Molecular mechanism and physiological role of mitophagy

• Project Area: Multimode autophagy: Diverse pathways and selectivity
• Project/Area Number: 19H05712
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Niigata University
• Principal Investigator: Kanki Tomotake 新潟大学, 医歯学系, 教授 (50398088)
• Co-Investigator(Kenkyū-buntansha): 松田 憲之 東京医科歯科大学, 難治疾患研究所, 教授 (10332272) ; 佐藤 美由紀 群馬大学, 生体調節研究所, 教授 (70321768)
• Project Period (FY): 2019-06-28 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥119,340,000 (Direct Cost: ¥91,800,000、Indirect Cost: ¥27,540,000); Fiscal Year 2023: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2022: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2021: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2020: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2019: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
• Keywords: オートファジー / ミトコンドリア / マイトファジー / ユビキチン

Outline of Research at the Start

マクロオートファジーによる選択的ミトコンドリア分解はマイトファジーと呼ばれ、ミトコンドリア恒常性維持に関わる極めて重要な現象である。マイトファジーの分子機構は生物種ごとに特異性があるため、その分子機構や生理的意義には不明な点が多い。本研究では、複数の生物種（酵母、線虫、哺乳類）をモデル生物とし多面的な解析を行い、マイトファジーの統合的な理解を目指す。特に、マイトファジーを、「レセプター依存的マイトファジー」と「ユビキチン依存的マイトファジー」に大別して分子機構と生理的意義の解明を進める。

Outline of Final Research Achievements

To gain an integrated understanding of mitophagy, we analyzed the molecular mechanisms and physiological roles of mitophagy using multiple species as models. In budding yeast, we elucidated the role of the Far complex in the regulation of mitophagy. In fission yeast, we identified a novel mitophagy receptor, Atg43. We also identified a novel mitochondrial fission factor Atg44, which is essential for mitophagy. In cultured cells, we analyzed the physiological function of BNIP3/NIX-dependent mitophagy and the role of OPTN in ubiquitin-dependent mitophagy. In mice, we found that mitophagy is induced during disuse muscle atrophy. In C. elegans, the involvement of ALLO-1 and IKKE-1 in paternal mitochondrial degradation in fertilized eggs was elucidated.

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアは細胞が必要とするATPの大半を産生する重要なオルガネラであり、ミトコンドリアの機能異常は、様々な疾患や老化に関連する。マイトファジーは、細胞内の異常もしくは余剰なミトコンドリアを分解することで、ミトコンドリア恒常性を維持する機構である。本研究は、マイトファジーに関して様々なモデル生物を用いて研究を進め、その統合的理解に貢献した点や、ミトコンドリア遺伝子の母性遺伝の分子機構の理解に貢献した点で学術的意義が高い。また、マイトファジーの理解が進むとともに、この現象を老化抑制や疾患治療に応用しようとする研究が増加しており、本研究成果は、これら応用研究の基盤となる点で社会的意義が高い。

Research Products

• [Int'l Joint Research] ミシガン大学(米国)
• [Int'l Joint Research] カリフォルニア工科大学(米国)
• [Int'l Joint Research] Seoul National University(韓国)
• [Journal Article] Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species (2024)
  • Author(s): Yamashita Shun-ichi、Sugiura Yuki、Matsuoka Yuta、Maeda Rae、Inoue Keiichi、Furukawa Kentaro、Fukuda Tomoyuki、Chan David C.、Kanki Tomotake
  • Journal Title: Cell Death & Differentiation Volume: - Issue: 5 Pages: 651-661
  • DOI: 10.1038/s41418-024-01280-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice (2024)
  • Author(s): Aoyagi Kyota、Nishiwaki Chiyono、Nakamichi Yoko、Yamashita Shun-ichi、Kanki Tomotake、Ohara-Imaizumi Mica
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 6178-6178
  • DOI: 10.1038/s41598-024-56769-w
  • Peer Reviewed / Open Access
• [Journal Article] MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans (2024)
  • Author(s): Kawasaki Ichiro、Sugiura Kenta、Sasaki Taeko、Matsuda Noriyuki、Sato Miyuki、Sato Ken
  • Journal Title: Nature Communications Volume: 15 Issue: 1 Pages: 792-792
  • DOI: 10.1038/s41467-024-44928-6
  • Peer Reviewed / Open Access
• [Journal Article] ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy (2024)
  • Author(s): Sasaki Taeko、Kushida Yasuharu、Norizuki Takuya、Kosako Hidetaka、Sato Ken、Sato Miyuki
  • Journal Title: Nature Communications Volume: 15 Issue: 1 Pages: 1460-1460
  • DOI: 10.1038/s41467-024-45863-2
  • Peer Reviewed / Open Access
• [Journal Article] Optineurin provides a mitophagy contact site for TBK1 activation (2024)
  • Author(s): Yamano Koji、Sawada Momoha、Kikuchi Reika、Nagataki Kafu、Kojima Waka、Endo Ryu、Kinefuchi Hiroki、Sugihara Atsushi、Fujino Tomoshige、Watanabe Aiko、Tanaka Keiji、Hayashi Gosuke、Murakami Hiroshi、Matsuda Noriyuki
  • Journal Title: The EMBO Journal Volume: 43 Issue: 5 Pages: 754-779
  • DOI: 10.1038/s44318-024-00036-1
  • Peer Reviewed / Open Access
• [Journal Article] HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence (2024)
  • Author(s): 1.Cui, M., Yamano, K., Yamamoto, K., Yamamoto-Imoto, H., Minami, S., Yamamoto, T., Matsui, S., Kaminishi, T., Shima, T., Ogura, M., Tsuchiya, M., Nishino, K., Layden B., Kato, H., Ogawa, H., Oki, S., Okada, Y., Isaka, Y., Kosako, H., Matsuda, N., *Yoshimori, T., *Nakamura, S.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 121 Issue: 2
  • DOI: 10.1073/pnas.2306454120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis (2023)
  • Author(s): Tai Yen Teng、Fukuda Tomoyuki、Morozumi Yuichi、Hirai Hayato、Oda Arisa H.、Kamada Yoshiaki、Akikusa Yutaka、Kanki Tomotake、Ohta Kunihiro、Shiozaki Kazuhiro
  • Journal Title: Molecular and Cellular Biology Volume: 43 Issue: 12 Pages: 675-692
  • DOI: 10.1080/10985549.2023.2282349
  • Peer Reviewed / Open Access
• [Journal Article] Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity (2023)
  • Author(s): Shioda Tatsuya、Takahashi Ittetsu、Ikenaka Kensuke、Fujita Naonobu、Kanki Tomotake、Oka Toshihiko、Mochizuki Hideki、Antebi Adam、Yoshimori Tamotsu、Nakamura Shuhei
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 39
  • DOI: 10.1073/pnas.2221553120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy (2023)
  • Author(s): Fukuda Tomoyuki、Furukawa Kentaro、Maruyama Tatsuro、Noda Nobuo N.、Kanki Tomotake
  • Journal Title: Autophagy Volume: 19 Issue: 11 Pages: 3019-3021
  • DOI: 10.1080/15548627.2023.2237343
  • Peer Reviewed
• [Journal Article] Meet the authors: Tomoyuki Fukuda, Kentaro Furukawa, and Tomotake Kanki (2023)
  • Author(s): Fukuda Tomoyuki、Furukawa Kentaro、Kanki Tomotake
  • Journal Title: Molecular Cell Volume: 83 Issue: 12 Pages: 1953-1955
  • DOI: 10.1016/j.molcel.2023.05.016
• [Journal Article] The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy (2023)
  • Author(s): Fukuda Tomoyuki, Furukawa Kentaro, Maruyama Tatsuro, ..., Klionsky J. Daniel, Noda N. Nobuo, Kanki Tomotake.
  • Journal Title: Molecular Cell Volume: - Issue: 12 Pages: 2045-2058.e9
  • DOI: 10.1016/j.molcel.2023.04.022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein (2023)
  • Author(s): Fukuda Tomoyuki、Saigusa Tetsu、Furukawa Kentaro、Inoue Keiichi、Yamashita Shun-ichi、Kanki Tomotake
  • Journal Title: Autophagy Volume: 19 Issue: 10 Pages: 2657-2667
  • DOI: 10.1080/15548627.2023.2214029
  • Peer Reviewed
• [Journal Article] TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria (2023)
  • Author(s): Shiori Akabane, Kiyona Watanabe, Hidetaka Kosako, Shun-ichi Yamashita, Kohei Nishino, Masahiro Kato, Shiori Sekine, Tomotake Kanki, Noriyuki Matsuda, Toshiya Endo, Toshihiko Oka
  • Journal Title: Cell Reports Volume: 42 Issue: 5 Pages: 112454-112454
  • DOI: 10.1016/j.celrep.2023.112454
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method (2023)
  • Author(s): Hayashida Ryota、Kikuchi Reika、Imai Kenichiro、Kojima Waka、Yamada Tatsuya、Iijima Miho、Sesaki Hiromi、Tanaka Keiji、Matsuda Noriyuki、Yamano Koji
  • Journal Title: Journal of Biological Chemistry Volume: 299 Issue: 2 Pages: 102822-102822
  • DOI: 10.1016/j.jbc.2022.102822
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry (2023)
  • Author(s): Watanabe Kanako、Oka Tomoichiro、Takagi Hirotaka、Anisimov Sergei、Yamashita Shun-ichi、Katsuragi Yoshinori、Takahashi Masahiko、Higuchi Masaya、Kanki Tomotake、Saitoh Akihiko、Fujii Masahiro
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 1817-1817
  • DOI: 10.1038/s41467-023-37399-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy. (2023)
  • Author(s): Aoyagi K, Yamashita SI, Akimoto Y, Nishiwaki C, Nakamichi Y, Udagawa H, Abe M, Sakimura K, Kanki T, Ohara-Imaizumi M
  • Journal Title: Diabetologia Volume: 66 Issue: 1 Pages: 147-162
  • DOI: 10.1007/s00125-022-05800-8
  • Peer Reviewed
• [Journal Article] Dynamic rearrangement and autophagic degradation of mitochondria during spermiogenesis in the liverwort Marchantia polymorpha (2022)
  • Author(s): Norizuki Takuya、Minamino Naoki、Sato Miyuki、Tsukaya Hirokazu、Ueda Takashi
  • Journal Title: Cell Reports Volume: 39 Issue: 11 Pages: 110975-110975
  • DOI: 10.1016/j.celrep.2022.110975
  • Peer Reviewed / Open Access
• [Journal Article] Mitophagy in Yeast: Molecular Mechanism and Regulation (2021)
  • Author(s): Innokentev Aleksei、Kanki Tomotake
  • Journal Title: Cells Volume: 10 Issue: 12 Pages: 3569-3569
  • DOI: 10.3390/cells10123569
  • Peer Reviewed / Open Access
• [Journal Article] <i>Fis1</i> ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation (2021)
  • Author(s): Varuzhanyan Grigor、Ladinsky Mark S.、Yamashita Shun-ichi、Abe Manabu、Sakimura Kenji、Kanki Tomotake、Chan David C.
  • Journal Title: Development Volume: 148 Issue: 16
  • DOI: 10.1242/dev.199686
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43 (2021)
  • Author(s): Kakihana Taichi、Takahashi Masahiko、Katsuragi Yoshinori、Yamashita Shun-Ichi、Sango Junya、Kanki Tomotake、Onodera Osamu、Fujii Masahiro
  • Journal Title: iScience Volume: 24 Issue: 7 Pages: 102733-102733
  • DOI: 10.1016/j.isci.2021.102733
  • Peer Reviewed / Open Access
• [Journal Article] Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis (2021)
  • Author(s): Maruyama Tatsuro、Alam Jahangir Md.、Fukuda Tomoyuki、Kageyama Shun、Kirisako Hiromi、Ishii Yuki、Shimada Ichio、Ohsumi Yoshinori、Komatsu Masaaki、Kanki Tomotake、Nakatogawa Hitoshi、Noda Nobuo N.
  • Journal Title: Nature Structural &amp; Molecular Biology Volume: 28 Issue: 7 Pages: 583-593
  • DOI: 10.1038/s41594-021-00614-5
  • Peer Reviewed / Open Access
• [Journal Article] Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse‐induced muscle atrophy (2021)
  • Author(s): Yamashita Shun‐Ichi、Kyuuma Masanao、Inoue Keiichi、Hata Yuki、Kawada Ryu、Yamabi Masaki、Fujii Yasuyuki、Sakagami Junko、Fukuda Tomoyuki、Furukawa Kentaro、Tsukamoto Satoshi、Kanki Tomotake
  • Journal Title: Journal of Cellular Physiology Volume: N/A Issue: 11 Pages: 7612-7624
  • DOI: 10.1002/jcp.30404
  • Peer Reviewed
• [Journal Article] Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms (2021)
  • Author(s): Kato Shun、Arasaki Kohei、Tokutomi Natsuki、Imai Yuzuru、Inoshita Tsuyoshi、Hattori Nobutaka、Sasaki Taeko、Sato Miyuki、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
  • Journal Title: Journal of Cell Science Volume: 134 Issue: 22
  • DOI: 10.1242/jcs.258699
  • Peer Reviewed
• [Journal Article] Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy (2021)
  • Author(s): Kojima W, Yamano K, Kosako H, Imai K, Kikuchi R, Tanaka K, Matsuda N
  • Journal Title: Autophagy Volume: - Issue: 8 Pages: 1-26
  • DOI: 10.1080/15548627.2021.1874133
  • NAID: 120007174412
  • Peer Reviewed / Open Access
• [Journal Article] Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. (2021)
  • Author(s): Baba, T., Tanimura, S., Yamaguchi, A., Horikawa, K., Yokozeki, M., Hachiya, S., Iemura, S., Natsume, T., Matsuda, N. and Takeda, K.
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume: 11868 Issue: 7 Pages: 119045-119045
  • DOI: 10.1016/j.bbamcr.2021.119045
  • Peer Reviewed
• [Journal Article] Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase (2021)
  • Author(s): Yoshida Yukiko、Asahina Makoto、Murakami Arisa、Kawawaki Junko、Yoshida Meari、Fujinawa Reiko、Iwai Kazuhiro、Tozawa Ryuichi、Matsuda Noriyuki、Tanaka Keiji、Suzuki Tadashi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 27
  • DOI: 10.1073/pnas.2102902118
  • Peer Reviewed / Open Access
• [Journal Article] Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1 (2021)
  • Author(s): Queliconi BB, Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, Matsuda N
  • Journal Title: J Cell Sci Volume: 134 Issue: 22 Pages: 1-1
  • DOI: 10.1242/jcs.258653
  • Peer Reviewed / Open Access
• [Journal Article] Mitophagy regulation mediated by the Far complex in yeast (2021)
  • Author(s): Furukawa Kentaro、Innokentev Aleksei、Kanki Tomotake
  • Journal Title: Autophagy Volume: 17 Issue: 4 Pages: 1042-1043
  • DOI: 10.1080/15548627.2021.1885184
  • Peer Reviewed
• [Journal Article] Atg43, a novel autophagy-related protein, serves as a mitophagy receptor to bridge mitochondria with phagophores in fission yeast (2021)
  • Author(s): Fukuda Tomoyuki、Kanki Tomotake
  • Journal Title: Autophagy Volume: 17 Issue: 3 Pages: 826-827
  • DOI: 10.1080/15548627.2021.1874662
• [Journal Article] MITOL promotes cell survival by degrading Parkin during mitophagy (2021)
  • Author(s): Shiiba Isshin、Takeda Keisuke、Nagashima Shun、Ito Naoki、Tokuyama Takeshi、Yamashita Shun‐Ichi、Kanki Tomotake、Komatsu Toru、Urano Yasuteru、Fujikawa Yuuta、Inatome Ryoko、Yanagi Shigeru
  • Journal Title: EMBO reports Volume: 22 Issue: 3
  • DOI: 10.15252/embr.201949097
  • Peer Reviewed / Open Access
• [Journal Article] Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase (2021)
  • Author(s): Fukuda Tomoyuki、Sofyantoro Fajar、Tai Yen Teng、Chia Kim Hou、Matsuda Takato、Murase Takaaki、Morozumi Yuichi、Tatebe Hisashi、Kanki Tomotake、Shiozaki Kazuhiro
  • Journal Title: eLife Volume: 10
  • DOI: 10.7554/elife.60969
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular mechanisms and physiological functions of mitophagy (2021)
  • Author(s): Onishi Mashun、Yamano Koji、Sato Miyuki、Matsuda Noriyuki、Okamoto Koji
  • Journal Title: The EMBO Journal Volume: 40 Issue: 3 Pages: 1-1
  • DOI: 10.15252/embj.2020104705
  • Peer Reviewed / Open Access
• [Journal Article] Degradation of paternal mitochondria via mitophagy (2021)
  • Author(s): Sasaki Taeko、Sato Miyuki
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1865 Issue: 6 Pages: 129886-129886
  • DOI: 10.1016/j.bbagen.2021.129886
  • Peer Reviewed
• [Journal Article] Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy (2020)
  • Author(s): Innokentev Aleksei、Furukawa Kentaro、Fukuda Tomoyuki、Saigusa Tetsu、Inoue Keiichi、Yamashita Shun-ichi、Kanki Tomotake
  • Journal Title: eLife Volume: 9
  • DOI: 10.7554/elife.63694
  • Peer Reviewed / Open Access
• [Journal Article] Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast (2020)
  • Author(s): Fukuda Tomoyuki、Ebi Yuki、Saigusa Tetsu、Furukawa Kentaro、Yamashita Shun-ichi、Inoue Keiichi、Kobayashi Daiki、Yoshida Yutaka、Kanki Tomotake
  • Journal Title: eLife Volume: 9
  • DOI: 10.7554/elife.61245
  • Peer Reviewed / Open Access
• [Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy (2020)
  • Author(s): Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
  • Journal Title: Journal of Cell Biology Volume: 219 Issue: 9 Pages: 1-23
  • DOI: 10.1083/jcb.201912144
  • Peer Reviewed / Open Access
• [Journal Article] ERdj8 governs the size of autophagosomes during the formation process (2020)
  • Author(s): Yamamoto Yo-hei、Kasai Ayano、Omori Hiroko、Takino Tomoe、Sugihara Munechika、Umemoto Tetsuo、Hamasaki Maho、Hatta Tomohisa、Natsume Tohru、Morimoto Richard I.、Arai Ritsuko、Waguri Satoshi、Sato Miyuki、Sato Ken、Bar-Nun Shoshana、Yoshimori Tamotsu、Noda Takeshi、Nagata Kazuhiro
  • Journal Title: Journal of Cell Biology Volume: 219 Issue: 8 Pages: 1-12
  • DOI: 10.1083/jcb.201903127
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. (2020)
  • Author(s): Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
  • Journal Title: Sci Rep. Volume: 10(1) Issue: 1 Pages: 1465-1465
  • DOI: 10.1038/s41598-020-58315-w
  • Peer Reviewed / Open Access
• [Journal Article] FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions (2020)
  • Author(s): Yoo Seung‐Min、Yamashita Shun‐ichi、Kim Hyunjoo、Na DoHyeong、Lee Haneul、Kim Seo Jin、Cho Dong‐Hyung、Kanki Tomotake、Jung Yong‐Keun
  • Journal Title: The FASEB Journal Volume: 34 Issue: 2 Pages: 2944-2957
  • DOI: 10.1096/fj.201901735r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin (2020)
  • Author(s): Matsuda Noriyuki、Yamano Koji
  • Journal Title: Neuroscience Research Volume: in press Pages: 16-24
  • DOI: 10.1016/j.neures.2020.03.009
  • Peer Reviewed / Open Access
• [Journal Article] Regulatory mechanisms of mitochondrial autophagy: Lessons from yeast (2019)
  • Author(s): Kentaro Furukawa, Aleksei Innokentev, Tomotake Kanki
  • Journal Title: Frontiers in Plant Science Volume: 10 Pages: 1479-1479
  • DOI: 10.3389/fpls.2019.01479
  • Peer Reviewed / Open Access
• [Journal Article] Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes (2019)
  • Author(s): Koyano Fumika、Yamano Koji、Kosako Hidetaka、Kimura Yoko、Kimura Mayumi、Fujiki Yukio、Tanaka Keiji、Matsuda Noriyuki
  • Journal Title: EMBO reports Volume: 20 Issue: 12
  • DOI: 10.15252/embr.201947728
  • NAID: 120006942558
  • Peer Reviewed / Open Access
• [Presentation] 新規ミトコンドリア分裂因子Mitofissin/Atg44の解析 (2023)
  • Author(s): 古川健太郎、早津学、芝田晋介、神吉智丈
  • Organizer: 日本ミトコンドリア学会
• [Presentation] Analyses of mechanisms of ALLO-1 targeting to the paternal organelles in embryos (2023)
  • Author(s): Takuya Norizuki, Taeko Sasaki, Yasuharu Kushida, Nobuo N. Noda, Ken Sato, and Miyuki Sato
  • Organizer: 24th International C. elegans Conference
  • Int'l Joint Research
• [Presentation] 線虫受精卵におけるALLO-1の父性オルガネラ局在化機構の解析 (2023)
  • Author(s): 法月拓也、佐々木妙子、櫛田康晴、野田展生、佐藤健、佐藤美由紀
  • Organizer: 第75回日本細胞生物学会年会
• [Presentation] PINK1-PARKIN介在性マイトファジー (2023)
  • Author(s): 松田憲之
  • Organizer: 第９回 ガンと代謝研究会
  • Invited
• [Presentation] パーキンソン病発症に関与するミトコンドリア品質管理と細胞死 (2023)
  • Author(s): 松田憲之
  • Organizer: 第３１回 日本 Cell Death 学会
  • Invited
• [Presentation] Atg44 drives mitochondrial fission required for mitophagy (2022)
  • Author(s): Tomotake Kanki
  • Organizer: The 10th International Symposium on Autophagy
• [Presentation] マイトファジーとミトコンドリア形態の関連 (2022)
  • Author(s): 神吉智丈
  • Organizer: 第95回日本生化学会大会
• [Presentation] ミトコンドリア形態変化とマイトファジー (2022)
  • Author(s): 神吉智丈
  • Organizer: 第74回日本細胞生物学会大会
• [Presentation] ミトコンドリアを軸にしたオートファジー制御因子の機能解析 (2022)
  • Author(s): 小島和華, 松田憲之, 山野晃史
  • Organizer: 第95回日本生化学会大会
• [Presentation] FAF2-p97/VCP complex suppresses pexophagy in a ubiquitylation-dependent fashion (2022)
  • Author(s): Noriyuki Matsuda, and Fumika Koyano
  • Organizer: The 10th International Symposium on Autophagy
• [Presentation] オートファジーアダプターALLO-1とIKKE-1キナーゼによる父性ミトコンドリア選択的分解のメカニズム (2022)
  • Author(s): 佐藤美由紀、佐々木妙子，櫛田康晴，小迫英尊、佐藤健
  • Organizer: 第74回日本細胞生物学会大会
• [Presentation] The underlying mechanism of selective elimination of paternal mitochondria in C. elegans (2022)
  • Author(s): Taeko Sasaki, Yasuharu Kushida, Hidetaka Kosako, Ken Sato, Miyuki Sato
  • Organizer: 第45回日本分子生物学会年会
• [Presentation] 廃用性筋萎縮時のマイトファジー (2021)
  • Author(s): 神吉 智丈
  • Organizer: 第7回日本筋学会学術集会
  • Invited
• [Presentation] リン酸化修飾によるマイトファジー制御 (2021)
  • Author(s): 神吉 智丈
  • Organizer: 第20回日本ミトコンドリア学会年会
• [Presentation] ミトコンドリアオートファジーの誘導機構 (2021)
  • Author(s): 神吉智丈
  • Organizer: J-mit 特別 オンラインシンポジウム
  • Invited
• [Presentation] ミトコンドリアオートファジーの分子機構 (2021)
  • Author(s): 神吉智丈
  • Organizer: 第23回植物オルガネラワークショップ
  • Invited
• [Presentation] Ppg1とFar複合体によるmitophagyの制御機構 (2019)
  • Author(s): 神吉智丈
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] PINK1, Parkin and the ubiquitin system (2019)
  • Author(s): Noriyuki Matsuda
  • Organizer: 5th World Parkinson Congress
  • Int'l Joint Research / Invited
• [Presentation] New role for PINK1/Parkin-mediated ubiquitylation (2019)
  • Author(s): Noriyuki Matsuda
  • Organizer: Singapore Mitochondrial Mini-Symposium 2019
  • Int'l Joint Research / Invited
• [Book] ミトコンドリア 疾患治療の新時代 (2023)
  • Author(s): 柳 茂、三牧 正和
  • Total Pages: 245
  • Publisher: 羊土社
  • ISBN: 9784758104098
• [Remarks] 新潟大学大学院医歯学総合研究科機能制御学分野
  • URL: https://www.med.niigata-u.ac.jp/mit/