Gene networks regulating development of primordial germ cells
Project Area | The germline: its developmental cycle and epigenome network |
Project/Area Number |
20062001
|
Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
|
Research Institution | Tohoku University |
Principal Investigator |
MATSUI Yasuhisa (YASUHISA Matsui) 東北大学, 加齢医学研究所, 教授 (40241575)
|
Co-Investigator(Kenkyū-buntansha) |
NOCE Toshiaki 慶應義塾大学, 先導研究センター, 特任教授 (70183902)
岡村 大治 東北大学, 加齢医学研究所, 助教 (80393263)
前田 郁麻 東北大学, 加齢医学研究所, 助教 (20376560)
|
Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Daiji 東北大学, 加齢医学研究所, 助教 (80393263)
MAEDA Ikuma 東北大学, 加齢医学研究所, 助教 (20376560)
|
Project Period (FY) |
2008 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥129,000,000 (Direct Cost: ¥129,000,000)
Fiscal Year 2012: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2011: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2010: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2009: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2008: ¥25,800,000 (Direct Cost: ¥25,800,000)
|
Keywords | 始原生殖細胞 / エピジェネティクス / 遺伝子改変マウス / ES細胞 / siRNA / DNAメチル化 / 転写制御 / Vasa |
Research Abstract |
In this research project, we have found the following three points. (1) Transcription regulators REST and Larp7 positively control survival and proliferation of primordial germ cells (PGCs), respectively, in mouse embryos. (2) The expression of PGC-specific genes is controlled by DNA demethylation of their regulatory regions. (3) Transcription regulator Max represses the expression of germ cell-specific genes in ES cells.
|
Report
(7 results)
Research Products
(104 results)
-
[Journal Article] Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells2013
Author(s)
Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M, Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A, Matsui, Y
-
Journal Title
Nature Communications
Volume: 4
Issue: 1
Pages: 1754-1754
DOI
Related Report
Peer Reviewed
-
[Journal Article] High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice2013
Author(s)
Kobayashi, H., Sakurai, T., Miura, F., Imai, M., Mochizuki, K., Yanagisawa, E., Sakashita, A., Wakai, T., Suzuki, Y., Ito, T., Matsui ,Y., Kono, T
-
Journal Title
Genome Research
Volume: 23
Issue: 4
Pages: 616-627
DOI
Related Report
Peer Reviewed
-
[Journal Article] Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells2012
Author(s)
Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J. C. and Matsui, Y
-
Journal Title
Genes & Development
Volume: 26
Issue: 22
Pages: 2477-2482
DOI
Related Report
Peer Reviewed
-
[Journal Article] REST and its downstream molecule Mek5 regulate survival of primordial germ cells2012
Author(s)
Okamura, D., Mochizuki, K., Taniguchi, H., Tokitake, Y., Ikeda, M., Yamada, Y., Tournier, C., Yamaguchi, S., Tada, T., Scholer, H.R. and Matsui, Y
-
Journal Title
Developmental Biology
Volume: 372
Pages: 190-202
URL
Related Report
Peer Reviewed
-
[Journal Article] Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility2012
Author(s)
Flachs, P., Mihola, O., .ime.ek, P., Gregorova, S., Schimenti, J.C., Matsui, Y., Baudat, F., de Massy, B, Pialek, J., Forejt, J, and Trachtulec, Z
-
Journal Title
PLoS Genetics
Volume: 8
Issue: 11
Pages: e1003044-e1003044
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes2011
Author(s)
Imamura, M., Aoi, T., Tokumasu, A., Mise, N., Abe, K., Yamanaka, S., and Noce, T
-
Journal Title
Molecular Reproduction and Development
Volume: 77
Pages: 802-811
Related Report
Peer Reviewed
-
-
[Journal Article] MVH in piRNA Processing and Gene Silencing of Retrotransposons2010
Author(s)
S. Kuramochi-Miyagawa, T.Watanabe, K. Gotoh, K. Takamatsu, S. Chuma, K. Kojima-Kita, Y. Shiromoto, N. Asada, T. Kimura, N. Nakatsuji, T. Noce, H. Sasaki and T. Nakano
-
Journal Title
Gene & Development
Volume: 24
Pages: 887-892
Related Report
Peer Reviewed
-
[Journal Article] Induction of germ cell marker genes during differentiation of mouse induced pluripotent stem cells derived from adult hepatocytes.2010
Author(s)
Imamura, M., Aoi, T., Tokumasu, A., Mise, N., Abe, K., Yamanaka, S., Noce, T.
-
Journal Title
Mol.Reprod.Dev. 77
Pages: 802-811
Related Report
-
-
-
-
-
-
-
[Journal Article] Single Nucleotide Polymorphisms in PRDM9 (MEISETZ) in Patients with Nonobstructive Azoospermia2009
Author(s)
Irie, S., Tsujimura, A., Miyagawa, Y., Ueda, T., Matsuoka, Y., Matsui, Y., Okuyama, A., Nishimune, Y., and Tanaka, H
-
Journal Title
Journal of Andorology
Volume: 30
Issue: 4
Pages: 426-431
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Identification of commonly expressed transcripts both in the hematopoietic and germline stem cells niche2008
Author(s)
Mizukami, T, Kuramitsu, M, Takizawa, K, Momose, H, Mochizuki, M, Masumi, A, Naito, S, Iwama, A, Ogawa, T, Noce, T, Hamaguchi, I and Yamaguchi, K
-
Journal Title
Stem Cell and Development
Volume: 17
Pages: 67-80
Related Report
Peer Reviewed
-
[Journal Article] Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed by global expression profiling2008
Author(s)
Mise,N.,Fuchikami,T., Sugimoto,M., Kobayakawa,S., Ike,F., Ogawa,T., Tada, T., Kanaya,S., Noce, T. and Abe, K
-
Journal Title
Genes to Cells
Volume: 13
Pages: 863-877
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-