|Budget Amount *help
¥82,900,000 (Direct Cost: ¥82,900,000)
Fiscal Year 2011: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2010: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2009: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2008: ¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 2007: ¥28,800,000 (Direct Cost: ¥28,800,000)
Subcellular localization of Cdk5 is a molecular mechanism that prevents cell death of neurons even when Cdk5 is expressed in post-mitotic neurons. It was shown here that Cdk5 bound to membrane organelles in the cytoplasm through myristoylated p35 Cdk5 activator and Cdk5 activity promoted export of the active Cdk5-p35 complex from the nucleus. We confirmed that Cdk5 suppressed excitation of neurons. One of the molecular mechanisms is phosphorylation of Sept5, which inhibited interaction with syntaxin1 SNARE protein. We also found a novel function of Cdk5, which was suppression of neurite outgrowth through LMTK1 neuron abundant novel Ser/Thr protein kinase.