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Cellular dynamics in autoimmune responses

Planned

Project AreaImmunological Self Recognition and its Disorders
Project/Area Number 19059004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUSHIMA Kouji  東京大学, 大学院・医学系研究科, 教授 (50222427)

Co-Investigator(Kenkyū-buntansha) FUKUI Yoshinori  九州大学, 生体防御医学研究所, 教授 (60243961)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Shinichi  金沢大学, 医薬保健研究域, 特任教授 (00313099)
KURACHI Makoto  東京大学, 大学院・医学系研究科, 助教 (00396722)
UEHA Satoshi  東京大学, 大学院・医学系研究科, 助教 (00447385)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥126,400,000 (Direct Cost: ¥126,400,000)
Fiscal Year 2011: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2010: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 2009: ¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 2008: ¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 2007: ¥28,800,000 (Direct Cost: ¥28,800,000)
Keywords免疫寛容 / 細胞動態 / ケモカイン / シグナル / 樹状細胞 / シグナル伝達 / リンパ球 / DOCK2 / 遊走 / regulatory T cells / CCR7 / リンパ節
Research Abstract

In this project, we aimed to clarify the trafficking of immune cells that are responsible for peripheral immune tolerance. We also addressed the mechanisms and immunological significance of such cellular trafficking. Following results were obtained through this project: 1) CCR7 and CXCR4 regulate the migration of nTreg into lymph node paracortex and medulla, respectively, 2) MDSC are composed of monocytic cells and neutrophils, and balance between these cell types are critically regulated by a chemokine receptor CCR2, 3) niche size of antibody-producing cells in lymph nodes are likely regulated by B-cell mediated remodeling of the niche, 4) novel mechanisms controlling DOCK2-mediated migration and activation of leukocytes were elucidated.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(85 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (38 results) Book (6 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes2012

    • Author(s)
      Jun Abe, et al
    • Journal Title

      Int Immunol.

      Volume: 24 Pages: 17-27

    • DOI

      10.1093/intimm/dxr116

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide profiling of DNA methylation in human cancer cells2012

    • Author(s)
      Katsumi Ogoshi, et al
    • Journal Title

      Genomics

      Volume: 98 Pages: 280-287

    • DOI

      10.1016/j.ygeno.2011.07.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK22012

    • Author(s)
      Nishikimi A, et al
    • Journal Title

      Chem.Biol.

      Volume: (印刷中)(掲載確定)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms2012

    • Author(s)
      Hanawa-Suetsugu K, et al
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 109 Pages: 3305-3310

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration2011

    • Author(s)
      Kurachi Makoto
    • Journal Title

      J. Exp. Med

      Volume: 208 Pages: 1605-1620

    • DOI

      10.1084/jem.20102101

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis2011

    • Author(s)
      Kayoko Kaneko, et al
    • Journal Title

      Arthritis Res. Ther

      Volume: 13

    • DOI

      10.1186/ar3475

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid cell population dynamics in healthy and tumor-bearing mice2011

    • Author(s)
      Satoshi Ueha, et al
    • Journal Title

      Int Immunopharmacol

      Volume: 11 Pages: 783-788

    • DOI

      10.1016/j.intimp.2011.03.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization2011

    • Author(s)
      Ippagunta SK, et al
    • Journal Title

      Nat. Immunol

      Volume: 12 Pages: 1010-1018

    • DOI

      10.1038/ni.2095

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid cell population dynamics in healthy and tumor-bearing mice2011

    • Author(s)
      Ueha S
    • Journal Title

      Int Immunopharmacol

      Volume: (掲載確定 in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow graft-versus-host disease: early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation2010

    • Author(s)
      Matsushima K(著者10名、10番目)
    • Journal Title

      Blood

      Volume: 115(26) Pages: 5401-5411

    • DOI

      10.1182/blood-2008-01-136895

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation2010

    • Author(s)
      Fukui Y(著者17名、17番目)
    • Journal Title

      J Exp Med

      Volume: 207 Pages: 721-730

    • DOI

      10.1084/jem.20091776

    • NAID

      40019145306

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A conceptual molecular network for chemotactic behaviors characterized by feedback of molecules cycling between the membrane and the cytosol.2010

    • Author(s)
      Otsuji M
    • Journal Title

      Sci Signal

      Volume: 3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers.2010

    • Author(s)
      Yoshiura C
    • Journal Title

      J Am Chem Soc

      Volume: 132 Pages: 6768-6777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of CD11b+ GR-1 low cells in autoimmune disorder in MRL-Fas 1pr mouse2010

    • Author(s)
      Iwata Y
    • Journal Title

      Clin Exp Nephrol

      Volume: 14 Pages: 411-417

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts2010

    • Author(s)
      Hoshino A
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 28826-28837

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4.2010

    • Author(s)
      Sanematsu F
    • Journal Title

      Circ.Res.

      Volume: 107 Pages: 1102-1105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow graft-versus-host disease: early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation.2010

    • Author(s)
      Matsushima K (著者10名、10番目)
    • Journal Title

      Blood. (in press)

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Bone marrow graft-versus-host disease : early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation2010

    • Author(s)
      Shono Y, et al
    • Journal Title

      Blood ((印刷中)掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective control of type I IFN induction by the Rae activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation2010

    • Author(s)
      Gotoh K, et al
    • Journal Title

      Journal of Experimental Medicine (掲載確定(印刷中))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveal redundant and non-redundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing2010

    • Author(s)
      Boscacci RT, et al
    • Journal Title

      Blood (掲載確定(印刷中))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway2010

    • Author(s)
      Kumar V, et al
    • Journal Title

      Blood (掲載確定(印刷中))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009

    • Author(s)
      Fukui Y(著者16名、16番目)
    • Journal Title

      Science

      Volume: 324 Pages: 384-387

    • DOI

      10.1126/science.1170179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.2009

    • Author(s)
      Fukui Y (著者16名、16番目)
    • Journal Title

      Science 324

      Pages: 384-387

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration2009

    • Author(s)
      Toda E, et al
    • Journal Title

      Journal of Immunology 183

      Pages: 6387-94

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR42009

    • Author(s)
      Kofuku Y, et al
    • Journal Title

      Journal of Biological chemistry 284

      Pages: 35240-50

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009

    • Author(s)
      Nishikimi A, et al
    • Journal Title

      Science 324

      Pages: 384-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Id2- RORγt-, and LTβR- independent lymphoid organogenesis in ocular immunity2009

    • Author(s)
      Nagatake T, et al
    • Journal Title

      Journal of Experimental Medicine 206

      Pages: 2351-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DOCK2 and DOCK180 in fetal thymus colonization2009

    • Author(s)
      Lei Y, et al
    • Journal Title

      European journal of immunology 39

      Pages: 2695-702

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCL21 mediates CD4+ T cell costimulation via a DOCK2/ Rae-dependent pathway2009

    • Author(s)
      Gollmer K, et al
    • Journal Title

      Blood 114

      Pages: 580-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009

    • Author(s)
      Nishikimi A, et.al.
    • Journal Title

      Science 324

      Pages: 384-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice2008

    • Author(s)
      Matsushima K(著者11名、11番目)
    • Journal Title

      Blood

      Volume: 111(12) Pages: 5457-5466

    • DOI

      10.1182/blood-2009-11-253559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine -mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.2008

    • Author(s)
      Matsushima K (著者11名、11番目)
    • Journal Title

      Blood. 111(12)

      Pages: 5457-5466

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice2008

    • Author(s)
      Sawanobori Y, et.al.
    • Journal Title

      Blood 111

      Pages: 5457-5466

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine luous2008

    • Author(s)
      Abe J, et.al.
    • Journal Title

      Am J Pathol 173

      Pages: 1682-1692

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells intumor-bearing mice.2008

    • Author(s)
      Sawanobori Y, et. al.
    • Journal Title

      Blood (印刷中)掲載確定

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock22007

    • Author(s)
      Fukui Y(著者13名、13番目)
    • Journal Title

      Nat. Immunol.

      Volume: 8 Pages: 1067-1075

    • DOI

      10.1038/ni1506

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules.2007

    • Author(s)
      Ueha S, et. al.
    • Journal Title

      J Leukoc Biol. 82

      Pages: 1230-1238

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2.2007

    • Author(s)
      Tanaka Y, et. al.
    • Journal Title

      Nature Immunology 8

      Pages: 1067-1075

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Delayed and aberrant immune reconstitution due to destruction of hematological and immunological niches in the acute and chronic phases of GVHD2011

    • Author(s)
      MATSUSHIMA Kouji
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ、千葉(招待講演)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lymph node graft-versus host disease : CD8+ T cell-mediated destruction of lymph nodes after allogeneic hematopoietic stem cell transplantation2011

    • Author(s)
      SUENAGA Fumiko
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ、千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration2011

    • Author(s)
      TSUKUI Tatsuya
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ、千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cognate and non-cognate B cells mediate the remodeling of lymph node medulla that contributes to antibody response2011

    • Author(s)
      ABE Jun
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ、千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of phospholipid in DOCK family protein-mediated cellular functions2011

    • Author(s)
      FUKUI Yoshinori
    • Organizer
      第10回日本生化学会JBSバイオフロンティアシンポジウム
    • Place of Presentation
      Hotel Luigans、福岡(招待講演)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bone marrow graft-versus-host disease : immune attack to osteoblastic hematopoietic niche after allogeneic hematopoietic stem cell tansplantation2011

    • Author(s)
      UEHA Satoshi
    • Organizer
      19th International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      全日空ゲートタワーホテル大阪、大阪(招待講演)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immune regulatory functions of DOCK2 in health and disease2011

    • Author(s)
      Fukui Y
    • Organizer
      ESF-JSPS Frontier Science Conference Series for Young Researchers
    • Place of Presentation
      Amsterdam, Nederland
    • Year and Date
      2011-03-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immune regulatory functions of DOCK2 in health and disease2011

    • Author(s)
      Fukui Y
    • Organizer
      ESF-JSPS Frontier Science Conference Series for Young Researchers
    • Place of Presentation
      Amsterdam、オランダ
    • Related Report
      2011 Final Research Report
  • [Presentation] Depletion of allo-CD4 T cells protects hematopoietic niche while preserves graft-versus-tumor effects after allo-HSCT2010

    • Author(s)
      UEHA Satoshi, et al.
    • Organizer
      The 69th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Osaka, Japan (Osaka International Convention Center)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemokines as therapeutic targets of inflammatory diseases and cancer2010

    • Author(s)
      Matsushima K
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸ポートピアホテル、兵庫県
    • Year and Date
      2010-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemokines as therapeutic targets of inflammatory diseases and cancer2010

    • Author(s)
      Matsushima Kouji
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamics of CCR7+ tumor-infiltrating dendritic cells that regulate anti-tumor immune responses2010

    • Author(s)
      UEHA Satoshi
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemokine receptor CXCR3 regulates the generation of memory CTL2010

    • Author(s)
      Kurachi Makoto
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] The 5' -end transcriptome and methylome in murine memory CD4+ T cells2010

    • Author(s)
      Hashimoto Shinichi
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exploring molecule(s) responsible for CD8+ T cell memory senescence upon repeated antigenic challenges2010

    • Author(s)
      Kajiro Kouji
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bone marrow graft-versus-host disease does not require allogeneic MHC class II expression on host bone marrow stroma2010

    • Author(s)
      Wang Yong
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] B cells mediate the formation of a scaffold for antibody response in lymph nodes through medullary remodeling2010

    • Author(s)
      Abe Jun
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan (Kobe Convention Center)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Destruction of Bone Marrow Osteoblastic Niche for Hematopoiesis Mediated by Donor CD4 T Cells after Allogeneic Hematopoietic Stem Cell Transplantation.2010

    • Author(s)
      UEHA Satoshi
    • Organizer
      3^<rd> International Conference on Osteoimmunology
    • Place of Presentation
      Santorini, Greece
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] DynamicsofCCR7+tumor-infiltratingdendriticcellsthatregulate anti-tumor immune responses2010

    • Author(s)
      UEHA Satoshi
    • Organizer
      18th International Symposium on Molecular Cell Biology of Macrophages 2010
    • Place of Presentation
      Kumamoto, Japan (Parea Kumamoto)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of CCR7^+MHC class II^<hi> dendritic cells in mousetumor2010

    • Author(s)
      上羽悟史
    • Organizer
      Keystone symposia
    • Place of Presentation
      Keystone Resort(USA)
    • Year and Date
      2010-02-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells2010

    • Author(s)
      後藤和人
    • Organizer
      The 5^<th> Global COE International Symposium
    • Place of Presentation
      Singapore
    • Related Report
      2009 Annual Research Report
  • [Presentation] CDMファミリー分子を介した細胞運動の制御とその機能的意義2010

    • Author(s)
      福井宣規
    • Organizer
      がん特定研究5領域合同シンポジウム
    • Place of Presentation
      学術総合センター一橋記念講堂(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Medullary Remodeling in the Formation of Plasma Cell Niche in Lmyph Nodes2009

    • Author(s)
      阿部淳
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic regulation of tumor-infiltrating myeloid-cells by chemokines2009

    • Author(s)
      上羽悟史
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫系細胞高次機能を司るCDMファミリー分子DOCK2(その分子基盤と臨床応用の可能性)2009

    • Author(s)
      福井宣規
    • Organizer
      第1回膜生物学Global COE Students-Organized Symposium
    • Place of Presentation
      神戸大学医学部新緑会館多目的ホール(兵庫)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of CCR7^+MHC class II^<hi> dendritic cells in mousetumor2009

    • Author(s)
      上羽悟史
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] CHEMOKINE-MEDIATED RAPID TURNOVER OF INFLAMMATION-ASSOCIATED MACROPHAGES AND NEUTROPHILS IN TUMOR-BEARING MICE2009

    • Author(s)
      上羽悟史
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Medullary Islets : Possible Niche for the Differentiation and of Plasma Cells in the Reactive Lymph Nodes2009

    • Author(s)
      阿部淳
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2009-07-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemokines: From discovery to clinical development.2009

    • Author(s)
      Matsushima K
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2009-07-06
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Identification of CCR7^+MHC class II^<hi> dendritic cells in mousetumor2009

    • Author(s)
      上羽悟史
    • Organizer
      第17回マクロファージ分子細胞生物学国際シンポジウム
    • Place of Presentation
      金沢KKRホテル(石川)
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of CCR7^+MHC class II^<hi> dendritic cells in mousetumor2009

    • Author(s)
      上羽悟史
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 形質細胞様樹状細胞による1型インターフェロン産生におけるD0CK2の役割2009

    • Author(s)
      後藤和人
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical roles of the CDM family protein DOCK2 in the immune system2009

    • Author(s)
      福井宣規
    • Organizer
      The First CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Shanghai(中国)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫応答を司る免疫系受容体のメンブレントラフィックを介した時間的空間的制御2009

    • Author(s)
      田中芳彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism controlling intracellular DOCK2 dynamics during neutrophil chemotaxis2009

    • Author(s)
      Nishikimi A
    • Organizer
      The 5^<th> International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都大学医学部芝蘭会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice2008

    • Author(s)
      上羽悟史
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都市左京区・国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice2008

    • Author(s)
      上羽悟史
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市熱田区・名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] CTL一次応答による抗原特異的CTL応答の維持2007

    • Author(s)
      倉知 慎, 他
    • Organizer
      第37回日本免疫学会総会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Book] 改訂版 分子予防医学(分子予防環境医学会 編)2011

    • Author(s)
      松島 綱治(著者5名、1番目)
    • Publisher
      本の泉社
    • Related Report
      2011 Final Research Report
  • [Book] 分子予防環境医学2010

    • Author(s)
      分子予防環境医学研究会編
    • Total Pages
      850
    • Publisher
      本の泉社
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床粘膜免疫2010

    • Author(s)
      清野宏編
    • Total Pages
      736
    • Publisher
      シナジー
    • Related Report
      2010 Annual Research Report
  • [Book] 炎症・再生医学事典2009

    • Author(s)
      松島綱治・西脇徹 編
    • Publisher
      朝倉書店
    • Related Report
      2009 Self-evaluation Report
  • [Book] 炎症・再生医学事典2009

    • Author(s)
      松島綱治
    • Total Pages
      584
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Book] 免疫学イラストレイテッド2009

    • Author(s)
      福井宣規
    • Total Pages
      248
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.prevent.m.u-tokyo.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.prevent.m.u-tokyo.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 移植片対腫瘍効果を保存した免疫学的再構築促進剤または感染症予防剤2009

    • Inventor(s)
      松島綱治、上羽悟史、庄野雄介
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-01-04
    • Related Report
      2011 Final Research Report
    • Overseas

URL: 

Published: 2007-03-31   Modified: 2018-03-28  

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