Regulation of autoimmunity by self-reactive regulatory T cells
Project Area | Immunological Self Recognition and its Disorders |
Project/Area Number |
19059014
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
HORI Shogei (HORI Shohei) 独立行政法人理化学研究所, 免疫恒常性研究ユニット, ユニットリーダー (50392113)
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Project Period (FY) |
2007 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥83,000,000 (Direct Cost: ¥83,000,000)
Fiscal Year 2011: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2010: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2009: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2008: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2007: ¥16,600,000 (Direct Cost: ¥16,600,000)
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Keywords | 自己免疫 / 免疫寛容 / 自己反応性 / T細胞レセプター / 抗原特異性 / 制御性T細胞 / 細胞分化 / 自己免疫寛容 / 核移植ES細胞 / クローン動物 / 細胞化分 |
Research Abstract |
Foxp3^+ regulatory T (Treg) cells play a key role in establishing and maintaining natural self-tolerance. We have established a novel method for high-throughput analysis of the T cell receptor (TCR) repertoire using the next generation sequencing technology. By applying this method, we have analyzed the TCR repertoires of Foxp3^+ and Foxp3^- T cells and found that they are largely distinct. While this dissimilarity was established within the thymus, the repertoire of Foxp3^+ T cells was reshaped substantially in the periphery. In addition, we have also found that the normal T cell repertoire harbored a population of Foxp3- helper T cells with previous history of Foxp3 expression and that their TCR repertoire was distinct from Foxp3^+ Treg cells. Our results suggest that TCR specificity plays a central role in the lineage commitment of Treg cells.
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Report
(7 results)
Research Products
(78 results)
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[Journal Article] Induction of colonic regulatory T cells by indigenous Clostridium species2011
Author(s)
Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K.
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Journal Title
Science
Volume: 331
Pages: 337-341
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression2011
Author(s)
Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Issue: 16
Pages: 668-667
DOI
Related Report
Peer Reviewed
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[Journal Article] Activated regulatory T cells are the major T cell type emigrating from sensitized skin2010
Author(s)
Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K.
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Journal Title
Journal of Clinical Investigation
Volume: 120
Pages: 883-893
Related Report
Peer Reviewed
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[Journal Article] (*corresponding/senior authors) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.2009
Author(s)
Tsuji, M., Komatsu, N., Kawamoto, S., Kanagawa, O., Honjo, T., Hori, S., *Fagarasan, S.
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Journal Title
Science 323
Pages: 1488-1492
Related Report
Peer Reviewed
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[Journal Article] Heterogeneity of natural Foxp3+ T cells: a committed regulatory T cell lineage and an uncommitted minor population retaining plasticity.2009
Author(s)
Komatsu, N., Mariotti-Ferrandiz, M.E., Wang, Y., Malissen, B., Waldmann, H., Hori, S.
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Journal Title
PNAS 106
Pages: 1903-1908
Related Report
Peer Reviewed
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