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Hyper-adaptability to altered musculoskeletal system: cortical and subcortical mechanism.

Planned

Project AreaHyper-adaptability for overcoming body-brain dysfunction: Integrated empirical and system theoretical approaches
Project/Area Number 19H05724
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

関 和彦  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 モデル動物開発研究部, 部長 (00226630)

Project Period (FY) 2019-06-28 – 2024-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥94,120,000 (Direct Cost: ¥72,400,000、Indirect Cost: ¥21,720,000)
Fiscal Year 2022: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2019: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Keywordsマカクサル / 可塑性 / 筋シナジー / 筋電図 / 筋再配置 / tendon transfer / macaque monkey / muscle synergy / sensorimotor / ECoG / EMG / 超適応 / 霊長類 / 運動 / 感覚予測誤差 / 身体改変
Outline of Research at the Start

身体の障害や疾病などによってヒトの身体構造が急激に変化する場合がある。そのような状態でも短時間のリハビリテーション訓練などによって意図したとおりに運動を行うことができるのは,身体運動に関わる脳神経構造が、変化した身体に適応して再構成されているからである。身体の急激な変化は後天的で個体にとって未経験の現象であり、それに対する適応は超適応として定義することができる。この、超適応時の脳神経構造の再構成のメカニズムは明らかでない。そこで、本研究ではヒトと筋骨格構造が類似しているサルを対象に、身体構造を変化させ、それに対する中枢神経系の適応を神経細胞レベルで神経生理学的に評価する。

Outline of Annual Research Achievements

The musculoskeletal system changes over time (e.g. development, aging or by injury) and somatosensory and motor cortical areas, as well as subcortical areas are subject to substantial reorganization as a result of these changes. However, only little information is available about the central nervous system’s adaptations to this physically modified body and its underlying mechanisms. Aim of this study was to elucidate neural mechanism that underly this plasticity of the CNS to the bodily modification. This year, as well as improving surgical technique, we have finished analyzing muscle activity by using the concept of muscle synergy. We found that the activity of transferred muscles as well as the muscle synergy belonging to them could exhibit plasticity in rather complex patterns.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

In this year, we started to collaborate with a hand-surgeon to refine and improve our tendon-cross-transfer model and the underlying surgical procedure. Most significant adaptation being the use of a tendon graft consisting of the tendon taken from the ipsilateral leg which bridges the gap between tendon of two muscles. The new procedure was conducted in two monkeys and while histology has already confirmed the success of the procedure the EMG data collected during the behavioural task are now being analysed.
Furthermore, we started a second collaboration with neuro-surgeon and improved this way the implant of ECoG electrodes over the somato-sensory cortex of our non-human primates.

Strategy for Future Research Activity

Next year, we will start analyzing an additional electrophysiological recordings from the primary motor (M1) and sensory (S1) cortex using ECoG recording techniques showing that activity changes over time at specific electrode locations rostral to the central sulcus (M1). More specifically, we will observe test if a changes in activity during the hold period after tendon surgery.

Report

(1 results)
  • 2019 Annual Research Report

Research Products

(15 results)

All 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results)

  • [Journal Article] Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip2020

    • Author(s)
      Oya Tomomichi、Takei Tomohiko、Seki Kazuhiko
    • Journal Title

      Communications Biology

      Volume: 3 Pages: 0-0

    • DOI

      10.1038/s42003-020-0861-0

    • NAID

      120006823945

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decoding of muscle activity from the sensorimotor cortex in freely behaving monkeys2019

    • Author(s)
      Umeda Tatsuya、Koizumi Masashi、Katakai Yuko、Saito Ryoichi、Seki Kazuhiko
    • Journal Title

      NeuroImage

      Volume: 197 Pages: 512-526

    • DOI

      10.1016/j.neuroimage.2019.04.045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic recruitment of spinal reflex pathways from large‐diameter primary afferents in non‐transgenic rats transduced with AAV9/Channelrhodopsin 22019

    • Author(s)
      Kubota Shinji、Sidikejiang Wupuer、Kudo Moeko、Inoue Ken‐ichi、Umeda Tatsuya、Takada Masahiko、Seki Kazuhiko
    • Journal Title

      J Physiol

      Volume: 597 Pages: 5025-5040

    • DOI

      10.1113/jp278292

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Modular control of limb movement: from neural correlates to clinical relevance2019

    • Author(s)
      Seki K
    • Organizer
      WORKSHOP on NEUROROBOTICS
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural adaptation to surgical relocation of primate hand muscles2019

    • Author(s)
      Seki K
    • Organizer
      Tokyo Hand Meeting(NCM Ancillary Meeting)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spinal and cortical neural mechanism for active inference in volitional movement.2019

    • Author(s)
      Seki K
    • Organizer
      The Satellite Meeting/29th NCM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decoding muscle activity using electrocorticographic signals in freely behaving marmosets2019

    • Author(s)
      Umeda T, Koizumi M, Katakai Y, Saito R, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of spinomuscular and corticomuscular loops in dynamic vs. static phases of precision grip.2019

    • Author(s)
      Oya T, Takei T, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Linear summation of spinally-induced forearm force field in macaque monkeys.2019

    • Author(s)
      Yaron A, Yaguchi H, Kowalski D, Takei T, Seki K
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gain control of spinal proprioceptive reflex in awake, behaving monkeys.2019

    • Author(s)
      Seki K
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mini-symposium “Gain Control in the Sensorimotor System: From Neural Circuit Organization to Behavioral Function2019

    • Author(s)
      Seki K, E. Azim
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 協調的筋活動を作り出す神経機構2019

    • Author(s)
      関 和彦
    • Organizer
      第58回日本運動障害研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 自由行動下における皮質脳波から筋活動のデコーディング2019

    • Author(s)
      梅田 達也, 小泉 昌司 , 片貝 祐子, 齋藤 亮一, 関 和彦
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 後根神経節(DRG)細胞への細胞種特異的遺伝子導入法: 齧歯類と霊長類における比較2019

    • Author(s)
      工藤もゑこ, Wupuer Sidikejiang, 井上 謙一, 高田 昌彦, 関 和彦
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筋電解析による身体変化に対する神経適応メカニズムの解明2019

    • Author(s)
      内田直輝, Roland Philipp, 大屋知徹, 舩戸徹郎, 関和彦
    • Organizer
      第13回Motor Control研究会
    • Related Report
      2019 Annual Research Report

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Published: 2019-07-04   Modified: 2022-07-01  

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