pages: 27

    • Related Report
      2011 Final Research Report
  • [Journal Article] Kaposi's sarcoma-associated herpesvirus- encoded LANA positively affects on ubiquitylation of p532010

    • Author(s)
      Suzuki, T., Isobe, T., Kitagawa, M. and Ueda, K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 403 Pages: 194-197

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mellman, I. and Cantley, L.G.: Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly2010

    • Author(s)
      Togawa, A., Sfakianos, J., Ishibe, S., Suzuki, S., Fujigaki, Y., Kitagawa, M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 400 Pages: 271-277

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dual mode of regulation of Cdc25A protein by TRB32010

    • Author(s)
      Sakai, S., Ohoka, N., Onozaki, K., Kitagawa, M., Nakanishi, M. and Hayashi, H
    • Journal Title

      Biol. Pharm. Bull

      Volume: 33 Pages: 1112-1116

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reduction of transforming growth factor-s type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma2010

    • Author(s)
      Fukasawa, H., Yamamoto, T., Fujigaki, Y., Misaki, T., Ohashi, N., Takayama, T., Suzuki, S., Mugiya, S., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Hayashi, H., Ozono, S., Kitagawa, M. and Hishida, A
    • Journal Title

      Int. J. Cancer

      Volume: 127 Pages: 1517-1525

    • Related Report
      2011 Final Research Report
  • [Journal Article] p27 modulates tropism of mesenchymal stem cells toward brain tumors2010

    • Author(s)
      Gao, Y., Gu, C., Li, S., Tokuyama, T., Yokota, N., Nakayama, K.I., Kitagawa, M. and Namba, H
    • Journal Title

      Exp. Ther. Med

      Volume: 1 Pages: 695-699

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mapping of the interaction sites between Weel kinase and the regulatory b-subunit of protein kinase CK22010

    • Author(s)
      Olsen, BB., Kreutzer, N., Watanabe, N., Holm, T. and Guerra, B
    • Journal Title

      Int. J. Oncol

      Volume: 36 Pages: 1175-1182

    • Related Report
      2011 Final Research Report
  • [Journal Article] GSK3 regulates the expression of human and mouse c-Myb via different mechanisms.2010

    • Author(s)
      Kitagawa, K., et al.
    • Journal Title

      Cell Division

      Volume: 5 Pages: 27-27

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kaposi's sarcoma-associated herpesvirus-encoded LANA positively affects on ubiquitylation of p53.2010

    • Author(s)
      Suzuki, T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 403 Pages: 194-197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly.2010

    • Author(s)
      Togawa, A., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 400 Pages: 271-277

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual mode of regulatio of Cdc25A protein by TRB3.2010

    • Author(s)
      Sakai, S., et al.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 1112-1116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of transforming growth factor-ss type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.2010

    • Author(s)
      Fukasawa, H., et al.
    • Journal Title

      Int.J.Cancer

      Volume: 127 Pages: 1517-1525

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p27 modulates tropism of mesenchymal stem cells toward brain tumors.2010

    • Author(s)
      Gao, Y., et al.
    • Journal Title

      Exp.Ther.Med.

      Volume: 1 Pages: 695-699

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping of the interaction sites between Weel kinase and the regulatory beta-subunit of protein kinase CK22010

    • Author(s)
      Olsen B.B., et al.
    • Journal Title

      Int.J.Oncology

      Volume: 36 Pages: 1175-1182

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus E1A inhibits SCFFbw7 ubiquitin ligase2009

    • Author(s)
      Isobe, T., Hattori, T., Kitagawa, K., Uchida, C., Kotake, Y., Kosugi, I., Oda, T. and Kitagawa, M
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 27766-27779

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb2009

    • Author(s)
      Kitagawa, K., Hiramatsu, Y., Uchida, C., Isobe, T., Hattori, T., Oda, T., Shibata, K., Nakamura, S., Kikuchi, A. and Kitagawa, M
    • Journal Title

      Oncogene

      Volume: 28 Pages: 2383-2405

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ubiquitin-mediated control of oncogene and tumor suppressor gene products2009

    • Author(s)
      Kitagawa, K., Kotake, Y. and Kitagawa, M
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 1374-1381

    • Related Report
      2011 Final Research Report
  • [Journal Article] Decrease in TRADD resulted from ubiquitin-dependent degradation in the obstructive renal injury in rats2009

    • Author(s)
      Misaki, T., Yamamoto, T., Suzuki, S., Fukasawa, H., Togawa, A., Ohashi, N., Suzuki, H., Fujigaki, Y., Oda, T, Uchida, C., Kitagawa, K., Hattori, T., Kitagawa, M. and Hishida, A
    • Journal Title

      Am. J. Pathol

      Volume: 175 Pages: 74-83

    • Related Report
      2011 Final Research Report
  • [Journal Article] High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers2009

    • Author(s)
      Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., Abe, K., Kotake, Y., Oda, T., Suzuki, H., Hashimoto, K. and Kitagawa, M
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 866-872

    • Related Report
      2011 Final Research Report
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009

    • Author(s)
      Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N., and Osada, H
    • Journal Title

      Oncogene

      Volume: 28 Pages: 107-116

    • Related Report
      2011 Final Research Report
  • [Journal Article] Deficiency in chromosome congression by the inhibition of PLK1 polo box domain-dependent recognition2009

    • Author(s)
      Watanabe, N., Sekine, T., Takagi, M., Iwasaki, J., Imamoto, N., Kawasaki, H., and Osada, H
    • Journal Title

      J Biol. Chem

      Volume: 284 Pages: 2344-2353

    • Related Report
      2011 Final Research Report
  • [Journal Article] Adenovirus E1A inhibits SCF-Fbw7 ubiquitin ligase.2009

    • Author(s)
      Isobe, T., Hattori, T., Kitagawa, K., Uchida, C., Kotake, Y., Kosugi, I., Oda, T., *Kitagawa, M.
    • Journal Title

      J Biol Chem. 284

      Pages: 27766-27779

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Fbw7 promotes ubiquitin-dependent degradation of c-Myb-involvement of GSK3- mediated phosphorylation of Thr-572 in mouse c-Myb.2009

    • Author(s)
      Kitagawa, K., Hiramatsu, Y., Uchida, C., Isobe, T., Hattori, T., Oda, T., Shibata, K., Nakamura, S., Kikuchi, A., *Kitagawa, M.
    • Journal Title

      Oncogene 28

      Pages: 2383-2405

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Deficiency in chromosome congression by the inhibition of PLK1 polo box domain-dependent recognition.2009

    • Author(s)
      Watanabe, N., Sekine, T., Takagi, M., Iwasaki, J., Imamoto, N., Kawasaki, H., Osada, H.
    • Journal Title

      J Biol. Chem. 284

      Pages: 2344-2353

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Adenovirus E1A inhibits SCFFbw7 ubiquittin ligase.2009

    • Author(s)
      Isobe, T., et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 27766-27779

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbw7 promotes ubiquitin-dependent degradation of c-Myb-involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.2009

    • Author(s)
      Kitagawa, K., et al.
    • Journal Title

      Oncogene 28

      Pages: 2383-2405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-mediated control of oncogene and tumor wuppressor gene products.2009

    • Author(s)
      Kitagawa, K., et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 1374-1381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in TRADD resulted from ubiquitin-dependent degradation in the obstructive renal injury in rats.2009

    • Author(s)
      Misaki, T., et al.
    • Journal Title

      Am.J.Pathol. 175

      Pages: 74-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 poor prognosis in head and neck cancers.2009

    • Author(s)
      Shimada, M., et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 866-872

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping of the interaction sites between Weel Kinase and the regulatory beta-subunit of protein kinase CK22009

    • Author(s)
      Olsen, B., et al
    • Journal Title

      Int.J.Oncology 36

      Pages: 1175-1182

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-X_L during pironetin-induced apoptosis2009

    • Author(s)
      Tamura, Y., et.al.
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency in chromosome congression by the inhibition of PLK1 polo box domain-dependent recognition2009

    • Author(s)
      Watanabe, N., et.al.
    • Journal Title

      J Biol. Chem 284

      Pages: 2344-2353

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌細胞の細胞周期異常2009

    • Author(s)
      渡邉信元, ら
    • Journal Title

      日本臨休 67

      Pages: 71-76

    • Related Report
      2008 Annual Research Report
  • [Journal Article] TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche2008

    • Author(s)
      Yamamoto, M., Kikuchi, H., Ohta, M., Kawabata, T., Hiramatsu, Y., Kondo, K., Baba, M,. Kamiya, K., Tanaka, T., Kitagawa M. and Konno, H
    • Journal Title

      Cancer Res

      Volume: 68 Pages: 9754-9762

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats2008

    • Author(s)
      Ohashi, N., Yamamoto, T., Huang, Y., Misaki, T., Fukasawa, H., Suzuki, H., Togawa, A., Suzuki, S., Fujigaki, Y., Nakagawa, T., Nakamura, Y., Suzuki, F., Kitagawa, M. and Hishida, A
    • Journal Title

      Am. J. Physiol Renal Physiol

      Volume: 295 Pages: F1512-1518

    • Related Report
      2011 Final Research Report
  • [Journal Article] Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF/b-TrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD12008

    • Author(s)
      Hayakawa, M., Matsushima, M., Hagiwara, H., Oshima, T., Fujino, T., Ando, K., Kikugawa, K., Tanaka, H., Miyazawa,K. and Kitagawa, M
    • Journal Title

      Genes to Cells

      Volume: 13 Pages: 329-442

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit2008

    • Author(s)
      Abe, K., Hattori, T., Isobe, T., Kitagawa, K., Oda, T., Uchida, C., and Kitagawa, M
    • Journal Title

      Biomed Res

      Volume: 29 Pages: 53-60

    • Related Report
      2011 Final Research Report
  • [Journal Article] Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells2008

    • Author(s)
      Kurata, K., Yanagisawa, R., Ohira, M., Kitagawa, M., Nakagawara, A. and Kamijo, T
    • Journal Title

      Oncogene

      Volume: 27 Pages: 741-754

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of TGF-beta signaling by Smads and its roles in tissue fibrosis2008

    • Author(s)
      Fukasawa, H., Yamamato, T., Kitagawa, M. and Hishida, A
    • Journal Title

      Current signal transduction therapy (review article)

      Volume: 3 Pages: 1-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC22008

    • Author(s)
      Kamata, M., Watanabe, N., Nagaoka, Y., and Chen, IS
    • Journal Title

      J Virol

      Volume: 82 Pages: 5672-5682

    • Related Report
      2011 Final Research Report
  • [Journal Article] The regulatory b-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis2008

    • Author(s)
      Yde, C.W., Olsen, B.B., Meek, D., Watanabe, N., and Guerra, B
    • Journal Title

      Oncogene

      Volume: 27 Pages: 4986-4997

    • Related Report
      2011 Final Research Report
  • [Journal Article] Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF-F1ND1/β-TRCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD12008

    • Author(s)
      Hayakawa, M., et.al.
    • Journal Title

      Genes to Cells 13

      Pages: 329-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal RAS activity and urinary angiotensinogen excretion inanti-thymocyte serum nephritis rats2008

    • Author(s)
      Ohashi, N., et.al.
    • Journal Title

      Am J. Physiol Renal Physiol 295

      Pages: F1512-1518

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche2008

    • Author(s)
      Yamamoto, M., et.al.
    • Journal Title

      Cancer Res 68

      Pages: 9754-9762

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The regulatory β-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis2008

    • Author(s)
      Yde, C. W., et.al.
    • Journal Title

      Oncogene 27

      Pages: 4986-4997

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Weel kinase domain and enhances kinase activity for CDC22008

    • Author(s)
      Kamata, M., et.al.
    • Journal Title

      J Virol 82

      Pages: 5672-5682

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 acts as an E3 Ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation2008

    • Author(s)
      Kanei-Ishii, C., et.al.
    • Journal Title

      J Biol. Chem 283

      Pages: 30540-30548

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Weel2008

    • Author(s)
      Watanabe, N
    • Journal Title

      UCSD-Nature Molecule Pages http://www.signaling-gateway.org/molecule/query?afcsid=A002371

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pirh2 interacts with and ubiquitylates signal recognition particle recept or beta subunit2008

    • Author(s)
      Abe, K., et. al.
    • Journal Title

      Biomed Res. 29

      Pages: 58-60

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 Vpr binds to the N-lobe of Weel kinase domain and enhances kinase activity for Cdc22008

    • Author(s)
      Kamata, M., et. al.
    • Journal Title

      J.Virol. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The regulatory β-subunit of protein kinase CK2 regulates cell cycle progression at the onset of mitosis.2008

    • Author(s)
      Yde, CW, et. al.
    • Journal Title

      Oncogene. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip12007

    • Author(s)
      Hattori, T., Isobe, T., Abe, K., Kikuchi, H., Kitagawa, K., Oda, T., Uchida, C. and Kitagawa, M
    • Journal Title

      Cancer Res

      Volume: 67 Pages: 10789-10795

    • Related Report
      2011 Final Research Report
  • [Journal Article] Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion2007

    • Author(s)
      Ohoka, N., Hattori, T., Kitagawa, M., Onozaki, K. and Hayashi H
    • Journal Title

      J. Biol. Chem

      Volume: 282 Pages: 35687-35694

    • Related Report
      2011 Final Research Report
  • [Journal Article] Contribution of Extracellular Signal-Regulated Kinases to the IL-1-induced Growth Inhibition of Human Melanoma Cells A3752007

    • Author(s)
      Arakawa, T., Yamamura, T., Hattori, T., Hayashi H., Mori, A., Yoshida, A., Uchida, C., Kitagawa, M. and Onozaki, K
    • Journal Title

      Int. Immunopharm

      Volume: 8 Pages: 80-89

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia2007

    • Author(s)
      Kono, S., Suzuki, H., Oda, T., Takahashi, Y., Shirakawa, K., Takahashi, Y., Kitagawa, M. and Miyajima, H
    • Journal Title

      J. Hepatology

      Volume: 47 Pages: 844-850

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors2007

    • Author(s)
      Kikuchi, H., Yamamoto, M., Hiramatsu, Y., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Sugimura, H., Kitagawa, M., Kanai, T., Kitayama, Y., Kanda, T., Nishikura, K. and Konno, H
    • Journal Title

      Cancer Sci

      Volume: 98 Pages: 1734-1739

    • Related Report
      2011 Final Research Report
  • [Journal Article] ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells2007

    • Author(s)
      Kikuchi, H., Uchida, C., Hattori, T., Isobe, T., Hiramatsu, Y., Kitagawa, K., Oda, T., Konno, H. and Kitagawa, M
    • Journal Title

      Carcinogenesis

      Volume: 28 Pages: 1752-1758

    • Related Report
      2011 Final Research Report
  • [Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice2007

    • Author(s)
      Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T. and Kitagawa, M
    • Journal Title

      Am. J. Pathol

      Volume: 171 Pages: 473-483

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage2007

    • Author(s)
      Inoue, Y., Kitagawa, M. and Taya, Y
    • Journal Title

      EMBO J

      Volume: 26 Pages: 2083-2093

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites2007

    • Author(s)
      Li, S., Gao, Y., Tokuyama, T., Yamamoto, J., Yokota, N., Yamamoto, S., Terakawa, S., Kitagawa, M. and Namba, H
    • Journal Title

      Cancer Lett

      Volume: 251 Pages: 220-227

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip1.2007

    • Author(s)
      Hattori, T., Isobe, T., Abe, K., Kikuchi, H., Kitagawa, K., Oda, T., Uchida, C., *Kitagawa, M.
    • Journal Title

      Cancer Res. 67

      Pages: 10789-10795

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitorp27Kip12007

    • Author(s)
      Hattori, T., et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 10789-10795

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARA54 is involved in transcriptional regulation of the cyclin D1 gene inhuman cancer cells2007

    • Author(s)
      Kikuchi.H., et. al.
    • Journal Title

      Carcinogenesis. 28

      Pages: 1752-1758

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficientmice2007

    • Author(s)
      Suzuki.S., et. al.
    • Journal Title

      Am.J.Pathol. 171

      Pages: 473-483

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of loss of heterozygosity of the c-kit gene on prognosis after hepa tectomy for metastatic liver gastrointestinal stromal tumors2007

    • Author(s)
      Kikuchi.H., et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 1734-1739

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia2007

    • Author(s)
      Kono, S, et. al.
    • Journal Title

      J.Hepatology. 47

      Pages: 844-850

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells2007

    • Author(s)
      Kurata, K., et. al.
    • Journal Title

      Oncogene. 27

      Pages: 741-754

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical and functional regulation of CHOP (C/EBP homologous protein)through the N-terminal portion2007

    • Author(s)
      Ohoka, N., et. al.
    • Journal Title

      J Biol Chem. 282

      Pages: 35687-35694

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of Extracellular Signal-Regulated Kinases to the IL-I-induced Growth Inhibition of Human Melanoma Cells A3752007

    • Author(s)
      Arakawa, T., et. al.
    • Journal Title

      International Immunopharmacology. 8

      Pages: 80-89

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 染色体複製から分裂開始までを監視するチェラクポイント経路-その活性化と不活性化の分子機構-2007

    • Author(s)
      渡辺信元
    • Journal Title

      実験医学 25

      Pages: 662-670

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Roles of the Skp2/p27 axis in the progression of chronic nephropathy

    • Author(s)
      Suzuki, S., Ohashi, N. and Kitagawa, M
    • Journal Title

      Cell Mol Life Sci

      Volume: (in press)

    • DOI

      10.1007/s00018-012-1232-x

    • Related Report
      2011 Final Research Report
  • [Presentation] Recent Progress of long non-coding RNA research2012

    • Author(s)
      大畑樹也, 他
    • Organizer
      日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chk1 phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling2012

    • Author(s)
      北川雅敏、劉寧
    • Organizer
      第45回日本発生生物学会、第64回日本細胞生物学会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      2012-05-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Chkl phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling.2012

    • Author(s)
      北川雅敏、劉寧
    • Organizer
      第45回日本発生生物学会、第64回日本細胞生物学会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      2012-05-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phosphorylation-mediated regulation of the tumor suppressor Mig-62011

    • Author(s)
      北川雅敏
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Chk1の新機能2011

    • Author(s)
      北川雅敏
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Chklの新機能2011

    • Author(s)
      北川雅敏
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 長鎖ノンコーディングRNA ANRILは INK4 locusの転写抑制を介し細胞増殖に関与する2011

    • Author(s)
      北川雅敏
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 長鎖ノンコーアィングRNA ANRILはINK4 locusの転写抑制を介し細胞増殖に関与する2011

    • Author(s)
      北川雅敏
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of phosphorylation dependent protein-protein interaction on the cell cycle progression2010

    • Author(s)
      Watanabe, N
    • Organizer
      MEXT Priority Research Project "Cell Proliferation Control" International Symposium Cell Cycle and Cell Differentiation From A to Z
    • Place of Presentation
      名古屋
    • Year and Date
      20101100
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 増殖シグナルの新たな制御機構2010

    • Author(s)
      北川雅敏, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌抑制遺伝子産物Mig-6のリン酸化とその責任酵素の解析2010

    • Author(s)
      Ning Liu, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性進行性腎障害におけるCks1およびSkp2の発現亢進の意義2010

    • Author(s)
      鈴木小由里, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新しいHIV-1Vpr阻害小分子によるVprの活性部位解析2010

    • Author(s)
      Eugene Ong, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] SCF β TrCPによるCdc25B分解におけるPEST配列の役割2010

    • Author(s)
      内田早苗, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] CUL4-DDB1/MLL complex activates the p16 transcription through histone H3K4 methylation2010

    • Author(s)
      Yojiro Kotake, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] GSK3によるc-Mybの量的制御機構2010

    • Author(s)
      北川恭子, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel target and function of Chk12010

    • Author(s)
      Masatoshi Kitagawa
    • Organizer
      MEXT Priority Research Project "Cell Proliferation Control" International Symposium Cell Cycle and Cell Differentiation From A to Z
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小分子阻害剤を用いたPin1のM期進行への役割の解析2010

    • Author(s)
      渡邉信元, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 14-3-3タンパク質阻害小分子探索系の構築2010

    • Author(s)
      真田英美子, 他
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] リン酸化特異的プロリン異性化酵素Pin1阻害小分子の探索2010

    • Author(s)
      渡邉信元, 他
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] RIKEN NPDepoから単離した新しいHIV-1Vpr阻害小分子とその構造活性相関解析2010

    • Author(s)
      Eugene Ong, 他
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] A small molecule inhibitor of phosphorylation-dependent protein-protein interaction2010

    • Author(s)
      Watanabe, N. et al.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      ハワイ州、ワイコロア
    • Year and Date
      2010-02-09
    • Related Report
      2011 Final Research Report
  • [Presentation] A small molecule inhibitor of phosphorylation-dependent protein-protein interaction.2010

    • Author(s)
      Watanabe N., et al.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer A ssociation
    • Place of Presentation
      ハワイ州、ワイコロア
    • Year and Date
      2010-02-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] アデノウイルスE1A蛋白質はSCF-Fbw7ユビキチンリガーゼを阻害する2009

    • Author(s)
      北川雅敏、磯部智康
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of peptidyl prolyl isomerization during M-phase progression2009

    • Author(s)
      渡邉信元 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] アデノウイルスE1A蛋白質はSCF-Fbw7ユビキチンリガーゼを阻害する。2009

    • Author(s)
      北川雅敏、磯部智康
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Screening of small molecule inhibitors for polo box domain dependent interaction2009

    • Author(s)
      渡邉信元 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Pirh2はp27のユビキチンリガーゼとしてヒトの癌の悪性化に関与する2009

    • Author(s)
      北川雅敏 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Pirh2はp27のユビキチンリガーゼとしてヒトの癌の悪性化に関与する。2009

    • Author(s)
      北川雅敏, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] SCFbeta-TrCPによるCdc25Bの制御2008

    • Author(s)
      内田早苗, 等
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小分子阻害剤を用いた細胞分裂におけるPBD依存性結合の役割の解析2008

    • Author(s)
      渡邉信元 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] GPR48による癌転移機構の解析2008

    • Author(s)
      磯部智康, 等
    • Organizer
      第31回日本分子生物学会、第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小分子阻害剤を用いた細胞分裂におけるPBD依存性結合の役割の解析2008

    • Author(s)
      渡邉信元, 等
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質過剰発現誘導性小胞体の構造と機能2008

    • Author(s)
      小田敏明, 等
    • Organizer
      第31回日本分子生物学会、第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小分子阻害剤によるP1k1ポロボックス依存性結合の細胞分裂進行における役割の解析2008

    • Author(s)
      渡邉信元, 等
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Small molecule inhibitors of phosphorylation dependent protein-protein interactions2008

    • Author(s)
      Watanabe, N., et.al.
    • Organizer
      Friday seminar by USM visiting professors
    • Place of Presentation
      Univ. Sains, Malaysia, Penang
    • Year and Date
      2008-07-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of a screening system for HIV-1 Vpr Inhibitors and the study of its mechanism of action2008

    • Author(s)
      Ong, E., et.al.
    • Organizer
      4th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      日光
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞分裂期進行におけるP1k1ポロボックスドメイン依存性結合の役割の化学生物学的解析2008

    • Author(s)
      渡邉信元, 等
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞周期制御分子p27のユビキチン依存的分解機構と病態2007

    • Author(s)
      北川雅敏
    • Organizer
      第30回日本分子生物学会第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞周期制御分子p27のユビキチン依存的分解機構と病態2007

    • Author(s)
      北川雅敏
    • Organizer
      第30回日本分子生物学会第, 80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Plk1のポロボックスドメイン依存結合は分裂中期染色体の速やかな整列に必要である2007

    • Author(s)
      渡辺信元, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Small Molecule inhibitors for Polo Box Domain Dependent Recognition2007

    • Author(s)
      Watanabe, N., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Moscone West Convention Center,San Franciso,米国
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel regulatory mechanisms of Cyclin D1 expression2007

    • Author(s)
      Kitagawa, M. et al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel regulatory mechannsms of Cyclin Dlexpression2007

    • Author(s)
      KitagaWa, M., et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Screening for small molecule inhibitors of polo box domain dependent recognition2007

    • Author(s)
      Watanabe, N., et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of Small Molecule Inhibitors of Box Domain Dependsnt Recognition2007

    • Author(s)
      Watanabe, N., et. al.
    • Organizer
      the 5th Salk Institute Cell Cycle Meeting
    • Place of Presentation
      Salk Inst.San Diego,米国
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌関連核内因子のユビキチン依存的制御機構2007

    • Author(s)
      北川雅敏
    • Organizer
      Nuclear Signaling JAPAN 2007シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-07-13
    • Related Report
      2011 Final Research Report 2009 Self-evaluation Report
  • [Presentation] 癌関連核内因子のユビキチン依存的制御機構2007

    • Author(s)
      北川雅敏
    • Organizer
      Nuclear Signaling JAPAN2007シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Book] 細胞分裂期を制御する蛋白質分解システム2010

    • Author(s)
      渡邉信元
    • Total Pages
      58-63
    • Publisher
      共立出版
    • Related Report
      2010 Annual Research Report
  • [Book] 癌細胞の細胞周期異常日本臨牀, 67巻増刊号1 「癌薬物療法学 基礎・臨床研究のアップデート」2009

    • Author(s)
      渡邉信元 他
    • Related Report
      2011 Final Research Report
  • [Book] がん化学療法・分子標的治療 update (西條長広、西尾和人 編) 第2章 がん化学療法の標的 3. 細胞周期2009

    • Author(s)
      渡邉信元 他
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] がん化学療法・分子標的治療update第2章がん化学療法の標的 3.細胞周期2009

    • Author(s)
      渡辺信元, 他
    • Total Pages
      19-26
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seika1.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.hama-med.ac.jp/uni_education_igakubu_igaku_seika1.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1a/bio1/index-j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1a/bio1/index-j.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1a/biol/index-j.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1a/bio1/index-j.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌治療用組成物2012

    • Inventor(s)
      北川雅敏、高芸、北川恭子
    • Industrial Property Rights Holder
      浜松医科大学
    • Industrial Property Number
      特許、4967137
    • Filing Date
      2012-02-16
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 癌の転移性及び浸潤能の検査方法2011

    • Inventor(s)
      北川雅敏、高芸、北川恭子
    • Industrial Property Rights Holder
      浜松医科大学
    • Industrial Property Number
      特許、4887505
    • Filing Date
      2011-12-22
    • Related Report
      2011 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2018-03-28  

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