|Budget Amount *help
¥71,240,000 (Direct Cost: ¥54,800,000、Indirect Cost: ¥16,440,000)
Fiscal Year 2012: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2011: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2010: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2009: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
In recent years, improvement of culture technique is desired to achieve effective cellular differentiation of not only cell lines but also stem cells. However, cells are subj ected to various stresses when they attach the culture equipment. Accordingly, it is essential to design a new biointerface, which gives minimum or no damage to cells. In this study, we have fbcused on reactive oxygen species (ROS), which is generated by contact with culture substrates. Because excessively generated ROS tends to increase cellular activation, we designed surface coating materials, which scavenge ROS effectively. ROS-induced-differentiation of leukemic cells which contacted with our polymer surface was investigated in this study.