| Budget Amount *help |
¥184,730,000 (Direct Cost: ¥142,100,000、Indirect Cost: ¥42,630,000)
Fiscal Year 2023: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2022: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2021: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2020: ¥37,700,000 (Direct Cost: ¥29,000,000、Indirect Cost: ¥8,700,000)
Fiscal Year 2019: ¥32,630,000 (Direct Cost: ¥25,100,000、Indirect Cost: ¥7,530,000)
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| Outline of Final Research Achievements |
This study aimed at elucidating mechanisms underlying membrane dynamics and target selection during macroautophagy. The results largely advanced our understanding of the mechanism of autophagosome precursor formation and also revealed a novel mechanism by which the morphology of the forming autophagosomal membrane is regulated. In addition, we revealed the mechanisms of organelle deformation during selective macroautophagy of the endoplasmic reticulum and the nucleus. Our analyses also identified nuclear pore complexes and glycogen granules as novel selective targets for macroautophagy. Moreover, the interplay between macroautophagy and microautophagy in degradation of nuclear components was unraveled.
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