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Reconstruction of totipotency using stem cells derived from preimplantation embryos

Planned Research

Project AreaProgram of totipotency: From decoding to designing
Project/Area Number 19H05757
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University (2022-2023)
Tohoku University (2019-2021)

Principal Investigator

Hiroaki Okae  熊本大学, 発生医学研究所, 教授 (10582695)

Co-Investigator(Kenkyū-buntansha) 大日向 康秀  千葉大学, 大学院医学研究院, 講師 (70415107)
Project Period (FY) 2019-06-28 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥124,800,000 (Direct Cost: ¥96,000,000、Indirect Cost: ¥28,800,000)
Fiscal Year 2023: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2022: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2021: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2020: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2019: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Keywords全能性 / ES/iPS細胞 / 栄養膜幹細胞(TS細胞) / 原始内胚葉幹細胞(PrES細胞) / ES細胞 / 胚体外性幹細胞 / 栄養膜幹細胞 / 原始内胚葉幹細胞 / 幹細胞 / 人工胚盤胞 / 人工胎盤
Outline of Research at the Start

唯一全能性を保持する受精卵は、卵割を繰り返し、胚盤胞と呼ばれる初期胚を形成する。胚盤胞はエピブラスト、栄養膜、原始内胚葉の3種類、数10個の細胞で構成されるが、何故、この単純な構造から個体生命を形成できるのか、その機構は謎に包まれている。本研究では、個々の細胞に全能性を誘導するのではなく、胚盤胞に由来する幹細胞を組み合わせることで、胚発生能を有するマウス人工胚盤胞を作製する。さらに、ヒト胚盤胞を構成する全系列の幹細胞化、ヒトTS細胞の3次元培養技術の確立、ヒト人工栄養膜幹細胞の作製を実施する。

Outline of Final Research Achievements

This study aims to generate mouse artificial blastocysts and to derive stem cells from all cell lineages constituting a human blastocyst. In mice, we succeeded in establishing primitive endoderm stem cells (PrES cells) for the first time (Science 2022). In humans, we established a differentiation system from ES/iPS cells to TS cells and found that the primate-specific microRNA cluster C19MC is important in this process (Nat Commun 2022). Furthermore, we have established a new stem cell line from human yolk sac tissue.

Academic Significance and Societal Importance of the Research Achievements

本研究では、マウスPrES細胞やヒト卵黄嚢幹細胞を樹立することに初めて成功した。さらに、マウスPrES細胞を用いた人工胚盤胞の再構築、ヒトTS細胞を用いた栄養膜系列への運命決定機構の解析などを通して、幹細胞を用いて哺乳類の初期発生を研究するための技術基盤を確立した。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (55 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (6 results) Journal Article (20 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 20 results,  Open Access: 20 results) Presentation (25 results) (of which Int'l Joint Research: 7 results,  Invited: 19 results) Book (4 results)

  • [Int'l Joint Research] CNRS(フランス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] University of Kansas Medical Center(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] CBI Toulouse/Universite de Nantes(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University/University of Western Ontario(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Kansas Medical Center(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] CNRS(フランス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Trophoblast stem cell-based organoid models of the human placental barrier2024

    • Author(s)
      Hori Takeshi、Okae Hiroaki、Shibata Shun、Kobayashi Norio、Kobayashi Eri H.、Oike Akira、Sekiya Asato、Arima Takahiro、Kaji Hirokazu
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41467-024-45279-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modeling embryo-endometrial interface recapitulating human embryo implantation2024

    • Author(s)
      Shibata Shun、Endo Shun、Nagai Luis A. E.、H. Kobayashi Eri、Oike Akira、Kobayashi Norio、Kitamura Akane、Hori Takeshi、Nashimoto Yuji、Nakato Ryuichiro、Hamada Hirotaka、Kaji Hirokazu、Kikutake Chie、Suyama Mikita、Saito Masatoshi、Yaegashi Nobuo、Okae Hiroaki、Arima Takahiro
    • Journal Title

      Science Advances

      Volume: 10 Issue: 8

    • DOI

      10.1126/sciadv.adi4819

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of human trophoblast gene expression by endogenous retroviruses2023

    • Author(s)
      Frost Jennifer M.、Amante Samuele M.、Okae Hiroaki、Jones Eleri M.、Ashley Brogan、Lewis Rohan M.、Cleal Jane K.、Caley Matthew P.、Arima Takahiro、Maffucci Tania、Branco Miguel R.
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: - Issue: 4 Pages: 527-538

    • DOI

      10.1038/s41594-023-00960-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape2023

    • Author(s)
      Varberg Kaela M.、Dominguez Esteban M.、Koseva Boryana、Varberg Joseph M.、McNally Ross P.、Moreno-Irusta Ayelen、Wesley Emily R.、Iqbal Khursheed、Cheung Warren A.、Schwendinger-Schreck Carl、Smail Craig、Okae Hiroaki、Arima Takahiro、Lydic Michael、Holoch Kristin、Marsh Courtney、Soares Michael J.、Grundberg Elin
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 4826-4826

    • DOI

      10.1038/s41467-023-40424-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development2023

    • Author(s)
      Takanori Shimizu*, Akira Oike*, Eri H. Kobayashi*, Asato Sekiya, Norio Kobayashi, Shun Shibata, Hirotaka Hamada, Masatoshi Saito, Nobuo Yaegashi, Mikita Suyama, Takahiro Arima, and Hiroaki Okae. *T.S., A.O., and E.H.K. contributed equally to this work.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 51

    • DOI

      10.1073/pnas.2311372120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of Mouse Primitive Endoderm Stem Cells2023

    • Author(s)
      Yasuhide Ohinata、Atsunori Saraya、Haruhiko Koseki
    • Journal Title

      BIO-PROTOCOL

      Volume: 13(22) Issue: 22

    • DOI

      10.21769/bioprotoc.4878

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CITED2 is a conserved regulator of the uterine-placental interface.2023

    • Author(s)
      Kuna Marija、Dhakal Pramod、Iqbal Khursheed、Dominguez Esteban M.、Kent Lindsey N.、Muto Masanaga、Moreno-Irusta Ayelen、Kozai Keisuke、Varberg Kaela M.、Okae Hiroaki、Arima Takahiro、Sucov Henry M.、Soares Michael J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 3 Pages: 120-123

    • DOI

      10.1073/pnas.2213622120

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic imprinting in human placentation2022

    • Author(s)
      Kobayashi Eri H.、Shibata Shun、Oike Akira、Kobayashi Norio、Hamada Hirotaka、Okae Hiroaki、Arima Takahiro
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12490

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The multifaceted role of GCM1 during trophoblast differentiation in the human placenta2022

    • Author(s)
      Jeyarajah Mariyan J.、Jaju Bhattad Gargi、Kelly Rachel D.、Baines Kelly J.、Jaremek Adam、Yang Fei-Hung P.、Okae Hiroaki、Arima Takahiro、Dumeaux Vanessa、Renaud Stephen J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 49

    • DOI

      10.1073/pnas.2203071119

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells2022

    • Author(s)
      Kobayashi Norio、Okae Hiroaki、Hiura Hitoshi、Kubota Naoto、Kobayashi Eri H.、Shibata Shun、Oike Akira、Hori Takeshi、Kikutake Chie、Hamada Hirotaka、Kaji Hirokazu、Suyama Mikita、Bortolin-Cavaill? Marie-Line、Cavaill? J?r?me、Arima Takahiro
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 3071-3071

    • DOI

      10.1038/s41467-022-30775-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic, Genomic, and Imaging Approaches to Dissect the Role of Polycomb Group Epigenetic Regulators in Mice2022

    • Author(s)
      Yakushiji-Kaminatsui Nayuta、Kondo Takashi、Ohinata Yasuhide、Takano Junichiro、Koseki Haruhiko
    • Journal Title

      Methods in Molecular Biology

      Volume: - Pages: 207-228

    • DOI

      10.1007/978-1-0716-2481-4_10

    • ISBN
      9781071624807, 9781071624814
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intersection of regulatory pathways controlling hemostasis and hemochorial placentation2021

    • Author(s)
      Muto Masanaga、Chakraborty Damayanti、Varberg Kaela M.、Moreno-Irusta Ayelen、Iqbal Khursheed、Scott Regan L.、McNally Ross P.、Choudhury Ruhul H.、Aplin John D.、Okae Hiroaki、Arima Takahiro、Matsumoto Shoma、Ema Masatsugu、Mast Alan E.、Grundberg Elin、Soares Michael J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 50

    • DOI

      10.1073/pnas.2111267118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development2021

    • Author(s)
      Varberg Kaela M.、Iqbal Khursheed、Muto Masanaga、Simon Mikaela E.、Scott Regan L.、Kozai Keisuke、Choudhury Ruhul H.、Aplin John D.、Biswell Rebecca、Gibson Margaret、Okae Hiroaki、Arima Takahiro、Vivian Jay L.、Grundberg Elin、Soares Michael J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 10

    • DOI

      10.1073/pnas.2016517118

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome2020

    • Author(s)
      Cinkornpumin Jessica K.、Kwon Sin Young、Guo Yixin、Hossain Ishtiaque、Sirois Jacinthe、Russett Colleen S.、Tseng Hsin-Wei、Okae Hiroaki、Arima Takahiro、Duchaine Thomas F.、Liu Wanlu、Pastor William A.
    • Journal Title

      Stem Cell Reports

      Volume: 15 Issue: 1 Pages: 198-213

    • DOI

      10.1016/j.stemcr.2020.06.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts2020

    • Author(s)
      Jaju Bhattad Gargi、Jeyarajah Mariyan J.、McGill Megan G.、Dumeaux Vanessa、Okae Hiroaki、Arima Takahiro、Lajoie Patrick、B?rub? Nathalie G.、Renaud Stephen J.
    • Journal Title

      Cell Death & Disease

      Volume: 11 Issue: 5 Pages: 311-327

    • DOI

      10.1038/s41419-020-2500-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal?fetal exchange interface2020

    • Author(s)
      Bhattacharya Bhaswati、Home Pratik、Ganguly Avishek、Ray Soma、Ghosh Ananya、Islam Md. Rashedul、French Valerie、Marsh Courtney、Gunewardena Sumedha、Okae Hiroaki、Arima Takahiro、Paul Soumen
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 25 Pages: 14280-14291

    • DOI

      10.1073/pnas.1920201117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unique features and emerging in vitro models of human placental development.2020

    • Author(s)
      Shun Shibata, Eri H Kobayashi, Norio Kobayashi, Akira Oike, Hiroaki Okae, Takahiro Arima.
    • Journal Title

      Reprod Med Biol .

      Volume: 12 Issue: 4 Pages: 301-313

    • DOI

      10.1002/rmb2.12347

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells2020

    • Author(s)
      Castel G, Meistermann D, Bretin B, Firmin J, Blin J, Loubersac S, Bruneau A, Chevolleau S, Kilens S, Chariau C, Gaignerie A, Francheteau Q, Kagawa H, Charpentier E, Flippe L, Francois-Campion V, Haider S, Dietrich B, Knofler M, Arima T, Bourdon J, Rivron N, Masson D, Fournier T, Okae H, Freour T, David L
    • Journal Title

      Cell Reports

      Volume: 33 Issue: 8 Pages: 108419-108419

    • DOI

      10.1016/j.celrep.2020.108419

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] G protein subunit β1 is an important mediator of the late stage of endochondral ossification2020

    • Author(s)
      Ruengsinpinya Lerdluck、Murakami Tomohiko、Nakamura Eriko、Takahata Yoshifumi、Hata Kenji、Nakaminami Yuri、Okae Hiroaki、Nishimura Riko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 533 Issue: 1 Pages: 90-96

    • DOI

      10.1016/j.bbrc.2020.08.119

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of p57KIP2expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells2019

    • Author(s)
      Takahashi Sota、Okae Hiroaki、Kobayashi Norio、Kitamura Akane、Kumada Kanako、Yaegashi Nobuo、Arima Takahiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 52 Pages: 26606-26613

    • DOI

      10.1073/pnas.1916019116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒト栄養膜幹細胞を用いた胎盤研究2024

    • Author(s)
      岡江寛明
    • Organizer
      第4回 有性生殖学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 遺伝子機能にもとづくヒトとマウス胎盤の進化的対応関係の理解2023

    • Author(s)
      岡江寛明
    • Organizer
      第41回日本受精着床学会総会・学術講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Disease modeling with human trophoblast stem cells2023

    • Author(s)
      岡江寛明
    • Organizer
      The 18th International Symposium of the Institute Network for Biomedical Sciences
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 遺伝子からひも解くヒトとマウス胎盤の対応関係2023

    • Author(s)
      岡江寛明
    • Organizer
      第68回日本生殖医学会学術講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ヒトとマウス胎盤の対応関係の理解2023

    • Author(s)
      岡江寛明
    • Organizer
      新学術・全能性 第5回公開シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] Unlocking the mysteries of pregnancy with stem cells2023

    • Author(s)
      岡江寛明
    • Organizer
      熊本大学発生医学研究所セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human PSCs2023

    • Author(s)
      岡江寛明
    • Organizer
      IRCMS seminar "New Horizons in Developmental Biology"
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] C19MC confers differentiation potential into trophoblast lineages upon human PSCs2023

    • Author(s)
      岡江寛明
    • Organizer
      熊本大学発生医学研究所セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] C19MC is essential for the differentiation potential of hPSCs into trophoblast lineages2022

    • Author(s)
      岡江寛明
    • Organizer
      The 55th annual meeting of the Japanese Society of Developmental Biologists
    • Related Report
      2022 Annual Research Report
  • [Presentation] Critical role of genomic imprinting in human placental development2022

    • Author(s)
      岡江寛明
    • Organizer
      新学術・全能性 The International Symposium “Totipotency and Germ Cell Development”
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト胚着床モデル-母胎アセンブロイド-の開発2021

    • Author(s)
      柴田峻、岡江寛明、有馬隆博
    • Organizer
      ART FORUM’21 生殖の分子機構への新たなアプローチ
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生殖医学研究の最前線 進歩し続ける基礎研究2021

    • Author(s)
      岡江寛明、有馬隆博.
    • Organizer
      66th生殖医学会学術講演会・総会:シンポジウム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトES細胞からTS細胞への分化転換を阻害するエピジェネティックバリアの同定2021

    • Author(s)
      岡江寛明
    • Organizer
      AMED研究開発交流会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Modeling human placental development and disease with stem cells2021

    • Author(s)
      岡江寛明
    • Organizer
      第9回東北大学スマート・エイジング学際重点研究センター シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 分化全能性の消失に関わるインプリント遺伝子の同定2020

    • Author(s)
      岡江寛明、小林記緒、有馬隆博
    • Organizer
      日本繁殖生物学会第113回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Epigenetic restriction of human pluripotency by silencing of the chromosome 19 miRNA cluster2020

    • Author(s)
      岡江寛明
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 着床前胚に由来する幹細胞を用いた全能性の再構築2020

    • Author(s)
      岡江寛明
    • Organizer
      新学術領域研究「全能性プログラム」Webinar
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Identification of an epigenetic barrier between human embryonic and trophoblast stem cells2020

    • Author(s)
      岡江寛明
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ヒトES細胞からTS細胞への運命転換2020

    • Author(s)
      岡江寛明
    • Organizer
      新学術領域研究「配偶子インテグリティの構築」「全能性プログラム」合同公開シンポジウム2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] なぜ絨毛癌は稀なのか?ヒト栄養膜幹細胞を用いた胎盤の腫瘍化抑制機構の解析2019

    • Author(s)
      岡江 寛明
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト胚性幹細胞の栄養膜幹細胞への分化転換2019

    • Author(s)
      小林 記緒
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 雄核発生胚に由来するヒトTS細胞の樹立2019

    • Author(s)
      岡江 寛明
    • Organizer
      新学術領域キックオフシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Disease modeling with human trophoblast stem cells2019

    • Author(s)
      岡江 寛明
    • Organizer
      幹細胞・再生医学イノベーション創出プログラム 事業内交流会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒト胎盤異常のエピゲノム~全胞状奇胎の細胞特性の解析~2019

    • Author(s)
      有馬 隆博
    • Organizer
      日本人類遺伝学会第64回大会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 再生医療等に用いるヒト胎盤由来幹細胞の細胞特性の解明2019

    • Author(s)
      岡江 寛明
    • Organizer
      令和元年度AMED再生医療研究交流会
    • Related Report
      2019 Annual Research Report
  • [Book] ヒト胎盤発生と幹細胞2021

    • Author(s)
      柴田峻、岡江寛明、有馬隆博
    • Total Pages
      5
    • Publisher
      医学書院(金原出版)
    • Related Report
      2021 Annual Research Report
  • [Book] ヒト初期発生におけるエピジェネティクス2021

    • Author(s)
      岡江寛明、有馬隆博
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2021 Annual Research Report
  • [Book] トロホブラスト幹細胞と展開2021

    • Author(s)
      小林枝里、岡江寛明、有馬隆博
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2021 Annual Research Report
  • [Book] ヒトTS細胞を用いた胎盤疾患モデルの構築2021

    • Author(s)
      大池 輝, 小林 枝里, 小林 記緒, 柴田 峻, 岡江 寛明, 北村 茜, 宮内 尚子, 有馬 隆博
    • Total Pages
      5
    • Publisher
      北隆館/ニューサイエンス社
    • Related Report
      2021 Annual Research Report

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Published: 2019-07-04   Modified: 2025-01-30  

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