Thymic microenvironments for shaping T cell repertoire

• Project Area: Immunological Self Recognition and its Disorders
• Project/Area Number: 19059010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokushima
• Principal Investigator: TAKAHAMA Yousuke 徳島大学, 疾患ゲノム研究センター, 教授 (20183858)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Mitsuru 徳島大学, 疾患酵素学研究センター, 教授 (60221595)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥184,500,000 (Direct Cost: ¥184,500,000); Fiscal Year 2011: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2010: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2009: ¥31,500,000 (Direct Cost: ¥31,500,000); Fiscal Year 2008: ¥31,500,000 (Direct Cost: ¥31,500,000); Fiscal Year 2007: ¥31,500,000 (Direct Cost: ¥31,500,000)
• Keywords: 免疫学 / 自己識別 / 自己寛容 / 胸腺 / 胸腺微少環境 / 胸腺上皮細胞 / 胸腺プロテアソーム / β5t / Aire / RANKL / CCL21 / XCL1 / 胸腺微小環境 / 生命システム形成 / AIRE / Tリンパ球 / プロテアソーム

Research Abstract

Ｔ lymphocytes are the cells that play an essential role in distinguishing non-self from self. T lymphocytes acquirｅ this ability through shaping a ｒｅｐｅｒtｏirｅ of recognition specificity ｄｕring the development in the thymus. However, how T lymphocytes are generated and selected in the thymus is still not well understood. This study identified (1) chemokines that are produced by thymic medullary epithelial cells and are essential for establishment of sｅlf-tolerance, (2) cytokines that are essential for the growth and development of thymic medullary epithelial cells, (3) proteasomes that are ｅxpressed in thymic cortical epithelial cells and are essential for positive selection of immunocompetent CD8 T lymphocytes. In addition, (4) we revealed that Airｅ regulates the development of thymic medullary epithelial cells, and (5) we begun the analysis how medullary and cortical　thymic epithelial cells are generated from common epithelial progenitor cells.

Research Products

• [Journal Article] Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium (2012)
  • Author(s): Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G
  • Journal Title: Immunity Volume: 36 Issue: 3 Pages: 427-437
  • DOI: 10.1016/j.immuni.2012.01.016
  • Peer Reviewed
• [Journal Article] Thymic epithelial cells : working class heroes for T cell development and repertoire selection (2012)
  • Author(s): Anderson G
  • Journal Title: Trends in Immunology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Beta5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells (2012)
  • Author(s): Takahama Y
  • Journal Title: Current Opinion in Immunology Volume: 24 Issue: 1 Pages: 92-98
  • DOI: 10.1016/j.coi.2012.01.006
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• [Journal Article] XCL1 and XCR1 in the immune system (2012)
  • Author(s): Lei Y
  • Journal Title: Microbes and Infection Volume: 14 Issue: 3 Pages: 262-267
  • DOI: 10.1016/j.micinf.2011.10.003
  • Peer Reviewed
• [Journal Article] CCR7 with S1P1 signaling through AP1 for migration of Foxp3+ regulatory T cells controls autoimmune exocrinopathy (2012)
  • Author(s): Ishimaru N
  • Journal Title: American Journal of Pathology Volume: 180 Issue: 1 Pages: 199-208
  • DOI: 10.1016/j.ajpath.2011.09.027
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• [Journal Article] Parkin interacts with Klokinl for mitochondrial import and maintenance of membrane potential (2012)
  • Author(s): Kuroda Y
  • Journal Title: Human Molecular Genetics Volume: Vol.21 Issue: 5 Pages: 991-1003
  • DOI: 10.1093/hmg/ddr530
  • Peer Reviewed
• [Journal Article] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development (2011)
  • Author(s): Lei Y, Mat Ripen A, Ishimaru N, Ohigashi T, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y
  • Journal Title: J Exp Med. Volume: 208 Issue: 2 Pages: 383-394
  • DOI: 10.1084/jem.20102327
  • Peer Reviewed
• [Journal Article] Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t (2011)
  • Author(s): Mat Ripen A
  • Journal Title: European Journal of Immunology Volume: 41 Issue: 5 Pages: 1278-1287
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  • Peer Reviewed
• [Journal Article] Effects of RANKL on the thymic medulla (2011)
  • Author(s): Ohigashi I
  • Journal Title: European Journal of Immunology Volume: 41 Issue: 7 Pages: 1822-1827
  • DOI: 10.1002/eji.201141480
  • Peer Reviewed
• [Journal Article] Medullary interplay for central tolerance (2011)
  • Author(s): Takahama Y
  • Journal Title: Blood Volume: 118 Issue: 9 Pages: 2380-2381
  • DOI: 10.1182/blood-2010-07-293860
  • Peer Reviewed
• [Journal Article] Cytokine crosstalk for thymic medulla formation (2011)
  • Author(s): Nitta T
  • Journal Title: Current Opinion in Immunology Volume: 23 Issue: 2 Pages: 190-197
  • DOI: 10.1016/j.coi.2010.12.002
  • Peer Reviewed
• [Journal Article] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri Y
  • Journal Title: Journal of Immunology Volume: 186 Issue: 9 Pages: 5047-5057
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• [Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking (2011)
  • Author(s): Fukui R
  • Journal Title: Immunity Volume: 35 Issue: 1 Pages: 69-81
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• [Journal Article] Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit β5t (2011)
  • Author(s): Mat Ripen A, et al.
  • Journal Title: European Journal of Immunology Volume: (In press)
• [Journal Article] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla (2011)
  • Author(s): Matsumoto, M.
  • Journal Title: European Journal of Immunology Volume: 41 Pages: 12-17
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• [Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance (2011)
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  • Journal Title: Journal of Investigative Dermatology Volume: 131 Pages: 410-417
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• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. (2010)
  • Author(s): Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y
  • Journal Title: Immunity Volume: 32 Issue: 1 Pages: 29-40
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• [Journal Article] Biphasic Aire ｅxpression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation. (2010)
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  • Journal Title: J Exp Med. Volume: 207 Issue: 5 Pages: 963-971
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• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells (2010)
  • Author(s): Nitta T, et al.
  • Journal Title: Immunity Volume: 32 Pages: 29-40
  • Peer Reviewed
• [Journal Article] Role of thymic cortex-specific self-peptides in positive selection of T cells (2010)
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  • Journal Title: Seminars in Immunology Volume: 22 Pages: 287-293
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• [Journal Article] Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells (2010)
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  • Journal Title: Journal of Immunology Volume: 185 Pages: 4769-4776
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• [Journal Article] Another zinc finger in the pie of CD4-CD8 lineage choice (2010)
  • Author(s): Takada K, Takahama Y.
  • Journal Title: Nature Immunology Volume: 11 Pages: 370-371
  • Peer Reviewed
• [Journal Article] Undiminished regulatory T cells in the thymus of patients with myasthenia gravis (2010)
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  • Journal Title: Neurology Volume: 74 Pages: 816-820
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• [Journal Article] Differentiation of pharyngeal endoderm from mouse embryonic stem cells (2010)
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  • Journal Title: Stem Cells and Development Volume: 19 Pages: 1735-1743
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• [Journal Article] Identification of the transgenic integration site in immunodeficient tg ε 26 human CD3 ε transgenic mice (2010)
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  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy (2010)
  • Author(s): Ishimaru N, et al.
  • Journal Title: PLoS One Volume: 5
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• [Journal Article] Role of HIF-1 α in T cells as a negative regulator in development of vascular remodeling (2010)
  • Author(s): Kurobe H, et al.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 30 Pages: 210-217
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• [Journal Article] Critical function of death associated protein 3 in T cell receptor mediated-apoptosis induction (2010)
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  • Journal Title: Biochemical and Biophysical, Research Communications Volume: 395 Pages: 356-360
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• [Journal Article] Top three reasons to come to Kobe for the 14th International Congress of Immunology (2010)
  • Author(s): Takahama Y, Miyasaka M.
  • Journal Title: European Journal of Immunology Volume: 40 Pages: 10-11
• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. (2010)
  • Author(s): Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y.
  • Journal Title: Immunity 32 Pages: 29-40
  • NAID: 40017340869
  • Peer Reviewed
• [Journal Article] Another zinc finger in the pie of CD4-CD8 lineage choice (2010)
  • Author(s): Takada K, et al.
  • Journal Title: Nat Immunol. (In press)
  • Peer Reviewed
• [Journal Article] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Nishikawa Y, et al.
  • Journal Title: J Exp Med. (In press)
  • Peer Reviewed
• [Journal Article] Differentiation of pharyngeal endoderm from mouse embryonic stem cells (2010)
  • Author(s): Hidaka K, et al.
  • Journal Title: Stem Cells Dev. (In press)
  • Peer Reviewed
• [Journal Article] Undiminished regulatory T cells in the thymus of myasthenia gravis patients (2010)
  • Author(s): Matsui N, et al.
  • Journal Title: Neurology 74 Pages: 816-820
  • Peer Reviewed
• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells (2010)
  • Author(s): Nitta T, et al.
  • Journal Title: Immunity 32 Pages: 29-40
  • Peer Reviewed
• [Journal Article] Role of HIF-1α in T cells as a negative regulator in development of vascular remodeling (2010)
  • Author(s): Kurobe H, et al.
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology 30 Pages: 210-217
  • Peer Reviewed
• [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy (2010)
  • Author(s): Ishimaru N, et al.
  • Journal Title: PLoS One 5
  • Peer Reviewed
• [Journal Article] Top three reasons to come to Kobe for the 14th International Congress of Immunology (2010)
  • Author(s): Takahama Y, et al.
  • Journal Title: Eur J Immunol. 40 Pages: 10-11
  • Peer Reviewed
• [Journal Article] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens. (2009)
  • Author(s): Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y
  • Journal Title: Proc Natl Acad Sci USA. Volume: 106 Issue: 40 Pages: 17129-17133
  • DOI: 10.1073/pnas.0906956106
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• [Journal Article] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens. (2009)
  • Author(s): Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y
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  • Peer Reviewed
• [Journal Article] CCR7-mediated medulla migration of developing thymocytes is essential for negative selection to tissue-restricted antigens (2009)
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  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 17129-17133
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• [Journal Article] Gene expression profile of third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development (2009)
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  • Journal Title: Blood. 113 Pages: 2976-2987
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• [Journal Article] CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism (2009)
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  • Journal Title: J Immunol. 183 Pages: 3073-3080
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• [Journal Article] Role of DOCK2 and DOCK180 in fetal thymus colonization (2009)
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• [Journal Article] Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development (2009)
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• [Journal Article] The global thymus network : past, present, and future (2009)
  • Author(s): Takahama Y, et al.
  • Journal Title: Trends Immunol. 30 Pages: 191-192
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• [Journal Article] The role of autoimmune regulator (Aire) in the development of the immune system (2009)
  • Author(s): Matsumoto M.
  • Journal Title: Microbes Infect. 11 Pages: 928-934
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• [Journal Article] Gene expression profile of third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development (2009)
  • Author(s): Sultana DA, et.al.
  • Journal Title: Blood 113 Pages: 2976-2987
  • Peer Reviewed
• [Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. (2008)
  • Author(s): Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y
  • Journal Title: Immunity Volume: 29 Issue: 3 Pages: 438-450
  • DOI: 10.1016/j.immuni.2008.06.018
  • Peer Reviewed
• [Journal Article] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. (2008)
  • Author(s): Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima, D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Inoue J
  • Journal Title: Immunity Volume: 29 Issue: 3 Pages: 423-437
  • DOI: 10.1016/j.immuni.2008.06.015
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• [Journal Article] Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. (2008)
  • Author(s): Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Hollander GA, Reith W
  • Journal Title: Immunity Volume: 29 Issue: 3 Pages: 451-463
  • DOI: 10.1016/j.immuni.2008.08.007
  • Peer Reviewed
• [Journal Article] Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. (2008)
  • Author(s): Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M.
  • Journal Title: J Exp Med. Volume: 205 Issue: 12 Pages: 2827-2838
  • DOI: 10.1084/jem.20080046
  • NAID: 40016843480
  • Peer Reviewed
• [Journal Article] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. (2008)
  • Author(s): Matsumoto M, Zhou Y, Matsuo S, Nakanishi H, Hirose K, Oura H, Arase S, Ishida-Yamamoto A, Bando Y, Izumi K, Kiyonari H, Oshima N, Nakayama R, Matsushima A, Hirota F, Mouri Y, Kuroda N, Sano S, Chaplin DD.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 105 Issue: 18 Pages: 6720-6724
  • DOI: 10.1073/pnas.0709345105
  • Peer Reviewed
• [Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. (2008)
  • Author(s): Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.
  • Journal Title: Immunity 29 Pages: 438-450
  • Peer Reviewed
• [Journal Article] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. (2008)
  • Author(s): Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima, D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J.
  • Journal Title: Immunity. 29 Pages: 423-437
  • Peer Reviewed
• [Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator (2008)
  • Author(s): Hikosaka Y, et.al.
  • Journal Title: Immunity 29 Pages: 438-450
  • Peer Reviewed
• [Journal Article] Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity (2008)
  • Author(s): Irla M, et.al.
  • Journal Title: Immunity 29 Pages: 451-463
  • Peer Reviewed
• [Journal Article] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance (2008)
  • Author(s): Akiyama T, et.al.
  • Journal Title: Immunity 29 Pages: 423-437
  • Peer Reviewed
• [Journal Article] WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cellcycle progression, and teleost organ development (2008)
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  • Journal Title: PLoS Genetics 4
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• [Journal Article] One small step for immunologists (2008)
  • Author(s): Takahama Y, et.al.
  • Journal Title: European Journal of Immunology 38 Pages: 2056-2057
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• [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation (2008)
  • Author(s): Takahama Y, et.al.
  • Journal Title: Trends in Immunology 29 Pages: 251-255
  • Peer Reviewed
• [Journal Article] Thymic microenvironments for T-cell repertoire formation (2008)
  • Author(s): Nitta T, et.al.
  • Journal Title: Advances in Immunology 99 Pages: 59-94
  • Peer Reviewed
• [Journal Article] Thymoproteasome : probable role in generating positively selecting peptides (2008)
  • Author(s): Murata S, et.al.
  • Journal Title: Current Opinion in Immunology 20 Pages: 192-196
  • Peer Reviewed
• [Journal Article] Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance (2008)
  • Author(s): Yano M, et.al.
  • Journal Title: Journal of Experimental Medicine 205 Pages: 2827-2838
  • Peer Reviewed
• [Journal Article] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology (2008)
  • Author(s): Matsumoto M, et.al.
  • Journal Title: Proceedings of National Academy of Science USA 105 Pages: 6720-6724
  • Peer Reviewed
• [Journal Article] Regulation of CD8+ T cell development by thymus-specific proteasomes (2007)
  • Author(s): Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K.
  • Journal Title: Science Volume: 316 Issue: 5829 Pages: 1349-1353
  • DOI: 10.1126/science.1141915
  • Peer Reviewed
• [Journal Article] Regulation of CD8+T cell development by thymus-specificproteasomes (2007)
  • Author(s): Shigeo Murata
  • Journal Title: Science 316 Pages: 1349-1353
  • Peer Reviewed
• [Journal Article] Keratinocyte growth factor enhances post-natal T cell developmentviaimprovement in proliferation and function ofthymic epithelialcells (2007)
  • Author(s): Simona W. Rossi
  • Journal Title: Blood 109 Pages: 3803-3811
  • Peer Reviewed
• [Journal Article] Chemokines CCL19 and CCL21 promote activation-induced cell deathof antigen-responding T cells (2007)
  • Author(s): Takuwa Yasuda
  • Journal Title: Blood 109 Pages: 449-456
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• [Journal Article] The lymphocyte guard-IANs: regulation of lymphocyte survival byIAN/GIMAP family proteins (2007)
  • Author(s): Takeshi Nitta
  • Journal Title: Trends in Immunology 28 Pages: 58-65
  • Peer Reviewed
• [Journal Article] Noninvasive intravital imaging ofthymocyte dynamics in medaka (2007)
  • Author(s): Jie Li
  • Journal Title: Journal of Immunology 179 Pages: 1605-1615
  • Peer Reviewed
• [Journal Article] Chemokine receptor eχpression defines heterogeneity in theearliestthymic migrants (2007)
  • Author(s): William E. Jenkinson
  • Journal Title: European Journal of Immunology 37 Pages: 2090-2096
  • Peer Reviewed
• [Journal Article] Japanese Society for Immunology goes public: immunology outreach in Japan (2007)
  • Author(s): Yousuke Takahama
  • Journal Title: European Journal of Immunology 37 Pages: 1717-1719
  • Peer Reviewed
• [Journal Article] Development of an automated SNP analysis method using aparamagnetic beads handling robot (2007)
  • Author(s): Hiroko Hagiwara
  • Journal Title: Biotechnology and Bioengineering 98 Pages: 420-428
  • Peer Reviewed
• [Journal Article] Autoimmime regulator functions in autoimmunity control (2007)
  • Author(s): Mitsuru Matsumoto
  • Journal Title: Expert Review of Clinical Immunology 3 Pages: 891-900
  • Peer Reviewed
• [Presentation] Role of Hypoxia-Inducible Fetor1α in Macrophage as an aggravation regulator in development of vascular remodeling (2012)
  • Author(s): Taisuke Nakayama
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡サンパレス(福岡県)
  • Year and Date: 2012-03-18
• [Presentation] T lymphocyte repertoire formation in thymic microenvironments. (2012)
  • Author(s): Takahama Y.
  • Organizer: 5th Congress of the Federation of Immunological Societies of Asia Oceania.
  • Place of Presentation: インド, ニューデリー[招待講演]
  • Year and Date: 2012-03-15
• [Presentation] T lymphocyte repertoire formation in thymic microenvironments (2012)
  • Author(s): Yousuke Takahama
  • Organizer: 5th Congress of the Federation of Immunological Societies of Asia Oceania
  • Place of Presentation: Hotel Le Meridien(インド ニューデリー)(招待講演)
  • Year and Date: 2012-03-15
• [Presentation] Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells (2012)
  • Author(s): Nishijima H
  • Organizer: 4th International Conference on Drug Discovery&Therapy
  • Place of Presentation: United Arab Emirates(ドバイ)
  • Year and Date: 2012-02-13
• [Presentation] Thymic microenvironment and repertoire selection of T cells (2012)
  • Author(s): Yousuke Takahama
  • Organizer: New Horizons in the Immune System
  • Place of Presentation: 徳島大学(徳島県)(招待講演)
  • Year and Date: 2012-02-09
• [Presentation] マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺上皮性腫瘍解析法開発 (2012)
  • Author(s): 中川靖士
  • Organizer: 第31回日本胸腺研究会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2012-02-04
• [Presentation] Molecular Biology of Thymic Microenvironments (2011)
  • Author(s): Yousuke Takahama
  • Organizer: The 2011 CSI/FIMSA (3rd CSI) Advanced Course on Immunology
  • Place of Presentation: 北京大学(中国北京)(招待講演)
  • Year and Date: 2011-12-10
• [Presentation] Expression of Aire, a gene responsible for autoimmune disease, in ES cells (2011)
  • Author(s): Matsumoto M
  • Organizer: Cell Symposia : Stem Cell Programming & Reprogramming
  • Place of Presentation: Sheraton Lisboa Hotel and Spa(ポルトガルLisbon)
  • Year and Date: 2011-12-09
• [Presentation] 胸腺上皮細胞株におけるbeta5サブユニットの発現プロファイル (2011)
  • Author(s): Michiyuki Kasai
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Presentation] マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み (2011)
  • Author(s): Yasushi Nakagawa
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Presentation] IAN4とIAN5はT細胞のTCRを介した生存維持の制御に重要である (2011)
  • Author(s): Kouta Yano
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Presentation] Lympho-epithelial complexes in the thymic cortex (2011)
  • Author(s): Takeshi Nitta
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-28
• [Presentation] β5t欠損マウスにおける末梢CD8T細胞の解析 (2011)
  • Author(s): Kensuke Takada
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-28
• [Presentation] 免疫不全を呈するヒトCD3εトランスジェニックマウス系統tgε26におけるトランスジーン挿入部位の同定 (2011)
  • Author(s): Izumi Ohigashi
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance (2011)
  • Author(s): Matsumoto M
  • Organizer: 5th Asian Congress on Autoimmunity
  • Place of Presentation: Suntec Singapore(シンガポール)
  • Year and Date: 2011-11-19
• [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process (2011)
  • Author(s): Matsumoto M
  • Organizer: 5th International Conference on Autoimmunity : Mechanisms and Novel Treatments
  • Place of Presentation: Aldemar Knossos Village(ギリシャCrete)
  • Year and Date: 2011-09-24
• [Presentation] 胸腺プロテアソーム非依存的に分化したCD8T細胞の機能解析 (2011)
  • Author(s): 高田健介
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(大阪府)
  • Year and Date: 2011-09-19
• [Presentation] 胸腺の機能 (2011)
  • Author(s): 高浜洋介
  • Organizer: 2011 Tokushima Bioscience Retreat
  • Place of Presentation: リゾートホテルオリビアン(香川県)(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] 中枢性免疫寛容と自己免疫疾患 (2011)
  • Author(s): 高浜洋介
  • Organizer: 第35回阿蘇シンポジウム
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル(熊本県)(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] 胸腺プロテアソーム構成因子β5t欠損マウスに認められるメモリー様CD8T細胞 (2011)
  • Author(s): 高田健介
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-06-11
• [Presentation] 胸腺皮質上皮細胞と胸腺細胞の多細胞複合体 (2011)
  • Author(s): 新田剛
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-06-11
• [Presentation] マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み (2011)
  • Author(s): 中川靖士
  • Organizer: 第10回四国免疫フォーラム
  • Place of Presentation: 徳島大学(徳島県)
  • Year and Date: 2011-06-04
• [Presentation] Cytokine circuit that regulates T cell repertoire formation (2011)
  • Author(s): Yousuke Takahama
  • Organizer: JSICR-MMCB2011
  • Place of Presentation: ANAゲートタワーホテル(大阪府)(招待講演)
  • Year and Date: 2011-05-25
• [Presentation] Memory-like phenotype of CD8 T cells in β 5t-deficient mice (2011)
  • Author(s): Kensuke Takada
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Centre(オランダLeeuwenhorst)
  • Year and Date: 2011-05-24
• [Presentation] Chemokine regulation of central tolerance (2011)
  • Author(s): Yousuke Takahama
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Centre(オランダLeeuwenhorst)(招待講演)
  • Year and Date: 2011-05-22
• [Presentation] Maturation Of Intrathymic Dendritic Epidermal T-cell Progenitors And Aire-Expressing Medullary Epithelial Cells Are Reciprocally Linked (2011)
  • Author(s): Graham Anderson
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Centre(オランダLeeuwenhorst)(招待講演)
  • Year and Date: 2011-05-22
• [Presentation] Dicer-dependent miRNA are required for the postnatal maintenance of the thymic epithelial microenvironment (2011)
  • Author(s): Saulius Zuklys
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Centre(オランダLeeuwenhorst)(招待講演)
  • Year and Date: 2011-05-22
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance (2011)
  • Author(s): Matsumoto M
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Centre(オランダLeeuwenhorst)
  • Year and Date: 2011-05-22
• [Presentation] 生命科学の将来に向けたマスタープラン (2011)
  • Author(s): 山本格
  • Organizer: 日本学術会議生命科学系シンポジウム
  • Place of Presentation: 日本学術会議(東京都)
  • Year and Date: 2011-05-19
• [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri Y
  • Organizer: 13^<th> International TNF Conference, TNF 2011
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
  • Year and Date: 2011-05-16
• [Presentation] Mechanisms to establish self-tolerance in the thymic medulla (2011)
  • Author(s): Yousuke Takahama
  • Organizer: Lymphocyte development and autoimmunity
  • Place of Presentation: ルンド大学(フィンランド)
  • Year and Date: 2011-03-07
• [Presentation] Thymic microenvironments that shape T lymphocyte repertoire (2011)
  • Author(s): Yousuke Takahama
  • Organizer: 日本-欧州先端科学セミナーCutting Edge Immunology and its Clinical Application
  • Place of Presentation: Apollo Hotel de Beyaerd(オランダ)
  • Year and Date: 2011-03-02
• [Presentation] 「胸腺ナース細胞」型多細胞複合体のT細胞レパトア選択における役割 (2011)
  • Author(s): 新田剛
  • Organizer: 第30回日本胸腺研究会
  • Place of Presentation: 長崎大学(長崎市)
  • Year and Date: 2011-02-05
• [Presentation] マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺解析法開発の試み (2011)
  • Author(s): 中川靖士
  • Organizer: 第30回日本胸腺研究会
  • Place of Presentation: 長崎大学(長崎市)
  • Year and Date: 2011-02-05
• [Presentation] RANKL promotes thymic medulla formation (2010)
  • Author(s): Izumi Ohigashi
  • Organizer: The 2nd Workshop of Synthetic Immunology
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2010-12-17
• [Presentation] 胸腺特異的プロテアソームの発現制御機構の解析 (2010)
  • Author(s): 中山知美
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-10
• [Presentation] T細胞レパトア選択における胸腺皮質上皮細胞の役割 (2010)
  • Author(s): 新田剛
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-09
• [Presentation] 細胞内GTP結合タンパク質IAN4とIAN5はリンパ球の生存制御因子である (2010)
  • Author(s): 矢野弘太
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-09
• [Presentation] T-cell repertoire formation in the thymus (2010)
  • Author(s): Takahama Y.
  • Organizer: Cold Spring Harbor Asia Conferences -Frontiers of Immunology in Health and Diseases-
  • Place of Presentation: 中国蘇州[招待講演]
  • Year and Date: 2010-11-09
• [Presentation] T-cell repertoire formation in the thymus (2010)
  • Author(s): Yousuke Takahama
  • Organizer: Cold Spring Harbor Asia Conferences-Frontiers of Immunology in Health and Diseases-
  • Place of Presentation: 蘇州(中国)
  • Year and Date: 2010-11-09
• [Presentation] 乳児期早期胸腺全摘出が起こす術後免疫学的問題点とその対策 (2010)
  • Author(s): 黒部裕嗣
  • Organizer: 第63回日本胸部外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-10-26
• [Presentation] Critical signaling pathway via CCR7 of Foxp3+CD25+CD4+regulatory T cells for the egress from lymphnodes (2010)
  • Author(s): Naozumi Ishimaru
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-26
• [Presentation] Roles of thymic epithelial cells for the establishment of self-tolerance (2010)
  • Author(s): Mitsuru Matsumoto
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-26
• [Presentation] Kruppel-like factor 2 is dispensable for the quiescence of post-activated T cells (2010)
  • Author(s): Kensuke Takada
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-25
• [Presentation] Complete thymectomy at neonatal cardiac surgery reduces circulating T cells (2010)
  • Author(s): Hirotsugu Kurobe
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議揚(神戸市)
  • Year and Date: 2010-08-25
• [Presentation] Dicer is required for the postnatal maintenance of the thymic epithelial microenvironment (2010)
  • Author(s): Saulius Zuklys
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-25
• [Presentation] Role of cortical thymic epithelial cells in positive selection of T cells (2010)
  • Author(s): Takeshi Nitta
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells (2010)
  • Author(s): Yu Lei
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Thymic microenvironments that shape T cell repertoire (2010)
  • Author(s): Takahama Y.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸[招待講演]
  • Year and Date: 2010-08-23
• [Presentation] Thymic microenvironments that shape T cell repertoire (2010)
  • Author(s): Yousuke Takahama
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Undiminished Regulatory T Cells in the Thymus of Myasthenia Gravis Patients (2010)
  • Author(s): Naoko Matsui
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Yumiko Nishikawa
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] IAN4とIAN5はリンパ球の生存調節因子である (2010)
  • Author(s): 矢野弘太
  • Organizer: 第9回四国免疫フォーラム
  • Place of Presentation: 愛媛大学(東温市)
  • Year and Date: 2010-06-19
• [Presentation] T細胞レパトア選択における胸腺皮質上皮細胞の役割 (2010)
  • Author(s): 新田剛
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2010-06-04
• [Presentation] 胸腺プロテアソーム構成因子β5t非依存的に分化したCD8T細胞の抗原特異性 (2010)
  • Author(s): 高田健介
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2010-06-04
• [Presentation] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells (2010)
  • Author(s): Yu Lei
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2010-06-04
• [Presentation] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells (2010)
  • Author(s): Takahama Y.
  • Organizer: Gordon Research Conference on Chemotactic Cytokines
  • Place of Presentation: イタリア, ルッカ[招待講演]
  • Year and Date: 2010-06-01
• [Presentation] XCL1 regulates medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells (2010)
  • Author(s): Yousuke Takahama
  • Organizer: Gordon Research Conferences
  • Place of Presentation: ルッカ(イタリア)
  • Year and Date: 2010-06-01
• [Presentation] 胸腺におけるT細胞選択と自己免疫疾患 (2010)
  • Author(s): 高浜洋介
  • Organizer: 第5回小児重症筋無力症研究会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 2010-05-22
• [Presentation] AIRE and autoimmune disease (2010)
  • Author(s): Mitsuru Matsumoto
  • Organizer: 19th International Rheumatology Symposium
  • Place of Presentation: 神戸ポートピアホテル(神戸市)
  • Year and Date: 2010-04-23
• [Presentation] 血管リモデリング時の転写因子HIF-1αの役割 (2010)
  • Author(s): 黒部裕嗣
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2010-04-10
• [Presentation] 胸腺の構築 (2010)
  • Author(s): 高浜洋介
  • Organizer: 第1回Synthetic Immunology研究会
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2010-04-09
• [Presentation] Aire regulates XCL1-mediated medullary accumulation of thymic dendritic cells and thymic development of regulatory T cells (2010)
  • Author(s): Yousuke Takahama
  • Organizer: ThymOz International Conference VI
  • Place of Presentation: Gladstone, Australia
  • Year and Date: 2010-03-21
• [Presentation] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells (2010)
  • Author(s): Takeshi Nitta
  • Organizer: ThymOz International Conference VI
  • Place of Presentation: Gladstone, Australia
  • Year and Date: 2010-03-20
• [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Mitsuru Matsumoto
  • Organizer: ThymOz International Conference VI
  • Place of Presentation: Gladstone, Australia
  • Year and Date: 2010-03-19
• [Presentation] 自己免疫疾患と胸腺 (2010)
  • Author(s): 高浜洋介
  • Organizer: 第4回神奈川MGフォーラム
  • Place of Presentation: 横浜市
  • Year and Date: 2010-03-04
• [Presentation] 胸腺皮質上皮細胞の一部は「胸腺ナース細胞」である (2010)
  • Author(s): 新田剛
  • Organizer: 第29回日本胸腺研究会
  • Place of Presentation: 大阪大学(大阪市)
  • Year and Date: 2010-02-27
• [Presentation] マイクロアレイ解析による胸腺上皮細胞亜集団の新規分類法開発 (2010)
  • Author(s): 中川靖士
  • Organizer: 第29回日本胸腺研究会
  • Place of Presentation: 大阪大学(大阪市)
  • Year and Date: 2010-02-27
• [Presentation] Thymus-specific self-peptide repertoire shaped immunocompetent repertoire of T cells (2010)
  • Author(s): Yousuke Takahama
  • Organizer: International Symposium 2010 Cutting-edge Biomedical Research
  • Place of Presentation: 釜山大学(韓国釜山)
  • Year and Date: 2010-02-03
• [Presentation] 胸腺クロストークによるT細胞レパトア形成の制御 (2009)
  • Author(s): 新田剛
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-09
• [Presentation] 胸腺プロテアソームはCD8 T細胞の有用レパトア形成に必要である (2009)
  • Author(s): 新田剛
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-04
• [Presentation] Essential role of IAN4 and IAN5 in lymphocyte survival (2009)
  • Author(s): 矢野弘太
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-03
• [Presentation] ケモカインXCL1は胸腺樹状細胞の髄質集積と自己寛容誘導を制御する (2009)
  • Author(s): Yu Lei
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-03
• [Presentation] Thymus-specific self-peptide repertoirｅ shapes immunocompetent repertoire of T cells (2009)
  • Author(s): Takahama Y.
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪[招待講演]
  • Year and Date: 2009-12-02
• [Presentation] Thymus-specific self-peptide repertoire shapes immunocompetent repertoire of T cells (2009)
  • Author(s): Yousuke Takahama
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] Aire-dependent organization of thymic microenvironment (2009)
  • Author(s): Matsumoto M.
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes (2009)
  • Author(s): Mouri Y
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] マイクロアレイ解析による胸腺上皮細胞亜集団の新規分類法開発 (2009)
  • Author(s): 中川靖士
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] ヒトCD3εトランスジェニックマウスにおけるT細胞分化障害のHes5による回復 (2009)
  • Author(s): 大東いずみ
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] 臓器特異的自己免疫疾患における調節性T細胞の局在性 (2009)
  • Author(s): 石丸直澄
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] 胸腺プロロテアソーム構成鎖β5tの皮質上皮細胞特異的発現はFoxn1依存的であるが胸腺髄質形成に依存しない (2009)
  • Author(s): Adiratna Mat Ripen
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] 先天的遺伝子異常を伴った心疾患児心臓手術後の免疫動態の問題点について (2009)
  • Author(s): 黒部裕嗣
  • Organizer: 第62回日本胸部外科学会定期学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-10-13
• [Presentation] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells. (2009)
  • Author(s): Takahama Y.
  • Organizer: 2nd European Congress of Immunology
  • Place of Presentation: ドイツベルリン[招待講演]
  • Year and Date: 2009-09-14
• [Presentation] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells (2009)
  • Author(s): Yousuke Takahama
  • Organizer: 2nd European Congress of Immunology
  • Place of Presentation: International Congress Center (Berlin, Germany)
  • Year and Date: 2009-09-14
• [Presentation] 胸腺髄質上皮細胞機能的亜集団の分類および解析 (2009)
  • Author(s): 上野智雄
  • Organizer: 第8回四国免疫フォーラム
  • Place of Presentation: 香川大学(香川県木田郡)
  • Year and Date: 2009-06-27
• [Presentation] 術前遺伝子異常を伴った新生児・乳児における免疫能の検討～なぜ術前・術後に感染症が多いのか～ (2009)
  • Author(s): 黒部裕嗣
  • Organizer: 第52回関西胸部外科学会学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2009-06-05
• [Presentation] Positive selection by thymoproteasome-expressing thymic epithelial cells shapes immunocompetent repertoire of CD8 T cells (2009)
  • Author(s): Yousuke Takahama
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2009-06-03
• [Presentation] Analysis of thymic medullary epithelial cell subpopulations (2009)
  • Author(s): Tomoo Ueno
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2009-06-03
• [Presentation] Aire-dependent organization of thymic microenvironment (2009)
  • Author(s): Mitsuru Matsumoto
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2009-06-03
• [Presentation] Revisiting thymic nurse cells (2009)
  • Author(s): Takeshi Nitta
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2009-06-02
• [Presentation] 胸腺と自己免疫疾患 (2009)
  • Author(s): 高浜洋介
  • Organizer: 第50回日本神経学会
  • Place of Presentation: 仙台国際センター(仙台市)
  • Year and Date: 2009-05-22
• [Presentation] Foxnl is required for thymic vascularization (2009)
  • Author(s): Nancy R Manley
  • Organizer: The 96^<th> Annual Meeting of The American Association of Immunologists
  • Place of Presentation: Seattle, USA
  • Year and Date: 2009-05-11
• [Presentation] Elevated IL-17 detectable in the thymus of myasthenia gravis (2009)
  • Author(s): Naoko Matsui
  • Organizer: 2009 Annual Meeting of The American Academy of Neurology
  • Place of Presentation: Seattle, USA
  • Year and Date: 2009-04-27
• [Presentation] Roles of NIK in thymic epithelial cells for the establishment of central tolerance (2009)
  • Author(s): Mouri Y
  • Organizer: 12^<th> International TNF Conference
  • Place of Presentation: San Lorenzo de El Escorial (Madrid, Spain)
  • Year and Date: 2009-04-26
• [Presentation] 重症筋無力症患者に対する胸腺摘出術の予後と胸腺IL-17の解析 (2009)
  • Author(s): 松井尚子
  • Organizer: 第21回日本神経免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-13
• [Presentation] 重症筋無力症患者胸腺におけるFoxp 3とIL17の解析 (2009)
  • Author(s): 松井尚子
  • Organizer: 第28回日本胸腺研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-14
• [Presentation] 新生児期・乳児期早期の心臓手術に伴う胸腺切除が免疫能に及ぼす影響 (2009)
  • Author(s): 黒部裕嗣
  • Organizer: 第28回日本胸腺研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-14
• [Presentation] 正の選択によって胸腺細胞に発現するRANKLを介した胸腺髄質形成 (2009)
  • Author(s): 彦坂雄
  • Organizer: 第28回日本胸腺研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-14
• [Presentation] マウスES細胞からの咽頭内胚葉の分化 (2008)
  • Author(s): 日高京子
  • Organizer: 第31回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 胸腺プテアソームはCD8T細胞の「正の選択」を制御する (2008)
  • Author(s): 新田剛
  • Organizer: 第31回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 胸腺髄質上皮細胞亜集団における組織特異的抗原の発現機構 (2008)
  • Author(s): 上野智雄
  • Organizer: 第31回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 免疫細胞特異的GTP結合タンパク質IAN5はCD8T細胞の生存に必要である (2008)
  • Author(s): 矢野弘太
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] 胸腺樹状細胞の髄質集積はXCL1によって制御される (2008)
  • Author(s): 雷宇
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Notch 3によるtgε26マウスT細胞分化異常の回復 (2008)
  • Author(s): 大東いずみ
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 正の選択を受けた胸腺細胞によって産生されるRANKLがAIREの発現を含む胸腺髄質上皮細胞の増加をもたらす (2008)
  • Author(s): 彦坂雄
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 胸腺プロテアソームはCD8 T細胞の正の選択を制御する (2008)
  • Author(s): 新田剛
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Lymphotoxinは胸腺髄質上皮細胞のAire非依存性無差別遺伝子発現を制御する (2008)
  • Author(s): 上野智雄
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 胸腺プロテアソームβ5tの皮質上皮細胞における発現は胸腺細胞分化および髄質形成に依存しない (2008)
  • Author(s): Adiratna Mat Ripen
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Aire-dependent organization of thymic microenvironment (2008)
  • Author(s): 松本満
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 重症筋無力症の胸腺におけるIL-17上昇 (2008)
  • Author(s): 松井尚子
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Thymoproteasome governs positive selection of CD8 T cells (2008)
  • Author(s): Yousuke Takahama
  • Organizer: Thym US 2008
  • Place of Presentation: プエルトリコ
  • Year and Date: 2008-11-12
• [Presentation] RANKL produced by positively selected thymocytes fosters Aire + mTEC (2008)
  • Author(s): Takeshi Nitta
  • Organizer: Thym US 2008
  • Place of Presentation: プエルトリコ
  • Year and Date: 2008-11-10
• [Presentation] Aire controls the differentiation program of medullary thymic epithelial cells (2008)
  • Author(s): Mitsuru Matsumoto
  • Organizer: Thym US 2008
  • Place of Presentation: プエルトリコ
  • Year and Date: 2008-11-10
• [Presentation] Elevated detection of IL-17 in the thymus of myasthenia gravis (2008)
  • Author(s): Naoko Matsui
  • Organizer: 9th International Congress of Neuroimmunology
  • Place of Presentation: アメリカ
  • Year and Date: 2008-10-28
• [Presentation] RANK ligand produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. (2008)
  • Author(s): Takahama Y.
  • Organizer: 4th Congress of the Federation of Immunology Societies of Asia-Oceania
  • Place of Presentation: 台湾台北[招待講演]
  • Year and Date: 2008-10-18
• [Presentation] RANK ligand produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator (2008)
  • Author(s): Yousuke Takahama
  • Organizer: The 4th Congress of the Federation of Immunology Societies of Asia-Oceania
  • Place of Presentation: 台湾
  • Year and Date: 2008-10-18
• [Presentation] 胸腺プロテアソーム構成因子β5tの発現と機能の解析 (2008)
  • Author(s): Adiratna Mat Ripen
  • Organizer: 四国免疫フォーラム
  • Place of Presentation: 高知
  • Year and Date: 2008-06-21
• [Presentation] Lymphotoxin欠損マウスにおける胸腺ストロマ細胞の異常 (2008)
  • Author(s): 上野智雄
  • Organizer: 第18回KTCC学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-14
• [Presentation] 正の選択によって発現されるRANKLが胸腺髄質形成を制御する (2008)
  • Author(s): 彦坂雄
  • Organizer: 第18回KTCC学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-14
• [Presentation] 胸腺プロテアソーム構成因子β5tによる正の選択の制御 (2008)
  • Author(s): 新田剛
  • Organizer: 第18回KTCC学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-13
• [Presentation] Tge26マウスのT細胞初期分化異常とNotchシグナル (2008)
  • Author(s): 大東いずみ
  • Organizer: 第18回KTCC学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-13
• [Presentation] Pharyngeal endoderm development from embryonic stem cells (2008)
  • Author(s): Kyoko Hidaka
  • Organizer: International Society for Stem Cell Research Meeting
  • Place of Presentation: アメリカ
  • Year and Date: 2008-06-11
• [Presentation] Development of thymus and T lymphocytes in medaka (2008)
  • Author(s): 高浜洋介
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] 中枢性自己寛容と自己免疫疾患 (2008)
  • Author(s): 高浜洋介
  • Organizer: 第20回日本神経免疫学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 重症筋無力症患者胸腺における制御性T細胞とTh17細胞の解析 (2008)
  • Author(s): 松井尚子
  • Organizer: 第20回日本神経免疫学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] Tリンパ球レパトア形成の分子基盤 (2008)
  • Author(s): 高浜洋介
  • Organizer: 第3回産業医科大学大学院シンポジウム
  • Place of Presentation: 北九州
  • Year and Date: 2008-03-08
• [Presentation] Medaka ENU-mutagenesis for studying thymus development (2008)
  • Author(s): Norimasa Iwanami
  • Organizer: The54thNIBB Conference
  • Place of Presentation: 岡崎
  • Year and Date: 2008-02-27
• [Presentation] 乳児期早期心臓・大血管手術時の胸腺摘除による術後免疫細胞発生の検討 (2008)
  • Author(s): 黒部裕嗣
  • Organizer: 第27回日本胸腺研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-02-16
• [Presentation] 正の選択による胸腺髄質形成はRANKLシグナルによって制御される (2008)
  • Author(s): 彦坂 雄
  • Organizer: 第27回日本胸腺研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-02-16
• [Presentation] 重症筋無力症患者胸腺における制御性T細胞とTh17細胞の解析 (2008)
  • Author(s): 松井尚子
  • Organizer: 第27回日本胸腺研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-02-16
• [Presentation] The chemokine system in the construction and function of the thymus (2008)
  • Author(s): Takahama Y.
  • Organizer: Keystone Symposium on Chemokines and Chemokine Receptors
  • Place of Presentation: 米国, デンバー[招待講演]
  • Year and Date: 2008-01-14
• [Presentation] The chemokine system in the construction and function of the thymus. (2008)
  • Author(s): Takahama Y.
  • Organizer: Keystone Symposia
  • Place of Presentation: デンバー
  • Year and Date: 2008-01-14
• [Presentation] The chemokine system in the construction and function of the thymus (2008)
  • Author(s): Yousuke Takahama
  • Organizer: Keystone Symposium
  • Place of Presentation: 米国・デンバー
  • Year and Date: 2008-01-14
• [Presentation] Analysis of genes required for thymus organogenesis in medaka (2007)
  • Author(s): 岡田 稔
  • Organizer: 第30回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] RANKL mediates positive selection-induced medulla formation in the thymus (2007)
  • Author(s): 新田 剛
  • Organizer: 第30回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Regulation of CD8 T cell positive selection by thymus-specific proteasomes (2007)
  • Author(s): 村田茂穂
  • Organizer: 第30回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Lymphoid progenitor cells of tg ε 26 CD3 ε-transgenic mice are destined to become B cells even in the thymic environment and even in the presence of Notch signals (2007)
  • Author(s): Izumi Ohigashi
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] The role of HIF-1 in fetal thymus development (2007)
  • Author(s): Shuichi Hirai
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] CCR7-mediated medulla migration of developing thymocytes regulates negative selection to tissue-restricted antigens (2007)
  • Author(s): Takeshi Nitta
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Thymic microenvironments for shaping T-cell repertoire (2007)
  • Author(s): Takahama Y.
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京[招待講演]
  • Year and Date: 2007-11-21
• [Presentation] Thymic microenvironments for shaping T-cell repertoire (2007)
  • Author(s): Yousuke Takahama
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance (2007)
  • Author(s): Mitsuru Matsumoto
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Identification of genes responsible for defective thymus development in medaka (2007)
  • Author(s): Norimasa Iwanami
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Role of MafB in the development of the thymus (2007)
  • Author(s): Shuhei Tomita
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Selection signals that regulate medulla formation in the thymus (2007)
  • Author(s): Yu Hikosaka
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Thymic microenvironments and central tolerance (2007)
  • Author(s): Takahama Y.
  • Organizer: 13th International Congress of Immunology
  • Place of Presentation: ブラジル, リオデジャネイロ[招待講演]
  • Year and Date: 2007-08-22
• [Presentation] Thymic microenvironments and central tolerance (2007)
  • Author(s): Yousuke Takahama
  • Organizer: 13th International Congress of Immunology
  • Place of Presentation: ブラジル・リオデジャネイロ
  • Year and Date: 2007-08-22
• [Presentation] Transcriptional regulation in the thymus for the establishment of self-tolerance (2007)
  • Author(s): Mitsuru Matsumoto
  • Organizer: 13th International Congress of Immunology
  • Place of Presentation: ブラジル・リオデジャネイロ
  • Year and Date: 2007-08-21
• [Presentation] Non-invasive intra-vital imaging of thymocyte dynamics in medaka (2007)
  • Author(s): Norimasa Iwanami
  • Organizer: Model systems for infectious disease and cancer in zebrafish
  • Place of Presentation: オランダ・ライデン
  • Year and Date: 2007-07-17
• [Presentation] WDR55 is a regulator of ribosomal RNA processing essential for cell cycle progression and teleost thymus development (2007)
  • Author(s): Norimasa Iwanami
  • Organizer: The 5th European Zebrafish Genetics and Development Meeting
  • Place of Presentation: オランダ・アムステルダム
  • Year and Date: 2007-07-14
• [Presentation] 胸腺初期発生における低酸素応答の役割 (2007)
  • Author(s): 平井宗一
  • Organizer: 四国免疫フォーラム
  • Place of Presentation: 愛媛
  • Year and Date: 2007-07-14
• [Presentation] 髄質形成を担う「胸腺クロストーク」シグナル (2007)
  • Author(s): 彦坂 雄
  • Organizer: 四国免疫フォーラム
  • Place of Presentation: 愛媛
  • Year and Date: 2007-07-14
• [Presentation] 胸腺低形成変異体のゲノム網羅的収集から明らかになったWDR55の機能 (2007)
  • Author(s): 岩波礼将
  • Organizer: 第17回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2007-06-15
• [Presentation] 正の選択による胸腺髄質形成を担うTNFファミリー分子群 (2007)
  • Author(s): 新田 剛
  • Organizer: 第17回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2007-06-15
• [Presentation] 第三咽頭嚢発現遺伝子の探索から明らかになったMafBの胸腺発生への関与 (2007)
  • Author(s): 冨田修平
  • Organizer: 第17回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2007-06-15
• [Presentation] Lessons learned from ENU-mutagenized athymic medaka mutants (2007)
  • Author(s): Yousuke Takahama
  • Organizer: JSI-RCAI Immunology Workshop
  • Place of Presentation: 横浜
  • Year and Date: 2007-05-25
• [Presentation] Cortex-medulla microenvironments for thymocyte development (2007)
  • Author(s): Yousuke Takahama
  • Organizer: Rolduc Workshop on T Cell Biology
  • Place of Presentation: オランダ・ケルクラーデ
  • Year and Date: 2007-05-22
• [Book] 疾患モデルの作製と利用免疫疾患 (2011)
  • Author(s): 新田剛
  • Publisher: (株)エル・アイ・シー
• [Book] Basic Cell Culture Protocols, Fourth Edition (The development of T lymphocytes in fetal thymus organ culture) (2011)
  • Author(s): Nitta T, et al.
  • Publisher: Humana Press, Springer(In press)
• [Book] Systems Biology: The Challenge of Complexity. eds. Nakanishi S, Kageyama R, Watanabe D., Toward understanding how the immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments. (2009)
  • Author(s): Nitta T, Takahama Y.
  • Publisher: Springer
• [Book] Systems Biology: The Challenge of Complexity(Toward understanding how the immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments.) (2009)
  • Author(s): Nitta T, Takahama Y., Nakanishi S, Kageyama R, Watanabe D.
  • Publisher: Springer
• [Book] Systems Biology : The Challenge of Complexity(Toward understanding how the immune system establishes a diverseyet self-tolerant T-cell repertoire : stepwise roles of thymic microenvironments.) (2009)
  • Author(s): Takeshi Nitta
• [Book] Systems Biology (2009)
  • Author(s): Takeshi Nitta
  • Publisher: Springer
• [Book] 免疫学最新イラストレイテッド改訂第2版 (2009)
  • Author(s): 高浜洋介
  • Publisher: 羊土社
• [Book] 免疫の事典 (2009)
  • Author(s): 上野智雄
  • Publisher: 朝倉書店(印刷中)
• [Book] Effector CD4+ T Cells in Health and Disease., Development of helper and regulatory CD4+ T cells in the thymus. (2008)
  • Author(s): Liu C, Takahama Y.
  • Publisher: Transworld
• [Book] 改訂版抗体実験マニュアル (2008)
  • Author(s): 斉藤ふみ
  • Publisher: 羊土社
• [Book] Effector CD4+T Cells in Health and Disease, edited by S. Na and C.Venkataraman (2008)
  • Author(s): Cunlan Liu
  • Publisher: Transworld Research Network.
• [Remarks] 徳島新聞 免疫システム制御細胞生成メカニズム解明 20110507
• [Remarks] 日本経済新聞 キラーＴ細胞生成の酵素解明 20100530
• [Remarks] 朝日新聞 がん攻撃キラーＴ細胞生成のカギは胸腺内の酵素 20100126
• [Remarks] 読売新聞 自己免疫疾患抑制たんぱく質を発見 20081208
• [Remarks] 朝日新聞 自己免疫病のカギ握るたんぱく質確認 20080929
• [Remarks] 日本免疫学会主催の科学コミュニケーション活動「免疫ふしぎ未来」 参加(東京) 20110821
• [Remarks] 日本免疫学会主催の科学コミュニケーション活動「免疫ふしぎ未来」 参加(東京) 20090502-03
• [Remarks] 日本免疫学会主催の科学コミュニケーション活動「免疫ふしぎ未来」 主催(東京) 20080503-4
• [Remarks] 日本免疫学会主催の科学コミュニケーション活動「免疫ふしぎ未来」 創設と主催(東京, 徳島) 20070503-04
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• [Remarks]
  • URL: http://immself.umin.jp
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei
• [Remarks]
  • URL: http://www.tokushima-u.ac.jp/ier/autoimmunity/
• [Remarks]
  • URL: http://immself.umin.jp/
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei/index.html
• [Remarks]
  • URL: http://www.ier.tokushima-u.ac.jp/article/0017775.html
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei/index.html
• [Remarks]
  • URL: http://www.ier.tokushima-u.ac.jp/article/0017775.html
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei
• [Remarks]
  • URL: http://www.genome.tokushima-u.ac.jp/dei
• [Patent(Industrial Property Rights)] Evaluation device for fluorescent group, computer-executable evaluation program for fluorescent group, and evaluation system for fluorescent group. (2010)
  • Inventor(s): Takahama Y, Nitta T, Nakano Y.
  • Industrial Property Rights Holder: 国立大学法人徳島大学, 株式会社二コン
  • Filing Date: 2010-12-28
  • Overseas
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2010)
  • Inventor(s): Takahama Y.
  • Industrial Property Rights Holder: Takahama Y, JST.
  • Acquisition Date: 2010-03-02
  • Overseas
• [Patent(Industrial Property Rights)] Evaluation device for fluorescent group, computer-executable evaluation program for fluorescent group, and evaluation system for fluorescent group. (2010)
  • Inventor(s): Takahama Y, Nitta T, Nakano Y.
  • Industrial Property Rights Holder: 国立大学法人徳島大学、株式会社ニコン
  • Filing Date: 2010-12-28
  • Overseas
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2010)
  • Inventor(s): Takahama Y.
  • Industrial Property Rights Holder: Takahama Y, JST.
  • Acquisition Date: 2010-03-02
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2010)
  • Inventor(s): 高浜洋介
  • Industrial Property Rights Holder: 高浜洋介・科学技術振興機構
  • Acquisition Date: 2010-01-14
  • Overseas
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2010)
  • Inventor(s): 高浜洋介
  • Industrial Property Rights Holder: 高浜洋介・科学技術振興機構
  • Acquisition Date: 2010-03-02
  • Overseas
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2009)
  • Inventor(s): Takahama Y
  • Industrial Property Rights Holder: 科学技術振興機構
  • Filing Date: 2009-02-24
  • Overseas
• [Patent(Industrial Property Rights)] 蛍光集団の評価装置、コンピュータ実行可能な蛍光集団の評価プログラム、及び蛍光集団の評価システム (2008)
  • Inventor(s): 高浜洋介, 新田剛, 中野義太郎
  • Industrial Property Rights Holder: (株)二コン, 徳島大学
  • Filing Date: 2008-07-10
• [Patent(Industrial Property Rights)] 蛍光集団の評価装置、コンピュータ実行可能な蛍光集団の評価プログラム、及び蛍光集団の評価システム (2008)
  • Inventor(s): 高浜洋介、新田剛、中野義太郎
  • Industrial Property Rights Holder: (株)ニコン、徳島大学
  • Filing Date: 2008-07-10
• [Patent(Industrial Property Rights)] 蛍光集団の評価装置、コンピュータ実行可能な蛍光集団の評価プログラム、及び蛍光集団の評価システム (2008)
  • Inventor(s): 高浜洋介、新田剛、中野義太郎
  • Industrial Property Rights Holder: 株式会社ニコン、国立大学法人徳島大学
  • Filing Date: 2008-07-10
• [Patent(Industrial Property Rights)] Compositions for acquiring immunological tolerance (2008)
  • Inventor(s): Takahama Y
  • Industrial Property Rights Holder: 科学技術振興機構
  • Filing Date: 2008-08-20
  • Overseas
• [Patent(Industrial Property Rights)] Method of acquiring immunological tolerance (2007)
  • Inventor(s): Yousuke Takahama
  • Industrial Property Rights Holder: JST
  • Acquisition Date: 2007-10-02
  • Overseas