|Budget Amount *help
¥62,400,000 (Direct Cost: ¥48,000,000、Indirect Cost: ¥14,400,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2010: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2009: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
To consider cell-materials interaction, we studied to understand the initial cell adhesion behavior on the materials surface using quartz crystal microbalance with dissipation (QCM-D). The first phase of cell-material interactions is protein adsorption and after that cells start to attach, adhere and spread on the protein adsorption layer. A total series of the protein adsorption behavior and cell adhesion behavior on different material surfaces has been evaluated clearly by QCM-D.
The adhesion strength of cell-materials interface can be also evaluated by QCM-D. QCM-D is one of the analytical tools for evaluating the adhesive strength, which is an index of the interaction between cell and materials and is characterized by real time monitoring.