|Budget Amount *help
¥135,500,000 (Direct Cost: ¥135,500,000)
Fiscal Year 2011: ¥34,600,000 (Direct Cost: ¥34,600,000)
Fiscal Year 2010: ¥34,600,000 (Direct Cost: ¥34,600,000)
Fiscal Year 2009: ¥35,100,000 (Direct Cost: ¥35,100,000)
Fiscal Year 2008: ¥19,500,000 (Direct Cost: ¥19,500,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥11,700,000)
In this project, we have studies the detailed mechanisms of both positive and negative controls of the cell cycle during early development of the amphibian Xenopus. We showed that the activity of Emi2, an meiotic inhibitor in unfertilized egg, is finely regulated by both various kinases and phosphatases. Furthermore, we demonstrated that neurogenesis and morphogenesis in early embryos are regulated by various cell-cycle regulators, such as FoxM1, Wee1, Chk1 and Cdc25A. Thus,our results revealed the important roles of various cell cycle regulators in early development of Xenopus.