| Budget Amount *help |
¥71,000,000 (Direct Cost: ¥71,000,000)
Fiscal Year 2011: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2010: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2009: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2008: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2007: ¥14,200,000 (Direct Cost: ¥14,200,000)
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| Research Abstract |
The functional molecules move around in the cell and interact with other molecules, and then support higher function of the cell. Moreover, even aggregate prone protein acts as aggregate and disaggregate under specific condition, so that each element of these aggregate protein is exchanged with free its molecules in solution. FCS (fluorescence correlation spectroscopy) detects the fluorescence fluctuations, the diffusion coefficient, molecular concentration and molecular interactions of molecules. We developed a multipoint FCS system which was based on an objective-type total internal reflection-FCS (TIR-FCS) in order to analysis molecular interaction in living cell and system of protein community.
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