| Budget Amount *help |
¥82,940,000 (Direct Cost: ¥63,800,000、Indirect Cost: ¥19,140,000)
Fiscal Year 2023: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2022: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2021: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2020: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2019: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Outline of Final Research Achievements |
We reported several new findings related to the mechanism by which zinc transported by zinc transporters is supplied to and coordinated by target proteins. Specifically, we demonstrated that zinc transported by the early secretory pathway-resident ZNT5-6 and ZNT7 is supplied to the acid sphingomyelinase (Sphingomyelin Phosphodiesterase 1, SMPD1), GPI-anchored biosynthetic enzymes and tyrosinase-related protein 1 (TYRP1). We also elucidated the regulatory mechanism of the expression of the zinc transporter ZNT1, which is important for zinc efflux from the cells, and generated a model for the regulatory mechanism of zinc absorption conducted by ZNT1 in the intestinal epithelial cells. Furthermore, we found that manganese competes with zinc in animal cells and reported novel findings that excess manganese disrupts zinc metabolism in mammalian cells.
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